Data/hora: 09/06/2024 11:22:21

Biblioteca(s): 	Embrapa Agricultura Digital; Embrapa Pecuária Sudeste.	
Tipo da produção científica: 	Artigo em Periódico Indexado	
Circulação/Nível: 	A - 1	
Data corrente: 	01/09/2016	
Data da última atualização: 	19/03/2019	
Autoria: 	SOUZA, M. M. de; NICIURA, S. C. M.; TIZIOTO, P. C.; IBELLI, A. M. G.; GASPARIN, G.; ROCHA, M. I. P.; DONATONI, F. A. B.; MALAGO JUNIOR, W.; DINIZ, W. J. S.; OLIVEIRA, P. S. N. de; LIMA, A. O.; MUDADU, M. de A.; BARIONI JUNIOR, W.; COUTINHO, L. L.; REGITANO, L. C. de A.	
Afiliação: 	M.M. de Souza, UFSCAR; SIMONE CRISTINA MEO NICIURA, CPPSE; P.C. Tizioto, FAPESP; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; G. Gasparin, USP-ESALQ; M. I. P. Rocha, UFSCAR; FLAVIA ALINE BRESSANI DONATONI, CPPSE; WILSON MALAGO JUNIOR, CPPSE; W. J. S. Diniz, UFSCAR; Priscila Silva Neubern de Oliveira, FAPESP; A. O. Lima, UFSCAR; MAURICIO DE ALVARENGA MUDADU, CNPTIA; WALDOMIRO BARIONI JUNIOR, CPPSE; L. L. Coutinho, USP-ESALQ; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.	
Título: 	Allele- and parent-of-origin-specific effects on expression of the KCNJ11 gene: a candidate for meat tenderness in cattle.	
Ano de publicação: 	2016	
Fonte/Imprenta: 	Genetics and Molecular Research, v.15, n.3, aug. 2016.	
Volume: 	15	
DOI: 	http://dx.doi.org/10.4238/gmr.15038549	
Idioma: 	Inglês
Português	
Conteúdo: 	In contrast to the Mendelian inheritance model, parental alleles can contribute unequally to gene expression, which may result in phenotypic variance among individuals and bias in the predicted additive effect of molecular markers associated with production traits. Given the need to understand the effects of allelic variation and parent-of-origin effects on the expression of genes with a commercial interest in cattle, we analyzed the expression of KCNJ11 (potassium inwardly rectifying channel, subfamily J, member 11), which was previously described as a functional candidate gene for meat tenderness. Allele-specific and parent-of-origin-dependent expression of this gene were assessed in bovine muscle using the rs379610823 single nucleotide polymorphism as a reference. Biallelic expression was observed; however, the T allele was expressed at significantly higher levels than the C allele. Furthermore, increased expression of KCNJ11 was found in animals harboring the maternal T allele. This study is the first to describe the differential allelic expression of bovine KCNJ11. Our findings are important for understanding the mechanisms that underlie the pattern of KCNJ11 expression and its potential impact on the phenotypic variation of meat tenderness in Nelore beef cattle. This reinforces the need for further investigation of allelic- and parent-of-origin expression deviation in genetic markers eligible for the selection of target traits.	
Palavras-Chave: 	Differential allelic expression; Expressão alélica diferencial; Maciez da carne; Nelore; Potassium inwardly rectifying channel.	
Thesagro: 	Gado de corte; Gado Nelore; Gado Zebu.	
Thesaurus Nal: 	Alleles; Beef cattle; Meat tenderness; Nellore; Zebu.	
Categoria do assunto: 	G Melhoramento Genético
X Pesquisa, Tecnologia e Engenharia	
URL: 	http://ainfo.cnptia.embrapa.br/digital/bitstream/item/147026/1/Souza-et-al-2016.pdf	
Registro original: 	Embrapa Pecuária Sudeste (CPPSE)	
Exemplares: 	CPPSE - (23698-1) - UPC - AP - DD - PROCI-2016.00057 - SOU - 2016.00098 - DIS
CNPTIA - (18972-1) - UPC - AP - DD -  -  -  - DIS