Data/hora: 13/06/2024 14:26:12

Biblioteca(s): | Embrapa Mandioca e Fruticultura.
Data corrente: | 25/11/2021
Data da última atualização: | 25/11/2021
Autoria: | MIRANDA, Í. K. S. P. B.; SANTANA, F. R.; CAMILLOTO, G. P.; DETONI, C. B.; SOUZA, F. V. D.; CABRAL-ALBUQUERQUE, E. C. de M.; ALVES, S. L.; NECO, G. L.; LIMA, F. O. de; ASSIS, S. A. de.
Afiliação: | ÍNGARA KEISLE SÃO PAULO BARRETTO MIRANDA, UEFS; FERNANDO ROCHA SANTANA, UEFS; GEANY PERUCH CAMILLOTO, UEFS; CASSIA BRITTO DETONI; FERNANDA VIDIGAL DUARTE SOUZA, CNPMF; ELAINE CHRISTINE DE MAGALHÃES CABRAL-ALBUQUERQUE, UFBA; SARA LIMA ALVES, UEFS; GLAUCIA LAIS NECO, UEFS; FLÁVIA OLIVEIRA DE LIMA, UEFS; SANDRA APARECIDA DE ASSIS.
Título: | Development of membranes based on carboxymethyl cellulose/acetylated arrowroot starch containing bromelain extract carried on nanoparticles and liposomes.
Ano de publicação: | 2021
Fonte/Imprenta: | Journal of Pharmaceutical Sciences, 2021.
ISSN: | 1520-6017
DOI: | 10.1016/j.xphs.2021.02.031
Idioma: | Inglês
Notas: | Online first.
Conteúdo: | Polymeric membranes have been used in several applications, including their use as curatives in cutaneous wounds. Bromelain has long been used for anti-inflammatory purposes, so the objective of this work was to produce carboxymethylcellulose-acetylated blends, incorporate bromelain, characterize the systems, compare the blends with bromelain loaded in nanoparticles and liposomes and, finally, to evaluate their healing potential. Four membrane formulations were produced by solvent evaporation: the control, membranes containing free bromelain, bromelain-loaded nanoparticles (NPs) and bromelain-loaded liposomes (LIPs). The enzyme concentration was the same for all formulations. Transparent, flexible and intact films were obtained. The membranes containing free bromelain, bromelain-loaded NPs and bromelain-loaded LIPs had higher water content, lower water vapor permeability and maximum tensile strength, and greater elongation at rupture. The capacity to absorb simulated exudate was higher in samples containing free bromelain, and bioadhesion was reduced in the presence of free bromelain compared to the control. An in vivo assay was performed to verify the membranes' healing potential. Histological analysis revealed no edema on the 14th day in animals treated with membranes containing bromelain-loaded NPs and LIPs.
Thesaurus Nal: | Carbon nanoparticles; Liposomes (artificial); Nanoparticles.
Categoria do assunto: | --
Registro original: | Embrapa Mandioca e Fruticultura (CNPMF)
Exemplares: | CNPMF - (33434-1) - UPC - AP - DD - Publicação digital -  -  - DIS