Data/hora: 16/06/2024 03:45:12

Biblioteca(s): | Embrapa Instrumentação.
Data corrente: | 08/06/2021
Data da última atualização: | 10/06/2022
Autoria: | FACCHINATTO, W. M.; GALANTE, J.; MESQUITA, L.; SILVA, D. S.; SANTOS, D. M. dos; MORAES, T. B.; CAMPANA-FILHO, S. P.; COLNAGO, L. A.; SARMENTO, B.; NEVES, J. das.
Afiliação: | LUIZ ALBERTO COLNAGO, CNPDIA.
Título: | Clotrimazole-loaded N-(2-hydroxy)-propyl-3-trimethylammonium, O-palmitoyl chitosan nanoparticles for topical treatment of vulvovaginal candidiasis.
Ano de publicação: | 2021
Fonte/Imprenta: | Acta Biomaterialia, v. 125, 2021.
Páginas: | 312?321
ISSN: | 172-7061
DOI: | https://doi.org/10.1016/j.actbio.2021.02.029
Idioma: | Inglês
Conteúdo: | Vulvovaginal candidiasis (VVC) represents a considerable health burden for women. Despite the availability of a significant array of antifungal drugs and topical products, the management of the infection is not always effective, and new approaches are needed. Here, we explored cationic N-(2-hydroxy)- propyl-3-trimethylammonium, O-palmitoyl chitosan nanoparticles (NPs) as carriers of clotrimazole (CLT) for the topical treatment of VVC. CLT-NPs with approximately 280 nm in diameter were obtained by selfassembly in water and subsequent stabilization by ionic crosslinking with tripolyphosphate. The nanosystem featured pH-independent sustained drug release up to 24 h, which affected both in vitro anti-Candida activity and cytotoxicity. The CLT-loaded nanostructured platform yielded favorable selectivity index values for a panel of standard strains and clinical isolates of Candida spp. and female genital tract cell lines (HEC-1-A, Ca Ski and HeLa), as compared to the free drug. CLT-NPs also improved in vitro drug permeability across HEC-1-A and Ca Ski cell monolayers, thus suggesting that the nanocarrier may provide higher mucosal tissue levels of the active compound. Overall, data support that CLT-NPs may be a valuable asset for the topical treatment of VVC.
Palavras-Chave: | Health; Vaginal drug delivery; Women s health.
Categoria do assunto: | --
Registro original: | Embrapa Instrumentação (CNPDIA)
Exemplares: | CNPDIA - (17783-1) - UPC - AP - DD - PROCI.21/43 -  - 2021/43 - DIS