Data/hora: 25/06/2024 06:25:52

Biblioteca(s): | Embrapa Cerrados.
Data corrente: | 04/02/2010
Data da última atualização: | 04/02/2010
Autoria: | SARDINA, M. T.; ROSA, A. J. de M.; BRAGLIA, S.; SCOTTI, E.; PORTOLANO, B.
Afiliação: | MARIA TERESA SARDINA, UNIVERSITÁ DI PALERMO; ARTUR JORDÃO DE MAGALHÃES ROSA, CPAC; SILVIA BRAGLIA, UNIVERSITÁ DI BOLOGNA; EMILIO SCOTTI, UNIVERSITÁ DI BOLOGNA; BALDASSARE PORTOLANO, UNIVERSITÁ DI PALERMO.
Título: | Identification of SNPs in the promoter of ?-lactoglobulin gene in three Sicilian goat breeds.
Ano de publicação: | 2009
Fonte/Imprenta: | Italian Journal of Animal Science, v. 8 (Suplemento 2), p. 147-149, 2009.
Idioma: | Inglês
Conteúdo: | The aim of this work was to sequence the full-lenght promoter region of the caprine ?-lactoglobulin (?-lg) gene in three Sicilian goat breeds (Girgentana, Maltese and Derivata do Siria), in order to identify polymorphisms, to search for transcription factors (TFs) sites, and to check if polymorphisms found lay within TFs binding sites. The promoter region of ?-lg gene in Sicilian goat breeds showed high level of polymorphism due to the presence of 31 SNPs. Binding sites for several TFs werw found within the goat ?-lg promoter and within the goat ?-lg promoter and within regions conserved between ovine and caprine species. Two SNPs were detected within TFs binding sites, such as MPBF and NF-1. Further studies are in progress to confirm polymophic sites, to evaluate the possible effect of these mutations on binding affinity of TFs, their relationship with ?-lg gene expression, and functional role of SNPs within the TFs sites of the promoter region on milk traits.
Palavras-Chave: | Beta-Lactoglobulina; SNPs.
Thesagro: | Cabra; Caprino.
Categoria do assunto: | --
Registro original: | Embrapa Cerrados (CPAC)
Exemplares: | CPAC - (31150-1) - UPC - SP - PP - S1286 -  - S1286 - DIS