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Registros recuperados : 8 | |
2. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | OKI, Y.; GOTO, B. T.; JOBIM, K.; ROSA, L. H.; FERREIRA, M. C.; COUTINHO, E. S.; XAVIER, J. H. de A.; CARVALHO, F.; MOREIRA, F. M. de S.; SOUZA, F. A. de; BERBARA, R. L. L.; FERNANDES, G. W. Arbuscular mycorrhiza and endophytic fungi in ruspestrian grasslands. In: FERNANDES, G. W. (Ed.). Ecology and conservation of mountaintop grasslands in Brazil. Switzerland: Springer International Publishing, 2016. cap. 8, p. 157-179. Biblioteca(s): Embrapa Milho e Sorgo. |
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3. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | BORDIGNON, L.; PIRES, A. C. V.; LADEIRA, F.; OKI, Y.; TAMEIRÃO, L. B. S.; CASTRO, M. S. M. de; CORDEIRO, A. R.; MOTA, E. R. G. D.; FERNANDES, G. W.; MENDES, S. M.; BOREGAS, K. G. B. O efeito do aumento do CO2 e da temperatura na preferência e consumo de folhas de Glycine max (Fabaceae) por Spodoptera frugiperda (Lepidoptera: noctuidae). In: CONGRESSO NACIONAL DE BOTÂNICA, 64.; ENCONTRO REGIONAL DE BOTÂNICOS MG, BA E ES, 23., 2013, Belo Horizonte. Anais... Belo Horizonte: SBB, 2013. Biblioteca(s): Embrapa Milho e Sorgo. |
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4. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | FREITAS, C. D. de; OKI, Y.; RESENDE, F. M.; ZAMUDIO, F.; FREITAS, G. S. de; REZENDE, K. M. de; SOUZA, F. A. de; JONG, D. de; QUESADA, M.; CARVALHO, A. S.; PIRES, C. S. S.; FERNANDES, G. W. Impacts of pests and diseases on the decline of managed bees in Brazil: a beekeeper perspective. Journal of Apicultural Research, 2022. Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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5. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | PEREIRA, R. S.; COSTA, V. V.; GOMES, G. L. M.; CAMPANA, P. R. V.; PÁDUA, R. M. de; BARBOSA, M.; OKI, Y.; HEIDEN, G.; FERNANDES, G. W.; OLIVEIRA, D. M. de; SOUZA, D. G.; TEIXEIRA, M. M.; BRAGA, F. C. Anti-Zika Virus Activity of Plant Extracts Containing Polyphenols and Triterpenes on Vero CCL-81 and Human Neuroblastoma SH-SY5Y Cells. Chemistry & Biodiversity, v. 19, n. 4, e202100842, April 2022. Biblioteca(s): Embrapa Clima Temperado. |
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6. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | FIGUEIREDO, J. C. G.; ÁVILA, M. A. de; SOUZA, C. S.; NEVES, J. G. S.; TOLENTINO, G. S.; OKI, Y.; AZEVEDO, I. F. P. de; NEGREIROS, D.; VIANA, J. H. M.; SANTOS, R. M. dos; FONSECA, R. S.; FERNANDES, G. W.; NUNES, Y. R. F. Relationship of woody species composition with edaphic characteristics in threatened riparian Atlantic Forest remnants in the upper Rio Doce basin, Brazil. Nordic Journal of Botany, v. 2022, n. 11, e03679, 2022. Biblioteca(s): Embrapa Milho e Sorgo. |
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7. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | FERNANDES, G. W.; ARANTES-GARCIA, L.; BARBOS, M.; BARBOS, N. P. U.; BATISTA, E. K. L.; BEIROZ, W.; RESENDE, F. M.; ABRAHÃO, A.; ALMADA, E. D.; ALVES, E.; ALVES, N. J.; ANGRISANO, P.; ARISTA, M.; ARROYO, J.; ARRUDA, A. J.; BAHIA, T. de O.; BRAGA, L.; BRITO, L.; CALLISTO, M.; CAMINHA-PAIVA, D.; CARVALHO, M.; CONCEIÇÃO, A. A.; COSTA, L. N.; CRUZ, A.; CUNHA-BLUM, J.; DAGEVOS, J.; DIAS, B. F. S.; PINTO, V. D.; DIRZO, R.; DOMINGOS, D. Q.; ECHTERNACHT, L.; FERNANDES, S.; FIGUEIRA, J. E. C.; FIORINI, C. F.; GIULIETTI, A. M.; GOMES, A.; GOMES, V. M.; GONTIJO, B.; GOULART, F.; GUERRA, T. J.; JUNQUEIRA, P. A.; LIMA-SANTOS, D.; MARQUES, J.; MEIRA-NETO, J.; MIOLA, D. T. B.; MORELLATO, L. P. C.; NEGREIROS, D.; NEIRE, E.; NEVES, A. C.; NEVES, F. S.; NOVAIS, S.; OKI, Y.; OLIVEIRA, E.; OLIVEIRA, R. S.; PIVARI, M. O.; PONTES JUNIOR, E.; RANIERI, B. D.; RIBAS, R. P.; SCARIOT, A.; ECHAEFER, C. E.; SENA, L.; SILVA, P. G. da; SIQUEIRA, P. R.; SOARES, N. C.; SOARES-FILHO, B.; SOLAR, R.; TABARELLI, M.; VASCONCELLOS, R.; VILELA, E.; SILVEIRA, F. A. O. Biodiversity and ecosystem services in the Campo Rupestre: a road map for the sustainability of the hottest Brazilian biodiversity hotspot. Perspectives in Ecology and Conservation, v. 18, p. 213-222, 2020 Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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8. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | ROSA C.; BACCARO, F.; CRONEMBERGER, C.; HIPÓLITO, J.; BARROS, C. F.; RODRIGUES, D. de J.; NECKEL-OLIVEIRA, S.; OVERBECK, G. E.; DRECHSLER-SANTOS, E. R.; ANJOS, M. R. dos; FERREGUETTI, A. C.; AKAMA, A.; MARTINS, M. B.; TOMAS, W. M.; SANTOS, S. A.; FERREIRA, V. L.; CUNHA, C. N. da; PENHA, J.; PINHO, J. B. de; SALIS, S. M.; DORIA, C. R. da C.; PILLAR, V. D.; PODGAISKI, L. R.; MENIN, M.; BÍGIO, N, C.; ARAGÓN, S.; MANZATTO, A. G.; VÉLEZ-MARTIN, E.; SILVA, A. C. B. L. e; IZZO, T. J.; MORTATI, A. F.; GIACOMIN, L. L.; ALMEIDA, T. E.; ANDRÉ, T.; SILVEIRA, M. A. P. de A.; SILVEIRA, A. L. P. da; MESSIAS, M. R.; MARQUES, M. C. M.; PADIAL, A. A.; MARQUES, R.; BITAR, Y. O. C.; SILVEIRA, M.; MORATO, E. F.; PAGOTTO, R. de C.; STRUSSMANN, C.; MACHADO, R. B.; AGUIAR, L. M. de S.; FERNANDES, G. W.; OKI, Y.; NOVAIS, S.; FERREIRA, G. B.; BARBOSA, F. R.; OCHOA, A. C.; MANGIONE, A. M.; GATICA, A.; CARRIZO, M. C.; RETTA, L. M.; JOFRÉ, L. E.; CASTILLO, L. L.; NEME, A. M.; RUEDA, C.; TOLEDO, J. J. de; GRELLE, C. E. V.; VALE, M. M.; VIEIRA, M. V.; CERQUEIRA, R.; HIGASHIKAWA, E. M.; MENDONÇA, F. P. de; GUERREIRO, Q. L de M.; BANHOS, A.; HERO, JEAN-MARC; KOBLITZ, R.; COLLEVATTI, R. G.; SILVEIRA, L. F.; VASCONCELOS, H. L.; VIEIRA, C. R.; COLLI, G. R.; CECHIN, S. Z.; SANTOS, T. G. dos; FONTANA, C. S.; JARENKOW, J. A.; MALABARBA, L. R.; RUEDA, M. P. R.; ARAUJO, P. A.; PALOMO, L.; ITURRE, M. C.; BERGALLO, H. G.; MAGNUSSON, W. E. The program for biodiversity research in Brazil: The role of regional networks for biodiversity knowledge, dissemination, and conservation. Anais da Academia Brasileira de Ciências, v. 93, n. 2, e20201604, 2021. Biblioteca(s): Embrapa Pantanal. |
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Registros recuperados : 8 | |
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Registro Completo
Biblioteca(s): |
Embrapa Clima Temperado. |
Data corrente: |
04/08/2023 |
Data da última atualização: |
04/08/2023 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 4 |
Autoria: |
PEREIRA, R. S.; COSTA, V. V.; GOMES, G. L. M.; CAMPANA, P. R. V.; PÁDUA, R. M. de; BARBOSA, M.; OKI, Y.; HEIDEN, G.; FERNANDES, G. W.; OLIVEIRA, D. M. de; SOUZA, D. G.; TEIXEIRA, M. M.; BRAGA, F. C. |
Afiliação: |
ROSÂNGELA SANTOS PEREIRA, Universidade Federal de Minas Gerais; VIVIAN VASCONCELOS COSTA, Universidade Federal de Minas Gerais; GABRIEL LUIZ MENEZES GOMES, Universidade Federal de Minas Gerais; PRISCILLA RODRIGUES VALADARES CAMPANA, Universidade Federal de Minas Gerais; RODRIGO MAIA DE PÁDUA, Universidade Federal de Minas Gerais; MILTON BARBOSA, Universidade Federal de Minas Gerais; YUMI OKI, Universidade Federal de Minas Gerais; GUSTAVO HEIDEN, CPACT; GERALDO WILSON FERNANDES, Universidade Federal de Minas Gerais; DJALMA MENEZES DE OLIVEIRA, Universidade Estadual do Sudoeste da Bahia; DANIELE G. SOUZA, Universidade Federal de Minas Gerais; MAURO MARTINS TEIXEIRA, Universidade Federal de Minas Gerais; FERNÃO CASTRO BRAGA, Universidade Federal de Minas Gerais. |
Título: |
Anti-Zika Virus Activity of Plant Extracts Containing Polyphenols and Triterpenes on Vero CCL-81 and Human Neuroblastoma SH-SY5Y Cells. |
Ano de publicação: |
2022 |
Fonte/Imprenta: |
Chemistry & Biodiversity, v. 19, n. 4, e202100842, April 2022. |
DOI: |
https://doi.org/10.1002/cbdv.202100842 |
Idioma: |
Inglês |
Conteúdo: |
Zika virus (ZIKV) infection is a global threat associated to neurological disorders in adults and microcephaly in children born to infected mothers. No vaccine or drug is available against ZIKV. We herein report the anti-ZIKV activity of 36 plant extracts containing polyphenols and/or triterpenes. ZIKV-infected Vero CCL-81 cells were treated with samples at non-cytotoxic concentrations, determined by MTT and LDH assays. One third of the extracts elicited concentration-dependent anti-ZIKV effect, with viral loads reduction from 0.4 to 3.8?log units. The 12 active extracts were tested on ZIKV-infected SH-SY5Y cells and significant reductions of viral loads (in log units) were induced by Maytenus ilicifolia (4.5?log), Terminalia phaeocarpa (3.7?log), Maytenus rigida (1.7?log) and Echinodorus grandiflorus (1.7?log) extracts. Median cytotoxic concentration (CC50) of these extracts in Vero cells were higher than in SH-SY5Y lineage. M. ilicifolia (IC50=16.8±10.3??g/mL, SI=3.4) and T. phaeocarpa (IC50=22.0±6.8??g/mL, SI=4.8) were the most active extracts. UPLC-ESI-MS/MS analysis of M. ilicifolia extract led to the identification of 7 triterpenes, of which lupeol and a mixture of friedelin/friedelinol showed no activity against ZIKV. The composition of T. phaeocarpa extract comprises phenolic acids, ellagitannins and flavonoids, as recently reported by us. In conclusion, the anti-ZIKV activity of 12 plant extracts is here described for the first time and polyphenols and triterpenes were identified as the probable bioactive constituents of T. phaeocarpa and M. ilicifolia, respectively. MenosZika virus (ZIKV) infection is a global threat associated to neurological disorders in adults and microcephaly in children born to infected mothers. No vaccine or drug is available against ZIKV. We herein report the anti-ZIKV activity of 36 plant extracts containing polyphenols and/or triterpenes. ZIKV-infected Vero CCL-81 cells were treated with samples at non-cytotoxic concentrations, determined by MTT and LDH assays. One third of the extracts elicited concentration-dependent anti-ZIKV effect, with viral loads reduction from 0.4 to 3.8?log units. The 12 active extracts were tested on ZIKV-infected SH-SY5Y cells and significant reductions of viral loads (in log units) were induced by Maytenus ilicifolia (4.5?log), Terminalia phaeocarpa (3.7?log), Maytenus rigida (1.7?log) and Echinodorus grandiflorus (1.7?log) extracts. Median cytotoxic concentration (CC50) of these extracts in Vero cells were higher than in SH-SY5Y lineage. M. ilicifolia (IC50=16.8±10.3??g/mL, SI=3.4) and T. phaeocarpa (IC50=22.0±6.8??g/mL, SI=4.8) were the most active extracts. UPLC-ESI-MS/MS analysis of M. ilicifolia extract led to the identification of 7 triterpenes, of which lupeol and a mixture of friedelin/friedelinol showed no activity against ZIKV. The composition of T. phaeocarpa extract comprises phenolic acids, ellagitannins and flavonoids, as recently reported by us. In conclusion, the anti-ZIKV activity of 12 plant extracts is here described for the first time and polyphenols and triterpenes w... Mostrar Tudo |
Thesagro: |
Biodiversidade; Extrato Vegetal; Vírus. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1155672/1/Artigo-Anti8208Zika-Virus-Activity-of-Plant-Extracts.pdf
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Marc: |
LEADER 02560naa a2200313 a 4500 001 2155672 005 2023-08-04 008 2022 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1002/cbdv.202100842$2DOI 100 1 $aPEREIRA, R. S. 245 $aAnti-Zika Virus Activity of Plant Extracts Containing Polyphenols and Triterpenes on Vero CCL-81 and Human Neuroblastoma SH-SY5Y Cells.$h[electronic resource] 260 $c2022 520 $aZika virus (ZIKV) infection is a global threat associated to neurological disorders in adults and microcephaly in children born to infected mothers. No vaccine or drug is available against ZIKV. We herein report the anti-ZIKV activity of 36 plant extracts containing polyphenols and/or triterpenes. ZIKV-infected Vero CCL-81 cells were treated with samples at non-cytotoxic concentrations, determined by MTT and LDH assays. One third of the extracts elicited concentration-dependent anti-ZIKV effect, with viral loads reduction from 0.4 to 3.8?log units. The 12 active extracts were tested on ZIKV-infected SH-SY5Y cells and significant reductions of viral loads (in log units) were induced by Maytenus ilicifolia (4.5?log), Terminalia phaeocarpa (3.7?log), Maytenus rigida (1.7?log) and Echinodorus grandiflorus (1.7?log) extracts. Median cytotoxic concentration (CC50) of these extracts in Vero cells were higher than in SH-SY5Y lineage. M. ilicifolia (IC50=16.8±10.3??g/mL, SI=3.4) and T. phaeocarpa (IC50=22.0±6.8??g/mL, SI=4.8) were the most active extracts. UPLC-ESI-MS/MS analysis of M. ilicifolia extract led to the identification of 7 triterpenes, of which lupeol and a mixture of friedelin/friedelinol showed no activity against ZIKV. The composition of T. phaeocarpa extract comprises phenolic acids, ellagitannins and flavonoids, as recently reported by us. In conclusion, the anti-ZIKV activity of 12 plant extracts is here described for the first time and polyphenols and triterpenes were identified as the probable bioactive constituents of T. phaeocarpa and M. ilicifolia, respectively. 650 $aBiodiversidade 650 $aExtrato Vegetal 650 $aVírus 700 1 $aCOSTA, V. V. 700 1 $aGOMES, G. L. M. 700 1 $aCAMPANA, P. R. V. 700 1 $aPÁDUA, R. M. de 700 1 $aBARBOSA, M. 700 1 $aOKI, Y. 700 1 $aHEIDEN, G. 700 1 $aFERNANDES, G. W. 700 1 $aOLIVEIRA, D. M. de 700 1 $aSOUZA, D. G. 700 1 $aTEIXEIRA, M. M. 700 1 $aBRAGA, F. C. 773 $tChemistry & Biodiversity$gv. 19, n. 4, e202100842, April 2022.
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