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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste; Embrapa Solos. |
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Data corrente: |
23/02/2017 |
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Data da última atualização: |
10/11/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
GONZALEZ, M. H.; SILVA, C. S. da; AMARAL, C. D. B.; BIANCHI, S. R.; OLIVEIRA, L. H. B. de; COELHO, J. S.; OLIVEIRA, A.; NOGUEIRA, A. R. de A. |
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Afiliação: |
Mario Henrique Gonzalez, UNESP; Caroline Santos da Silva, UFSCar; Clarice Dias Britto do Amaral, UFSCar; SILMARA ROSSANA BIANCHI, CNPS; Luciano Henrique Barca de Oliveira, UNESP; Jessica Silva Coelho, UNESP; Andrea Oliveira, UFPR; ANA RITA DE ARAUJO NOGUEIRA, CPPSE. |
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Título: |
Determination of elemental impurities in acyclovir ointment and raw materials using microwave acid digestion (MW-AD) and ICP-MS. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Journal of the Brazilian Chemical Society, v. 28, n. 1, p. 98-105, 2017. |
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DOI: |
https://doi.org/10.5935/0103-5053.20160151 |
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Idioma: |
Inglês
Português |
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Conteúdo: |
Inorganic elements present in pharmaceutical products were determined by inductively coupled plasma-mass spectrometer (ICP-MS), employing microwave acid digestion as a sample preparation method. The most abundant isotopes, 75As+ , 65Cu+ , 52Cr+ , 58Ni+ , 208Pb+ , and 51V+ , were determined in acyclovir ointment and its constituents. Elemental impurities in the pharmaceutical samples were determined using an inductively coupled plasma-universal cell technology-mass spectrometer (ICP-UCT-MS) operated in kinetic energy discrimination (KED) and standard mode. The accuracy of the method was assessed by means of addition and recovery experiments. Except for Cr, spiked recoveries of the elements added to the samples before microwave acid digestion (MW-AD) step were between 95.1 and 126%, and after MW-AD step ranged from 85.6 to 132%. Limits of detection (LOD) obtained by proposed method is in agreement to those required by the U.S. Pharmacopeia Convention (USP), showing that the ICP-MS technique is well suited for quantification of these elements. The LOD's (ng L-1) for 51V+ , 52Cr+ , 58Ni+ , 65Cu+ , 75As+ and 208Pb+ in 1% v v-1 HNO3 medium were: 2.2, 81.3, 91.9, 6.9, 0.2 and 3.1, respectively. The concentration of the analytes in these samples presented a wide range, varying from 2.3 ± 0.8 µg kg-1 for As to 3446 ± 47 µg kg-1 for Cr. |
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Palavras-Chave: |
Acyclovir; Elemental impurity; Impureza elementar; Pharmaceutical product; Produto farmacêutico. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/156641/1/0103-5053-jbchs-28-01-0098.pdf
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Marc: |
LEADER 02269naa a2200277 a 4500
001 2067515
005 2021-11-10
008 2017 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.5935/0103-5053.20160151$2DOI
100 1 $aGONZALEZ, M. H.
245 $aDetermination of elemental impurities in acyclovir ointment and raw materials using microwave acid digestion (MW-AD) and ICP-MS.$h[electronic resource]
260 $c2017
520 $aInorganic elements present in pharmaceutical products were determined by inductively coupled plasma-mass spectrometer (ICP-MS), employing microwave acid digestion as a sample preparation method. The most abundant isotopes, 75As+ , 65Cu+ , 52Cr+ , 58Ni+ , 208Pb+ , and 51V+ , were determined in acyclovir ointment and its constituents. Elemental impurities in the pharmaceutical samples were determined using an inductively coupled plasma-universal cell technology-mass spectrometer (ICP-UCT-MS) operated in kinetic energy discrimination (KED) and standard mode. The accuracy of the method was assessed by means of addition and recovery experiments. Except for Cr, spiked recoveries of the elements added to the samples before microwave acid digestion (MW-AD) step were between 95.1 and 126%, and after MW-AD step ranged from 85.6 to 132%. Limits of detection (LOD) obtained by proposed method is in agreement to those required by the U.S. Pharmacopeia Convention (USP), showing that the ICP-MS technique is well suited for quantification of these elements. The LOD's (ng L-1) for 51V+ , 52Cr+ , 58Ni+ , 65Cu+ , 75As+ and 208Pb+ in 1% v v-1 HNO3 medium were: 2.2, 81.3, 91.9, 6.9, 0.2 and 3.1, respectively. The concentration of the analytes in these samples presented a wide range, varying from 2.3 ± 0.8 µg kg-1 for As to 3446 ± 47 µg kg-1 for Cr.
653 $aAcyclovir
653 $aElemental impurity
653 $aImpureza elementar
653 $aPharmaceutical product
653 $aProduto farmacêutico
700 1 $aSILVA, C. S. da
700 1 $aAMARAL, C. D. B.
700 1 $aBIANCHI, S. R.
700 1 $aOLIVEIRA, L. H. B. de
700 1 $aCOELHO, J. S.
700 1 $aOLIVEIRA, A.
700 1 $aNOGUEIRA, A. R. de A.
773 $tJournal of the Brazilian Chemical Society$gv. 28, n. 1, p. 98-105, 2017.
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Registro original: |
Embrapa Solos (CNPS) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Instrumentação. Para informações adicionais entre em contato com cnpdia.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
13/10/2020 |
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Data da última atualização: |
16/08/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
B - 2 |
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Autoria: |
GANDRA, J. R.; PEDRINI, C. A.; CÔNSOLO, N. R. B.; ACOSTA, A. P.; SENO, L. O.; BARBOSA, L. C. G. S.; NOIA, I. Z.; BUARQUE, V. L. M.; PADILLA, A. R. H.; COLNAGO, L. A.; GANDRA, E. R. S. |
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Afiliação: |
LUIZ ALBERTO COLNAGO, CNPDIA. |
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Título: |
Metabolome fingerprints, performance and carcass quality of beef calves supplemented with antibiotic free additive. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Animal Biotechnology, 2020. |
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Páginas: |
1-13 |
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DOI: |
https://doi.org/10.1080/10495398.2020.1828095 |
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Idioma: |
Inglês |
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Conteúdo: |
The aim of this study was to investigate the effects of probiotics on pre-weaning performance, muscle, and fat deposition and serum metabolite profiles in male and female Senepol calves. Thirty new-born Senepol calves, 15 males and 15 females, were randomly allocated to the following treatments: CON a control group that received the basal creep feeding diet and PRO animals that received the basal diet with addition of 2 g/100 kg of body weight (BW) of probiotic. PRO supplementation did not change the DMI but increased average BW, final BW, ADG relative to animals fed CON. Additionally, PRO improved LMA and marbling. Regardless of the serum metabolite profile, the important metabolites for discriminating PRO and CON were glutamine, leucine, creatine, acetate, creatinine, arginine, glutamate, hippurate, glycerol, carnitine, lactate, carnosine, myo-inositol and histidine. According to gender, males had an overabundance of glutamine, glycerol, isoleucine, creatinine and glucose, whereas females had an overabundance of acetyl carnitine, glutamate and carnitine. In conclusion, the addition of PRO in the pre-weaning diet of calves increases performance, weight at weaning and muscle and fat deposition on the carcass, improving proteins and fatty acid metabolism, the immune system response and rumen development. |
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Palavras-Chave: |
Nuclear Magnetic Resonance; Probiotic. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02195naa a2200289 a 4500
001 2125472
005 2022-08-16
008 2020 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1080/10495398.2020.1828095$2DOI
100 1 $aGANDRA, J. R.
245 $aMetabolome fingerprints, performance and carcass quality of beef calves supplemented with antibiotic free additive.$h[electronic resource]
260 $c2020
300 $a1-13
520 $aThe aim of this study was to investigate the effects of probiotics on pre-weaning performance, muscle, and fat deposition and serum metabolite profiles in male and female Senepol calves. Thirty new-born Senepol calves, 15 males and 15 females, were randomly allocated to the following treatments: CON a control group that received the basal creep feeding diet and PRO animals that received the basal diet with addition of 2 g/100 kg of body weight (BW) of probiotic. PRO supplementation did not change the DMI but increased average BW, final BW, ADG relative to animals fed CON. Additionally, PRO improved LMA and marbling. Regardless of the serum metabolite profile, the important metabolites for discriminating PRO and CON were glutamine, leucine, creatine, acetate, creatinine, arginine, glutamate, hippurate, glycerol, carnitine, lactate, carnosine, myo-inositol and histidine. According to gender, males had an overabundance of glutamine, glycerol, isoleucine, creatinine and glucose, whereas females had an overabundance of acetyl carnitine, glutamate and carnitine. In conclusion, the addition of PRO in the pre-weaning diet of calves increases performance, weight at weaning and muscle and fat deposition on the carcass, improving proteins and fatty acid metabolism, the immune system response and rumen development.
653 $aNuclear Magnetic Resonance
653 $aProbiotic
700 1 $aPEDRINI, C. A.
700 1 $aCÔNSOLO, N. R. B.
700 1 $aACOSTA, A. P.
700 1 $aSENO, L. O.
700 1 $aBARBOSA, L. C. G. S.
700 1 $aNOIA, I. Z.
700 1 $aBUARQUE, V. L. M.
700 1 $aPADILLA, A. R. H.
700 1 $aCOLNAGO, L. A.
700 1 $aGANDRA, E. R. S.
773 $tAnimal Biotechnology, 2020.
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Embrapa Instrumentação (CNPDIA) |
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