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| Registros recuperados : 74 | |
| 6. |  | SERRA, V.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; LIMA, A. O. de; GASPARIN, G.; COUTINHO, L. L.; MOURÃO, G. B.; REGITANO, L. C. de A. Análise de qualidade de RNA para estudo do perfil transcriptômico de animais extremos para eficiência alimentar da raça Nelore. In: JORNADA CIENTÍFICA - EMBRAPA SÃO CARLOS, 5., 2013, São Carlos, SP. Anais... São Carlos, SP: Embrapa Pecuária Sudeste: Embrapa Instrumentação , 2013. p. 12 (Embrapa Pecuária Sudeste. Documentos, 110). Editado por Ana Rita de Araújo nogueira, simone Cristina Méo Nicura| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 9. | | HOMEM JÚNIOR, A. C.; EZEQUIEL, J. M. B.; FÁVARO, V. R.; OLIVEIRA, P. S. N.; D'AUREA, A. P.; SANTOS, V. C.; GONÇALVES, J. S. Fermentação ruminal de ovinos alimentados com alto concentrado e grãos de girassol ou gordura protegida. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, Belo Horizonte, v. 62, n. 1, p. 144-153, fev., 2010.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 10. | | DINIZ, W. J. S.; ROSA, K. O. da; TIZIOTO, P. C.; MOURÃO, G. B.; OLIVEIRA, P. S. N. de; SOUZA, M. M. de; REGITANO, L. C. de A. FABP1 and SLC2A5 expression levels affect feed efficiency-related traits. Agri Gene, v. 15, p. 1-7, e100100, mar. 2020.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 11. | | OLIVEIRA, P. S. N. de; TIZIOTO, P. C.; NORONHA, C. T.; MALAGO JUNIOR, W.; MUDADU, M. de A.; REGITANO, L. C. de A. A SNP in NEUROD1 is associated with production traits in Nelore beef cattle. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 51., 2014, Barra dos Coqueiros. A produção animal frente às mudanças climáticas e tecnológicas - anais. Barra dos coqueiros: Sociedade Brasileira de Zootecnia, 2014. 1 CD-ROM.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 12. | | TIZIOTO, P. C.; MEIRELLES, S. L.; SOUZA, M. M. de; OLIVEIRA, P. S. N. de; SIQUEIRA, F.; ROSA, A. do N.; TULLIO, R. R. Screening for single nucleotide polymorphisms in MYOD1 gene and its association with meat tenderness in cattle. In: INTERNATIONAL CONFERENCE OF BRAZIL ASSOCIATION AND COMPUTER BIOLOGY 7.; INTERNATIONAL CONFERENCE OF THE IBEROAMERICAN SOCIETY FOR BIOINFORMATICS, 3., 2011, Florianópolis. Proceedings... Florianóplis: ABC3C: SolBio, 2011. ID 126| Biblioteca(s): Embrapa Gado de Corte; Embrapa Pecuária Sudeste. |
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| 13. | | OLIVEIRA, P. S. N.; MALAGO JUNIOR, W.; TIZIOTO, P. C.; NASCIMENTO, M. L. do; MUDADU, M. de A.; REGITANO, L. C. de A. NEUROD1 gene is not associated with feed efficiency in Nellore cattle. In: INTERNATIONAL SYMPOSIUM ON ANIMAL FUNCTIONAL GENOMICS, 5., 2013, Guarujá. Abstract... Guarujá:[ s.n.], 2013. AB.28.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 14. | | SOUZA, M. M.; MOKRY, F. C.; TIZIOTO, P. C.; OLIVEIRA, P. S. N.; SOMAVILLA, A.; CESAR, A. S. M.; MORÉ, D.; MOURÃO, G.; DINIZ, W. J. S.; MUDADU, M. A.; NICIURA, S. C. M.; ZERLOTINI, A.; REGITANO, L. C. Allele specific expression analysis in bovine muscle tissue. In: INTERNATIONAL CONFERENCE OF TH AB3C, 11.; BRAZILIAN SYMPOSIUM OF BIOINFORMATICS, 2015, São Paulo. Proceedings... São Paulo: USP-São Paulo, 2015.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 15. | | ROCHA, M. I. P.; SOUZA, M. M. de; ZERLOTINI NETO, A.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; LIMA, A. O. de; AFONSO, J.; COUTINHO, L. L.; REGITANO, L. C. de A.; NICIURA, S. C. M. Allele-specific gene expression in liver of Nelore cattle extremes for feed efficiency. In: INTERNATIONAL SOCIETY FOR ANIMAL GENETICS CONFERENCE, 36., 2017, Dublin. Proceedings... Dublin: University College Dublin, 2017. p. 156 - 157.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 16. | | DINIZ, W. J. S.; ROSA, K. O.; COUTINHO, L. L.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; SOUZA, M. M. de S.; CHAVES, A. S.; LANNA, D. P. D.; MOURÃO, G. B.; REGITANO, L. C. de A. KCNJ11 gene expression is associated to feed consumption and growth traits in Nelore beef cattle. Agri Gene, v. 9, p. 1-4, 2018.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 17. | | DINIZ, W. J. da S.; COUTINHO, L. L.; TIZIOTO, P. C.; CESAR, A. S. M.; GROMBONI, C. F.; NOGUEIRA, A. R. de A.; OLIVEIRA, P. S. N. de; SOUZA, M. M. de; REGITANO, L. C. de A. Iron content affects lipogenic gene expression in the muscle of nelore beef cattle. Plos One, aug. 2016.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 18. | | BUSS, C. E.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; MUDADU, M. de A.; CESAR, A. S. M.; VENTURA, R. V.; AFONSO, J.; LIMA, A. O. de; COUTINHO, L. L.; TULLIO, R. R.; REGITANO, L. C. de A. Genome-wide efficient mixed-model study for meat quality in Nellore cattle. Journal of Animal Science, v. 94, e-suppl. 5; Journal of Dairy Science, v. 99, e-suppl. 1, p. 159, jul. 2016.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 19. | | BUSS, C. E.; TIZIOTO, P. C.; OLIVEIRA, P. S. N.; MUDADU, M. de A.; CESAR, A. S. M.; VENTURA, R. V.; AFONSO, J.; LIMA, A. O. D.; COUTINHO, L. L.; TULLIO, R. R.; REGITANO, L. C. de A. Genome-wide efficient mixed-model study for meat quality in Nellore cattle. Journal of Animal Science, v. 94, p. 428-429, 2016. Supplement 5. Na publicação: M. A. Mudadu.| Biblioteca(s): Embrapa Agricultura Digital. |
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| 20. | | SOMAVILLA, A. L.; REGITANO, L. C. de A.; ROSA, G. J. M.; MOKRY, F. B.; MUDADU, M. de A.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; SOUZA, M. M. de; COUTINHO, L. L.; MUNARI, D. P. Genome-enabled prediction of breeding values for feedlot average daily weight gain in nelore cattle. G3: Genes, Genomes, Genetics, v. 7, p. 1-17, 2017.| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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| Registros recuperados : 74 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
15/03/2019 |
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Data da última atualização: |
02/12/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
DINIZ, W. J. S.; MAZZONI, G.; COUTINHO; BANERJEE, P.; GEISTLINGER, L.; CESAR, A. S. M.; BERTOLINI. F.; AFONSO, J.; OLIVEIRA, P. S. N.; TIZIOTO, P. C.; KADARMIDEEN, H. N.; REGITANO, L. C. de A. |
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Afiliação: |
Wellison J. S. Diniz, UFSCAR; Gianluca Mazzoni, Technical University of Denmark; Luiz L. Coutinho, USP; Priyanka Banerjee, Technical University of Denmark; Ludwig Geistlinger, Graduate School of Public Health and Health Policy; Aline S. M. Cesar, USP; Francesca Bertolini, Technical University of DenmarK; Juliana Afonso, UFSCAR; Priscila S. N. de Oliveira, Bolsista/Embrapa Pecuária Sudeste; Polyana C. Tizioto, USP; Haja N. Kadarmideen, Technical University of Denmark; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
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Título: |
Detection of Co-expressed pathway modules associated with mineral concentration and meat quality in nelore cattle. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Frontiers in genetics, v. 10, n. 210, p. 1-12, 2019. |
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DOI: |
10.3389/fgene.2019.00210 |
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Idioma: |
Inglês |
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Conteúdo: |
Meat quality is a complex trait that is influenced by genetic and environmental factors, which includes mineral concentration. However, the association between mineral concentration and meat quality, and the specific molecular pathways underlying this association, are not well explored. We therefore analyzed gene expression as measured with RNA-seq in Longissimus thoracis muscle of 194 Nelore steers for association with three meat quality traits (intramuscular fat, meat pH, and tenderness) and the concentration of 13 minerals (Ca, Cr, Co, Cu, Fe, K, Mg, Mn, Na, P, S, Se, and Zn). We identified seven sets of co-expressed genes (modules) associated with at least two traits, which indicates that common pathways influence these traits. From pathway analysis of module hub genes, we further found an over-representation for energy and protein metabolism (AMPK and mTOR signaling pathways) in addition to muscle growth, and protein turnover pathways. Among the identified hub genes FASN, ELOV5, and PDE3B are involved with lipid metabolism and were affected by previously identified eQTLs associated to fat deposition. The reported hub genes and over-represented pathways provide evidence of interplay among gene expression, mineral concentration, and meat quality traits. Future studies investigating the effect of different levels of mineral supplementation in the gene expression and meat quality traits could help us to elucidate the regulatory mechanism by which the genes/pathways are affected. MenosMeat quality is a complex trait that is influenced by genetic and environmental factors, which includes mineral concentration. However, the association between mineral concentration and meat quality, and the specific molecular pathways underlying this association, are not well explored. We therefore analyzed gene expression as measured with RNA-seq in Longissimus thoracis muscle of 194 Nelore steers for association with three meat quality traits (intramuscular fat, meat pH, and tenderness) and the concentration of 13 minerals (Ca, Cr, Co, Cu, Fe, K, Mg, Mn, Na, P, S, Se, and Zn). We identified seven sets of co-expressed genes (modules) associated with at least two traits, which indicates that common pathways influence these traits. From pathway analysis of module hub genes, we further found an over-representation for energy and protein metabolism (AMPK and mTOR signaling pathways) in addition to muscle growth, and protein turnover pathways. Among the identified hub genes FASN, ELOV5, and PDE3B are involved with lipid metabolism and were affected by previously identified eQTLs associated to fat deposition. The reported hub genes and over-represented pathways provide evidence of interplay among gene expression, mineral concentration, and meat quality traits. Future studies investigating the effect of different levels of mineral supplementation in the gene expression and meat quality traits could help us to elucidate the regulatory mechanism by which the genes/pathways are affe... Mostrar Tudo |
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Palavras-Chave: |
AMPK pathway; Co-expression analysis; RNA sequencing; Tenderness. |
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Thesagro: |
Gado de Corte; Gordura Animal. |
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Thesaurus NAL: |
Beef cattle; Beef quality; Intramuscular fat. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/194304/1/fgene-10-00210.pdf
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Marc: |
LEADER 02585naa a2200373 a 4500
001 2107117
005 2019-12-02
008 2019 bl uuuu u00u1 u #d
024 7 $a10.3389/fgene.2019.00210$2DOI
100 1 $aDINIZ, W. J. S.
245 $aDetection of Co-expressed pathway modules associated with mineral concentration and meat quality in nelore cattle.$h[electronic resource]
260 $c2019
520 $aMeat quality is a complex trait that is influenced by genetic and environmental factors, which includes mineral concentration. However, the association between mineral concentration and meat quality, and the specific molecular pathways underlying this association, are not well explored. We therefore analyzed gene expression as measured with RNA-seq in Longissimus thoracis muscle of 194 Nelore steers for association with three meat quality traits (intramuscular fat, meat pH, and tenderness) and the concentration of 13 minerals (Ca, Cr, Co, Cu, Fe, K, Mg, Mn, Na, P, S, Se, and Zn). We identified seven sets of co-expressed genes (modules) associated with at least two traits, which indicates that common pathways influence these traits. From pathway analysis of module hub genes, we further found an over-representation for energy and protein metabolism (AMPK and mTOR signaling pathways) in addition to muscle growth, and protein turnover pathways. Among the identified hub genes FASN, ELOV5, and PDE3B are involved with lipid metabolism and were affected by previously identified eQTLs associated to fat deposition. The reported hub genes and over-represented pathways provide evidence of interplay among gene expression, mineral concentration, and meat quality traits. Future studies investigating the effect of different levels of mineral supplementation in the gene expression and meat quality traits could help us to elucidate the regulatory mechanism by which the genes/pathways are affected.
650 $aBeef cattle
650 $aBeef quality
650 $aIntramuscular fat
650 $aGado de Corte
650 $aGordura Animal
653 $aAMPK pathway
653 $aCo-expression analysis
653 $aRNA sequencing
653 $aTenderness
700 1 $aMAZZONI, G.
700 1 $aCOUTINHO
700 1 $aBANERJEE, P.
700 1 $aGEISTLINGER, L.
700 1 $aCESAR, A. S. M.
700 1 $aBERTOLINI. F.
700 1 $aAFONSO, J.
700 1 $aOLIVEIRA, P. S. N.
700 1 $aTIZIOTO, P. C.
700 1 $aKADARMIDEEN, H. N.
700 1 $aREGITANO, L. C. de A.
773 $tFrontiers in genetics$gv. 10, n. 210, p. 1-12, 2019.
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