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Registro Completo |
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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
15/01/2008 |
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Data da última atualização: |
25/03/2014 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CASTRO, V. L. S. S. de; CHIORATO, S. H. |
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Afiliação: |
Vera Lúcia Scherholz Salgado de Castro, Embrapa Meio Ambiente; Selma Heloísa Chiorato, FMVZ-USP. |
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Título: |
Effects of separate and combined exposure to the pesticides methamidophos and chlorothalonil on the development of suckling rats. |
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Ano de publicação: |
2007 |
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Fonte/Imprenta: |
International Journal of Hygiene and Environmental Health, Jena, v. 210, n.2, p. 169-176, 2007. |
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Idioma: |
Inglês |
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Conteúdo: |
It has been suggested that, in some cases, exposure to environmental contaminants affects children more profoundly than adults. It is important to evaluate adverse health outcomes in children, a population susceptible to toxic chemicals and mixtures. We examined the effects that maternal exposure to two pesticides had on maturational aspects of offspring development during the nursing period. Nursing female rats were exposed to 1-4 mg/kg of intraperitoneal methamidophos, 200?800 mg/kg of chlorothalonil, or both. The higher doses of methamidophos affected pup viability by day 21 of life. Both pesticides, alone or together, affected body weight gain of dams and offspring. Developmental milestones evaluated in the pups were incisor eruption, ear unfolding, eye opening and testis descent. Although no clear dose-response relationship was established between these milestones and exposure to methamidophos or chlorothalonil, incisor eruption was accelerated in many groups, and the majority of rat offspring exposed to methamidophos presented later ear unfolding and eye opening than did the control group offspring. Sexual maturation (testis descent) was significantly delayed in some groups. For dams and pups alike, simultaneous exposure to both pesticides was not found to have a greater toxic effect than that resulting from exposure to only one of the two. Taken together, these results demonstrate exposure-related influences on several developmental measures. Detection of more subtle effects may be improved through the use of the developmental temporal response protocols utilized in this study. MenosIt has been suggested that, in some cases, exposure to environmental contaminants affects children more profoundly than adults. It is important to evaluate adverse health outcomes in children, a population susceptible to toxic chemicals and mixtures. We examined the effects that maternal exposure to two pesticides had on maturational aspects of offspring development during the nursing period. Nursing female rats were exposed to 1-4 mg/kg of intraperitoneal methamidophos, 200?800 mg/kg of chlorothalonil, or both. The higher doses of methamidophos affected pup viability by day 21 of life. Both pesticides, alone or together, affected body weight gain of dams and offspring. Developmental milestones evaluated in the pups were incisor eruption, ear unfolding, eye opening and testis descent. Although no clear dose-response relationship was established between these milestones and exposure to methamidophos or chlorothalonil, incisor eruption was accelerated in many groups, and the majority of rat offspring exposed to methamidophos presented later ear unfolding and eye opening than did the control group offspring. Sexual maturation (testis descent) was significantly delayed in some groups. For dams and pups alike, simultaneous exposure to both pesticides was not found to have a greater toxic effect than that resulting from exposure to only one of the two. Taken together, these results demonstrate exposure-related influences on several developmental measures. Detection of more subtle ... Mostrar Tudo |
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Palavras-Chave: |
Clorotalonil; Erupção; Metamidafós; Protocolo; Saúde humana; Teste. |
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Thesagro: |
Agrotóxico; Contaminação; Exposição; Pesticida; Toxidez. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/100096/1/2007AP-029.pdf
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Marc: |
LEADER 02399naa a2200265 a 4500
001 1015998
005 2014-03-25
008 2007 bl uuuu u00u1 u #d
100 1 $aCASTRO, V. L. S. S. de
245 $aEffects of separate and combined exposure to the pesticides methamidophos and chlorothalonil on the development of suckling rats.
260 $c2007
520 $aIt has been suggested that, in some cases, exposure to environmental contaminants affects children more profoundly than adults. It is important to evaluate adverse health outcomes in children, a population susceptible to toxic chemicals and mixtures. We examined the effects that maternal exposure to two pesticides had on maturational aspects of offspring development during the nursing period. Nursing female rats were exposed to 1-4 mg/kg of intraperitoneal methamidophos, 200?800 mg/kg of chlorothalonil, or both. The higher doses of methamidophos affected pup viability by day 21 of life. Both pesticides, alone or together, affected body weight gain of dams and offspring. Developmental milestones evaluated in the pups were incisor eruption, ear unfolding, eye opening and testis descent. Although no clear dose-response relationship was established between these milestones and exposure to methamidophos or chlorothalonil, incisor eruption was accelerated in many groups, and the majority of rat offspring exposed to methamidophos presented later ear unfolding and eye opening than did the control group offspring. Sexual maturation (testis descent) was significantly delayed in some groups. For dams and pups alike, simultaneous exposure to both pesticides was not found to have a greater toxic effect than that resulting from exposure to only one of the two. Taken together, these results demonstrate exposure-related influences on several developmental measures. Detection of more subtle effects may be improved through the use of the developmental temporal response protocols utilized in this study.
650 $aAgrotóxico
650 $aContaminação
650 $aExposição
650 $aPesticida
650 $aToxidez
653 $aClorotalonil
653 $aErupção
653 $aMetamidafós
653 $aProtocolo
653 $aSaúde humana
653 $aTeste
700 1 $aCHIORATO, S. H.
773 $tInternational Journal of Hygiene and Environmental Health, Jena$gv. 210, n.2, p. 169-176, 2007.
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Embrapa Meio Ambiente (CNPMA) |
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| 1. |  | THEODORO, J. M. V.; TOLEDO, R. C. L.; PRADO, P. V. C.; CARVALHO, C. W. P. de; MARTINO, H. S. D. Efeito antioxidante de farinhas de milheto (Pennisetum glaucum (L.) R. Br.) convencional, germinado e extrusado em ratos induzidos à deficiência de ferro. In: SIMPÓSIO LATINO AMERICANO DE CIÊNCIA DE ALIMENTOS E NUTRIÇÃO, 15., 2023, Campinas. A revolução da ciência de alimentos e nutrição: alimentando o mundo de forma sustentável: caderno [eletrônico] de resumos. Campinas: Galoá, 2023. 162802 Pôster. SLACAN.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agroindústria de Alimentos. |
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