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| Registros recuperados : 9 | |
| 1. |  | RIBEIRO, I. M.; BORGES, C. C. H.; ARBEX, W. A.; SILVA, B. Z. da. Programação genética com inicialização baseada em floresta randômica em estudos de associação do genooma completo. In: INTERNATIONAL SODEBRAS CONGRESS, 35., 2016, Foz do Iguaçu. Anais... Publicado na Revista Sodebras, v. 11, n. 129, set. 2016. 6 p.| Biblioteca(s): Embrapa Gado de Leite. |
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| 5. | | ZONOVELLI, B.; BORGES, C. C. H.; ARBEX, W. A.; OLIVEIRA, F. C. de; RIBEIRO, I. M. Regressão com máquinas de vetores suporte e seleção de atributos via algoritmo genético aplicada em seleção genômica. Revista Sodebras, v. 11, n. 129, set. 2016. Edição do 35º International Sodebras Congress, Foz do Iguaçu, 2016.| Biblioteca(s): Embrapa Gado de Leite. |
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| 6. | | RIBEIRO, I. M.; GADIOLI, J. L.; NICK, J. A.; GAMA, M. A. P.; MELEM JUNIOR, N. J.; TRAVAGLINI JUNIOR, N. Amostragem de solo em soqueira de cana-de-açúcar. In: ENCONTRO DE INICIAÇÃO CIENTÍFICA, 2., 1997, Taubaté. Anais... Taubaté: UNITAU, 1997. p. 21-22.| Biblioteca(s): Embrapa Amapá. |
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| 7. | | CURADO, F. F.; SEGUNDO, W. T. B.; SANTOS, B. A. C.; SOUZA JUNIOR, I. P.; OLIVEIRA, L. C. L. de; RIBEIRO, I. M. Gestão participativa para o desenvolvimento sustentável da comunidade Ilha Mem de Sá, Itaporanga D'Ajuda, Sergipe. In: CONGRESSO BRASILEIRO DE AGROECOLOGIA, 6.; CONGRESSO LATINO AMERICANO DE AGROECOLOGIA, 2., 2009, Curitiba. Agricultura familiar e camponesa experiências passadas e presentes construindo um futuro sustentável: anais. Curitiba: ABA: SOCLA, 2009. p. 2367| Biblioteca(s): Embrapa Tabuleiros Costeiros. |
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| 8. | | NUNES, J. F.; LIMA, I. M. de M.; ARAÚJO, M. T. de; TRALDI, A. de S.; SOUZA, O.; RANGEL, J. H. de A.; RIBEIRO, I. M. da S.; PESSOA, A. L. P.; TABOSA, J. H. C.; CÂNCIO, C. R. B. Produção de caprinos leiteiros: recomendações técnicas. Maceio: EPEAL; CODEVASF, 1985. 85 p. il.| Biblioteca(s): Embrapa Caprinos e Ovinos; Embrapa Meio-Norte; Embrapa Semiárido. |
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| 9. | | CURADO, F. F.; SEGUNDO, W. T. B.; RIBEIRO, I. M. R.; LIMA, L. C.; SANTOS, B. A. C.; SOUSA JUNIOR, I. P. de; SANTOS, A. da S. dos; RODRIGUES, R. F. de A. Diagnóstico preliminar para a gestão participativa da comunidade Ilha Mem de Sá, Itaporanga D'Ajuda, Sergipe. Aracaju: Embrapa Tabuleiros Costeiros, 2009.| Biblioteca(s): Embrapa Tabuleiros Costeiros. |
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| Registros recuperados : 9 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
26/12/2018 |
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Data da última atualização: |
24/01/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
B - 3 |
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Autoria: |
RIBEIRO, I. M.; BORGES, C. C. H.; SILVA, B. Z.; ARBEX, W. A. |
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Afiliação: |
WAGNER ANTONIO ARBEX, CNPGL. |
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Título: |
A genetic programming model for association studies to detect epistasis in low heritability data. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Revista de Informática Teórica e Aplicada, v. 25, n. 2, p. 85-92, 2018. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract The genome-wide associations studies (GWAS) aims to identify the most influential markers in relation to the phenotype values. One of the substantial challenges is to find a non-linear mapping between genotype and phenotype, also known as epistasis, that usually becomes the process of searching and identifying functional SNPs more complex. Some diseases such as cervical cancer, leukemia and type 2 diabetes have low heritability. The heritability of the sample is directly related to the explanation defined by the genotype, so the lower the heritability the greater the influence of the environmental factors and the less the genotypic explanation. In this work, an algorithm capable of identifying epistatic associations at different levels of heritability is proposed. The developing model is a aplication of genetic programming with a specialized initialization for the initial population consisting of a random forest strategy. The initialization process aims to rank the most important SNPs increasing the probability of their insertion in the initial population of the genetic programming model. The expected behavior of the presented model for the obtainment of the causal markers intends to be robust in relation to the heritability level. The simulated experiments are case-control type with heritability level of 0.4, 0.3, 0.2 and 0.1 considering scenarios with 100 and 1000 markers. Our approach was compared with the GPAS software and a genetic programming algorithm without the initialization step. The results show that the use of an efficient population initialization method based on ranking strategy is very promising compared to other models. MenosAbstract The genome-wide associations studies (GWAS) aims to identify the most influential markers in relation to the phenotype values. One of the substantial challenges is to find a non-linear mapping between genotype and phenotype, also known as epistasis, that usually becomes the process of searching and identifying functional SNPs more complex. Some diseases such as cervical cancer, leukemia and type 2 diabetes have low heritability. The heritability of the sample is directly related to the explanation defined by the genotype, so the lower the heritability the greater the influence of the environmental factors and the less the genotypic explanation. In this work, an algorithm capable of identifying epistatic associations at different levels of heritability is proposed. The developing model is a aplication of genetic programming with a specialized initialization for the initial population consisting of a random forest strategy. The initialization process aims to rank the most important SNPs increasing the probability of their insertion in the initial population of the genetic programming model. The expected behavior of the presented model for the obtainment of the causal markers intends to be robust in relation to the heritability level. The simulated experiments are case-control type with heritability level of 0.4, 0.3, 0.2 and 0.1 considering scenarios with 100 and 1000 markers. Our approach was compared with the GPAS software and a genetic programming algorithm without... Mostrar Tudo |
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Palavras-Chave: |
Computational Modeling; Genetic Programming; GWAS; Mathematical Modeling; Random Forest; SNP. |
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Thesaurus NAL: |
Bioinformatics. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/189322/1/Artigo-RevInfTeorApl.pdf
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Marc: |
LEADER 02397naa a2200241 a 4500
001 2102526
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008 2018 bl uuuu u00u1 u #d
100 1 $aRIBEIRO, I. M.
245 $aA genetic programming model for association studies to detect epistasis in low heritability data.$h[electronic resource]
260 $c2018
520 $aAbstract The genome-wide associations studies (GWAS) aims to identify the most influential markers in relation to the phenotype values. One of the substantial challenges is to find a non-linear mapping between genotype and phenotype, also known as epistasis, that usually becomes the process of searching and identifying functional SNPs more complex. Some diseases such as cervical cancer, leukemia and type 2 diabetes have low heritability. The heritability of the sample is directly related to the explanation defined by the genotype, so the lower the heritability the greater the influence of the environmental factors and the less the genotypic explanation. In this work, an algorithm capable of identifying epistatic associations at different levels of heritability is proposed. The developing model is a aplication of genetic programming with a specialized initialization for the initial population consisting of a random forest strategy. The initialization process aims to rank the most important SNPs increasing the probability of their insertion in the initial population of the genetic programming model. The expected behavior of the presented model for the obtainment of the causal markers intends to be robust in relation to the heritability level. The simulated experiments are case-control type with heritability level of 0.4, 0.3, 0.2 and 0.1 considering scenarios with 100 and 1000 markers. Our approach was compared with the GPAS software and a genetic programming algorithm without the initialization step. The results show that the use of an efficient population initialization method based on ranking strategy is very promising compared to other models.
650 $aBioinformatics
653 $aComputational Modeling
653 $aGenetic Programming
653 $aGWAS
653 $aMathematical Modeling
653 $aRandom Forest
653 $aSNP
700 1 $aBORGES, C. C. H.
700 1 $aSILVA, B. Z.
700 1 $aARBEX, W. A.
773 $tRevista de Informática Teórica e Aplicada$gv. 25, n. 2, p. 85-92, 2018.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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