Data/hora: 18/06/2024 02:51:20

Biblioteca(s): | Embrapa Gado de Leite.
Data corrente: | 19/02/2016
Data da última atualização: | 03/02/2024
Autoria: | SILVA, A. P. C.; MACÊDO, A. A.; SILVA, T. M. A.; XIMENES, L. C. A.; BRANDAO, H. de M.; PAIXÃO, T. A.; SANTOS, R. L.
Afiliação: | Ana Patrícia C. Silva, UFMG; Auricélio A. Macêdo, UFMG; Teane M. A. Silva, UFMG; Luana C. A. Ximenes, UFMG; HUMBERTO DE MELLO BRANDAO, CNPGL; Tatiane A. Paixão, UFMG; Renato L. Santos, UFMG.
Título: | Protection Provided by an Encapsulated Live Attenuated ?abcBA Strain of Brucella ovis against Experimental Challenge in a Murine Model.
Ano de publicação: | 2015
Fonte/Imprenta: | Clinical and Vaccine Immunology, v. 22, n. 7, p. 789-973, 2015.
Idioma: | Inglês
Conteúdo: | This study aimed to evaluate the Brucella ovis &#916;abcBA strain as a vaccine candidate in the murine model. BALB/c mice were subcutaneously or intraperitoneally immunized with a single dose or three doses of the B. ovis &#916;abcBA strain and then were challenged with wild-type B. ovis. Single or multiple immunizations provided only mild protection, with significantly smaller numbers of wild-type B. ovis CFU in the livers of immunized mice but not in the spleens. Encapsulation of B. ovis &#916;abcBA significantly improved protection against experimental challenges in both BALB/c and C57BL/6 mice. Furthermore, immunization with encapsulated B. ovis &#916;abcBA markedly prevented lesions in the spleens and livers of experimentally challenged mice. These results demonstrated that the encapsulated B. ovis &#916;abcBA strain confers protection to mice; therefore, this strain has potential as a vaccine candidate for rams.
Palavras-Chave: | Vaccine.
Thesaurus Nal: | animal health.
Categoria do assunto: | L Ciência Animal e Produtos de Origem Animal
Registro original: | Embrapa Gado de Leite (CNPGL)
Exemplares: | CNPGL - (22381-1) - UPC - AP - DD -  -  -  - DIS