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Registro Completo |
Biblioteca(s): |
Embrapa Amazônia Ocidental. |
Data corrente: |
02/12/2008 |
Data da última atualização: |
15/05/2018 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
PINTO, A. C. S.; SILVA, L. F. R. e; CAVALCANTI, B. C.; MELO, M. R. S.; CHAVES, F. C. M.; LOTUFO, L. V. C.; MORAIS, M. O. de; ANDRADE-NETO, V. F.; TADEI, W. P.; PESSOA, C. O.; VIEIRA, P. P. R.; POHLIT, A. M. |
Afiliação: |
Ana Cristina da Silva Pinto, UFAM; Luis Francisco Rocha e Silva, FMTAM; Bruno Coelho Cavalcanti, UFCE; Márcia Rúbia Silva Melo, INPA; FRANCISCO CELIO MAIA CHAVES, CPAA; Letícia Vera Costa Lotufo, UFCE; Manoel Odorico de Moraes, UFCE; Valter Ferreira de Andrade-Neto, Universidade Federal do Rio Grande do Norte; Wanderli Pedro Tadei, INPA; Claudia O. Pessoa, UFCE; Pedro Paulo Ribeiro Vieira, FMTAM; Adrian Martin Pohlit, INPA. |
Título: |
New antimalarial and cytotoxic 4-nerolidylcatechol derivatives. |
Ano de publicação: |
2009 |
Fonte/Imprenta: |
European Journal of Medicinal Chemistry, v. 44, n. 6, p. 2731-2735, June 2009. |
DOI: |
10.1016/j.ejmech.2008.10.025 |
Idioma: |
Inglês |
Conteúdo: |
4-nerolidylcatechol (1) was isolated from cultivated Pothomorphe peltata root on a multi-gram scale using straight-forward solvent extraction-column chromatography. New semisynthetic derivatives of 1 were prepared and tested in vitro against multidrug-resistant Plasmodium falciparum K1 strain. Mono-O-methyl, mono-O-benzyl, O,O-dibenzyl and O,Odibenzoyl derivatives 2-8 exhibited IC50 in the 0.67?22.52 ìM range. Mono-O-methyl ethers 6 and 7 inhibited the in vitro growth of human tumor cell lines HCT-8 (colon carcinoma), SF-295 (central nervous system), LH-60 (human myeloblastic leukemia) and MDA/MB-435 (melanoma). In general, derivatives 2-8 are more stable to light, air and pH at ambient temperatures than their labile, natural precursor 1. These derivatives provide leads for the development of a novel class of antimalarial drugs with enhanced chemical and pharmacological properties. |
Palavras-Chave: |
Plantas medicinais. |
Thesagro: |
Caapeba; Câncer; Química. |
Thesaurus Nal: |
malaria; Plasmodium falciparum. |
Categoria do assunto: |
-- |
Marc: |
LEADER 01861naa a2200337 a 4500 001 1683881 005 2018-05-15 008 2009 bl uuuu u00u1 u #d 024 7 $a10.1016/j.ejmech.2008.10.025$2DOI 100 1 $aPINTO, A. C. S. 245 $aNew antimalarial and cytotoxic 4-nerolidylcatechol derivatives.$h[electronic resource] 260 $c2009 520 $a4-nerolidylcatechol (1) was isolated from cultivated Pothomorphe peltata root on a multi-gram scale using straight-forward solvent extraction-column chromatography. New semisynthetic derivatives of 1 were prepared and tested in vitro against multidrug-resistant Plasmodium falciparum K1 strain. Mono-O-methyl, mono-O-benzyl, O,O-dibenzyl and O,Odibenzoyl derivatives 2-8 exhibited IC50 in the 0.67?22.52 ìM range. Mono-O-methyl ethers 6 and 7 inhibited the in vitro growth of human tumor cell lines HCT-8 (colon carcinoma), SF-295 (central nervous system), LH-60 (human myeloblastic leukemia) and MDA/MB-435 (melanoma). In general, derivatives 2-8 are more stable to light, air and pH at ambient temperatures than their labile, natural precursor 1. These derivatives provide leads for the development of a novel class of antimalarial drugs with enhanced chemical and pharmacological properties. 650 $amalaria 650 $aPlasmodium falciparum 650 $aCaapeba 650 $aCâncer 650 $aQuímica 653 $aPlantas medicinais 700 1 $aSILVA, L. F. R. e 700 1 $aCAVALCANTI, B. C. 700 1 $aMELO, M. R. S. 700 1 $aCHAVES, F. C. M. 700 1 $aLOTUFO, L. V. C. 700 1 $aMORAIS, M. O. de 700 1 $aANDRADE-NETO, V. F. 700 1 $aTADEI, W. P. 700 1 $aPESSOA, C. O. 700 1 $aVIEIRA, P. P. R. 700 1 $aPOHLIT, A. M. 773 $tEuropean Journal of Medicinal Chemistry$gv. 44, n. 6, p. 2731-2735, June 2009.
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Embrapa Amazônia Ocidental (CPAA) |
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| Acesso ao texto completo restrito à biblioteca da Embrapa Agrobiologia. Para informações adicionais entre em contato com cnpab.biblioteca@embrapa.br. |
Registro Completo
Biblioteca(s): |
Embrapa Agrobiologia. |
Data corrente: |
29/11/2023 |
Data da última atualização: |
29/11/2023 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
DONATTI-RICALDE, M. B.; SILVA, A. de C.; RICALDE, M. P.; ROUWS, J. R. C.; MAYHE-NUNES, A. J.; ABBOUD, A. C. de S. |
Afiliação: |
MICHELE GUIMARÃES DONATTI-RICALDE, UFRRJ; ALESSANDRA DE CARVALHO SILVA, CNPAB; MARCELO PERRONE RICALDE, CNPAB; JANAINA RIBEIRO COSTA ROUWS, CNPAB; ANTONIO JOSÉ MAYHÉ-NUNES, UFRRJ; ANTONIO CARLOS DE SOUZA ABBOUD, UFRRJ. |
Título: |
Abundance of natural enemies and aphids in okra crops (Abelmoschus esculentus - Malvaceae) diversified with Tithonia rotundifolia (Asteraceae). |
Ano de publicação: |
2023 |
Fonte/Imprenta: |
Biological Control, 17 November 2023. |
ISSN: |
1049-9644 |
DOI: |
https://doi.org/10.1016/j.biocontrol.2023.105399 |
Idioma: |
Inglês |
Conteúdo: |
Aphids are one of the main problems in okra culture. However, in Brazil, family farmers do not have sustainable alternatives for its control. This pest has numerous natural enemies, and diversified crops are indicated to attract and conserve these control agents. Thus, our research aimed to evaluate the abundance of natural enemies and the presence of Aphis gossypii in okra using Tithonia rotundifolia (Asteraceae) as a companion plant. The work was carried out in an area of 200 m2 , with three treatments (okra located at one, three and six meters from the companion plant) and two repetitions. Six samplings of aphids and natural enemies were carried out from December 2017 to March 2018. The natural enemies captured in the okra+T. rotundifolia system belong to 34 families, and the predators of the families Coccinellidae, Formicidae, Eutichuridae, Araneidae and Oxyopidae are the most frequent. Among the Coccinellidae, the species Scymnus loewii Mulsant & Easter was considered dominant, frequent and constant at the okra crop at three distances, being the only aphidophagous ladybug on the companion plant. The ant Solenopsis invicta Buren was dominant and frequent (62.55%) in the okra crop. The cited spiders were frequent in both plants. Crop diversification with T. rotundifolia contributed to the reduction in A. gossypii in okra located one meter from the companion plant, mainly at 110 DAP. The benefits did not extend to okra grown at three and six meters from the companion plant. We evaluated the possible interactions and causes of population fluctuation of natural enemies and of the studied pest. MenosAphids are one of the main problems in okra culture. However, in Brazil, family farmers do not have sustainable alternatives for its control. This pest has numerous natural enemies, and diversified crops are indicated to attract and conserve these control agents. Thus, our research aimed to evaluate the abundance of natural enemies and the presence of Aphis gossypii in okra using Tithonia rotundifolia (Asteraceae) as a companion plant. The work was carried out in an area of 200 m2 , with three treatments (okra located at one, three and six meters from the companion plant) and two repetitions. Six samplings of aphids and natural enemies were carried out from December 2017 to March 2018. The natural enemies captured in the okra+T. rotundifolia system belong to 34 families, and the predators of the families Coccinellidae, Formicidae, Eutichuridae, Araneidae and Oxyopidae are the most frequent. Among the Coccinellidae, the species Scymnus loewii Mulsant & Easter was considered dominant, frequent and constant at the okra crop at three distances, being the only aphidophagous ladybug on the companion plant. The ant Solenopsis invicta Buren was dominant and frequent (62.55%) in the okra crop. The cited spiders were frequent in both plants. Crop diversification with T. rotundifolia contributed to the reduction in A. gossypii in okra located one meter from the companion plant, mainly at 110 DAP. The benefits did not extend to okra grown at three and six meters from the companion plant... Mostrar Tudo |
Palavras-Chave: |
Conservation biological control; Habitat management; Insectary plants; Red sunflower. |
Categoria do assunto: |
O Insetos e Entomologia |
Marc: |
LEADER 02464naa a2200253 a 4500 001 2158847 005 2023-11-29 008 2023 bl uuuu u00u1 u #d 022 $a1049-9644 024 7 $ahttps://doi.org/10.1016/j.biocontrol.2023.105399$2DOI 100 1 $aDONATTI-RICALDE, M. B. 245 $aAbundance of natural enemies and aphids in okra crops (Abelmoschus esculentus - Malvaceae) diversified with Tithonia rotundifolia (Asteraceae).$h[electronic resource] 260 $c2023 520 $aAphids are one of the main problems in okra culture. However, in Brazil, family farmers do not have sustainable alternatives for its control. This pest has numerous natural enemies, and diversified crops are indicated to attract and conserve these control agents. Thus, our research aimed to evaluate the abundance of natural enemies and the presence of Aphis gossypii in okra using Tithonia rotundifolia (Asteraceae) as a companion plant. The work was carried out in an area of 200 m2 , with three treatments (okra located at one, three and six meters from the companion plant) and two repetitions. Six samplings of aphids and natural enemies were carried out from December 2017 to March 2018. The natural enemies captured in the okra+T. rotundifolia system belong to 34 families, and the predators of the families Coccinellidae, Formicidae, Eutichuridae, Araneidae and Oxyopidae are the most frequent. Among the Coccinellidae, the species Scymnus loewii Mulsant & Easter was considered dominant, frequent and constant at the okra crop at three distances, being the only aphidophagous ladybug on the companion plant. The ant Solenopsis invicta Buren was dominant and frequent (62.55%) in the okra crop. The cited spiders were frequent in both plants. Crop diversification with T. rotundifolia contributed to the reduction in A. gossypii in okra located one meter from the companion plant, mainly at 110 DAP. The benefits did not extend to okra grown at three and six meters from the companion plant. We evaluated the possible interactions and causes of population fluctuation of natural enemies and of the studied pest. 653 $aConservation biological control 653 $aHabitat management 653 $aInsectary plants 653 $aRed sunflower 700 1 $aSILVA, A. de C. 700 1 $aRICALDE, M. P. 700 1 $aROUWS, J. R. C. 700 1 $aMAYHE-NUNES, A. J. 700 1 $aABBOUD, A. C. de S. 773 $tBiological Control, 17 November 2023.
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