| |
|
|
| Registros recuperados : 157 | |
| 81. |  | VERÍSSIMO, C. J.; TITTO, C. G.; KATIKI, L. M.; BUENO, M. S.; CUNHA, E. A. da; MOURÃO, G. B.; OTSUK, I. P.; PEREIRA, A. M. F.; NOGUEIRA FILHO, J. C. M.; TITTO, E. A. L. Tolerância ao calor em ovelhas Santa Inês de pelagem clara e escura. Revista Brasileira de Saúde e Produção Animal, Salvador, v. 10, n. 1, p. 159-167, jan./abr. 2009.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
|   |
| 82. | | SILVA, J. C. B.; SILVA, M. R.; MARINHO, D. B.; NOGUEIRA, E.; SAMPAIO, D. C.; OLIVEIRA, L. O. F. de; ABREU, U. G. P. de; MOURÃO, G. B.; SARTORI, R. Cooled semen for fixed-time artificial insemination in beef cattle. Reproduction, Fertility and Development, v. 28, n. 7, p. 1004-1008, 2016. Na publicação: Juliana Correa Borges-Silva.| Biblioteca(s): Embrapa Pantanal. |
|  |
| 83. | | OLIVEIRA, P. S. N. DE; ANDRADE, B. G.; CARDOSO, T. F.; PASCHOAL, J. J.; JOSAHKIAN, L. A.; ALMEIDA, L. F.; MARCONDES, C. R.; MOURÃO, G. B.; COUTINHO, L. L.; REECY, J. M.; REGITANO, L. C. de A. Differentially expressed miRNAs in the stool of Bos indicus divergent for feed efficiency. Italian Journal of Animal Science, v. 22, supplement 1, 2023. p. 193-194. Congress of the Animal Science and Production Association, 25., Monopoli (BARI – ITALY), June 13–16, 2023.| Biblioteca(s): Embrapa Pecuária Sudeste. |
|  |
| 84. | | MEIRA, A. N.; MORIEIRA, G. C. M.; COUTINHO, L. L.; MOURAO, G. B.; AZEVEDO, H. C.; MUNIZ, E. N.; MACHADO, A. L.; SOUSA JUNIOR, L. P.; PEDROSA, V. B.; PINTO, L. F. B. Carcass and commercial cut yield of Santa Ines sheep affected by polymorphisms of the LEP gene. Small Ruminant Research, v. 166, p. 121-128, Sep. 2018.| Biblioteca(s): Embrapa Tabuleiros Costeiros. |
| |
| 85. | | OLIVEIRA, P. S. N. DE; ANDRADE, B. G.; CONTEVILLE, L. C.; CARDOSO, T. F.; PASCHOAL, J. J.; JOSAHKIAN, L. A.; ALMEIDA, L. F.; MARCONDES, C. R.; MOURÃO, G. B.; COUTINHO, L. L.; REECY, J. M.; REGITANO, L. C. de A. Microbial diversity in the stool of Bos indicus divergent for feed efficiency. Italian Journal of Animal Science, v. 22, supplement 1, 2023. p. 194. Congress of the Animal Science and Production Association, 25., Monopoli (BARI – ITALY), June 13–16, 2023.| Biblioteca(s): Embrapa Pecuária Sudeste. |
| |
| 86. | | TREVISOLI, P. A.; MOREIRA, G. C. M.; BOSCHIERO, C.; CESAR, A. S. M.; PETRINI, J.; MARGARIDO, G. R. A.; LEDUR, M. C.; MOURÃO, G. B.; GARRICK, D.; COUTINHO, L. L. A missense mutation in the MYBPH gene is associated with abdominal fat traits in meat-type chickens. Frontiers in Genetics, v. 12, n. 698163, 2021.| Biblioteca(s): Embrapa Suínos e Aves. |
| |
| 87. | | DEFANT, H.; MEIRA, A. N.; COUTINHO, L. L.; REGITANO, L. C. de A.; POLETI, M. D.; MOREIRA, G. C. M.; PADUAN, M.; MARIANI, P.; ZERLOTINI NETO, A.; MOURÃO, G. B.; CESAR, A. S. M. Novel polymorphisms in the PLIN2 gene of Nellore cattle. Genetics and Molecular Research, v. 18, n. 3, 2019. Não paginado. Na publicação: Luciana CA Regitano, Adhemar Zerlotini. gmr16039963.| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
| |
| 88. | | MOURÃO, G. B.; SALEM, M. M. I; PACKER, U. I.; PINTO, L. F. B.; MACHADO, M. A.; GASPARIN, G.; AZEVEDO, A. L. S.; VERNEQUE, R. da S.; REGITANO, L. C. de A. Detection of quantitative trait loci for growth traits on bovine chromosome 2. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 9., 2010, Leipzig. Proceedings... Leipzig: German Society fo Animal Science, 2010. 1 CD-ROM.| Biblioteca(s): Embrapa Gado de Leite. |
| |
| 89. | | MOURÃO, G. B.; SALEM, M. M. I.; PACKER, U. I.; PINTO, L. F. B.; MACHADO, M. A.; GASPARIN, G.; AZEVEDO, A. L. S.; VERNEQUE, R. da S.; REGITANO, L. C. de A. Detection of quantitative trait loci for growth traits on bovine chromosome. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 9., 2010, Leipzig. Proceedings... Leipzig: German Society fo Animal Science, 2010. 1 CD-ROM| Biblioteca(s): Embrapa Pecuária Sudeste. |
| |
| 90. | | NUNES, S. F.; FERREIRA, J.; PAIVA, S. R.; FARIA, D. A. de; SOUSA, J. E. R. de; SOARES, C. E. A.; SILVEIRA, R. M. F.; MOURÃO, G. B.; FAÇANHA, D. A. E. Fine genetic structure of Brazilian white Morada Nova hair sheep breed from semi-arid region. Small Ruminant Research, v. 211, 2022. 106694.| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
| |
| 91. | | GONÇALVES, T. M.; REGITANO, L. C. de A.; KOLTES, J. E.; CESAR, A. S. M.; ANDRADE, S. C. da S.; MOURAO, G. B.; GASPARIN, G.; MOREIRA, G. C. M.; FRITZ-WATERS, E.; REECY, J. M.; COUTINHO, L. L. Gene co-expression analysis indicates potential pathways and regulators of beef tenderness in Nellore cattle. Frontiers in Genetics, v.9, n. 441, p. 1-18, 2018.| Biblioteca(s): Embrapa Pecuária Sudeste. |
| |
| 92. | | MOREIRA, G. C. M.; SALVIAN, M.; BOSCHIERO, C.; CESAR, A. S. M.; REECY, J. M.; GODOY, T. F.; LEDUR, M. C.; GARRICK, D.; MOURÃO, G. B.; COUTINHO, L. L. Genome-wide association scan for QTL and their positional candidate genes associated with internal organ traits in chickens. BMC Genomics, v. 20, n. 669, 2019.| Biblioteca(s): Embrapa Suínos e Aves. |
| |
| 93. | | PERTILLE, F.; MOREIRA, G. C. M. M.; ZANELLA, R.; NUNES, J. de R. da S.; BOSCHIERO, C.; ROVADOSCKI, G. A.; MOURÃO, G. B.; LEDUR, M. C.; COUTINHO, L. L. Genome-wide association study for performance traits in chickens using genotype by sequencing approach. Scientific Reports, v. 7, n. 41748, 2017.| Biblioteca(s): Embrapa Suínos e Aves. |
| |
| 94. | | DIAS, M. S.; MACHADO, A. de L.; MEIRA, A. N.; COUTINHO, L. L.; MOURAO, G. B.; AZEVEDO, H. C.; MUNIZ, E. N.; PEDROSA, V. B.; PINTO, L. F. B. Haplótipos do gene CAST associados com medidas morfométricas em ovinos Santa Inês. In: SIMPÓSIO BRASILEIRO DE MELHORAMENTO ANIMAL, 13., 2019, Salvador, BA. Anais... Salvador: SBMA, 2019.| Biblioteca(s): Embrapa Tabuleiros Costeiros. |
| |
| 95. | | CHAVES, N. M.; MACHADO, A. de L.; MEIRA, A. N.; COUTINHO, L. L.; MOURAO, G. B.; AZEVEDO, H. C.; MUNIZ, E. N.; PEDROSA, V. B.; PINTO, L. F. B. Haplótipos no gene IGF1 associados com medidas morfométricas em ovinos Santa Inês. In: SIMPÓSIO BRASILEIRO DE MELHORAMENTO ANIMAL, 13., 2019, Salvador, BA. Anais... Salvador: SBMA, 2019.| Biblioteca(s): Embrapa Tabuleiros Costeiros. |
| |
| 96. | | SENES, B. B.; MACHADO, A. de L.; MEIRA, A. N.; COUTINHO, L. L.; MOURAO, G. B.; AZEVEDO, H. C.; MUNIZ, E. N.; PEDROSA, V. B.; PINTO, L. F. B. Haplótipos no gene LEP associados com medidas morfométricas em ovinos Santa Inês. In: SIMPÓSIO BRASILEIRO DE MELHORAMENTO ANIMAL, 13., 2019, Salvador, BA. Anais... Salvador: SBMA, 2019.| Biblioteca(s): Embrapa Tabuleiros Costeiros. |
| |
| 97. | | DIAS, M. S.; SOUSA JUNIOR, L. P. B.; MEIRA, A. N.; COUTINHO, L. L.; MOURAO, G. B.; AZEVEDO, H. C.; MUNIZ, E. N.; PEDROSA, V. B.; PINTO, L. F. B. Haplótipos do gene MyF6 associados a maciez de carne em ovinos Santa Inês. In: SIMPÓSIO BRASILEIRO DE MELHORAMENTO ANIMAL, 13., 2019, Salvador, BA. Anais... Salvador: SBMA, 2019.| Biblioteca(s): Embrapa Tabuleiros Costeiros. |
| |
| 98. | | MOLLO, M. R.; MONTEIRO JÚNIOR, P. L. J.; SURJUS, R. S.; MARTINS, A. C.; RAMOS, A. F.; MOURÃO, G. B.; CARRIJO, L. H. D.; LOPES JÚNIOR, G. L.; RUMPF, R.; WILTBANK, M. C.; SARTORI, R. Embryo production in heifers with low or high dry matter intake submitted to superovulation. Theriogenology, v. 92, p. 30-35, 2017.| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
| |
| 99. | | SALEM, M. M. I.; MOURÃO, G. B.; PACKER, I. U.; PINTO, L. F. B.; MACHADO, M. A.; GASPARIN, G.; AZEVEDO, A. L. S.; VERNEQUE, R. da S.; REGITANO, L. C. de A. Identification of quantitative trait loci for growth curve in crossbred dairy cattle population. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 9., 2010, Leipzig. Proceedings... Leipzig: German Society fo Animal Science, 2010. 1 CD-ROM.| Biblioteca(s): Embrapa Gado de Leite; Embrapa Pecuária Sudeste. |
| |
| 100. | | MALHEIROS, J. M.; CORREIA, B. S. B.; CERIBELI, C.; CARDOSO, D. R.; COLNAGO, L. A.; BOGUSZ JUNIOR, S.; REECY, J. M.; MOURÃO, G. B.; COUTINHO, L. L.; PALHARES, J. C. P.; BERNDT, A.; REGITANO, L. C. de A. Comparative untargeted metabolome analysis of ruminal fluid and feces of Nelore steers (Bos indicus). Scientific Reports, v.11, n.1, e12752, 2021. 13 p.| Biblioteca(s): Embrapa Pecuária Sudeste. |
| |
| Registros recuperados : 157 | |
|
|
|
Registro Completo
|
Biblioteca(s): |
Embrapa Pecuária Sudeste. |
|
Data corrente: |
31/08/2022 |
|
Data da última atualização: |
17/11/2022 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Circulação/Nível: |
A - 1 |
|
Autoria: |
VIGNATO, B. S.; CESAR, A. S. M.; AFONSO, J.; MOREIRA, G. C. M.; POLETI, M. D.; PETRINI, J.; GARCIA, I. S.; CLEMENTE, L. G.; MOURÃO, G. B.; REGITANO, L. C. de A.; COUTINHO, L. L. |
|
Afiliação: |
BÁRBARA SILVA VIGNATO, UNIVERSIDADE DE SÃO PAULO; ALINE SILVA MELLO CESAR, UNIVERSIDADE DE SÃO PAULO; JULIANA AFONSO, UNIVERSIDADE FEDERAL DE SÃO CARLOS; GABRIEL COSTA MONTEIRO MOREIRA, UNIVERSIDADE DE SÃO PAULO; MIRELE DAIANA POLETI, UNIVERSIDADE DE SÃO PAULO; JULIANA PETRINI, UNIVERSIDADE DE SÃO PAULO; INGRID SOARES GARCIA, UNIVERSIDADE DE SÃO PAULO; LUAN GASPAR CLEMENTE, UNIVERSIDADE DE SÃO PAULO; GERSON BARRETO MOURÃO, UNIVERSIDADE DE SÃO PAULO; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; LUIZ LEHMANN COUTINHO, UNIVERSIDADE DE SÃO PAULO. |
|
Título: |
Integrative analysis between genome-wide association study and expression quantitative trait Loci reveals bovine muscle gene expression regulatory polymorphisms associated with intramuscular fat and backfat thickness. |
|
Ano de publicação: |
2022 |
|
Fonte/Imprenta: |
Frontiers in Genetics, v. 13, 935238, aug. 2022. |
|
Páginas: |
15 p. |
|
DOI: |
10.3389/fgene.2022.935238 |
|
Idioma: |
Inglês |
|
Conteúdo: |
Understanding the architecture of gene expression is fundamental to unravel the molecular mechanisms regulating complex traits in bovine, such as intramuscular fat content (IMF) and backfat thickness (BFT). These traits are economically important for the beef industry since they affect carcass and meat quality. Our main goal was to identify gene expression regulatory polymorphisms within genomic regions (QTL) associated with IMF and BFT in Nellore cattle. For that, we used RNA-Seq data from 193 Nellore steers to perform SNP calling analysis. Then, we combined the RNA-Seq SNP and a high-density SNP panel to obtain a new dataset for further genome-wide association analysis (GWAS), totaling 534,928 SNPs. GWAS was performed using the Bayes B model. Twenty-one relevant QTL were associated with our target traits. The expression quantitative trait loci (eQTL) analysis was performed using Matrix eQTL with the complete SNP dataset and 12,991 genes, revealing a total of 71,033 cis and 36,497 trans-eQTL (FDR < 0.05). Intersecting with QTL for IMF, we found 231 eQTL regulating the expression levels of 117 genes. Within those eQTL, three predicted deleterious SNPs were identified. We also identified 109 eQTL associated with BFT and affecting the expression of 54 genes. This study revealed genomic regions and regulatory SNPs associated with fat deposition in Nellore cattle. We highlight the transcription factors FOXP4, FOXO3, ZSCAN2, and EBF4, involved in lipid metabolism-related pathways. These results helped us to improve our knowledge about the genetic architecture behind important traits in cattle. MenosUnderstanding the architecture of gene expression is fundamental to unravel the molecular mechanisms regulating complex traits in bovine, such as intramuscular fat content (IMF) and backfat thickness (BFT). These traits are economically important for the beef industry since they affect carcass and meat quality. Our main goal was to identify gene expression regulatory polymorphisms within genomic regions (QTL) associated with IMF and BFT in Nellore cattle. For that, we used RNA-Seq data from 193 Nellore steers to perform SNP calling analysis. Then, we combined the RNA-Seq SNP and a high-density SNP panel to obtain a new dataset for further genome-wide association analysis (GWAS), totaling 534,928 SNPs. GWAS was performed using the Bayes B model. Twenty-one relevant QTL were associated with our target traits. The expression quantitative trait loci (eQTL) analysis was performed using Matrix eQTL with the complete SNP dataset and 12,991 genes, revealing a total of 71,033 cis and 36,497 trans-eQTL (FDR < 0.05). Intersecting with QTL for IMF, we found 231 eQTL regulating the expression levels of 117 genes. Within those eQTL, three predicted deleterious SNPs were identified. We also identified 109 eQTL associated with BFT and affecting the expression of 54 genes. This study revealed genomic regions and regulatory SNPs associated with fat deposition in Nellore cattle. We highlight the transcription factors FOXP4, FOXO3, ZSCAN2, and EBF4, involved in lipid metabolism-related pathways... Mostrar Tudo |
|
Palavras-Chave: |
Backfat thickness; Carcass and meat quality; Expression quantitative trait loci; Intramuscular fat content; Nellore cattle; RNA Seq; SNP. |
|
Thesaurus NAL: |
Nellore. |
|
Categoria do assunto: |
G Melhoramento Genético |
|
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1145918/1/IntegrativeAnalysisGenome.pdf
|
|
Marc: |
LEADER 02780naa a2200361 a 4500
001 2145918
005 2022-11-17
008 2022 bl uuuu u00u1 u #d
024 7 $a10.3389/fgene.2022.935238$2DOI
100 1 $aVIGNATO, B. S.
245 $aIntegrative analysis between genome-wide association study and expression quantitative trait Loci reveals bovine muscle gene expression regulatory polymorphisms associated with intramuscular fat and backfat thickness.$h[electronic resource]
260 $c2022
300 $a15 p.
520 $aUnderstanding the architecture of gene expression is fundamental to unravel the molecular mechanisms regulating complex traits in bovine, such as intramuscular fat content (IMF) and backfat thickness (BFT). These traits are economically important for the beef industry since they affect carcass and meat quality. Our main goal was to identify gene expression regulatory polymorphisms within genomic regions (QTL) associated with IMF and BFT in Nellore cattle. For that, we used RNA-Seq data from 193 Nellore steers to perform SNP calling analysis. Then, we combined the RNA-Seq SNP and a high-density SNP panel to obtain a new dataset for further genome-wide association analysis (GWAS), totaling 534,928 SNPs. GWAS was performed using the Bayes B model. Twenty-one relevant QTL were associated with our target traits. The expression quantitative trait loci (eQTL) analysis was performed using Matrix eQTL with the complete SNP dataset and 12,991 genes, revealing a total of 71,033 cis and 36,497 trans-eQTL (FDR < 0.05). Intersecting with QTL for IMF, we found 231 eQTL regulating the expression levels of 117 genes. Within those eQTL, three predicted deleterious SNPs were identified. We also identified 109 eQTL associated with BFT and affecting the expression of 54 genes. This study revealed genomic regions and regulatory SNPs associated with fat deposition in Nellore cattle. We highlight the transcription factors FOXP4, FOXO3, ZSCAN2, and EBF4, involved in lipid metabolism-related pathways. These results helped us to improve our knowledge about the genetic architecture behind important traits in cattle.
650 $aNellore
653 $aBackfat thickness
653 $aCarcass and meat quality
653 $aExpression quantitative trait loci
653 $aIntramuscular fat content
653 $aNellore cattle
653 $aRNA Seq
653 $aSNP
700 1 $aCESAR, A. S. M.
700 1 $aAFONSO, J.
700 1 $aMOREIRA, G. C. M.
700 1 $aPOLETI, M. D.
700 1 $aPETRINI, J.
700 1 $aGARCIA, I. S.
700 1 $aCLEMENTE, L. G.
700 1 $aMOURÃO, G. B.
700 1 $aREGITANO, L. C. de A.
700 1 $aCOUTINHO, L. L.
773 $tFrontiers in Genetics$gv. 13, 935238, aug. 2022.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
Fechar
|
| Nenhum registro encontrado para a expressão de busca informada. |
|
|
