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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Oriental. |
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Data corrente: |
30/08/2017 |
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Data da última atualização: |
22/12/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
FIDELIS, Q. C.; CASTRO, R. N.; GUILHON, G. M. S. P.; RODRIGUES, S. T.; SALLES, C. M. C. de; SALLES, J. B. de; CARVALHO, M. G. de. |
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Afiliação: |
Queli C. Fidelis, Universidade Federal Rural do Rio de Janeiro; Rosane N. Castro, Universidade Federal Rural do Rio de Janeiro; Giselle M. S. P. Guilhon, UFPA; SILVANE TAVARES RODRIGUES, CPATU; Cristiane M. C. de Salles, Universidade Federal Rural do Rio de Janeiro; João B. de Salles, UEZO; Mario G. de Carvalho, Universidade Federal Rural do Rio de Janeiro. |
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Título: |
Flavonoids and other compounds from Ouratea ferruginea (Ochnaceae) as anticancer and chemopreventive agents. |
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Ano de publicação: |
2012 |
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Fonte/Imprenta: |
Molecules, v. 17, n. 7, p. 7989-8000, 2012. |
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Idioma: |
Inglês |
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Conteúdo: |
The chemical study of the extracts from leaves and stems of Ouratea ferruginea allowed the identification of a new isoflavone, 5-hydroxy-7,3′4′5′-tetramethoxyisoflavone, and twenty two known compounds, including friedelin, 3β-friedelinol, lupeone, a mixture of sitosterol, stigmasterol and campesterol, sitosteryl- and stigmasteryl-3-O-b-D-glucopyranosides, 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 5,4′-dihydroxy-7,3′-di-methoxyisoflavone (7,3′-di-O-methylorobol), 5,7,4′-trihydroxy-3′,5′-dimethoxyisoflavone (piscigenin), 2R,3R-epicatechin, syringic acid, 2,6-dimethoxybenzoquinone, 2,6-dimethoxyhydroquinone, syringic and ferulic aldehyde, a mixture of vanillic acid, 1-hydroxy-2-methoxy-4-(1E-3-hydroxy-1-propenyl)-benzene and 3,5-dimethoxy-4-hydroxy-dihydrocinamaldehyde, besides amenthoflavone and 7-O-methylamenthoflavone (sequoiaflavone) which are considered as chemotaxonomic markers of Ouratea. The structures were identified by IR, 1H- and 13C-NMR and GC-MS, HPLC-MS, besides comparison with literature data. The inhibitory effects of 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 7,3′-di-O-methylorobol, piscigenin and 7-O-methylamenthoflavone on cytochrome P450-dependent 7-ethoxycoumarin O-deethylase (ECOD) and glutathione S-transferase (GST) were evaluated in vitro. The 5,4′-dihydroxy-7,5′,3′-trimethoxy-isoflavone was the best inhibitor, inhibiting almost 75% of GST activity. Sequoiaflavone was the most potent inhibitor, inhibiting ECOD assay in 75%. These activities allow us to consider both these flavonoids as potential anticancer and chemopreventive agents. MenosThe chemical study of the extracts from leaves and stems of Ouratea ferruginea allowed the identification of a new isoflavone, 5-hydroxy-7,3′4′5′-tetramethoxyisoflavone, and twenty two known compounds, including friedelin, 3β-friedelinol, lupeone, a mixture of sitosterol, stigmasterol and campesterol, sitosteryl- and stigmasteryl-3-O-b-D-glucopyranosides, 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 5,4′-dihydroxy-7,3′-di-methoxyisoflavone (7,3′-di-O-methylorobol), 5,7,4′-trihydroxy-3′,5′-dimethoxyisoflavone (piscigenin), 2R,3R-epicatechin, syringic acid, 2,6-dimethoxybenzoquinone, 2,6-dimethoxyhydroquinone, syringic and ferulic aldehyde, a mixture of vanillic acid, 1-hydroxy-2-methoxy-4-(1E-3-hydroxy-1-propenyl)-benzene and 3,5-dimethoxy-4-hydroxy-dihydrocinamaldehyde, besides amenthoflavone and 7-O-methylamenthoflavone (sequoiaflavone) which are considered as chemotaxonomic markers of Ouratea. The structures were identified by IR, 1H- and 13C-NMR and GC-MS, HPLC-MS, besides comparison with literature data. The inhibitory effects of 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 7,3′-di-O-methylorobol, piscigenin and 7-O-methylamenthoflavone on cytochrome P450-dependent 7-ethoxycoumarin O-deethylase (ECOD) and glutathione S-transferase (GST) were evaluated in vitro. The 5,4′-dihydroxy-7,5′,3′-trimethoxy-isoflavone was the best inhibitor, inhibiting almost 75%... Mostrar Tudo |
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Palavras-Chave: |
Agentes quimiopreventivos; Biflavonoides; Isoflavonas. |
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Categoria do assunto: |
W Química e Física |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/163259/1/molecules-17-07989.pdf
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Marc: |
LEADER 02407naa a2200229 a 4500
001 2074725
005 2021-12-22
008 2012 bl uuuu u00u1 u #d
100 1 $aFIDELIS, Q. C.
245 $aFlavonoids and other compounds from Ouratea ferruginea (Ochnaceae) as anticancer and chemopreventive agents.$h[electronic resource]
260 $c2012
520 $aThe chemical study of the extracts from leaves and stems of Ouratea ferruginea allowed the identification of a new isoflavone, 5-hydroxy-7,3′4′5′-tetramethoxyisoflavone, and twenty two known compounds, including friedelin, 3β-friedelinol, lupeone, a mixture of sitosterol, stigmasterol and campesterol, sitosteryl- and stigmasteryl-3-O-b-D-glucopyranosides, 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 5,4′-dihydroxy-7,3′-di-methoxyisoflavone (7,3′-di-O-methylorobol), 5,7,4′-trihydroxy-3′,5′-dimethoxyisoflavone (piscigenin), 2R,3R-epicatechin, syringic acid, 2,6-dimethoxybenzoquinone, 2,6-dimethoxyhydroquinone, syringic and ferulic aldehyde, a mixture of vanillic acid, 1-hydroxy-2-methoxy-4-(1E-3-hydroxy-1-propenyl)-benzene and 3,5-dimethoxy-4-hydroxy-dihydrocinamaldehyde, besides amenthoflavone and 7-O-methylamenthoflavone (sequoiaflavone) which are considered as chemotaxonomic markers of Ouratea. The structures were identified by IR, 1H- and 13C-NMR and GC-MS, HPLC-MS, besides comparison with literature data. The inhibitory effects of 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 7,3′-di-O-methylorobol, piscigenin and 7-O-methylamenthoflavone on cytochrome P450-dependent 7-ethoxycoumarin O-deethylase (ECOD) and glutathione S-transferase (GST) were evaluated in vitro. The 5,4′-dihydroxy-7,5′,3′-trimethoxy-isoflavone was the best inhibitor, inhibiting almost 75% of GST activity. Sequoiaflavone was the most potent inhibitor, inhibiting ECOD assay in 75%. These activities allow us to consider both these flavonoids as potential anticancer and chemopreventive agents.
653 $aAgentes quimiopreventivos
653 $aBiflavonoides
653 $aIsoflavonas
700 1 $aCASTRO, R. N.
700 1 $aGUILHON, G. M. S. P.
700 1 $aRODRIGUES, S. T.
700 1 $aSALLES, C. M. C. de
700 1 $aSALLES, J. B. de
700 1 $aCARVALHO, M. G. de
773 $tMolecules$gv. 17, n. 7, p. 7989-8000, 2012.
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Registro original: |
Embrapa Amazônia Oriental (CPATU) |
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Registro Completo
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Biblioteca(s): |
Embrapa Solos. |
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Data corrente: |
11/02/2014 |
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Data da última atualização: |
03/11/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
NASCIMENTO, A. F. do; MENDONÇA, E. de S.; LEITE, L. F. C.; SCHOLBERG, J.; NEVES, J. C. L. |
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Afiliação: |
ALEXANDRE FERREIRA DO NASCIMENTO, CNPS; EDUARDO DE SÁ MENDONÇA, UFV/UFES; LUIZ FERNANDO CARVALHO LEITE, CPAMN; JOHANNES SCHOLBERG, University of Wageningen; JULIO CESAR LIMA NEVES, UFV. |
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Título: |
Calibration and validation of models for short-term decomposition and N mineralization. |
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Ano de publicação: |
2012 |
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Fonte/Imprenta: |
Scientia Agricola, Piracicaba, v. 69, n. 6, p. 393-401, Nov./Dec. 2012. |
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DOI: |
https://doi.org/10.1590/S0103-90162012000600008 |
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Idioma: |
Inglês |
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Conteúdo: |
Insight of nutrient release patterns associated with the decomposition of plant residues is important for their effective use as a green manure in food production systems. Thus, this study aimed to evaluate the ability of the Century, APSIM and NDICEA simulation models for predicting the decomposition and N mineralization of crop residues in the tropical Atlantic forest biome, Brazil. The simulation models were calibrated based on actual decomposition and N mineralization rates of three types of crop residues with different chemical and biochemical composition. The models were also validated for different pedo-climatic conditions and crop residues conditions. In general, the accuracy of decomposition and N mineralization improved after calibration. Overall RMSE values for the decomposition and N mineralization of the crop materials varied from 7.4 to 64.6 % before models calibration compared to 3.7 to 16.3 % after calibration. Therefore, adequate calibration of the models is indispensable for use them under humid tropical conditions. The NDICEA model generally outperformed the other models. However, the decomposition and N mineralization was not very accurate during the first 30 days of incubation, especially for easily decomposable crop residues. An additional model variable may be required to capture initial microbiological growth as affected by the moisture dynamics of the residues, as is the case in surface residues decomposition models |
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Palavras-Chave: |
Modeling; Nutrient cycling; Organic agriculture. |
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Thesaurus NAL: |
soil organic matter. |
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Categoria do assunto: |
P Recursos Naturais, Ciências Ambientais e da Terra |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/96969/1/artigo-alexandre2.pdf
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Marc: |
LEADER 02205naa a2200229 a 4500
001 1979454
005 2021-11-03
008 2012 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1590/S0103-90162012000600008$2DOI
100 1 $aNASCIMENTO, A. F. do
245 $aCalibration and validation of models for short-term decomposition and N mineralization.$h[electronic resource]
260 $c2012
520 $aInsight of nutrient release patterns associated with the decomposition of plant residues is important for their effective use as a green manure in food production systems. Thus, this study aimed to evaluate the ability of the Century, APSIM and NDICEA simulation models for predicting the decomposition and N mineralization of crop residues in the tropical Atlantic forest biome, Brazil. The simulation models were calibrated based on actual decomposition and N mineralization rates of three types of crop residues with different chemical and biochemical composition. The models were also validated for different pedo-climatic conditions and crop residues conditions. In general, the accuracy of decomposition and N mineralization improved after calibration. Overall RMSE values for the decomposition and N mineralization of the crop materials varied from 7.4 to 64.6 % before models calibration compared to 3.7 to 16.3 % after calibration. Therefore, adequate calibration of the models is indispensable for use them under humid tropical conditions. The NDICEA model generally outperformed the other models. However, the decomposition and N mineralization was not very accurate during the first 30 days of incubation, especially for easily decomposable crop residues. An additional model variable may be required to capture initial microbiological growth as affected by the moisture dynamics of the residues, as is the case in surface residues decomposition models
650 $asoil organic matter
653 $aModeling
653 $aNutrient cycling
653 $aOrganic agriculture
700 1 $aMENDONÇA, E. de S.
700 1 $aLEITE, L. F. C.
700 1 $aSCHOLBERG, J.
700 1 $aNEVES, J. C. L.
773 $tScientia Agricola, Piracicaba$gv. 69, n. 6, p. 393-401, Nov./Dec. 2012.
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