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| Registros recuperados : 116 | |
| 81. |  | CARNEIRO, A. V.; STOCK, L. A.; OLIVEIRA, V. M.; ZOCCAL, R.; CARVALHO, G. R.; MARTINS, P. do C.; YAMAGUCHI, L. C. T. Mastite clínica: prevalência e custo de tratamento em rebanho leiteiro. In: REUNIÓN ASOCIACÓN LATINOAMERICANA DE PRODUCCIÓN ANIMAL, 20.; REUNIÓN ASOCIACIÓN PERUANA DE PRODUCCIÓN ANIMAL, 30.; CONGRESO INTERNACIONAL DE GANADERIA DOBLE PROPOSITO, 5., 2007, Cuzco. Resumenes... Cuzco: ALPA/APPA, 2007.| Biblioteca(s): Embrapa Gado de Leite. |
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| 82. | | OTTONI, J. R.; BELOTI, L. L.; SANTIAGO, A. S.; COSTA, B. Z.; MELO, I. S. de; SOUZA, A. P.; MARSAIOLI, A. J.; OLIVEIRA, V. M. Molecular cloning and functional characterization of a catalase gene from a Bacillus safensis strain isolated from an oil-impacted Brazilian mangrove sediment. Hechos Microbiológicos, v. 5, n. 2, p. 29, 2014. Suplemento. Edição das Memorias do 22º Congreso Latinoamericano de Microbiologia e 4º Congreso Colombiano de Microbiologia, Cartagena, 2014. Ref. TLO-7.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 84. | | OLIVEIRA, V. M. de; CARNEIRO, A. V.; YAMAGUCHI, L. C. T.; BRITO NETO, E. P. de; MORAIS, R. J. da S. Tuberculose bovina no Estado de Minas Gerais e em outras regiões do País e principais fatores relacionados ao controle desta enfermidade. In: YAMAGUCHI, L. C. T.; MENDES, L. C. R.; LIMA, I. B. de; RODRIGUES, C. do C.; RESENDE, M. L. de. (Ed.). Aspectos sócio-econômicos e ambientais da produção de leite. Juiz de Fora: Embrapa Gado de Leite, 2007. p. 187-197.| Biblioteca(s): Embrapa Gado de Leite. |
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| 85. | | COSTA, R. R.; ROCHA, A. S.; ARAUJO, F. R.; SILVA, M. R.; GUIMARAES, M. D. C.; SUFFYS, P. N.; OLIVEIRA, V. M. Tuberculose zoonótica devida a Mybacterium bovis em Juiz de Fora, Minas Gerais, Brasil. Revista Médica de Minas Gerais, v. 22, supl. 2, p. S147, 2012. Edição dos resumos do 3º Fórum Científico da Fundação Hospitalar do Estado de Minas Gerais, Juiz de Fora, 2012.| Biblioteca(s): Embrapa Gado de Leite. |
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| 87. | | RIBEIRO, A. C. de C. L.; PRATA, M. C. de A.; RIBEIRO, M. T.; OLIVEIRA, V. M. de; SA, W. F. DE. Saúde animal. In: CAMPOS, O. F. de; MIRANDA, J. E. C. de (ed.). Gado de leite: o produtor pergunta, a Embrapa responde. 3. ed. rev. ampl. Brasília, DF: Embrapa; Juiz de Fora: Embrapa Gado de Leite, 2012. p. 213-234. (Coleção 500 perguntas 500 respostas).| Biblioteca(s): Embrapa Gado de Leite. |
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| 88. | | OTTONI, J. R.; DUARTE, A. W. F.; BELOTI, L. L.; COSTA, B. Z.; MELO, I. S. de; SOUZA, A. P.; MARSAIOLI, A. J.; OLIVEIRA, V. M. Screening of bacterial isolates from Brazilian oil-impacted mangrove for lipase and esterase activities. Hechos Microbiológicos, v. 5, n. 2, p. 93, 2014. Suplemento. Edição das Memorias do 22º Congreso Latinoamericano de Microbiologia e 4º Congreso Colombiano de Microbiologia, Cartagena, 2014. Ref. TLP-155.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 89. | | DIAMANTINO, G. M. L.; PIEREZAN, F.; FERREIRA, M. I. C.; ROCHA, W. S. D. da; OLIVEIRA, V. M. de; MARTINS, C. E.; VEIGA, M. O.; SOTO-BLANCO, B. Photosensitization by Brachiaria ruziziensis in a sheep herd. Toxicon, v. 185, p. 1-4, 2020.| Biblioteca(s): Embrapa Caprinos e Ovinos; Embrapa Gado de Leite. |
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| 90. | | SILVA, M. R.; ROCHA, A. S.; COSTA, R. R.; OLIVEIRA, V. M. de; SOUZA, G. N. de; ARAUJO, F. R.; SUFFYS, P. N.; GUIMARAES, M. D. Prevalencia de infecções humanas por Mycobacterium bovis e micobactérias não tuberculosas e fatores associados no Brasil. In: CONGRESSO BRASILEIRO DE SAUDE COLETIVA, 10., 2012, Porto Alegre. Anais... Rio de Janeiro: Associação Brasileira de Saúde Coletiva, 2012.| Biblioteca(s): Embrapa Gado de Leite. |
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| 91. | | LACERDA JÚNIOR, G. V.; NORONHA, M. F.; SOUSA, S. T. P. de; CABRAL, L.; DOMINGOS, D. F.; SÁBER, M. L.; MELO, I. S. de; OLIVEIRA, V. M. Potential of semiarid soil from Caatinga biome as a novel source for mining lignocellulose-degrading enzymes. FEMS Microbiology Ecology, v. 93, n. 2, p. 1-15, 2017.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 92. | | DOMINGOS, D. F.; OTTONI, J. R.; SILVA, C. C.; DELLAGNEZZE, B. M.; VASCONCELLOS, S. P.; MELO, I. S. de; OLIVEIRA, V. M. Prospecção de novos biossurfactantes a partir da biblioteca metagenômica de manguezal utilizando High Throughput Screening (HTS). In: CONGRESSO BRASILEIRO DE MICROBIOLOGIA, 26., 2011, Foz do Iguaçu. Anais... Foz do Iguaçu: Sociedade Brasileira de Microbiologia, 2011. Resumo 1250-1.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 93. | | SILVA, M. R.; OLIVEIRA, V. M. de; SOUZA, G. N. de; ROCHA, A. S.; COSTA, R. R.; ARAUJO, F. R.; SUFFYS, P. M.; GUIMARAES, M. D. C. Risk factors for Mycobacterium bovis and M. avium-intracellulare human infections in Brazil. In: Simpósio Embrapa LabEx EUA de Sanidade Animal, 2., 2012, Brasília. Proceedings... Brasília: Embrapa Estudos e Capacitação, 2012 p. 52| Biblioteca(s): Embrapa Gado de Leite. |
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| 94. | | SILVA, M. R.; OLIVEIRA, V. M. de; SOUZA, G. N. de; ROCHA, A. DA S.; COSTA, R. R.; ARAUJO, F. R.; SUFFYS, P. N.; GUIMARAES, M. D. C. Risk factors for Mycobacterium bovis and M. avium-intracellulare human infections in Brazil. In: Simpósio Embrapa LabEx EUA de Sanidade Animal, 2., 2012, Brasília. Proceedings... Brasília: Embrapa Estudos e Capacitação, 2012 p. 53| Biblioteca(s): Embrapa Gado de Leite. |
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| 95. | | TEIXEIRA, S. R.; MIRANDA, J. E. C. de; OLIVEIRA, V. M. de; STOCK, L. A.; CARVALHO, A. da C.; SOUZA, R. C. V. de; BARBOSA, V. de S. C.; MAGALHAES, V. M. A. de. Administrando a propriedade leiteira: cartilhas elaboradas conforme a metodologia e-Rural. Brasília, DF: Embrapa, 2016. 52 p. il. color| Biblioteca(s): Embrapa Caprinos e Ovinos; Embrapa Semiárido. |
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| 96. | | TEIXEIRA, S. R.; MIRANDA, J. E. C. de; OLIVEIRA, V. M. de; STOCK, L. A.; CARVALHO, A. da C.; SOUZA, R. C. V. de; BARBOSA, V. de S. C.; MAGALHAES, V. M. A. de. Administrando a propriedade leiteira: cartilhas elaboradas conforme a metodologia e-Rural. Brasília, DF: Embrapa, 2016 52 p. il. color| Biblioteca(s): Embrapa Gado de Leite. |
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| 97. | | SILVA, L. J. da; CREVELIN, E. J.; SOUZA, D. T.; LACERDA JÚNIOR, G. V.; OLIVEIRA, V. M.; RUIZ, A. L. T. G.; ROSA, L. H.; MORAES, L. A. B.; MELO, I. S. de. Actinobacteria from Antarctica as a source for anticancer discovery. Scientific Reports, v. 10, article 13870, 2020. p. 1-15.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 98. | | OLIVEIRA, V. M. de; MENDONCA, L. C.; PIRES, M. de F. A.; REIS, E. S. dos; MIRANDA, J. E. C. de; DINIZ, F. H.; VICENTINI, N. M.; COSTA, L. R. da; MAGALHAES, V. M. A. de. Boas práticas de ordenha na propriedade familiar para obtenção de leite e queijo artesanal de qualidade : cartilhas elaboradas conforme metologia e-Rural. Brasília, DF: Embrapa, 2017. 40 p. il. color| Biblioteca(s): Embrapa Gado de Leite. |
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| 99. | | SILVA, T. R. e; DUARTE, A. W. F.; PASSARINI, M. R. Z.; RUIZ, A. L. T. G.; FRANCO, C. H.; MORAES, C. B.; MELO, I. S. de; RODRIGUES, R. A.; FANTINATTI-GARBOGGINI, F.; OLIVEIRA, V. M. Bacteria from Antarctic environments: diversity and detection of antimicrobial, antiproliferative, and antiparasitic activities. Polar Biology, v. 41, n. 7, p. 1505-1519, 2018.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 100. | | SILVA, M. R.; GUIMARAES, M. D. C.; OLIVEIRA, V. M. de; COSTA, R. R.; ABI-ZAID, K. C. L.; ARAUJO, F. R.; ROCHA, A. DA S.; SUFFYS, P. N. Identification of Mycobacterium tuberculosis complex based on amplification and sequencing of the oxyP pseudogene from stored Ziehl-Neelsen-stained sputum smears in Brazil. In: Simpósio Embrapa LabEx EUA de Sanidade Animal, 2., 2012, Brasília. Proceedings... Brasília: Embrapa Estudos e Capacitação, 2012 57 p.| Biblioteca(s): Embrapa Gado de Leite. |
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| Registros recuperados : 116 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
29/12/2020 |
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Data da última atualização: |
29/12/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
SILVA, L. J. da; CREVELIN, E. J.; SOUZA, D. T.; LACERDA JÚNIOR, G. V.; OLIVEIRA, V. M.; RUIZ, A. L. T. G.; ROSA, L. H.; MORAES, L. A. B.; MELO, I. S. de. |
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Afiliação: |
LEONARDO JOSÉ SILVA, ESALQ-USP; EDUARDO JOSÉ CREVELIN, FFCLRP-USP; DANILO TOSTA SOUZA, FFCLRP-USP; GILENO VIEIRA LACERDA JÚNIOR; VALERIA MAIA DE OLIVEIRA, CPQBA-UNICAMP; ANA LUCIA TASCA GOIS RUIZ, FCF-UNICAMP; LUIZ HENRIQUE ROSA, UFMG; LUIZ ALBERTO BERALDO MORAES, FFCLRP-USP; ITAMAR SOARES DE MELO, CNPMA. |
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Título: |
Actinobacteria from Antarctica as a source for anticancer discovery. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Scientific Reports, v. 10, article 13870, 2020. |
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Páginas: |
p. 1-15. |
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ISSN: |
2045-2322 |
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DOI: |
https://doi.org/10.1038/s41598-020-69786-2 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Although many advances have been achieved to treat aggressive tumours, cancer remains a leading cause of death and a public health problem worldwide. Among the main approaches for the discovery of new bioactive agents, the prospect of microbial secondary metabolites represents an effective source for the development of drug leads. In this study, we investigated the actinobacterial diversity associated with an endemic Antarctic species, Deschampsia antarctica, by integrated culture-dependent and culture-independent methods and acknowledged this niche as a reservoir of bioactive strains for the production of antitumour compounds. The 16S rRNA-based analysis showed the predominance of the Actinomycetales order, a well-known group of bioactive metabolite producers belonging to the Actinobacteria phylum. Cultivation techniques were applied, and 72 psychrotolerant Actinobacteria strains belonging to the genera Actinoplanes, Arthrobacter, Kribbella, Mycobacterium, Nocardia, Pilimelia, Pseudarthrobacter, Rhodococcus, Streptacidiphilus, Streptomyces and Tsukamurella were identified. The secondary metabolites were screened, and 17 isolates were identified as promising antitumour compound producers. However, the bio-guided assay showed a pronounced antiproliferative activity for the crude extracts of Streptomyces sp. CMAA 1527 and Streptomyces sp. CMAA 1653. The TGI and LC50 values revealed the potential of these natural products to control the proliferation of breast (MCF-7), glioblastoma (U251), lung/non-small (NCI-H460) and kidney (786-0) human cancer cell lines. Cinerubin B and actinomycin V were the predominant compounds identified in Streptomyces sp. CMAA 1527 and Streptomyces sp. CMAA 1653, respectively. Our results suggest that the rhizosphere of D. antarctica represents a prominent reservoir of bioactive actinobacteria strains and reveals it as an important environment for potential antitumour agents. MenosAbstract: Although many advances have been achieved to treat aggressive tumours, cancer remains a leading cause of death and a public health problem worldwide. Among the main approaches for the discovery of new bioactive agents, the prospect of microbial secondary metabolites represents an effective source for the development of drug leads. In this study, we investigated the actinobacterial diversity associated with an endemic Antarctic species, Deschampsia antarctica, by integrated culture-dependent and culture-independent methods and acknowledged this niche as a reservoir of bioactive strains for the production of antitumour compounds. The 16S rRNA-based analysis showed the predominance of the Actinomycetales order, a well-known group of bioactive metabolite producers belonging to the Actinobacteria phylum. Cultivation techniques were applied, and 72 psychrotolerant Actinobacteria strains belonging to the genera Actinoplanes, Arthrobacter, Kribbella, Mycobacterium, Nocardia, Pilimelia, Pseudarthrobacter, Rhodococcus, Streptacidiphilus, Streptomyces and Tsukamurella were identified. The secondary metabolites were screened, and 17 isolates were identified as promising antitumour compound producers. However, the bio-guided assay showed a pronounced antiproliferative activity for the crude extracts of Streptomyces sp. CMAA 1527 and Streptomyces sp. CMAA 1653. The TGI and LC50 values revealed the potential of these natural products to control the proliferation of breast (MCF-7)... Mostrar Tudo |
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Palavras-Chave: |
Anticancer activity; Antitumoral activity. |
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Thesagro: |
Bactéria não Patogênica; Câncer. |
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Thesaurus NAL: |
Actinobacteria; Antarctica. |
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Categoria do assunto: |
S Ciências Biológicas |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/219757/1/Melo-Actinobacteria-Antarctica-2020.pdf
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Marc: |
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001 2128824
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008 2020 bl uuuu u00u1 u #d
022 $a2045-2322
024 7 $ahttps://doi.org/10.1038/s41598-020-69786-2$2DOI
100 1 $aSILVA, L. J. da
245 $aActinobacteria from Antarctica as a source for anticancer discovery.$h[electronic resource]
260 $c2020
300 $ap. 1-15.
520 $aAbstract: Although many advances have been achieved to treat aggressive tumours, cancer remains a leading cause of death and a public health problem worldwide. Among the main approaches for the discovery of new bioactive agents, the prospect of microbial secondary metabolites represents an effective source for the development of drug leads. In this study, we investigated the actinobacterial diversity associated with an endemic Antarctic species, Deschampsia antarctica, by integrated culture-dependent and culture-independent methods and acknowledged this niche as a reservoir of bioactive strains for the production of antitumour compounds. The 16S rRNA-based analysis showed the predominance of the Actinomycetales order, a well-known group of bioactive metabolite producers belonging to the Actinobacteria phylum. Cultivation techniques were applied, and 72 psychrotolerant Actinobacteria strains belonging to the genera Actinoplanes, Arthrobacter, Kribbella, Mycobacterium, Nocardia, Pilimelia, Pseudarthrobacter, Rhodococcus, Streptacidiphilus, Streptomyces and Tsukamurella were identified. The secondary metabolites were screened, and 17 isolates were identified as promising antitumour compound producers. However, the bio-guided assay showed a pronounced antiproliferative activity for the crude extracts of Streptomyces sp. CMAA 1527 and Streptomyces sp. CMAA 1653. The TGI and LC50 values revealed the potential of these natural products to control the proliferation of breast (MCF-7), glioblastoma (U251), lung/non-small (NCI-H460) and kidney (786-0) human cancer cell lines. Cinerubin B and actinomycin V were the predominant compounds identified in Streptomyces sp. CMAA 1527 and Streptomyces sp. CMAA 1653, respectively. Our results suggest that the rhizosphere of D. antarctica represents a prominent reservoir of bioactive actinobacteria strains and reveals it as an important environment for potential antitumour agents.
650 $aActinobacteria
650 $aAntarctica
650 $aBactéria não Patogênica
650 $aCâncer
653 $aAnticancer activity
653 $aAntitumoral activity
700 1 $aCREVELIN, E. J.
700 1 $aSOUZA, D. T.
700 1 $aLACERDA JÚNIOR, G. V.
700 1 $aOLIVEIRA, V. M.
700 1 $aRUIZ, A. L. T. G.
700 1 $aROSA, L. H.
700 1 $aMORAES, L. A. B.
700 1 $aMELO, I. S. de
773 $tScientific Reports$gv. 10, article 13870, 2020.
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Embrapa Meio Ambiente (CNPMA) |
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