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| Registros recuperados : 92 | |
| 41. |  | VALENTE, M. S. F.; CHAVES, F. C. M.; LOPES, M. T. G.; OKA, J. M.; RODRIGUES, R. A. F. Crop yield, genetic parameter estimation and selection of sacha inchi in central Amazon. Pesquisa Agropecuária Tropical, Goiânia, v. 47, n. 2, p. 226-236, Apr./Jun. 2017.| Biblioteca(s): Embrapa Amazônia Ocidental. |
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| 42. | | RODRIGUES, R. A.; OLIVEIRA, L. T. S.; SILVA, V. K.; KIMPARA, J. M.; ARAUJO, C. R. de. Efeito do uso de farinha de feijão-caupi no desenvolvimento e reprodução de Tenebrio molitor (L.) (Coleoptera: Tenebrionidae). In: JORNADA DE INICIAÇÃO CIENTÍFICA DA EMBRAPA MEIO-NORTE, 3., 2017, Teresina, PI. Anais da III Jornada Científica da Embrapa Meio-Norte. Teresina: Embrapa Meio-Norte, 2017. p. 52.| Biblioteca(s): Embrapa Meio-Norte. |
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| 43. | | BORGHI, E.; WILDA, L. R. M.; RESENDE, A. V. de; PEREIRA FILHO, I. A.; RODRIGUES, R. A. L. Índice de vegetação, teor de clorofila e eficiência de uso de nitrogênio por híbridos de milho. In: CONGRESSO NACIONAL DE MILHO E SORGO, 31., 2016, Bento Gonçalves. Milho e sorgo: inovações, mercados e segurança alimentar: anais. Sete Lagoas: Associação Brasileira de Milho e Sorgo, 2016.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 44. | | SILVA, M. G. da S.; ARF, O.; Sá, M. E. de; RODRIGUES, R. A. F.; BRUZETTI, S. Manejo do solo e adubação nitrogenada em feijoeiro de inverno Sci. Agric. (Piracicaba, Braz.), v.61, n.3, p.307-312, May/June 2004| Biblioteca(s): Embrapa Rondônia. |
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| 45. | | SARTI, E. C. F. B.; RODRIGUES, R. A.; DUARTE, L. F. C.; BACANELLI, G. M.; LILENBAUM, W.; ARAUJO, F. R. Detection of Potentially Pathogenic Non-Tuberculous Mycobacteria in Artisanal Coalho Cheese from the State of Paraiba, Northeast Brazil. Mycobacterial Diseases, v. 8, n. 3, 2018| Biblioteca(s): Embrapa Gado de Corte. |
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| 46. | | COSTA, R. B. da; RODRIGUES, R. A.; MARTINS, W. J.; OLIVEIRA, L. C. S. de; ARRUDA, E. J. de. Avaliação genética de progênies de seringueira: subsídios para estabelecimento de SAF's em área de assentamento rural no Município de Dois Irmãos do Buriti, MS. In: CONGRESSO BRASILEIRO DE SISTEMAS AGROFLORESTAIS, 5., 2004, Curitiba. SAFs: desenvolvimento com proteção ambiental: anais. Colombo: Embrapa Florestas, 2004. p. 277-279. (Embrapa Florestas. Documentos, 98).| Biblioteca(s): Embrapa Florestas. |
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| 47. | | TOSI, H.; RODRIGUES, R. A.; JOBIM, C. C.; OLIVEIRA, M. S.; SAMPAIO, A. A. M.; ROSAS, B. Avaliacao da ensilagem do capim-elefante Anao (Pennisetum purpureum Schum) cv Mott, sob diferentes tratamentos. In: REUNIAO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 32., 1995, Brasilia. Anais... Brasilia: SBZ, 1995. p.264-266| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 49. | | OLIVEIRA, P. R. de; ANHOLETO, L. A.; RODRIGUES, R. A. F.; BECHARA, G. H.; CASTRO, K. N. de C.; MATHIAS, M. I. C. The potential of Acmella oleracea (Jambu) extract in the control of semi-engorged Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae) female ticks. International Journal of Acarology, v. 44, n. 4-5, p. 192-197, 2018. Published online: 04 Jun. 2018.| Biblioteca(s): Embrapa Meio-Norte. |
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| 51. | | ANHOLETO, L. A.; CAMARGO-MATHIAS, M. I.; OLIVEIRA, P. R. de; RODRIGUES, R. A. F.; LABRUNA, M. B.; PIZANO, M. A.; CASTRO, K. N. de C. Potential action of extract of Acmella oleracea (L.) R. K. Jansen to control Amblyomma cajennense (Fabricius, 1787) (Acari: Ixodidae) ticks. In: CONGRESO LATINOAMERICANO DE ACAROLOGÍA, 2., 2016, Montenegro, Quindío, Colombia. Proceedings... Colombia: Sociedad Latinoamericana de Acarologia, 2016. Publicación electrónica. p. 45. IICLAc. v. 2.| Biblioteca(s): Embrapa Meio-Norte. |
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| 52. | | ANHOLETO, L. A.; OLIVEIRA, P. R. de; RODRIGUES, R. A. F.; SPINDOLA, C. S.; LABRUNA, M. B.; PIZANO, M. A.; CASTRO, K. N. C.; CAMARGO-MARTINS, M. I. Potential action of extract of Acmella oleracea (L.) R.K. Jansen to control Amblyomma cajennense (Fabricius, 1787) (Acari: Ixodidae) ticks. Ticks and Tick-borne Diseases, 8, 2017. p. 65-72| Biblioteca(s): Embrapa Meio Norte / UEP-Parnaíba. |
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| 53. | | CHAVES, F. C. M.; SILVA, E. S. da; LOPES, M. T. G.; VALENTE, M. S. F.; RODRIGUES, R. A. F.; RODRIGUES, H. S. Plukenetia volubilis: amendoim-amazônico. In: CORADIN, L.; CAMILLO, J.; VIEIRA, I. C. G. (ed.). Espécies nativas da flora brasileira de valor econômico atual ou potencial: plantas para o futuro: região Norte. Brasília, DF: MMA, 2022. p. 1261-1268. (Série Biodiversidade, 53).| Biblioteca(s): Embrapa Amazônia Ocidental. |
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| 57. | | LEAL, S. T.; TARSITANO, M. A. A.; GOES, R. J.; TAKASU, A. T.; RODRIGUES, R. A. F.; ARF, O.; ROSSETTO, J. E.; LEAL, C. T. Análise econômica da produção de sorgo na safrinha com diferente fontes de nitrogenio em cobertura. Revista Brasileira de Milho e Sorgo, Sete Lagoas, v. 12, n. 2, p. 85-91, 2013.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 58. | | SCIVITTARO, W. B.; JARDIM, T. M.; GUEVARA, M, D. F.; BARROS, L. M.; RODRIGUES, R. A.; SOUSA, R. O. de; CASTILHOS, R. M. V. Annual methane emissions of production systems in lowlands of Rio Grande do Sul. In: WORLD CONGRESS OF SOIL SCIENCE, 21., 2018, Rio de Janeiro. Soil science: beyond food and fuel: proceedings. Rio de Janeiro: SBCS, 2018.| Biblioteca(s): Embrapa Clima Temperado. |
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| 59. | | SCIVITTARO, W. B.; FARIAS, M. de O.; JARDIM, T. M.; BARROS, L. M.; RODRIGUES, R. A.; GUEVARA, M. D. F.; SOUSA, R. O. de; BAYER, C. Emissões de gases de efeito estufa em terras baixas cultivada e sob condição natural. In: CONGRESSO BRASILEIRO DE ARROZ IRRIGADO, 10., 2017, Gramado. Intensificação sustentável: anais. Gramado: Sosbai, 2017.| Biblioteca(s): Embrapa Clima Temperado. |
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| 60. | | ANHOLETO, L. A.; CAMARGO-MATHIAS, M. I.; OLIVEIRA, P. R.; RODRIGUES, R. A. F.; YAMANE, L. T.; CASTRO, K. N. de C. Toxic action of Acmella oleracea extract on the Amblyomma cajennense (Acari: ixodidae) male reproductive system. In: CONGRESSO LATINOAMERICANO DE ACAROLOGIA, 3.; SIMPÓSIO BRASILEIRO DE ACAROLOGIA, 6., 2018, Pirenopólis. Acarologia para saúde pública. [Brasília, DF]: Embrapa: UNB; [Goiânia]: UFG, 2018. CLAC/SIBAC, 2018.| Biblioteca(s): Embrapa Meio-Norte. |
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| Registros recuperados : 92 | |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Agroindústria Tropical; Embrapa Gado de Leite; Embrapa Instrumentação; Embrapa Pecuária Sudeste. |
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Data corrente: |
25/01/2024 |
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Data da última atualização: |
11/04/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
ANHOLETO, L. A.; BRANCAGLION, G. A.; SANTOS, D. M. DOS; KAPRITCHKOFF, R. T. I.; CASTRO, K. N. de C.; CANUTO, K. M.; RODRIGUES, R. A. F.; CORREA, D. S.; CHAGAS, A. C. de S.; PASTRE, J. C. |
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Afiliação: |
LUIS ADRIANO ANHOLETO; GUILHERME ANDRADE BRANCAGLION, UNIVERSIDADE DE CAMPINAS; DANILO MARTINS DOS SANTOS; RAFAELA TAMI IKEDA KAPRITCHKOFF, UNIVERSIDADE DE SÃO PAULO; KARINA NEOOB DE CARVALHO CASTRO, CNPGL; KIRLEY MARQUES CANUTO, CNPAT; RODNEY ALEXANDRE FERREIRA RODRIGUES, UNIVERSIDADE DE CAMPINAS; DANIEL SOUZA CORREA, CNPDIA; ANA CAROLINA DE SOUZA CHAGAS, CPPSE; JULIO CEZAR PASTRE, UNIVERSIDADE DE CAMPINAS. |
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Título: |
Acaricidal activity of synthetic spilanthol derivative against ticks of medical and veterinary importance. |
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Ano de publicação: |
2024 |
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Fonte/Imprenta: |
Veterinary Parasitology, v. 327, Apr. 2024, 110137. |
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Páginas: |
9 p. |
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DOI: |
10.1016/j.vetpar.2024.110137 |
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Idioma: |
Inglês |
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Conteúdo: |
The ANESPSAT, a synthetic spilanthol derivative, and its nanoformulation were evaluated against Rhipicephalus microplus and Amblyomma sculptum ticks. ANESPSAT activity was compared with spilanthol and derivatives (ANESPE and others). The compound was synthesized in a gram-scale by a 2-step process, comprising a direct ester amidation and a Horner-Wadsworth- Emmons reaction. The nanoemulsions were produced by coarse homogenization followed by high-energy ultrasonication, in which hydrodynamic diameter, polydispersity index, and zeta potential remained stable. The spilanthol-eugenol hybrid derivatives did not show significant acaricidal activity. ANESPE killed 83% of the R. microplus larvae at 30 mg.mL−1, while ANESPSAT killed 97% at 0.5 mg.mL−1, showing to be the most active compound. Spilanthol and ANESPSAT had similar high mortality rates for tick larvae, with LC50 values of 0.10 and 0.14 mg.mL−1 for R. microplus larvae, and 0.04 and 0.48 mg.mL−1 for A. sculptum larvae, respectively. The efficacy of spilanthol was lower against R. microplus engorged females when compared with ANESPSAT, which was highly effective (>98%) against R. microplus engorged females. The nanoemulsion with ANESPSAT was effective against tick females, preventing egg laying and achieving 100% efficacy at 2.5 mg.mL−1. Spilanthol had only 59% efficacy at 10 mg.mL−1. The results suggest that ANESPSAT, a natural product derivative, could be used in novel formulations for tick management that might be safer and environmentally friendly. MenosThe ANESPSAT, a synthetic spilanthol derivative, and its nanoformulation were evaluated against Rhipicephalus microplus and Amblyomma sculptum ticks. ANESPSAT activity was compared with spilanthol and derivatives (ANESPE and others). The compound was synthesized in a gram-scale by a 2-step process, comprising a direct ester amidation and a Horner-Wadsworth- Emmons reaction. The nanoemulsions were produced by coarse homogenization followed by high-energy ultrasonication, in which hydrodynamic diameter, polydispersity index, and zeta potential remained stable. The spilanthol-eugenol hybrid derivatives did not show significant acaricidal activity. ANESPE killed 83% of the R. microplus larvae at 30 mg.mL−1, while ANESPSAT killed 97% at 0.5 mg.mL−1, showing to be the most active compound. Spilanthol and ANESPSAT had similar high mortality rates for tick larvae, with LC50 values of 0.10 and 0.14 mg.mL−1 for R. microplus larvae, and 0.04 and 0.48 mg.mL−1 for A. sculptum larvae, respectively. The efficacy of spilanthol was lower against R. microplus engorged females when compared with ANESPSAT, which was highly effective (>98%) against R. microplus engorged females. The nanoemulsion with ANESPSAT was effective against tick females, preventing egg laying and achieving 100% efficacy at 2.5 mg.mL−1. Spilanthol had only 59% efficacy at 10 mg.mL−1. The results suggest that ANESPSAT, a natural product derivative, could be used in novel formulations for tick management that might be safer ... Mostrar Tudo |
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Palavras-Chave: |
Acmella oleracea; Bovine parasite sadness; Brazilian Spotted Fever; Cattle tick; Control; Nanoformulation; Spilanthol. |
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Thesagro: |
Bovino; Carrapato. |
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Thesaurus NAL: |
Rickettsia rickettsii. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 02636naa a2200373 a 4500
001 2161314
005 2024-04-11
008 2024 bl uuuu u00u1 u #d
024 7 $a10.1016/j.vetpar.2024.110137$2DOI
100 1 $aANHOLETO, L. A.
245 $aAcaricidal activity of synthetic spilanthol derivative against ticks of medical and veterinary importance.$h[electronic resource]
260 $c2024
300 $a9 p.
520 $aThe ANESPSAT, a synthetic spilanthol derivative, and its nanoformulation were evaluated against Rhipicephalus microplus and Amblyomma sculptum ticks. ANESPSAT activity was compared with spilanthol and derivatives (ANESPE and others). The compound was synthesized in a gram-scale by a 2-step process, comprising a direct ester amidation and a Horner-Wadsworth- Emmons reaction. The nanoemulsions were produced by coarse homogenization followed by high-energy ultrasonication, in which hydrodynamic diameter, polydispersity index, and zeta potential remained stable. The spilanthol-eugenol hybrid derivatives did not show significant acaricidal activity. ANESPE killed 83% of the R. microplus larvae at 30 mg.mL−1, while ANESPSAT killed 97% at 0.5 mg.mL−1, showing to be the most active compound. Spilanthol and ANESPSAT had similar high mortality rates for tick larvae, with LC50 values of 0.10 and 0.14 mg.mL−1 for R. microplus larvae, and 0.04 and 0.48 mg.mL−1 for A. sculptum larvae, respectively. The efficacy of spilanthol was lower against R. microplus engorged females when compared with ANESPSAT, which was highly effective (>98%) against R. microplus engorged females. The nanoemulsion with ANESPSAT was effective against tick females, preventing egg laying and achieving 100% efficacy at 2.5 mg.mL−1. Spilanthol had only 59% efficacy at 10 mg.mL−1. The results suggest that ANESPSAT, a natural product derivative, could be used in novel formulations for tick management that might be safer and environmentally friendly.
650 $aRickettsia rickettsii
650 $aBovino
650 $aCarrapato
653 $aAcmella oleracea
653 $aBovine parasite sadness
653 $aBrazilian Spotted Fever
653 $aCattle tick
653 $aControl
653 $aNanoformulation
653 $aSpilanthol
700 1 $aBRANCAGLION, G. A.
700 1 $aSANTOS, D. M. DOS
700 1 $aKAPRITCHKOFF, R. T. I.
700 1 $aCASTRO, K. N. de C.
700 1 $aCANUTO, K. M.
700 1 $aRODRIGUES, R. A. F.
700 1 $aCORREA, D. S.
700 1 $aCHAGAS, A. C. de S.
700 1 $aPASTRE, J. C.
773 $tVeterinary Parasitology$gv. 327, Apr. 2024, 110137.
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Embrapa Agroindústria Tropical (CNPAT) |
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