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Biblioteca(s): |
Embrapa Suínos e Aves. |
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Data corrente: |
31/03/2015 |
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Data da última atualização: |
09/04/2015 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
BRESSAN, C. R.; KUNZ, A.; SCHMIDELL, W.; SOARES, H. M. |
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Afiliação: |
CLEO R. BRESSAN, UFSC; AIRTON KUNZ, CNPSA; WILLIBALDO SCHMIDELL, UFSC; HUGO MOREIRA SOARES, UFSC. |
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Título: |
Toxicity of the colistin sulfate antibiotic used in animal farming to mixed cultures of nitrifying organisms. |
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Ano de publicação: |
2013 |
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Fonte/Imprenta: |
Water, Air and Soil Pollution, v. 224, n. 1441, 2013. |
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DOI: |
10.1007/s11270-013-1441-4. |
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Idioma: |
Português |
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Conteúdo: |
Colistin is a peptide antibiotic widely used as a food additive in animal farming, specially swine and poultry, and also has recently been applied in human medicine to treat infections caused by multiresistant gram-negative bacteria strains. When orally administered, colistin is eliminated in feces virtually unaltered; thus, it may reach water bodies and wastewater treatment facilities in its active form. Apart from the risks associated with development of antimicrobial resistance and environmental toxicity issues, the presence of antimicrobials in wastewater can, additionally, interfere in biological processes commonly used to treat them. Nitrifying bacteria are among the most sensitive microorganisms to inhibitory compounds, including pharmaceuticals, and are useful as biosensors to access contaminant toxicity information in wastewater treatment plants. Therefore, in order to assess the colistin acute toxicity to the microorganisms involved in the nitrification processes, the nitritation and nitratation kinetics were monitored under different colistin concentrations. The results showed that only ammonia-oxidizing bacteria are sensitive to the antibiotic, presenting an IC50 of 10.8 mg L−1 of colistin when used as a commercial formulation and 67.0 mg L−1 when used as raw colistin sulfate. For nitrite-oxidizing bacteria, even the highest colistin concentration used in the assays (316 mg L−1) was not sufficient to inhibit the process. According to these results, the colistin concentrations expected in animal farming wastewater, when its dosage is used as a growth promoter, would not be enough to keep nitrification from taking place. Nevertheless, when used in higher concentrations, such as for therapeutic purposes, it could endanger the maintenance of the process. MenosColistin is a peptide antibiotic widely used as a food additive in animal farming, specially swine and poultry, and also has recently been applied in human medicine to treat infections caused by multiresistant gram-negative bacteria strains. When orally administered, colistin is eliminated in feces virtually unaltered; thus, it may reach water bodies and wastewater treatment facilities in its active form. Apart from the risks associated with development of antimicrobial resistance and environmental toxicity issues, the presence of antimicrobials in wastewater can, additionally, interfere in biological processes commonly used to treat them. Nitrifying bacteria are among the most sensitive microorganisms to inhibitory compounds, including pharmaceuticals, and are useful as biosensors to access contaminant toxicity information in wastewater treatment plants. Therefore, in order to assess the colistin acute toxicity to the microorganisms involved in the nitrification processes, the nitritation and nitratation kinetics were monitored under different colistin concentrations. The results showed that only ammonia-oxidizing bacteria are sensitive to the antibiotic, presenting an IC50 of 10.8 mg L−1 of colistin when used as a commercial formulation and 67.0 mg L−1 when used as raw colistin sulfate. For nitrite-oxidizing bacteria, even the highest colistin concentration used in the assays (316 mg L−1) was not sufficient to inhibit the process. Accord... Mostrar Tudo |
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Thesagro: |
Antibiótico; Dejeto; Microbiologia do solo; Nitrificação; Produção animal; Resíduo químico. |
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Thesaurus Nal: |
Acute toxicity; Animal diseases; Antibiotics; Colistin; Nitrification; Polymyxins. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02733naa a2200313 a 4500
001 2012508
005 2015-04-09
008 2013 bl uuuu u00u1 u #d
024 7 $a10.1007/s11270-013-1441-4.$2DOI
100 1 $aBRESSAN, C. R.
245 $aToxicity of the colistin sulfate antibiotic used in animal farming to mixed cultures of nitrifying organisms.$h[electronic resource]
260 $c2013
520 $aColistin is a peptide antibiotic widely used as a food additive in animal farming, specially swine and poultry, and also has recently been applied in human medicine to treat infections caused by multiresistant gram-negative bacteria strains. When orally administered, colistin is eliminated in feces virtually unaltered; thus, it may reach water bodies and wastewater treatment facilities in its active form. Apart from the risks associated with development of antimicrobial resistance and environmental toxicity issues, the presence of antimicrobials in wastewater can, additionally, interfere in biological processes commonly used to treat them. Nitrifying bacteria are among the most sensitive microorganisms to inhibitory compounds, including pharmaceuticals, and are useful as biosensors to access contaminant toxicity information in wastewater treatment plants. Therefore, in order to assess the colistin acute toxicity to the microorganisms involved in the nitrification processes, the nitritation and nitratation kinetics were monitored under different colistin concentrations. The results showed that only ammonia-oxidizing bacteria are sensitive to the antibiotic, presenting an IC50 of 10.8 mg L−1 of colistin when used as a commercial formulation and 67.0 mg L−1 when used as raw colistin sulfate. For nitrite-oxidizing bacteria, even the highest colistin concentration used in the assays (316 mg L−1) was not sufficient to inhibit the process. According to these results, the colistin concentrations expected in animal farming wastewater, when its dosage is used as a growth promoter, would not be enough to keep nitrification from taking place. Nevertheless, when used in higher concentrations, such as for therapeutic purposes, it could endanger the maintenance of the process.
650 $aAcute toxicity
650 $aAnimal diseases
650 $aAntibiotics
650 $aColistin
650 $aNitrification
650 $aPolymyxins
650 $aAntibiótico
650 $aDejeto
650 $aMicrobiologia do solo
650 $aNitrificação
650 $aProdução animal
650 $aResíduo químico
700 1 $aKUNZ, A.
700 1 $aSCHMIDELL, W.
700 1 $aSOARES, H. M.
773 $tWater, Air and Soil Pollution$gv. 224, n. 1441, 2013.
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