Data/hora: 21/09/2024 21:18:31

Biblioteca(s): 	Embrapa Agricultura Digital; Embrapa Pecuária Sudeste.	
Data corrente: 	26/07/2022	
Data da última atualização: 	10/11/2022	
Autoria: 	CARDOSO, T. F.; BRUSCADIN, J. J.; AFONSO, J.; PETRINI, J.; ANDRADE, B. G. N.; OLIVEIRA, P. S. N. de; MALHEIROS, J. M.; ROCHA, M. I. P.; ZERLOTINI NETO, A.; FERRAZ, J. B. S.; MOURÃO, G. B.; COUTINHO, L. L.; REGITANO, L. C. de A.	
Afiliação: 	UFSCar; ESALQ/USP; Munster Technological University; UFSCar; Federal University of Latin American Integration, Foz do Iguaçu; UFSCar; ADHEMAR ZERLOTINI NETO, CNPTIA; FZEA/USP; ESALQ/USP; ESALQ/USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.	
Título: 	EEF1A1 transcription cofactor gene polymorphism is associated with muscle gene expression and residual feed intake in Nelore cattle.	
Ano de publicação: 	2022	
Fonte/Imprenta: 	Mammalian Genome, v. 33, n. 4, p. 619-628, Dec. 2022.	
DOI: 	https://doi.org/10.1007/s00335-022-09959-8	
Idioma: 	Inglês	
Conteúdo: 	Abstract. Cis-acting effects of noncoding variants on gene expression and regulatory molecules constitute a significant factor for phenotypic variation in complex traits. To provide new insights into the impacts of single-nucleotide polymorphisms (SNPs) on transcription factors (TFs) and transcription cofactors (TcoF) coding genes, we carried out a multi-omic analysis to identify cis-regulatory effects of SNPs on these genes? expression in muscle and describe their association with feed efficiency-related traits in Nelore cattle. As a result, we identified one SNP, the rs137256008C > T, predicted to impact the EEF1A1 gene expression (? = 3.02; P-value = 3.51E-03) and the residual feed intake trait (? = -3.47; P-value = 0.02). This SNP was predicted to modify transcription factor sites and overlaps with several QTL for feed efficiency traits. In addition, coexpression network analyses showed that animals containing the T allele of the rs137256008 SNP may be triggering changes in the gene network. Therefore, our analyses reinforce and contribute to a better understanding of the biological mechanisms underlying gene expression control of feed efficiency traits in bovines. The cis-regulatory SNP can be used as biomarker for feed efficiency in Nelore cattle.	
Palavras-Chave: 	Cofatores de transcrição; Expressão gênica; Fatores de transcrição; Loci de característica quantitativa; Nelore cattle; Polimorfismos de nucleotídeo único.	
Thesagro: 	Gado Nelore.	
Thesaurus Nal: 	Gene expression; Quantitative trait loci; Single nucleotide polymorphism; Transcription (genetics); Transcription factors.	
Categoria do assunto: 	--
G Melhoramento Genético	
Registro original: 	Embrapa Agricultura Digital (CNPTIA)	
Exemplares: 	CNPTIA - (21230-1) - UPC - AP - DD -  -  -  - DIS
CPPSE - (25684-1) - UPC - AP - DD - PROCI-2022.00052 - CAR - 2022.00107 - DIS