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| Registros recuperados : 4 | |
| 1. |  | TOGAWA, R. C.; RIBEIRO, C.; MAZONI, I.; PELLIGRINELLI, T.; JARDINE, J. G.; NESHICH, G. The table of interface forming residues as the specificity indicator for serine proteases bound to different inhibitors. In: INTERNATIONAL CONFERENCE ON BIOINFORMATICS & COMPUTATIONAL BIOLOGY, 2008, Georgia. Las Vegas Nevada: CSREA, 2008, p. 811-817. BIOCOMP 2008. WORLDCOMP'08| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Recursos Genéticos e Biotecnologia. |
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| 3. | | JARDINE, J. G.; MAZONI, I.; MANCINI, A. L.; BORRO, L. C.; ALVARENGA, D.; CECÍLIO, P. L.; PELLIGRINELLI, T. V.; NESHICH, G. How did the structure function descriptors of proteins change with introduction of 'remediated' PDB files. In: RED IBEROAMERICANA DE BIOINFORMÁTICA CONGRESS, 5., 2008, Santiago. Program and abstracts... Santiago. Pontificia Universidade Católica de Chile, 2008. p. 15.| Biblioteca(s): Embrapa Agricultura Digital. |
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| 4. | | MANCINI, A. L.; JARDINE, J. G.; MAZONI, I.; BORRO, L. C.; ALVARENGA, D.; CECILIO, P. L.; PELLIGRINELLI, T. V.; NESHICH, G. Structure descriptors of chameleon sequences. In: RED IBEROAMERICANA DE BIOINFORMÁTICA CONGRESS, 5., 2008, Chile. Program and abstracts... Santiago: Pontificia Universidad Católica de Chile, 2008. Não paginado. RIB 2008.| Biblioteca(s): Embrapa Agricultura Digital. |
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| Registros recuperados : 4 | |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Agricultura Digital. Para informações adicionais entre em contato com cnptia.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Agricultura Digital. |
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Data corrente: |
26/03/2009 |
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Data da última atualização: |
15/01/2020 |
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Tipo da produção científica: |
Resumo em Anais de Congresso |
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Autoria: |
MANCINI, A. L.; JARDINE, J. G.; MAZONI, I.; BORRO, L. C.; ALVARENGA, D.; CECILIO, P. L.; PELLIGRINELLI, T. V.; NESHICH, G. |
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Afiliação: |
ADAUTO LUIZ MANCINI, CNPTIA; JOSE GILBERTO JARDINE, CNPTIA; IVAN MAZONI, CNPTIA; LUIZ CÉSAR BORRO; DANIEL ALVARENGA; PABLO LIRA CECÍLIO; THAÍS VITAL PELLIGRINELLI; GORAN NESHICH, CNPTIA. |
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Título: |
Structure descriptors of chameleon sequences. |
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Ano de publicação: |
2008 |
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Fonte/Imprenta: |
In: RED IBEROAMERICANA DE BIOINFORMÁTICA CONGRESS, 5., 2008, Chile. Program and abstracts... Santiago: Pontificia Universidad Católica de Chile, 2008. |
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Páginas: |
Não paginado. |
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Idioma: |
Inglês |
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Notas: |
RIB 2008. |
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Conteúdo: |
It has been know since the early work by Sander and Kabsch in 1984 that some identical sequence motifs make completely different local (but extented) folds. In that work, Sander and Kabsch showed the existence of a number of pentapeptides, capable of nucleating both alpha helix and beta strand in different sequence and structure constellations. However, the authors had at that time a very limited universe on which to base their conclusions; namely, the size of the PDB at that time (1984) was only 154 protein structure available. In 2008 the number of available structure is 51,079 (May 27th), 47137containing proteins only. Consequenly, the database is 306 times larger and we took full advantage of this fact. In order to analyze chameleon sequences, we established very strict rules and considered only those ones that passed the test of consensus among HSSP and STRIDE definitions for the Secondary Structure Elements. This is a major difference in our approach versus that of Sander and Kabsch. We then created a data mart of sequences and respective structures with variable size and subjected them to analysis of structure descriptors stored in STING_RDB. Results are discussed in terms of the influence that a local 3D environment has on SSE necleation. |
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Palavras-Chave: |
Bioinformática; Proteinas. |
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Thesaurus NAL: |
Bioinformatics; Proteins. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
LEADER 02073nam a2200265 a 4500
001 1031817
005 2020-01-15
008 2008 bl uuuu u00u1 u #d
100 1 $aMANCINI, A. L.
245 $aStructure descriptors of chameleon sequences.$h[electronic resource]
260 $aIn: RED IBEROAMERICANA DE BIOINFORMÁTICA CONGRESS, 5., 2008, Chile. Program and abstracts... Santiago: Pontificia Universidad Católica de Chile$c2008
300 $aNão paginado.
500 $aRIB 2008.
520 $aIt has been know since the early work by Sander and Kabsch in 1984 that some identical sequence motifs make completely different local (but extented) folds. In that work, Sander and Kabsch showed the existence of a number of pentapeptides, capable of nucleating both alpha helix and beta strand in different sequence and structure constellations. However, the authors had at that time a very limited universe on which to base their conclusions; namely, the size of the PDB at that time (1984) was only 154 protein structure available. In 2008 the number of available structure is 51,079 (May 27th), 47137containing proteins only. Consequenly, the database is 306 times larger and we took full advantage of this fact. In order to analyze chameleon sequences, we established very strict rules and considered only those ones that passed the test of consensus among HSSP and STRIDE definitions for the Secondary Structure Elements. This is a major difference in our approach versus that of Sander and Kabsch. We then created a data mart of sequences and respective structures with variable size and subjected them to analysis of structure descriptors stored in STING_RDB. Results are discussed in terms of the influence that a local 3D environment has on SSE necleation.
650 $aBioinformatics
650 $aProteins
653 $aBioinformática
653 $aProteinas
700 1 $aJARDINE, J. G.
700 1 $aMAZONI, I.
700 1 $aBORRO, L. C.
700 1 $aALVARENGA, D.
700 1 $aCECILIO, P. L.
700 1 $aPELLIGRINELLI, T. V.
700 1 $aNESHICH, G.
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Embrapa Agricultura Digital (CNPTIA) |
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