Data/hora: 23/09/2024 21:50:26

Biblioteca(s): 	Embrapa Gado de Leite.	
Data corrente: 	20/08/2021	
Data da última atualização: 	15/09/2021	
Autoria: 	OTTO, P. I.; GUIMARAES, S. E. F.; VERARDO, L. L.; AZEVEDO, A. L. S.; SEVILLANO, C. A.; PRATA, M. C. de A.; FURLONG, J.; FREITAS, C. de; VERNEQUE, R. da S.; MARTINS, M. F.; PANETTO, J. C. do C.; CARVALHO, W. A.; GARCIA, A. O.; DAIBERT, R. M. de P.; SILVA, M. V. G. B.; MACHADO, M. A.	
Afiliação: 	PAMELA I. OTTO, Universidade Federal de Viçosa; SIMONE E. F. GUIMARAES, Universidade Federal de Viçosa; LUCAS L. VERARDO, Universidade Federal de Viçosa; ANA LUISA SOUSA AZEVEDO, CNPGL; CLAUDIA A. SEVILLANO, Topigs Norsvin Research Center; MARCIA CRISTINA DE AZEVEDO PRATA, CNPGL; JOHN FURLONG; CELIO DE FREITAS, CNPGL; RUI DA SILVA VERNEQUE, CNPGL; MARTA FONSECA MARTINS, CNPGL; JOAO CLAUDIO DO CARMO PANETTO, CNPGL; WANESSA ARAUJO CARVALHO, CNPGL; ARIELLY O. GARCIA, Universidade Federal de Viçosa; RAQUEL M. DE PAIVA DAIBERT, Universidade Federal de Juiz de Fora; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; MARCO ANTONIO MACHADO, CNPGL.	
Título: 	Genome wide association study for gastrointestinal nematodes resistance in Bos taurus x Bos indicus crossbred cattle.	
Ano de publicação: 	2021	
Fonte/Imprenta: 	Livestock Science, v. 245, 104403, 2021.	
DOI: 	https://doi.org/10.1016/j.livsci.2021.104403	
Idioma: 	Inglês	
Notas: 	Short communication.	
Conteúdo: 	Gastrointestinal nematodes (GIN) parasitism is a very important problem on livestock production, especially in cattle, where the infections are usually subclinical making difficult the diagnosis and aggravating the losses caused by these parasites. This study aimed to identify genomic regions associated with nematode fecal egg count (FEC) in a Gir x Holstein F2 experimental population and to identify candidate genes within the quantitative trait loci (QTL) regions. The FEC phenotypes were evaluated in F2 animals during dry and rainy seasons. Illumina BovineSNP50 BeadChip was used to genotype the animals for single-SNP genome wide association studies. Three significant SNPs on chromosome 15 were found to be associated with FEC. From the QTL regions containing the SNPs, one functional candidate gene was identified: the myogenic differentiation 1 (MYOD1) gene, which plays an important role in the myogenesis and muscle repair. Further studies are needed to refine the QTL region identified here and to pursue additional SNPs associated to FEC trait in the Gir x Holstein genome, as well as to deeply investigate and validate the effect of this functional candidate gene.	
Palavras-Chave: 	Post-GWAS analyses.	
Thesagro: 	Bovino; Gado Mestiço; Helminto; Infecção.	
Thesaurus Nal: 	Endoparasites; Helminths; Infection.	
Categoria do assunto: 	L Ciência Animal e Produtos de Origem Animal	
Registro original: 	Embrapa Gado de Leite (CNPGL)	
Exemplares: 	CNPGL - (25254-1) - UPC - AP - DD -  -  -  - DIS