Data/hora: 23/06/2024 17:55:54

Biblioteca(s): 	Embrapa Meio Ambiente.	
Tipo da produção científica: 	Artigo em Periódico Indexado	
Circulação/Nível: 	A - 1	
Data corrente: 	06/07/2021	
Data da última atualização: 	15/03/2022	
Autoria: 	JORGE, B. C.; REIS, A. C. C.; STERDE, E. T.; BALIN, P. da S.; SCARANO, W. R.; HISANO, H.; ARENA, A. C.	
Afiliação: 	BÁRBARA CAMPOS JORGE, IBB-UNESP; ANA CAROLINA CASALI REIS, IBB-UNESP; ÉRIKA TISSIANA STERDE, IBB-UNESP; PAOLA DA SILVA BALIN, IBB-UNESP; WELLERSON RODRIGO SCARANO, IBB-UNESP; HAMILTON HISANO, CNPMA; ARIELLE CRISTINA ARENA, IBB-UNESP.	
Título: 	Exposure to benzo(a)pyrene from juvenile period to peripubertal impairs male reproductive parameters in adult rats.	
Ano de publicação: 	2021	
Fonte/Imprenta: 	Chemosphere, v. 263, article 128016, 2021.	
ISSN: 	0045-6535	
DOI: 	https://doi.org/10.1016/j.chemosphere.2020.128016	
Idioma: 	Inglês	
Conteúdo: 	Abstract: Benzo(a)pyrene (BaP) is a persistent organic pollutant and endocrine disruptor that can compromise the steroidogenesis process by interacting with the StAR protein, causing adverse effects on male reproduction. However, consequences of prepubertal BaP exposure and its impacts on adult life are yet unknown. This study investigated the effects of BaP exposure from the juvenile period to peripubertal on reproductive parameters in adult male rats. Males were exposed to 0; 0.1; 1 or 10 microgram/kg/day of BaP from post-natal (PND) 23 to PND 53 (by gavage). The lowest dose of BaP was able to compromise the male copulatory behavior, as evidenced by the delay in the first mount, intromission and ejaculation. Furthermore, BaP-treated groups showed lower sperm quality (disrupted motility and morphology) and quantity, reduced relative weights of the thyroid and seminal gland. Serum testosterone levels and the Leydig cells nuclei volume were decreased by BaP exposure whereas the StAR expression was increased. Histopathological changes in the testis also were detected in the males exposed to BaP. These results showed that prepubertal BaP-exposure adversely influenced the male reproductive system in the adult life, indicating that a comprehensive risk assessment of BaP-exposure on prepubertal period is necessary.	
Palavras-Chave: 	Hidrocarboneto policíclico aromático.	
Thesagro: 	Fisiologia Reprodutiva; Hidrocarboneto; Impacto Ambiental; Rato.	
Thesaurus Nal: 	Abnormal development; Benzo(a)pyrene; Ecotoxicology; Health effects assessments; Rats; Reproductive disorders.	
Categoria do assunto: 	H Saúde e Patologia	
Registro original: 	Embrapa Meio Ambiente (CNPMA)	
Exemplares: 	CNPMA - (16985-1) - UPC - AP - DD -  -  -  - DIS