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| Registros recuperados : 128 | |
| 81. |  | GIGLIOTI, R.; AZEVEDO, B. T.; OLIVEIRA, H. N. DE; KATIKI, L. M.; VERCESI FILHO, A. E.; OLIVEIRA, M. C. de S.; OKINO, C. H. How long does the mRNA remains stable in untreated whole bovine blood? Molecular Biology Reports, v. 49, n. 1, p. 789-795, jan. 2021.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 82. | | ROOS, D.; KLEIN, T. A. P.; ESTEVES, P. A.; D'ÁVILA, A.; MUNHOZ, L. S.; BRENTANO, L.; OKINO, C. H.; TREVISOL, I. M.; CARON, L.; SILVA, V. S. Identificação do vírus de bronquite infecciosa das galinhas através de isolamento em ovos SPF e técnicas de diagnóstico molecular. In: JORNADA DE INICIAÇÃO CIENTÍFICA EMBRAPA , 5., 2011, Concórdia. Resumos. Concórdia: Embrapa Suínos e Aves, 2011. p. 47 . JINC. Projeto/Plano de Ação: 02.09.01.030.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 83. | | TOSCANO, J. H. B.; LOPES, L. G.; GIRALDELO, L. A.; SILVA, M. H. da; OKINO, C. H.; CHAGAS, A. C. de S. Identification of appropriate reference genes for local immune-related studies in Morada Nova sheep infected with Haemonchus contortus. Molecular Biology Reports, v.45, n.5, p.1253-1262, out. 2018.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 84. | | OKINO, C. H.; MORES, M. A. Z.; MATTOS, G. L. M.; ESTEVES, P. A.; BRENTANO, L.; TREVISOL, I. M.; COLDEBELLA, A. Indução de imunidade inata diferencial após desafio com isolados de campo brasileiros do vírus da bronquite infecciosa. In: CONFERÊNCIA APINCO DE CIÊNCIA E TECNOLOGIA AVÍCOLAS, 2015, Campinas, SP. Anais... Campinas: FACTA, 2015.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 85. | | VAZ, C. S. L.; RECH, D. V.; TREVISOL, I. M.; BRENTANO, L.; OKINO, C. H.; MORES, M. A. Z.; JAENISCH, F. R. F.; COLDEBELLA, A.; SILVA, V. S. Infectividade de micro-organismos em cama de frangos de corte submetida a diferentes tratamentos. Concórdia: Embrapa Suínos e Aves, 2017. 6 p. (Embrapa Suínos e Aves. Comunicado Técnico, 546).| Biblioteca(s): Embrapa Pecuária Sudeste; Embrapa Suínos e Aves. |
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| 86. | | MARKS, F. S.; RODENBUSCH, C. R.; OKINO, C. H.; HEIN, H. E.; COSTA, E. de F.; MACHADO, G.; CANAL, C. W.; BRENTANO, L.; CORBELLINI, L. G. Targeted survey of newcastle disease virus in backyard poultry flocks located in wintering site for migratory birds from southern Brazil. Preventive Veterinary Medicine, St. Louis, v. 116, p.197-202, 2014.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 88. | | NICIURA, S. C. M.; MINHO, A. P.; MCINTYRE, J.; BENAVIDES, M. V.; OKINO, C. H.; ESTEVES, S. N.; CHAGAS, A. C. de S.; AMARANTE, A. F. T. DO. In vitro culture of parasitic stages of Haemonchus contortus. Revista Brasileira de Parasitologia Veterinária, v. 32, n. 1, 2023, e010122. 12 p.| Biblioteca(s): Embrapa Pecuária Sudeste; Embrapa Pecuária Sul. |
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| 89. | | RITTERBUSCH, G. A.; HUBNER, S. O.; COSTA, C.; SILVA, A. D. da; TREVISOL, I. M.; KLEIN, T. A. P.; OKINO, C. H.; ESTEVES, P. A. Variation in nucleotide homology obtained by amplification, cloning and sequencing of complete S1 gene from field samples of avian infectious bronchitis virus. In: BRAZILIAN CONGRESS OF VIROLOGY, 23.; MERCOSUR MEETING OF VIROLOGY, 7., 2012, Foz do Iguaçu. Virus and Research? Foz do Iguaçu: SBV, 2012. p. 493-494. Journal of the Brazilian Society for Virology, v. 17, n. 2, suppl. 1, 2012. Projeto/Plano de Ação: 02.09.01.030.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 90. | | TREVISOL, I. M.; BRENTANO, L.; JAENISCH, F. R. F.; OKINO, C. H.; RECH, R. R.; SILVA, A. D. da; RITTERBUSCH, G. A.; ESTEVES, P. A. In vivo assay of vaccine protection to infectious bronchitis vírus in comercial broiler and SPF chicks. In: BRAZILIAN CONGRESS OF VIROLOGY, 23.; MERCOSUR MEETING OF VIROLOGY, 7., 2012, Foz do Iguaçu. Virus and Research? Foz do Iguaçu: SBV, 2012. p. 512. Journal of the Brazilian Society for Virology, v. 17, n. 2, suppl. 1, 2012. Projeto/Plano de Ação: 03.09.00.018.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 91. | | KAPRITCHKOFF, R. T. I.; OKINO, C. H.; NICIURA, S. C. M.; BELLO, H. J. S.; MATOS, R. S.; MELITO, G. R.; DONATONI, F. A. B.; ESTEVES, S. N.; CHAGAS, A. C. de S. Association of β-globin polymorphisms and tolerance to haemonchosis in ewes and lambs of different sheep breeds. Veterinary Parasitology, v. 328, June 2024, 110163. 8 p.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 92. | | MATTOS, G. L. M.; OKINO, C. H.; TREVISOL, I. M.; MORES, M. A. Z.; BRENTANO, L.; ESTEVES, P. A.; LOPES, L. dos S.; BASTOS, A. P. de A.; CARON, L.; FILHO, T. F.; DUARTE, I.; MONTASSIER, H. J. Cellular imune response of avian infectious bronchitis variant by flow citometry. In: Journal of the Brazilian Society for Virology, Ribeirão Preto, v. 19, 2014. Suppl. 2. Edição dos anais do 25º. Brazilian Congress of Virology e 9º. Mercosur Meeting of Virology, Ribeirão Preto, set./out, 2014. p. 238| Biblioteca(s): Embrapa Suínos e Aves. |
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| 93. | | SILVA, W. DOS S.; CARDOSO, T. F.; ANDRADE, B. G. N.; SILVA, J. V.; CONTEVILLE, L. C.; AFONSO, J.; BRUSCADIN, J.; OKINO, C. H.; KAPRITCHKOFF, R. T. I.; CHAGAS, A. C. de S.; REGITANO, L. C. de A. Componentes do microbioma fecal e ruminal associados à suscetibilidade à infecção por Haemonchus contortus em ovinos Morada Nova. In: JORNADA CIENTÍFICA DA EMBRAPA SÃO CARLOS, 14., 2022, São Carlos, SP. Anais... São Carlos, SP: Embrapa Instrumentação; Embrapa Pecuária Sudeste, 2022. p. 77. (Embrapa Instrumentação. Documentos, 73).| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 94. | | OKINO, C. H.; CAMINOTTO, L. C. F.; KAPRITCHKOFF, R. T. I.; NICIURA, S. C. M.; ESTEVES, S. N.; SANTOS, I. B. DOS; TOSCANO, J. H. B.; OLIVEIRA, M. C. de S.; CHAGAS, A. C. de S. Comparison of ovine B-globin haplotype sequences and a new multiplex PCR for identification. Veterinary Parasitology, v.300, 109592, dec. 2021. 5 p.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 95. | | TOSCANO, J. H. B.; OKINO, C. H.; SANTOS, I. B. dos; GIRALDELO, L. A.; HAEHLING, M. B. von; ESTEVES, S. N.; BASSETTO, C. C.; AMARANTE, A. F. T. do; CHAGAS, A. C. de S. Local and systemic immune mediators of Morada Nova lambs with divergent Haemonchus contortus resistance phenotypes. Parasite Immunology, v. 42, e12790, 2020. 10 p.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 96. | | MARTINS, M. D. R.; GOMES, H. C. S. F.; VELTRONI, Y. K.; SILVA, P. C.; TONELLI, M. F.; OLIVEIRA, H. N. DE; OKINO, C. H.; OLIVEIRA, M. C. de S. Avaliação dos níveis de infecção por Babesia bigemina em amostras de sangue de bezerros usando qPCR com sistema de sondas de hidrólise. In: JORNADA CIENTÍFICA DA EMBRAPA SÃO CARLOS, 12., 2020, São Carlos, SP. Anais... São Carlos, SP: Embrapa Instrumentação; Embrapa Pecuária Sudeste, 2020. p.24. (Embrapa Instrumentação. Documentos, 71).| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 97. | | CAVANI, L.; BRAZ, C. U.; GIGLIOTI, R.; OKINO, C. H.; GULIAS GOMES, C. C.; CAETANO, A. R.; OLIVEIRA, M. C. de S.; CARDOSO, F. F.; OLIVEIRA, H. N. de. Genomic study of Babesia bovis infection level and its association with tick count in Hereford and Braford cattle. Frontiers in Immunology, v. 11, article 1905, aug. 2020. 11 p.| Biblioteca(s): Embrapa Pecuária Sudeste; Embrapa Pecuária Sul; Embrapa Recursos Genéticos e Biotecnologia. |
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| 98. | | OKINO, C. H.; TOSCANO, J. H. B; GIRALDELO, L. A.; VON HAEHLING, M. B.; SANTOS, I. B. dos; ESTEVES, S. N.; FERRAZ JUNIOR, R. S.; CHAGAS, A. C. de S. Differential local immune responses against Haemonchus contortus in a resistant Brazilian sheep breed (Morada Nova). In: INTERNATIONAL VETERINARY IMMUNOLOGY SYMPOSIUM, 12., 2019, Seattle. proceedings... Seattle: AAVI, 2019. 114.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 99. | | OKINO, C. H.; NICIURA, S. C. M.; GIARETTA, P. R.; MELITO, G. R.; KAPRITCHKOFF, R. T. I.; SANTOS, I. B. DOS; RECH, R. R.; MINHO, A. P.; ESTEVES, S. N.; CHAGAS, A. C. de S. Enhanced mucosal response in sheep harbouring BetaA beta-globin against haemonchosis. Parasite Immunology, v. 45, n. 9, e13003, sep. 2023. 12 p.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 100. | | KAPRITCHKOFF, R. T. I.; OKINO, C. H.; MATOS, R. S.; BELLO, H. J. S.; MELITO, G. R.; DONATONI, F. A. B.; NICIURA, S. C. M.; CHAGAS, A. C. de S. Efeito do polimorfismo da β-globina na anemia por Hemoncose em ovinos de diferentes raças. In: CONGRESSO PAULISTA DE PARASITOLOGIA, 10., Jaboticabal, 2023. Jaboticabal: Sociedade Paulista de Parasitologia, 2023.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| Registros recuperados : 128 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Pecuária Sudeste; Embrapa Pecuária Sul; Embrapa Recursos Genéticos e Biotecnologia. |
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Data corrente: |
17/11/2020 |
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Data da última atualização: |
17/11/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
CAVANI, L.; BRAZ, C. U.; GIGLIOTI, R.; OKINO, C. H.; GULIAS GOMES, C. C.; CAETANO, A. R.; OLIVEIRA, M. C. de S.; CARDOSO, F. F.; OLIVEIRA, H. N. de. |
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Afiliação: |
LIGIA CAVANI, UNESP; CAMILA URBANO BRAZ, UNESP; RODRIGO GIGLIOTI, Instituto de Zootecnia; CINTIA HIROMI OKINO, CPPSE; CLAUDIA CRISTINA GULIAS GOMES, CPPSUL; ALEXANDRE RODRIGUES CAETANO, Cenargen; MARCIA CRISTINA DE SENA OLIVEIRA, CPPSE; FERNANDO FLORES CARDOSO, CPPSUL; HENRIQUE NUNES DE OLIVEIRA, UNESP. |
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Título: |
Genomic study of Babesia bovis infection level and its association with tick count in Hereford and Braford cattle. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Frontiers in Immunology, v. 11, article 1905, aug. 2020. |
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Páginas: |
11 p. |
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DOI: |
https://doi.org/10.3389/fimmu.2020.01905 |
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Idioma: |
Inglês |
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Conteúdo: |
Bovine babesiosis is a tick-borne disease caused by intraerythrocytic protozoa and leads to substantial economic losses for the livestock industry throughout the world. Babesia bovis is considered the most pathogenic species, which causes bovine babesiosis in Brazil. Genomic data could be used to evaluate the viability of improving resistance against B. bovis infection level (IB) through genomic selection, and, for that, knowledge of genetic parameters is needed. Furthermore, genome-wide association studies (GWAS) could be conducted to provide a better understanding of the genetic basis of the host response to B. bovis infection. No previous work in quantitative genetics of B. bovis infection was found. Thus, the objective of this study was to estimate the genetic correlation between IB and tick count (TC), evaluate predictive ability and applicability of genomic selection, and perform GWAS in Hereford and Braford cattle. The single-step genomic best linear unbiased prediction method was used, which allows the estimation of both breeding values and marker effects. Standard phenotyping was conducted for both traits. IB quantifications from the blood of 1,858 animals were carried using quantitative PCR assays. For TC, one to three subsequent tick counts were performed by manually counting adult female ticks on one side of each animal's body that was naturally exposed to ticks. Animals were genotyped using the Illumina BovineSNP50 panel. The posterior mean of IB heritability, estimated by the Bayesian animal model in a bivariate analysis, was low (0.10), and the estimations of genetic correlation between IB and TC were also low (0.15). The cross-validation genomic prediction accuracy for IB ranged from 0.18 to 0.35 and from 0.29 to 0.32 using k-means and random clustering, respectively, suggesting that genomic predictions could be used as a tool to improve genetics for IB, especially if a larger training population is developed. The top 10 single nucleotide polymorphisms from the GWAS explained 5.04% of total genetic variance for IB, which were located on chromosomes 1, 2, 5, 6, 12, 17, 18, 16, 24, and 26. Some candidate genes participate in immunity system pathways indicating that those genes are involved in resistance to B. bovis in cattle. Although the genetic correlation between IB and TC was weak, some candidate genes for IB were also reported in tick infestation studies, and they were also involved in biological resistance processes. This study contributes to improving genetic knowledge regarding infection by B. bovis in cattle. MenosBovine babesiosis is a tick-borne disease caused by intraerythrocytic protozoa and leads to substantial economic losses for the livestock industry throughout the world. Babesia bovis is considered the most pathogenic species, which causes bovine babesiosis in Brazil. Genomic data could be used to evaluate the viability of improving resistance against B. bovis infection level (IB) through genomic selection, and, for that, knowledge of genetic parameters is needed. Furthermore, genome-wide association studies (GWAS) could be conducted to provide a better understanding of the genetic basis of the host response to B. bovis infection. No previous work in quantitative genetics of B. bovis infection was found. Thus, the objective of this study was to estimate the genetic correlation between IB and tick count (TC), evaluate predictive ability and applicability of genomic selection, and perform GWAS in Hereford and Braford cattle. The single-step genomic best linear unbiased prediction method was used, which allows the estimation of both breeding values and marker effects. Standard phenotyping was conducted for both traits. IB quantifications from the blood of 1,858 animals were carried using quantitative PCR assays. For TC, one to three subsequent tick counts were performed by manually counting adult female ticks on one side of each animal's body that was naturally exposed to ticks. Animals were genotyped using the Illumina BovineSNP50 panel. The posterior mean of IB heritability, e... Mostrar Tudo |
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Palavras-Chave: |
Bovine babesiosis; Cross validation; Genetic parameters; Genome wide association studies; Genomic selection. |
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Thesagro: |
Babesia Bovis. |
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Categoria do assunto: |
H Saúde e Patologia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/217858/1/GenomicStudyBabesia.pdf
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Marc: |
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100 1 $aCAVANI, L.
245 $aGenomic study of Babesia bovis infection level and its association with tick count in Hereford and Braford cattle.$h[electronic resource]
260 $c2020
300 $a11 p.
520 $aBovine babesiosis is a tick-borne disease caused by intraerythrocytic protozoa and leads to substantial economic losses for the livestock industry throughout the world. Babesia bovis is considered the most pathogenic species, which causes bovine babesiosis in Brazil. Genomic data could be used to evaluate the viability of improving resistance against B. bovis infection level (IB) through genomic selection, and, for that, knowledge of genetic parameters is needed. Furthermore, genome-wide association studies (GWAS) could be conducted to provide a better understanding of the genetic basis of the host response to B. bovis infection. No previous work in quantitative genetics of B. bovis infection was found. Thus, the objective of this study was to estimate the genetic correlation between IB and tick count (TC), evaluate predictive ability and applicability of genomic selection, and perform GWAS in Hereford and Braford cattle. The single-step genomic best linear unbiased prediction method was used, which allows the estimation of both breeding values and marker effects. Standard phenotyping was conducted for both traits. IB quantifications from the blood of 1,858 animals were carried using quantitative PCR assays. For TC, one to three subsequent tick counts were performed by manually counting adult female ticks on one side of each animal's body that was naturally exposed to ticks. Animals were genotyped using the Illumina BovineSNP50 panel. The posterior mean of IB heritability, estimated by the Bayesian animal model in a bivariate analysis, was low (0.10), and the estimations of genetic correlation between IB and TC were also low (0.15). The cross-validation genomic prediction accuracy for IB ranged from 0.18 to 0.35 and from 0.29 to 0.32 using k-means and random clustering, respectively, suggesting that genomic predictions could be used as a tool to improve genetics for IB, especially if a larger training population is developed. The top 10 single nucleotide polymorphisms from the GWAS explained 5.04% of total genetic variance for IB, which were located on chromosomes 1, 2, 5, 6, 12, 17, 18, 16, 24, and 26. Some candidate genes participate in immunity system pathways indicating that those genes are involved in resistance to B. bovis in cattle. Although the genetic correlation between IB and TC was weak, some candidate genes for IB were also reported in tick infestation studies, and they were also involved in biological resistance processes. This study contributes to improving genetic knowledge regarding infection by B. bovis in cattle.
650 $aBabesia Bovis
653 $aBovine babesiosis
653 $aCross validation
653 $aGenetic parameters
653 $aGenome wide association studies
653 $aGenomic selection
700 1 $aBRAZ, C. U.
700 1 $aGIGLIOTI, R.
700 1 $aOKINO, C. H.
700 1 $aGULIAS GOMES, C. C.
700 1 $aCAETANO, A. R.
700 1 $aOLIVEIRA, M. C. de S.
700 1 $aCARDOSO, F. F.
700 1 $aOLIVEIRA, H. N. de
773 $tFrontiers in Immunology$gv. 11, article 1905, aug. 2020.
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Embrapa Pecuária Sudeste (CPPSE) |
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