Data/hora: 28/05/2024 12:35:42

Biblioteca(s): 	Embrapa Amapá.	
Tipo da produção científica: 	Artigo em Periódico Indexado	
Circulação/Nível: 	A - 4	
Data corrente: 	27/12/2022	
Data da última atualização: 	28/12/2022	
Autoria: 	ÇIÇEK, S. S.; BARBOSA, A. L. P.; WENZEL-STORJOHANN, A.; SEGOVIA, J. F. O.; BEZERRA, R. M.; SÖNNICHSEN, F.; ZIDORN, C.; KANZAKI, I.; TASDEMIR, D.	
Afiliação: 	SERHAT SEZAI ÇIÇEK, CHRISTIAN-ALBRECHTS-UNIVERSITÄT ZU KIEL; ANNA LAÍS PFEIFER BARBOSA, CHRISTIAN-ALBRECHTS-UNIVERSITÄT ZU KIEL; ARLETTE WENZEL-STORJOHANN, GEOMAR HELMHOLTZ-ZENTRUM FÜR OZEANFORSCHUNG KIEL; JORGE FEDERICO ORELLANA SEGOVIA, CPAF-AP; ROBERTO MESSIAS BEZERRA, UNIVERSIDADE FEDERAL DO AMAPÁ; FRANK SÖNNICHSEN, CHRISTIAN-ALBRECHTS-UNIVERSITÄT ZU KIEL; CHRISTIAN ZIDORN, CHRISTIAN-ALBRECHTS-UNIVERSITÄT ZU KIEL; ISAMU KANZAKI, UNIVERSIDADE DE BRASÍLIA; DENIZ TASDEMIR, GEOMAR HELMHOLTZ-ZENTRUM FÜR OZEANFORSCHUNG KIEL.	
Título: 	Chemical and biological evaluation of Amazonian medicinal plant Vouacapoua americana Aubl.	
Ano de publicação: 	2023	
Fonte/Imprenta: 	Plants, v. 12, n. 1, 99, 2023.	
DOI: 	https://doi.org/10.3390/plants12010099	
Idioma: 	Inglês	
Conteúdo: 	Vouacapoua americana (Fabaceae) is an economically important tree in the Amazon region and used for its highly resistant heartwood as well as for medicinal purposes. Despite its frequent use, phytochemical investigations have been limited and rather focused on ecological properties than on its pharmacological potential. In this study, we investigated the phytochemistry and bioactivity of V. americana stem bark extract and its constituents to identify eventual lead structures forfurther drug development. Applying hydrodistillation and subsequent GC-MS analysis, we investigated the composition of the essential oil and identified the 15 most abundant components. Moreover, the diterpenoids deacetylchagresnone (1), cassa-13(14),15-dien-oic acid (2), isoneocaesalpin H (3), (+)-vouacapenic acid (4), and (+)-methyl vouacapenate (5) were isolated from the stem bark, with compounds 2 and 4 showing pronounced effects on Methicillin-resistant Staphylococcus aureus and Enterococcus faecium, respectively. During the structure elucidation of deacetylchagresnone (1), which was isolated from a natural source for the first time, we detected inconsistencies regarding the configuration of the cyclopropane ring. Thus, the structure was revised for both deacetylchagresnone (1) and the previously isolated chagresnone. Following our works on Copaifera reticulata and Vatairea guianensis, the results of this study further contribute to the knowledge of Amazonian medicinal plants.	
Thesagro: 	Acapu.	
Thesaurus Nal: 	Antibacterial plants; Caesalpinioideae; Cytotoxicity.	
Categoria do assunto: 	--	
URL: 	http://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1150380/1/CPAFAP-ChemicalBiologicalEvaluation.pdf	
Registro original: 	Embrapa Amapá (CPAF-AP)	
Exemplares: 	CPAF-AP - (18561-1) - UPC - AP - DD -  -  -  - DIS