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| Registros recuperados : 73 | |
| Registros recuperados : 73 | |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Meio Ambiente. Para informações adicionais entre em contato com cnpma.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
06/07/2021 |
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Data da última atualização: |
15/03/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
MOREIRA, S. da S.; INOCÊNCIO, L. C. de L.; JORGE, B. C.; REIS, A. C. C.; HISANO, H.; ARENA, A. C. |
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Afiliação: |
SUYANE DA SILVA MOREIRA, IBB-UNESP; LEONARDO CESAR DE LIMA INOCÊNCIO, IBB-UNESP; BÁRBARA CAMPOS JORGE, IBB-UNESP; ANA CAROLINA CASALI REIS, IBB-UNESP; HAMILTON HISANO, CNPMA; ARIELLE CRISTINA ARENA, IBB-UNESP. |
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Título: |
Effects of benzo(a)pyrene at environmentally relevant doses on embryo-fetal development in rats. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Environmental Toxicology, v. 36, n. 5, p. 831-839, 2021. |
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ISSN: |
1520-4081 |
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DOI: |
https://doi.org/10.1002/tox.23085 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Studies have demonstrated that Benzo(a)Pyrene (BaP), a polycyclic aromatic hydrocarbon ubiquituous in the environment, can cause teratogenic effects. Since the majority of studies used in vitro models or high doses of BaP, this study evaluated the teratogenicity, reproductive and developmental performance of low doses of BaP through maternal and fetus examination after daily oral administration of BaP (0; 0.1; 1.0 or 10 microgram/kg) to pregnant Wistar rats from Gestational day (GD) 6 to GD 15 (the organogenesis period). Pregnant rats did not exhibit clinical signs of toxicity during the exposure period. However, dams exposed to the lowest dose of BaP showed a reduction in the erythrocytes number and in the creatinine levels. The groups exposed to 0.1 and 1.0 microgram/kg presented a decrease in placental efficiency, as well as an increase in placental weight. After fetal examination, the treated group with the lowest dose showed a reduced relative anogenital distance, while the curve of normal distribution of weight was changed in the highest dose group. In addition, anomalies evidenced by changes in the renal size and degree of fetal ossification were observed in treated-fetus. In conclusion, treatment with BaP during organogenesis at this dose level is detrimental to the normal development of fetuses. |
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Palavras-Chave: |
Hidrocarboneto policíclico aromático; Teratogênese. |
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Thesagro: |
Embrião Animal; Feto; Hidrocarboneto; Impacto Ambiental; Rato. |
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Thesaurus NAL: |
Abnormal development; Benzo(a)pyrene; Health effects assessments; Skeletal development; Teratogenicity. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 02378naa a2200349 a 4500
001 2132808
005 2022-03-15
008 2021 bl uuuu u00u1 u #d
022 $a1520-4081
024 7 $ahttps://doi.org/10.1002/tox.23085$2DOI
100 1 $aMOREIRA, S. da S.
245 $aEffects of benzo(a)pyrene at environmentally relevant doses on embryo-fetal development in rats.$h[electronic resource]
260 $c2021
520 $aAbstract: Studies have demonstrated that Benzo(a)Pyrene (BaP), a polycyclic aromatic hydrocarbon ubiquituous in the environment, can cause teratogenic effects. Since the majority of studies used in vitro models or high doses of BaP, this study evaluated the teratogenicity, reproductive and developmental performance of low doses of BaP through maternal and fetus examination after daily oral administration of BaP (0; 0.1; 1.0 or 10 microgram/kg) to pregnant Wistar rats from Gestational day (GD) 6 to GD 15 (the organogenesis period). Pregnant rats did not exhibit clinical signs of toxicity during the exposure period. However, dams exposed to the lowest dose of BaP showed a reduction in the erythrocytes number and in the creatinine levels. The groups exposed to 0.1 and 1.0 microgram/kg presented a decrease in placental efficiency, as well as an increase in placental weight. After fetal examination, the treated group with the lowest dose showed a reduced relative anogenital distance, while the curve of normal distribution of weight was changed in the highest dose group. In addition, anomalies evidenced by changes in the renal size and degree of fetal ossification were observed in treated-fetus. In conclusion, treatment with BaP during organogenesis at this dose level is detrimental to the normal development of fetuses.
650 $aAbnormal development
650 $aBenzo(a)pyrene
650 $aHealth effects assessments
650 $aSkeletal development
650 $aTeratogenicity
650 $aEmbrião Animal
650 $aFeto
650 $aHidrocarboneto
650 $aImpacto Ambiental
650 $aRato
653 $aHidrocarboneto policíclico aromático
653 $aTeratogênese
700 1 $aINOCÊNCIO, L. C. de L.
700 1 $aJORGE, B. C.
700 1 $aREIS, A. C. C.
700 1 $aHISANO, H.
700 1 $aARENA, A. C.
773 $tEnvironmental Toxicology$gv. 36, n. 5, p. 831-839, 2021.
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