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Registro Completo |
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Biblioteca(s): |
Ebooks. |
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Data corrente: |
15/08/2008 |
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Data da última atualização: |
16/06/2011 |
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Autoria: |
HUANG, L.; HUNG, M.-C.; WAGNER, E. |
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Afiliação: |
Leaf Huang; Mien-chie. Hung; Ernst Wagner. |
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Título: |
Nonviral vectors for gene therapy |
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Ano de publicação: |
1999 |
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Fonte/Imprenta: |
San Diego, CA : Academic Press, c1999. |
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Páginas: |
xxv, 442 p. |
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Descrição Física: |
ill. (some col.) ;24 cm. |
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ISBN: |
9780123584656 |
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Idioma: |
Inglês |
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Conteúdo: |
Introduction, L.Huang and E. Viroonhatapan. -- Cationic Liposomes: -- Progress in Gene Delivery Research and Development, P. Felgner. -- Cationic Lipid-Mediated Gene Delivery to the Airways, J. Marshall, N. Yew, S. Eastman, C. Jiang, R. Scheule, S. Cheng. -- Structure and Structure-Activity Relationship of Lipid-Based Gene Delivery Systems, D. Lasic. -- Self-Assembled Structures of Lipid/DNA Nonviral Gene Delivery Systems from Synchorotron X-Ray Diffraction, C. Safinya, I. Koltover. -- Sites of Uptake and Expression of Cationic Liposome/DNA Complexes Injected Intravenously, J. McLean, G. Thurston, D. McDonald. -- Other Vectors: -- Nuclear Transport of Exogenous DNA, M. Sebestyâen and J. Wolff. -- Particle-Mediated Gene Delivery: Applications to Canine and Other Larger Animal Systems, N.-S. Yang, G. Hogge, E.G. MacEwen. -- Polyethylenimines: A Family of Potent Polymers for Nucleic Acid Delivery, A. Kichler, J.-P. Behr, P. Erbacher. -- Ligand-Polycation Conjugates for Receptor-Targeted Gene Transfer, E. Wagner. -- The Perplexing Delivery Mechanism of Lipoplexes, L. Barron and F. Szoka, Jr.. -- Biopolymer-DNA Nanospheres, K. Leong. -- Novel Lipidic Vectors for Gene Transfer, S. Li, L. Huang. -- Animal Models and Clinical Trials: -- Mechanisms of Cationic Liposome-Mediated Transfection of the Lung Endothelium, D. Liu, J. Knapp, Y. Song. -- Cystic Fibrosis Gene Therapy, U. Griesenbach, D. Geddes, E. Alton. -- Targeting HER-2/neu-Overexpressing Cancer Cells with Transcriptional Repressor Genes Delivered by Cationic Liposome, M.-C. Hung, S.-C. Wang, G. Hortobagyi. -- Immune Pathways Used in Nucleic Acid Vaccination, G. Rhodes. -- A Novel Gene Regulatory System, S. Chua, M. Burcin, Y. Wang, S. Tsai. -- Index.Gene transfer within humans has been an obstacle until about 10 years ago. At that time, it was found that viral vectors were effective carriers of "healthy genes" into patients' cells. The problem, however, was that viral vectors proved unnecessarily harmful to humans: subjects experienced inflamatory activity and negative immunological responses to the genes. Viral vectors were also unable to meet the needs of the pharmaceutical community: they were not reproducible in large-scale proportions in cost-effective ways. Thus, research was undertaken to find a safer way to transfer genes to patients without jeopardizing the safety of the patient. And so non-viral vectors were discovered. This volume presents the various non-viral vectors currently under development. Although not methodologically oriented, it will provide the necessary details behind the development of the vectors. This information will prove useful to both researchers and clinicians. Key Features * Presents state-of-the art developments of nonviral vectors as tools for modern molecular medicine * Covers all types of nonviral vectors, from molecular structure to therapeutic application Provides a comprehensive review of synthetic vectors * Includes contributions from major investigators and leading experts in the field. MenosIntroduction, L.Huang and E. Viroonhatapan. -- Cationic Liposomes: -- Progress in Gene Delivery Research and Development, P. Felgner. -- Cationic Lipid-Mediated Gene Delivery to the Airways, J. Marshall, N. Yew, S. Eastman, C. Jiang, R. Scheule, S. Cheng. -- Structure and Structure-Activity Relationship of Lipid-Based Gene Delivery Systems, D. Lasic. -- Self-Assembled Structures of Lipid/DNA Nonviral Gene Delivery Systems from Synchorotron X-Ray Diffraction, C. Safinya, I. Koltover. -- Sites of Uptake and Expression of Cationic Liposome/DNA Complexes Injected Intravenously, J. McLean, G. Thurston, D. McDonald. -- Other Vectors: -- Nuclear Transport of Exogenous DNA, M. Sebestyâen and J. Wolff. -- Particle-Mediated Gene Delivery: Applications to Canine and Other Larger Animal Systems, N.-S. Yang, G. Hogge, E.G. MacEwen. -- Polyethylenimines: A Family of Potent Polymers for Nucleic Acid Delivery, A. Kichler, J.-P. Behr, P. Erbacher. -- Ligand-Polycation Conjugates for Receptor-Targeted Gene Transfer, E. Wagner. -- The Perplexing Delivery Mechanism of Lipoplexes, L. Barron and F. Szoka, Jr.. -- Biopolymer-DNA Nanospheres, K. Leong. -- Novel Lipidic Vectors for Gene Transfer, S. Li, L. Huang. -- Animal Models and Clinical Trials: -- Mechanisms of Cationic Liposome-Mediated Transfection of the Lung Endothelium, D. Liu, J. Knapp, Y. Song. -- Cystic Fibrosis Gene Therapy, U. Griesenbach, D. Geddes, E. Alton. -- Targeting HER-2/neu-Overexpressing Cancer Cells with Transcriptional Re... Mostrar Tudo |
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Palavras-Chave: |
Gene Therapymethods; Gene Transfer Techniques; Genetic; therapeutic use; Transformation. |
|
Thesaurus Nal: |
genetic transformation. |
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Categoria do assunto: |
-- |
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URL: |
https://www.sciencedirect.com/science/book/9780123584656
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|
Marc: |
LEADER 03668nam a2200229 a 4500
001 1711309
005 2011-06-16
008 1999 bl uuuu u0uu1 u #d
020 $a9780123584656
100 1 $aHUANG, L.
245 $aNonviral vectors for gene therapy$h[electronic resource]
260 $aSan Diego, CA : Academic Press$c1999
300 $axxv, 442 p. $cill. (some col.) ;24 cm.
520 $aIntroduction, L.Huang and E. Viroonhatapan. -- Cationic Liposomes: -- Progress in Gene Delivery Research and Development, P. Felgner. -- Cationic Lipid-Mediated Gene Delivery to the Airways, J. Marshall, N. Yew, S. Eastman, C. Jiang, R. Scheule, S. Cheng. -- Structure and Structure-Activity Relationship of Lipid-Based Gene Delivery Systems, D. Lasic. -- Self-Assembled Structures of Lipid/DNA Nonviral Gene Delivery Systems from Synchorotron X-Ray Diffraction, C. Safinya, I. Koltover. -- Sites of Uptake and Expression of Cationic Liposome/DNA Complexes Injected Intravenously, J. McLean, G. Thurston, D. McDonald. -- Other Vectors: -- Nuclear Transport of Exogenous DNA, M. Sebestyâen and J. Wolff. -- Particle-Mediated Gene Delivery: Applications to Canine and Other Larger Animal Systems, N.-S. Yang, G. Hogge, E.G. MacEwen. -- Polyethylenimines: A Family of Potent Polymers for Nucleic Acid Delivery, A. Kichler, J.-P. Behr, P. Erbacher. -- Ligand-Polycation Conjugates for Receptor-Targeted Gene Transfer, E. Wagner. -- The Perplexing Delivery Mechanism of Lipoplexes, L. Barron and F. Szoka, Jr.. -- Biopolymer-DNA Nanospheres, K. Leong. -- Novel Lipidic Vectors for Gene Transfer, S. Li, L. Huang. -- Animal Models and Clinical Trials: -- Mechanisms of Cationic Liposome-Mediated Transfection of the Lung Endothelium, D. Liu, J. Knapp, Y. Song. -- Cystic Fibrosis Gene Therapy, U. Griesenbach, D. Geddes, E. Alton. -- Targeting HER-2/neu-Overexpressing Cancer Cells with Transcriptional Repressor Genes Delivered by Cationic Liposome, M.-C. Hung, S.-C. Wang, G. Hortobagyi. -- Immune Pathways Used in Nucleic Acid Vaccination, G. Rhodes. -- A Novel Gene Regulatory System, S. Chua, M. Burcin, Y. Wang, S. Tsai. -- Index.Gene transfer within humans has been an obstacle until about 10 years ago. At that time, it was found that viral vectors were effective carriers of "healthy genes" into patients' cells. The problem, however, was that viral vectors proved unnecessarily harmful to humans: subjects experienced inflamatory activity and negative immunological responses to the genes. Viral vectors were also unable to meet the needs of the pharmaceutical community: they were not reproducible in large-scale proportions in cost-effective ways. Thus, research was undertaken to find a safer way to transfer genes to patients without jeopardizing the safety of the patient. And so non-viral vectors were discovered. This volume presents the various non-viral vectors currently under development. Although not methodologically oriented, it will provide the necessary details behind the development of the vectors. This information will prove useful to both researchers and clinicians. Key Features * Presents state-of-the art developments of nonviral vectors as tools for modern molecular medicine * Covers all types of nonviral vectors, from molecular structure to therapeutic application Provides a comprehensive review of synthetic vectors * Includes contributions from major investigators and leading experts in the field.
650 $agenetic transformation
653 $aGene Therapymethods
653 $aGene Transfer Techniques
653 $aGenetic
653 $atherapeutic use
653 $aTransformation
700 1 $aHUNG, M.-C.
700 1 $aWAGNER, E.
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Registro original: |
Ebooks (Ebooks) |
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Nenhum exemplar cadastrado para este documento. |
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Registro Completo
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Biblioteca(s): |
Embrapa Pecuária Sul. |
|
Data corrente: |
08/01/1991 |
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Data da última atualização: |
03/09/2012 |
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Tipo da produção científica: |
Boletim de Pesquisa e Desenvolvimento |
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Autoria: |
OLIVEIRA, N. M. de; KENNEDY, J. P. |
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Título: |
Estudos sobre a relação diâmetro frequência de ondulações da lã de ovinos de distintas raças e idades, e em condições ambientais diversas. |
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Ano de publicação: |
1988 |
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Fonte/Imprenta: |
Bagé: EMBRAPA-CNPO, 1988. |
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Páginas: |
28 p. |
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Série: |
(EMBRAPA-CNPO. Boletim de pesquisa, 8). |
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Idioma: |
Português |
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Conteúdo: |
Foram estudados os efeitos da raça (Corriedale e Romney Marsh), idade do ovino (2-7 anos) e ano de amostragem (1978-81), sobre o relacionamento entre diâmetro médio de fibras (método airflow) e frequência de ondulações/2,5cm de mecha, em 2878 amostras de lã. |
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Thesagro: |
Lã; Ovino. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/65456/1/bpd8.pdf
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Marc: |
LEADER 00798nam a2200169 a 4500
001 1219174
005 2012-09-03
008 1988 bl uuuu u0uu1 u #d
100 1 $aOLIVEIRA, N. M. de
245 $aEstudos sobre a relação diâmetro frequência de ondulações da lã de ovinos de distintas raças e idades, e em condições ambientais diversas.
260 $aBagé: EMBRAPA-CNPO$c1988
300 $a28 p.
490 $a(EMBRAPA-CNPO. Boletim de pesquisa, 8).
520 $aForam estudados os efeitos da raça (Corriedale e Romney Marsh), idade do ovino (2-7 anos) e ano de amostragem (1978-81), sobre o relacionamento entre diâmetro médio de fibras (método airflow) e frequência de ondulações/2,5cm de mecha, em 2878 amostras de lã.
650 $aLã
650 $aOvino
700 1 $aKENNEDY, J. P.
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Embrapa Pecuária Sul (CPPSUL) |
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