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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital. |
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Data corrente: |
20/12/2018 |
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Data da última atualização: |
05/02/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
OLIVEIRA, P. S. N. de; COUTINHO, L. L.; TIZIOTO, P. C.; CESAR, A. S. M.; OLIVEIRA, G. B. de; DINIZ, W, J. da S.; LIMA, A. O. de; REECY, J. M.; MOURÃO, G. B.; ZERLOTINI NETO, A.; REGITANO, L. C. de A. |
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Afiliação: |
PRISCILA SILVA NEUBERN DE OLIVEIRA, Bolsista/Embrapa Pecuária Sudeste; LUIZ L. COUTINHO, USP; POLYANA C. TIZIOTO, NGS Genomic Solutions; ALINE S. M. CESAR, USP; GABRIELLA B. DE OLIVEIRA, USP; WELLISON J. DA S. DINIZ, UFSCar; ANDRESSA O. DE LIMA, UFSCar; JAMES M. REECY, Iowa State University; GERSON B. MOURÃO, USP; ADHEMAR ZERLOTINI NETO, CNPTIA; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
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Título: |
An integrative transcriptome analysis indicates regulatory mRNA-miRNA networks for residual feed intake in Nelore cattle. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Scientific Reports, v. 8, p. 1-12, 2018. |
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DOI: |
10.1038/s41598-018-35315-5 |
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Idioma: |
Inglês |
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Notas: |
Article number: 17072. Na publicação: Adhemar Zerlotini, Luciana C. A. Regitano. |
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Conteúdo: |
Residual Feed Intake (RFI) is an economically relevant trait in beef cattle. Among the molecular regulatory mechanisms, microRNAs (miRNAs) are an important dimension in post-transcriptional regulation and have been associated with different biological pathways. Here, we performed differential miRNAs expression and weighted gene co-expression network analyses (WGCNA) to better understand the complex interactions between miRNAs and mRNAs expressed in bovine skeletal muscle and liver. MiRNA and mRNA expression data were obtained from Nelore steers that were genetically divergent for RFI (N = 10 [low RFI or feed efficient]; N = 10 [high RFI or feed inefficient]). Differentially expressed and hub miRNAs such as bta-miR-486, bta-miR-7, bta-miR15a, bta-miR-21, bta-miR 29, btamiR-30b, bta-miR-106b, bta-miR-199a-3p, bta-miR-204, and bta-miR 296 may have a potential role in variation of RFI. Functional enrichment analysis of differentially expressed (DE) miRNA?s target genes and miRNA?mRNA correlated modules revealed that insulin, lipid, immune system, oxidative stress and muscle development signaling pathways might potentially be involved in RFI in this population. Our study identified DE miRNAs, miRNA - mRNA regulatory networks and hub miRNAs related to RFI. These findings suggest a possible role of miRNAs in regulation of RFI, providing new insights into the potential molecular mechanisms that control feed efficiency in Nelore cattle. |
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Palavras-Chave: |
MicroRNAs; Residual Feed Intake. |
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Thesagro: |
Gado Nelore. |
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Thesaurus Nal: |
Beef cattle; Nellore; Skeletal muscle. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/189126/1/AP-Integrative-Adhemar-etal.pdf
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Marc: |
LEADER 02518naa a2200337 a 4500
001 2102149
005 2019-02-05
008 2018 bl uuuu u00u1 u #d
024 7 $a10.1038/s41598-018-35315-5$2DOI
100 1 $aOLIVEIRA, P. S. N. de
245 $aAn integrative transcriptome analysis indicates regulatory mRNA-miRNA networks for residual feed intake in Nelore cattle.$h[electronic resource]
260 $c2018
500 $aArticle number: 17072. Na publicação: Adhemar Zerlotini, Luciana C. A. Regitano.
520 $aResidual Feed Intake (RFI) is an economically relevant trait in beef cattle. Among the molecular regulatory mechanisms, microRNAs (miRNAs) are an important dimension in post-transcriptional regulation and have been associated with different biological pathways. Here, we performed differential miRNAs expression and weighted gene co-expression network analyses (WGCNA) to better understand the complex interactions between miRNAs and mRNAs expressed in bovine skeletal muscle and liver. MiRNA and mRNA expression data were obtained from Nelore steers that were genetically divergent for RFI (N = 10 [low RFI or feed efficient]; N = 10 [high RFI or feed inefficient]). Differentially expressed and hub miRNAs such as bta-miR-486, bta-miR-7, bta-miR15a, bta-miR-21, bta-miR 29, btamiR-30b, bta-miR-106b, bta-miR-199a-3p, bta-miR-204, and bta-miR 296 may have a potential role in variation of RFI. Functional enrichment analysis of differentially expressed (DE) miRNA?s target genes and miRNA?mRNA correlated modules revealed that insulin, lipid, immune system, oxidative stress and muscle development signaling pathways might potentially be involved in RFI in this population. Our study identified DE miRNAs, miRNA - mRNA regulatory networks and hub miRNAs related to RFI. These findings suggest a possible role of miRNAs in regulation of RFI, providing new insights into the potential molecular mechanisms that control feed efficiency in Nelore cattle.
650 $aBeef cattle
650 $aNellore
650 $aSkeletal muscle
650 $aGado Nelore
653 $aMicroRNAs
653 $aResidual Feed Intake
700 1 $aCOUTINHO, L. L.
700 1 $aTIZIOTO, P. C.
700 1 $aCESAR, A. S. M.
700 1 $aOLIVEIRA, G. B. de
700 1 $aDINIZ, W, J. da S.
700 1 $aLIMA, A. O. de
700 1 $aREECY, J. M.
700 1 $aMOURÃO, G. B.
700 1 $aZERLOTINI NETO, A.
700 1 $aREGITANO, L. C. de A.
773 $tScientific Reports$gv. 8, p. 1-12, 2018.
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Registro original: |
Embrapa Agricultura Digital (CNPTIA) |
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Registro Completo
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Biblioteca(s): |
Embrapa Agroenergia; Embrapa Algodão. |
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Data corrente: |
29/09/2015 |
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Data da última atualização: |
15/03/2016 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
BARROS, T. F. S.; ARRIEL, N. H. C.; QUEIROZ, M. F.; FERNANDES, P. D.; MENDONCA, S.; RIBEIRO, J. A. de A.; MEDEIROS, E. de A. |
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Afiliação: |
Talita Farias Sousa Barros, UNIVERSIDADE DA PARAÍBA; Nair Helena Castro Arriel, EMBRAPA ALGODÃO; Messias Firmino Queiroz, UNIVERSIDADE DA PARAÍBA; Pedro Dantas Fernandes, UNIVERSIDADE DA PARAÍBA; SIMONE MENDONCA, CNPAE; JOSE ANTONIO DE AQUINO RIBEIRO, CNPAE; Everaldo Paulo Medeiros, EMBRAPA ALGODÃO. |
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Título: |
Fatty acid profiles of species of Jatropha curcas L., Jatropha molíssima (Pohl) Baill. and Jatropha gossypiifolia L. |
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Ano de publicação: |
2015 |
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Fonte/Imprenta: |
Industrial Crops and Products, v. 73, p. 106-108, 2015. |
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Idioma: |
Inglês |
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Conteúdo: |
The purpose of this study was to determine a standard of fatty acids from species of Jatropha curcas L., Jatropha mollissima (Pohl) Baill., and Jatropha gossypiifolia L. The sample set consisted of 11 samples with three repetitions for each species, resulting in a total of 99 samples. Matrix of fatty acid data, principal component analyses (PCA) techniques and hierarchical cluster analyses (HCA) were applied in order to verify the similarity and discrimination of the samples for fatty acid profile. The PC1 (x-axis) discriminates against samples of J. curcas, J. mollissima and J. gossypiifolia while these latter two species are discriminated in PC2 (y-axis). In the HCA, the dendrogram also shows the separation of the three species as was observed during the PCA. The major variations in this separation were oleic (C18:1), linoleic (C18:2), stearic (C18:0) and palmitic (C16:0) acids. In both J. mollissima and J. gossypiifolia there is a predominance of linoleic acid (C18:2), whereas for J. curcas there is a balance on the equivalent proportion of oleic (C18:1) and linoleic (C18:2) acids. Oleic (C18:1) and linoleic (C18:2) acids sum constitute a mean of 76.5%, 78.5%, 84.5% of the total sample composition of J. curcas, J. mollissima and J. gossypiifolia, respectively. For the studied species of Jatropha, the mean oil content was 35.0% for J. curcas, 18.3% for J. mollissima and 22.1 % for J. gossypiifolia. The difference between the oil content in the species comes from the proportion of fatty acids in the lipid composition, especially for oleic (C18:1) and linoleic (C18:2) acids. Overlapping similarities and differences in lipid composition did allow differentiation between species studied. MenosThe purpose of this study was to determine a standard of fatty acids from species of Jatropha curcas L., Jatropha mollissima (Pohl) Baill., and Jatropha gossypiifolia L. The sample set consisted of 11 samples with three repetitions for each species, resulting in a total of 99 samples. Matrix of fatty acid data, principal component analyses (PCA) techniques and hierarchical cluster analyses (HCA) were applied in order to verify the similarity and discrimination of the samples for fatty acid profile. The PC1 (x-axis) discriminates against samples of J. curcas, J. mollissima and J. gossypiifolia while these latter two species are discriminated in PC2 (y-axis). In the HCA, the dendrogram also shows the separation of the three species as was observed during the PCA. The major variations in this separation were oleic (C18:1), linoleic (C18:2), stearic (C18:0) and palmitic (C16:0) acids. In both J. mollissima and J. gossypiifolia there is a predominance of linoleic acid (C18:2), whereas for J. curcas there is a balance on the equivalent proportion of oleic (C18:1) and linoleic (C18:2) acids. Oleic (C18:1) and linoleic (C18:2) acids sum constitute a mean of 76.5%, 78.5%, 84.5% of the total sample composition of J. curcas, J. mollissima and J. gossypiifolia, respectively. For the studied species of Jatropha, the mean oil content was 35.0% for J. curcas, 18.3% for J. mollissima and 22.1 % for J. gossypiifolia. The difference between the oil content in the species comes from the propor... Mostrar Tudo |
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Palavras-Chave: |
Analise de agrupamentos hierárquicos; Análises dos componentes principais; Cromatografia em fase gasosa; Gas chrom atography; Hierarchical clusters analyses; Principal component analyses. |
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Thesagro: |
Jatropha curcas. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/141191/1/Fatty-acid-profiles-of-species-of-Jatropha-curcas-L.....pdf
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Marc: |
LEADER 02646naa a2200277 a 4500
001 2041000
005 2016-03-15
008 2015 bl uuuu u00u1 u #d
100 1 $aBARROS, T. F. S.
245 $aFatty acid profiles of species of Jatropha curcas L., Jatropha molíssima (Pohl) Baill. and Jatropha gossypiifolia L.$h[electronic resource]
260 $c2015
520 $aThe purpose of this study was to determine a standard of fatty acids from species of Jatropha curcas L., Jatropha mollissima (Pohl) Baill., and Jatropha gossypiifolia L. The sample set consisted of 11 samples with three repetitions for each species, resulting in a total of 99 samples. Matrix of fatty acid data, principal component analyses (PCA) techniques and hierarchical cluster analyses (HCA) were applied in order to verify the similarity and discrimination of the samples for fatty acid profile. The PC1 (x-axis) discriminates against samples of J. curcas, J. mollissima and J. gossypiifolia while these latter two species are discriminated in PC2 (y-axis). In the HCA, the dendrogram also shows the separation of the three species as was observed during the PCA. The major variations in this separation were oleic (C18:1), linoleic (C18:2), stearic (C18:0) and palmitic (C16:0) acids. In both J. mollissima and J. gossypiifolia there is a predominance of linoleic acid (C18:2), whereas for J. curcas there is a balance on the equivalent proportion of oleic (C18:1) and linoleic (C18:2) acids. Oleic (C18:1) and linoleic (C18:2) acids sum constitute a mean of 76.5%, 78.5%, 84.5% of the total sample composition of J. curcas, J. mollissima and J. gossypiifolia, respectively. For the studied species of Jatropha, the mean oil content was 35.0% for J. curcas, 18.3% for J. mollissima and 22.1 % for J. gossypiifolia. The difference between the oil content in the species comes from the proportion of fatty acids in the lipid composition, especially for oleic (C18:1) and linoleic (C18:2) acids. Overlapping similarities and differences in lipid composition did allow differentiation between species studied.
650 $aJatropha curcas
653 $aAnalise de agrupamentos hierárquicos
653 $aAnálises dos componentes principais
653 $aCromatografia em fase gasosa
653 $aGas chrom atography
653 $aHierarchical clusters analyses
653 $aPrincipal component analyses
700 1 $aARRIEL, N. H. C.
700 1 $aQUEIROZ, M. F.
700 1 $aFERNANDES, P. D.
700 1 $aMENDONCA, S.
700 1 $aRIBEIRO, J. A. de A.
700 1 $aMEDEIROS, E. de A.
773 $tIndustrial Crops and Products$gv. 73, p. 106-108, 2015.
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Embrapa Algodão (CNPA) |
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