Data/hora: 20/06/2024 07:55:30

Biblioteca(s): 	Embrapa Gado de Leite.	
Tipo da produção científica: 	Artigo em Periódico Indexado	
Circulação/Nível: 	A - 2	
Data corrente: 	05/02/2013	
Data da última atualização: 	08/02/2024	
Autoria: 	OTENIO, C. C. M.; FONSECA, I.; MARTINS, M. F.; RIBEIRO, L. C.; ASSIS, N. M. S. P.; FERREIRA, A. P.; RIBEIRO, R. A.	
Afiliação: 	C. C. M. OTENIO, UFJF; I. FONSECA, UFV; MARTA FONSECA MARTINS, CNPGL; L. C. RIBEIRO, UFV; N. M. S. P. ASSIS, UFJF; A. P. FERREIRA, UFJF; R. A. RIBEIRO, UFJF.	
Título: 	Expression of IL-1B, IL-6, TNF-a and iNOS in pregnant women with periodontal disease.	
Ano de publicação: 	2012	
Fonte/Imprenta: 	Genetics and Molecular Research, v. 11, n. 4, p. 4468-4478, 2012.	
DOI: 	https://doi.org/10.4238/2012.september.20.3	
Idioma: 	Inglês	
Conteúdo: 	Periodontal disease is one of the most prevalent oral diseases. An association between this disease and pregnancy has been suggested, but available findings are controversial. We evaluated the expression levels of interleukins (IL-1β and IL-6), tumor necrosis factor-alpha (TNF-α), and inducible nitric oxide synthase (iNOS) in pregnant women with and without periodontal disease in comparison with non-pregnant women with and without periodontal disease since studies have suggested a relationship between periodontitis and the expression levels of these genes. The women in the sample were distributed into four groups: pregnant and non-pregnant women, with or without periodontal disease, a total of 32 women. The periodontal condition was evaluated according to the probing depth, clinical attachment level and bleeding on probing. Analysis of gene expression was performed by real-time PCR. Comparisons were made of the level of gene expression among the four groups. Expression of IL-1β in the non-pregnant women with periodontal disease was 12.6 times higher than in the non-pregnant women without periodontal disease (P < 0.01), while expression of TNF-α in the non-pregnant women without periodontal disease was 3.5 times higher than in the pregnant women with periodontal disease (P < 0.05). Despite these differences, our overall findings indicate no differences in the expression levels of the cytokines IL-1β, IL-6, TNF-α, and iNOS in pregnant women with and without periodontal disease in comparison with expression of the same genes in non-pregnant women with and without periodontal disease, suggesting that periodontal disease is not influenced by pregnancy.	
Palavras-Chave: 	Gengiva; Periodonto.	
Categoria do assunto: 	H Saúde e Patologia	
URL: 	http://ainfo.cnptia.embrapa.br/digital/bitstream/doc/948391/1/Expression-of-IL-1B-IL-6-TNF-a-and-iNOS-in-pregnant.pdf	
Registro original: 	Embrapa Gado de Leite (CNPGL)	
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