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Registros recuperados : 3 | |
1. | | JORGE, B. C.; REIS, A. C. C.; STERDE, E. T.; BALIN, P. da S.; SCARANO, W. R.; HISANO, H.; ARENA, A. C. Exposure to benzo(a)pyrene from juvenile period to peripubertal impairs male reproductive parameters in adult rats. Chemosphere, v. 263, article 128016, 2021. Biblioteca(s): Embrapa Meio Ambiente. |
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2. | | MOREIRA, S. da S.; INOCÊNCIO, L. C. de L.; JORGE, B. C.; REIS, A. C. C.; HISANO, H.; ARENA, A. C. Effects of benzo(a)pyrene at environmentally relevant doses on embryo-fetal development in rats. Environmental Toxicology, v. 36, n. 5, p. 831-839, 2021. Biblioteca(s): Embrapa Meio Ambiente. |
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3. | | REIS, A. C. C.; JORGE, B. C.; PASCHALINI, B. R.; BUENO, J. N.; STEIN, J.; MOREIRA, S. da S.; MANOEL, B. de M.; FERNANDES, G. S. A.; HISANO, H.; ARENA, A. C. Long-term reproductive effects of benzo(a)pyrene at environmentally relevant dose on juvenile female rats. Drug and Chemical Toxicology, 2022. On-line first. Biblioteca(s): Embrapa Meio Ambiente. |
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Registros recuperados : 3 | |
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| Acesso ao texto completo restrito à biblioteca da Embrapa Meio Ambiente. Para informações adicionais entre em contato com cnpma.biblioteca@embrapa.br. |
Registro Completo
Biblioteca(s): |
Embrapa Meio Ambiente. |
Data corrente: |
28/11/2022 |
Data da última atualização: |
28/11/2022 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 2 |
Autoria: |
REIS, A. C. C.; JORGE, B. C.; PASCHALINI, B. R.; BUENO, J. N.; STEIN, J.; MOREIRA, S. da S.; MANOEL, B. de M.; FERNANDES, G. S. A.; HISANO, H.; ARENA, A. C. |
Afiliação: |
ANA CAROLINA CASALI REIS, UNIVERSIDADE ESTADUAL PAULISTA; BÁRBARA CAMPOS JORGE, UNIVERSIDADE ESTADUAL PAULISTA; BEATRIZ RIZZO PASCHOALINI, UNIVERSIDADE ESTADUAL PAULISTA; JÉSSICA NOGUEIRA BUENO, UNIVERSIDADE ESTADUAL PAULISTA; JULIA STEIN, UNIVERSIDADE ESTADUAL PAULISTA; SUYANE DA SILVA MOREIRA, UNIVERSIDADE ESTADUAL PAULISTA; BEATRIZ DE MATOS MANOEL, UNIVERSIDADE ESTADUAL PAULISTA; GLAURA SCANTAMBURLO ALVES FERNANDES, UNIVERSIDADE ESTADUAL DE LONDRINA; HAMILTON HISANO, CNPMA; ARIELLE CRISTINA ARENA, UNIVERSIDADE ESTADUAL PAULISTA. |
Título: |
Long-term reproductive effects of benzo(a)pyrene at environmentally relevant dose on juvenile female rats. |
Ano de publicação: |
2022 |
Fonte/Imprenta: |
Drug and Chemical Toxicology, 2022. |
ISSN: |
0148-0545 |
DOI: |
https://doi.org/10.1080/01480545.2022.2105864 |
Idioma: |
Inglês |
Notas: |
On-line first. |
Conteúdo: |
Abstract: Since studies on the reproductive consequences after the exposure to environmentally relevant doses of Benzo(a)pyrene (BaP) during critical stages of development are scarce, this study evaluated female reproductive parameters of adult rats exposed to a low dose of BaP during the juvenile phase. Female rats (Post-natal 21) were treated with BaP (0 or 0.1 µg/kg/day; gavage) for 21 consecutive days. During the treatment, no clinical signs of toxicity were observed. Nevertheless, the ages of vaginal opening and first estrus were anticipated by the BaP-exposure. At the sexual maturity, the juvenile exposure compromised the sexual behavior, as well as the placental efficiency, follicle stimulating hormone levels, placenta histological analysis, and ovarian follicle count. A decrease in erythrocyte, platelet, and lymphocyte counts also was observed in the exposed-females. Moreover, the dose of BaP used in this study was not able to produce estrogenic activity in vivo. These data showed that juvenile BaP-exposure, at environmentally relevant dose, compromised the female reproductive system, possibly by an endocrine deregulation; however, this requires further investigation. |
Palavras-Chave: |
Endocrine disruptor; Hidrocarboneto policíclico aromático; Juvenile period. |
Thesagro: |
Aparelho Reprodutor; Fêmea; Hidrocarboneto; Impacto Ambiental; Rato; Reprodução Animal. |
Thesaurus NAL: |
Benzo(a)pyrene; Female fertility; Female reproductive system; Health effects assessments; Polycyclic aromatic hydrocarbons; Puberty; Rats. |
Categoria do assunto: |
H Saúde e Patologia |
Marc: |
LEADER 02533naa a2200457 a 4500 001 2148863 005 2022-11-28 008 2022 bl uuuu u00u1 u #d 022 $a0148-0545 024 7 $ahttps://doi.org/10.1080/01480545.2022.2105864$2DOI 100 1 $aREIS, A. C. C. 245 $aLong-term reproductive effects of benzo(a)pyrene at environmentally relevant dose on juvenile female rats.$h[electronic resource] 260 $c2022 500 $aOn-line first. 520 $aAbstract: Since studies on the reproductive consequences after the exposure to environmentally relevant doses of Benzo(a)pyrene (BaP) during critical stages of development are scarce, this study evaluated female reproductive parameters of adult rats exposed to a low dose of BaP during the juvenile phase. Female rats (Post-natal 21) were treated with BaP (0 or 0.1 µg/kg/day; gavage) for 21 consecutive days. During the treatment, no clinical signs of toxicity were observed. Nevertheless, the ages of vaginal opening and first estrus were anticipated by the BaP-exposure. At the sexual maturity, the juvenile exposure compromised the sexual behavior, as well as the placental efficiency, follicle stimulating hormone levels, placenta histological analysis, and ovarian follicle count. A decrease in erythrocyte, platelet, and lymphocyte counts also was observed in the exposed-females. Moreover, the dose of BaP used in this study was not able to produce estrogenic activity in vivo. These data showed that juvenile BaP-exposure, at environmentally relevant dose, compromised the female reproductive system, possibly by an endocrine deregulation; however, this requires further investigation. 650 $aBenzo(a)pyrene 650 $aFemale fertility 650 $aFemale reproductive system 650 $aHealth effects assessments 650 $aPolycyclic aromatic hydrocarbons 650 $aPuberty 650 $aRats 650 $aAparelho Reprodutor 650 $aFêmea 650 $aHidrocarboneto 650 $aImpacto Ambiental 650 $aRato 650 $aReprodução Animal 653 $aEndocrine disruptor 653 $aHidrocarboneto policíclico aromático 653 $aJuvenile period 700 1 $aJORGE, B. C. 700 1 $aPASCHALINI, B. R. 700 1 $aBUENO, J. N. 700 1 $aSTEIN, J. 700 1 $aMOREIRA, S. da S. 700 1 $aMANOEL, B. de M. 700 1 $aFERNANDES, G. S. A. 700 1 $aHISANO, H. 700 1 $aARENA, A. C. 773 $tDrug and Chemical Toxicology, 2022.
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Embrapa Meio Ambiente (CNPMA) |
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