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Registro Completo |
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Biblioteca(s): |
Embrapa Agroindústria Tropical. |
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Data corrente: |
09/01/2020 |
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Data da última atualização: |
16/01/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CASTRO, C. B. DE; LUZ, L. DOS R.; GUEDES, J. A. C.; PORTO, D. D.; SILVA, M. F. S.; SILVA, G. S. DA; RIBEIRO, P. R. V.; CANUTO, K. M.; BRITO, E. S. de; ZAMPIERI, D. DE S.; Ó, C. DO; ZOCOLO, G. J. |
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Afiliação: |
CAIO BEZERRA DE CASTRO, Departamento de Química, Universidade Federal de São Carlos; LICIA DOS REIS LUZ, Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará; JHONYSON ARRUDA CARVALHO GUEDES, Embrapa Agroindústria Tropical; DIOGO DENARDI PORTO, CPATSA; MARIA FRANCILENE SOUZA SILVA, Núcleo de Pesquisa e Desenvolvimento de Medicamentos (NPDM), Universidade Federal do Ceará; GISELE SILVESTRE DA SILVA, Embrapa Agroindústria Tropical; PAULO RICELI VASCONCELOS RIBEIRO, CNPAT; KIRLEY MARQUES CANUTO, CNPAT; EDY SOUSA DE BRITO, CNPAT; DÁVILA DE SOUZA ZAMPIERI, Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará; CLÁUDIA DO Ó, Núcleo de Pesquisa e Desenvolvimento de Medicamentos (NPDM), Universidade Federal do Ceará; GUILHERME JULIAO ZOCOLO, CNPAT. |
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Título: |
Metabolomics-based discovery of biomarkers with cytotoxic potential in extracts of Myracrodruon urundeuva. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Journal of the Brazilian Chemical Society, v. 31,n. 4, p. 775-787, 2020. |
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DOI: |
http://dx.doi.org/10.21577/0103-5053.20190242 |
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Idioma: |
Inglês |
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Palavras-Chave: |
Atividade citotóxica; Cytotoxic activity; Dereplication; Desreplicação; Hemometrics; Quimiometria; UPLC-MS/MS. |
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Thesagro: |
Myracrodruon Urundeuva. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01080naa a2200349 a 4500
001 2118419
005 2023-01-16
008 2020 bl uuuu u00u1 u #d
024 7 $ahttp://dx.doi.org/10.21577/0103-5053.20190242$2DOI
100 1 $aCASTRO, C. B. DE
245 $aMetabolomics-based discovery of biomarkers with cytotoxic potential in extracts of Myracrodruon urundeuva.$h[electronic resource]
260 $c2020
650 $aMyracrodruon Urundeuva
653 $aAtividade citotóxica
653 $aCytotoxic activity
653 $aDereplication
653 $aDesreplicação
653 $aHemometrics
653 $aQuimiometria
653 $aUPLC-MS/MS
700 1 $aLUZ, L. DOS R.
700 1 $aGUEDES, J. A. C.
700 1 $aPORTO, D. D.
700 1 $aSILVA, M. F. S.
700 1 $aSILVA, G. S. DA
700 1 $aRIBEIRO, P. R. V.
700 1 $aCANUTO, K. M.
700 1 $aBRITO, E. S. de
700 1 $aZAMPIERI, D. DE S.
700 1 $aÓ, C. DO
700 1 $aZOCOLO, G. J.
773 $tJournal of the Brazilian Chemical Society$gv. 31,n. 4, p. 775-787, 2020.
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Registro original: |
Embrapa Agroindústria Tropical (CNPAT) |
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Registro Completo
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Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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Data corrente: |
16/08/2021 |
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Data da última atualização: |
17/08/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
BRUSCADIN, J. J.; SOUZA, M. M. de; OLIVEIRA, K. S. de; ROCHA, M. I. P.; AFONSO, J.; CARDOSO, T. F.; ZERLOTINI NETO, A.; COUTINHO, L. L.; NICIURA, S. C. M.; REGITANO, L. C. de A. |
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Afiliação: |
JENNIFER JESSICA BRUSCADIN, UFSCAR; MARCELA MARIA DE SOUZA, IOWA STATE UNIVERSITY; KARINA SANTOS DE OLIVEIRA, UFSCAR; MARINA IBELLI PEREIRA ROCHA, UFSCAR; JULIANA AFONSO, ESALQ/USP; TAINÃ FIGUEIREDO CARDOSO; ADHEMAR ZERLOTINI NETO, CNPTIA; LUIZ LEHMANN COUTINHO, ESALQ/USP; SIMONE CRISTINA MEO NICIURA, CPPSE; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
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Título: |
Muscle allele-specific expression QTLs may affect meat quality traits in Bos indicus. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Scientific Reports, v. 11, p. 1-14, 2021. |
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DOI: |
https://doi.org/10.1038/s41598-021-86782-2 |
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Idioma: |
Inglês |
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Notas: |
Article number: 7321. |
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Conteúdo: |
Abstract. Single nucleotide polymorphisms (SNPs) located in transcript sequences showing allele-specific expression (ASE SNPs) were previously identified in the Longissimus thoracis muscle of a Nelore (Bos indicus) population consisting of 190 steers. Given that the allele-specific expression pattern may result from cis-regulatory SNPs, called allele-specific expression quantitative trait loci (aseQTLs), in this study, we searched for aseQTLs in a window of 1 Mb upstream and downstream from each ASE SNP. After this initial analysis, aiming to investigate variants with a potential regulatory role, we further screened our aseQTL data for sequence similarity with transcription factor binding sites and microRNA (miRNA) binding sites. These aseQTLs were overlapped with methylation data from reduced representation bisulfite sequencing (RRBS) obtained from 12 animals of the same population. We identified 1134 aseQTLs associated with 126 different ASE SNPs. For 215 aseQTLs, one allele potentially affected the affinity of a muscle-expressed transcription factor to its binding site. 162 aseQTLs were predicted to affect 149 miRNA binding sites, from which 114 miRNAs were expressed in muscle. Also, 16 aseQTLs were methylated in our population. Integration of aseQTL with GWAS data revealed enrichment for traits such as meat tenderness, ribeye area, and intramuscular fat . To our knowledge, this is the first report of aseQTLs identification in bovine muscle. Our findings indicate that various cis-regulatory and epigenetic mechanisms can affect multiple variants to modulate the allelic expression. Some of the potential regulatory variants described here were associated with the expression pattern of genes related to interesting phenotypes for livestock. Thus, these variants might be useful for the comprehension of the genetic control of these phenotypes. MenosAbstract. Single nucleotide polymorphisms (SNPs) located in transcript sequences showing allele-specific expression (ASE SNPs) were previously identified in the Longissimus thoracis muscle of a Nelore (Bos indicus) population consisting of 190 steers. Given that the allele-specific expression pattern may result from cis-regulatory SNPs, called allele-specific expression quantitative trait loci (aseQTLs), in this study, we searched for aseQTLs in a window of 1 Mb upstream and downstream from each ASE SNP. After this initial analysis, aiming to investigate variants with a potential regulatory role, we further screened our aseQTL data for sequence similarity with transcription factor binding sites and microRNA (miRNA) binding sites. These aseQTLs were overlapped with methylation data from reduced representation bisulfite sequencing (RRBS) obtained from 12 animals of the same population. We identified 1134 aseQTLs associated with 126 different ASE SNPs. For 215 aseQTLs, one allele potentially affected the affinity of a muscle-expressed transcription factor to its binding site. 162 aseQTLs were predicted to affect 149 miRNA binding sites, from which 114 miRNAs were expressed in muscle. Also, 16 aseQTLs were methylated in our population. Integration of aseQTL with GWAS data revealed enrichment for traits such as meat tenderness, ribeye area, and intramuscular fat . To our knowledge, this is the first report of aseQTLs identification in bovine muscle. Our findings indicate that var... Mostrar Tudo |
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Palavras-Chave: |
Allele-specific expression; Allelic expression; Expressão alélica; Imprint genômico; Loci de característica quantitativa; Polimorfismo de nucleotídeo único. |
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Thesagro: |
Bos Indicus; Gado Nelore. |
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Thesaurus NAL: |
Genomic imprinting; Quantitative trait loci; Single nucleotide polymorphism. |
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Categoria do assunto: |
--
G Melhoramento Genético |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/225232/1/MuscleAlleleSpecific.pdf
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Marc: |
LEADER 03076naa a2200385 a 4500
001 2133623
005 2021-08-17
008 2021 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1038/s41598-021-86782-2$2DOI
100 1 $aBRUSCADIN, J. J.
245 $aMuscle allele-specific expression QTLs may affect meat quality traits in Bos indicus.$h[electronic resource]
260 $c2021
500 $aArticle number: 7321.
520 $aAbstract. Single nucleotide polymorphisms (SNPs) located in transcript sequences showing allele-specific expression (ASE SNPs) were previously identified in the Longissimus thoracis muscle of a Nelore (Bos indicus) population consisting of 190 steers. Given that the allele-specific expression pattern may result from cis-regulatory SNPs, called allele-specific expression quantitative trait loci (aseQTLs), in this study, we searched for aseQTLs in a window of 1 Mb upstream and downstream from each ASE SNP. After this initial analysis, aiming to investigate variants with a potential regulatory role, we further screened our aseQTL data for sequence similarity with transcription factor binding sites and microRNA (miRNA) binding sites. These aseQTLs were overlapped with methylation data from reduced representation bisulfite sequencing (RRBS) obtained from 12 animals of the same population. We identified 1134 aseQTLs associated with 126 different ASE SNPs. For 215 aseQTLs, one allele potentially affected the affinity of a muscle-expressed transcription factor to its binding site. 162 aseQTLs were predicted to affect 149 miRNA binding sites, from which 114 miRNAs were expressed in muscle. Also, 16 aseQTLs were methylated in our population. Integration of aseQTL with GWAS data revealed enrichment for traits such as meat tenderness, ribeye area, and intramuscular fat . To our knowledge, this is the first report of aseQTLs identification in bovine muscle. Our findings indicate that various cis-regulatory and epigenetic mechanisms can affect multiple variants to modulate the allelic expression. Some of the potential regulatory variants described here were associated with the expression pattern of genes related to interesting phenotypes for livestock. Thus, these variants might be useful for the comprehension of the genetic control of these phenotypes.
650 $aGenomic imprinting
650 $aQuantitative trait loci
650 $aSingle nucleotide polymorphism
650 $aBos Indicus
650 $aGado Nelore
653 $aAllele-specific expression
653 $aAllelic expression
653 $aExpressão alélica
653 $aImprint genômico
653 $aLoci de característica quantitativa
653 $aPolimorfismo de nucleotídeo único
700 1 $aSOUZA, M. M. de
700 1 $aOLIVEIRA, K. S. de
700 1 $aROCHA, M. I. P.
700 1 $aAFONSO, J.
700 1 $aCARDOSO, T. F.
700 1 $aZERLOTINI NETO, A.
700 1 $aCOUTINHO, L. L.
700 1 $aNICIURA, S. C. M.
700 1 $aREGITANO, L. C. de A.
773 $tScientific Reports$gv. 11, p. 1-14, 2021.
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Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
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