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| Registros recuperados : 157 | |
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| 82. | | MALHEIROS, J. M.; CORREIA, B. S. B.; CERIBELI, C.; CARDOSO, D. R.; COLNAGO, L. A.; BOGUSZ JUNIOR, S.; REECY, J. M.; MOURÃO, G. B.; COUTINHO, L. L.; PALHARES, J. C. P.; BERNDT, A.; REGITANO, L. C. de A. Comparative untargeted metabolome analysis of ruminal fluid and feces of Nelore steers (Bos indicus). Scientific Reports, v.11, n.1, e12752, 2021. 13 p.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 83. | | MALHEIROS, J. M.; CORREIA, B. S. B.; CERIBELI, C.; CARDOSO, D. R.; COLNAGO, L. A.; BOGUSZ JUNIOR, S.; REECY, J. M.; MOURÃO, G. B.; COUTINHO, L. L.; PALHARES, J. C. P.; BERNDT, A.; REGITANO, L. C. de A. Comparative untargeted metabolome analysis of ruminal fuid and feces of Nelore steers (Bos indicus). Scientific Reports, v. 11, n. 1, e12752, 2021.| Biblioteca(s): Embrapa Instrumentação; Embrapa Pecuária Sudeste. |
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| 84. | | MEIRA, A. N.; MORIEIRA, G. C. M.; COUTINHO, L. L.; MOURAO, G. B.; AZEVEDO, H. C.; MUNIZ, E. N.; MACHADO, A. L.; SOUSA JUNIOR, L. P.; PEDROSA, V. B.; PINTO, L. F. B. Carcass and commercial cut yield of Santa Ines sheep affected by polymorphisms of the LEP gene. Small Ruminant Research, v. 166, p. 121-128, Sep. 2018.| Biblioteca(s): Embrapa Tabuleiros Costeiros. |
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| 85. | | NUNES, S. F.; FERREIRA, J.; PAIVA, S. R.; FARIA, D. A. de; SOUSA, J. E. R. de; SOARES, C. E. A.; SILVEIRA, R. M. F.; MOURÃO, G. B.; FAÇANHA, D. A. E. Fine genetic structure of Brazilian white Morada Nova hair sheep breed from semi-arid region. Small Ruminant Research, v. 211, 2022. 106694.| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 86. | | VIGNATO, B. S.; CESAR, A. S. M.; AFONSO, J.; MOREIRA, G. C. M.; POLETI, M. D.; PETRINI, J.; GARCIA, I. S.; CLEMENTE, L. G.; MOURÃO, G. B.; REGITANO, L. C. de A.; COUTINHO, L. L. Integrative analysis between genome-wide association study and expression quantitative trait Loci reveals bovine muscle gene expression regulatory polymorphisms associated with intramuscular fat and backfat thickness. Frontiers in Genetics, v. 13, 935238, aug. 2022. 15 p.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 87. | | GONÇALVES, T. M.; REGITANO, L. C. de A.; KOLTES, J. E.; CESAR, A. S. M.; ANDRADE, S. C. da S.; MOURAO, G. B.; GASPARIN, G.; MOREIRA, G. C. M.; FRITZ-WATERS, E.; REECY, J. M.; COUTINHO, L. L. Gene co-expression analysis indicates potential pathways and regulators of beef tenderness in Nellore cattle. Frontiers in Genetics, v.9, n. 441, p. 1-18, 2018.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 88. | | SALEM, M. M. I.; MOURÃO, G. B.; PACKER, I. U.; PINTO, L. F. B.; MACHADO, M. A.; GASPARIN, G.; AZEVEDO, A. L. S.; VERNEQUE, R. da S.; REGITANO, L. C. de A. Identification of quantitative trait loci for growth curve in crossbred dairy cattle population. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 9., 2010, Leipzig. Proceedings... Leipzig: German Society fo Animal Science, 2010. 1 CD-ROM.| Biblioteca(s): Embrapa Gado de Leite; Embrapa Pecuária Sudeste. |
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| 89. | | DIAS, M. S.; MACHADO, A. de L.; MEIRA, A. N.; COUTINHO, L. L.; MOURAO, G. B.; AZEVEDO, H. C.; MUNIZ, E. N.; PEDROSA, V. B.; PINTO, L. F. B. Haplótipos do gene CAST associados com medidas morfométricas em ovinos Santa Inês. In: SIMPÓSIO BRASILEIRO DE MELHORAMENTO ANIMAL, 13., 2019, Salvador, BA. Anais... Salvador: SBMA, 2019.| Biblioteca(s): Embrapa Tabuleiros Costeiros. |
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| 90. | | CHAVES, N. M.; MACHADO, A. de L.; MEIRA, A. N.; COUTINHO, L. L.; MOURAO, G. B.; AZEVEDO, H. C.; MUNIZ, E. N.; PEDROSA, V. B.; PINTO, L. F. B. Haplótipos no gene IGF1 associados com medidas morfométricas em ovinos Santa Inês. In: SIMPÓSIO BRASILEIRO DE MELHORAMENTO ANIMAL, 13., 2019, Salvador, BA. Anais... Salvador: SBMA, 2019.| Biblioteca(s): Embrapa Tabuleiros Costeiros. |
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| 91. | | SENES, B. B.; MACHADO, A. de L.; MEIRA, A. N.; COUTINHO, L. L.; MOURAO, G. B.; AZEVEDO, H. C.; MUNIZ, E. N.; PEDROSA, V. B.; PINTO, L. F. B. Haplótipos no gene LEP associados com medidas morfométricas em ovinos Santa Inês. In: SIMPÓSIO BRASILEIRO DE MELHORAMENTO ANIMAL, 13., 2019, Salvador, BA. Anais... Salvador: SBMA, 2019.| Biblioteca(s): Embrapa Tabuleiros Costeiros. |
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| 92. | | DIAS, M. S.; SOUSA JUNIOR, L. P. B.; MEIRA, A. N.; COUTINHO, L. L.; MOURAO, G. B.; AZEVEDO, H. C.; MUNIZ, E. N.; PEDROSA, V. B.; PINTO, L. F. B. Haplótipos do gene MyF6 associados a maciez de carne em ovinos Santa Inês. In: SIMPÓSIO BRASILEIRO DE MELHORAMENTO ANIMAL, 13., 2019, Salvador, BA. Anais... Salvador: SBMA, 2019.| Biblioteca(s): Embrapa Tabuleiros Costeiros. |
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| Registros recuperados : 157 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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Data corrente: |
24/07/2019 |
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Data da última atualização: |
09/01/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
OLIVEIRA, P. S. N. de; COUTINHO, L. L.; CESAR, A. S. M.; DINIZ, W. J. da S.; SOUZA, M. de S.; ANDRADE, B. G.; KOLTES, J. E.; MOURÃO, G. B.; ZERLOTINI NETO, A.; REECY, J. M.; REGITANO, L. C. de A. |
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Afiliação: |
PRISCILA S. N. DE OLIVEIRA, CPPSE; LUIZ L. COUTINHO, Esalq/USP; ALINE S. M. CESAR, Esalq/USP; WELLISON J. DA SILVA DINIZ, UFSCar; MARCELA M. DE SOUZA, Iowa State University; BRUNO G. ANDRADE, CPPSE; JAMES E. KOLTES, Iowa State University; GERSON B. MOURÃO, Esalq/USP; ADHEMAR ZERLOTINI NETO, CNPTIA; JAMES M. REECY, Iowa State University; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
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Título: |
Co-expression networks reveal potential regulatory roles of miRNAs in fatty acid composition of nelore cattle. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Frontiers in Genetics, v. 10, p. 1-14, July 2019. |
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DOI: |
10.3389/fgene.2019.00651 |
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Idioma: |
Inglês |
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Notas: |
Article 651. Na publicação: Adhemar Zerlotini, Luciana C.A. Regitano. |
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Conteúdo: |
Fatty acid (FA) content affects the sensorial and nutritional value of meat and plays a significant role in biological processes such as adipogenesis and immune response. It is well known that, in beef, the main FAs associated with these biological processes are oleic acid (C18:1 cis9, OA) and conjugated linoleic acid (CLA-c9t11), which may have beneficial effects on metabolic diseases such as type 2 diabetes and obesity. Here, we performed differential expression and co-expression analyses, weighted gene co-expression network analysis (WGCNA) and partial correlation with information theory (PCIT), to uncover the complex interactions between miRNAs and mRNAs expressed in skeletal muscle associated with FA content. miRNA and mRNA expression data were obtained from skeletal muscle of Nelore cattle that had extreme genomic breeding values for OA and CLA. Insulin and MAPK signaling pathways were identified by WGCNA as central pathways associated with both of these fatty acids. Co-expression network analysis identified bta-miR-33a/b, bta-miR-100, bta-miR-204, bta-miR-365-5p, btamiR-660, bta-miR-411a, bta-miR-136, bta-miR-30-5p, bta-miR-146b, bta-let-7a-5p, bta-let-7f, bta-let-7, bta-miR 339, bta-miR-10b, bta-miR 486, and the genes ACTA1 and ALDOA as potential regulators of fatty acid synthesis. This study provides evidence and insights into the molecular mechanisms and potential target genes involved in fatty acid content differences in Nelore beef cattle, revealing new candidate pathways of phenotype modulation that could positively benefit beef production and human consumption. MenosFatty acid (FA) content affects the sensorial and nutritional value of meat and plays a significant role in biological processes such as adipogenesis and immune response. It is well known that, in beef, the main FAs associated with these biological processes are oleic acid (C18:1 cis9, OA) and conjugated linoleic acid (CLA-c9t11), which may have beneficial effects on metabolic diseases such as type 2 diabetes and obesity. Here, we performed differential expression and co-expression analyses, weighted gene co-expression network analysis (WGCNA) and partial correlation with information theory (PCIT), to uncover the complex interactions between miRNAs and mRNAs expressed in skeletal muscle associated with FA content. miRNA and mRNA expression data were obtained from skeletal muscle of Nelore cattle that had extreme genomic breeding values for OA and CLA. Insulin and MAPK signaling pathways were identified by WGCNA as central pathways associated with both of these fatty acids. Co-expression network analysis identified bta-miR-33a/b, bta-miR-100, bta-miR-204, bta-miR-365-5p, btamiR-660, bta-miR-411a, bta-miR-136, bta-miR-30-5p, bta-miR-146b, bta-let-7a-5p, bta-let-7f, bta-let-7, bta-miR 339, bta-miR-10b, bta-miR 486, and the genes ACTA1 and ALDOA as potential regulators of fatty acid synthesis. This study provides evidence and insights into the molecular mechanisms and potential target genes involved in fatty acid content differences in Nelore beef cattle, revealing new candidate... Mostrar Tudo |
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Palavras-Chave: |
Ácido linoleico conjugado; Ácido oleico; Ácidos graxos; Genômica; Integrative genomics; MiRNA; MRNA; Redes de co-expressão. |
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Thesagro: |
Bos Indicus; Gado de Corte. |
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Thesaurus NAL: |
Beef cattle; Conjugated linoleic acid; Oleic acid. |
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Categoria do assunto: |
--
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/199817/1/AP-Coexpression-networks.pdf
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Marc: |
LEADER 02877naa a2200421 a 4500
001 2110872
005 2020-01-09
008 2019 bl uuuu u00u1 u #d
024 7 $a10.3389/fgene.2019.00651$2DOI
100 1 $aOLIVEIRA, P. S. N. de
245 $aCo-expression networks reveal potential regulatory roles of miRNAs in fatty acid composition of nelore cattle.$h[electronic resource]
260 $c2019
500 $aArticle 651. Na publicação: Adhemar Zerlotini, Luciana C.A. Regitano.
520 $aFatty acid (FA) content affects the sensorial and nutritional value of meat and plays a significant role in biological processes such as adipogenesis and immune response. It is well known that, in beef, the main FAs associated with these biological processes are oleic acid (C18:1 cis9, OA) and conjugated linoleic acid (CLA-c9t11), which may have beneficial effects on metabolic diseases such as type 2 diabetes and obesity. Here, we performed differential expression and co-expression analyses, weighted gene co-expression network analysis (WGCNA) and partial correlation with information theory (PCIT), to uncover the complex interactions between miRNAs and mRNAs expressed in skeletal muscle associated with FA content. miRNA and mRNA expression data were obtained from skeletal muscle of Nelore cattle that had extreme genomic breeding values for OA and CLA. Insulin and MAPK signaling pathways were identified by WGCNA as central pathways associated with both of these fatty acids. Co-expression network analysis identified bta-miR-33a/b, bta-miR-100, bta-miR-204, bta-miR-365-5p, btamiR-660, bta-miR-411a, bta-miR-136, bta-miR-30-5p, bta-miR-146b, bta-let-7a-5p, bta-let-7f, bta-let-7, bta-miR 339, bta-miR-10b, bta-miR 486, and the genes ACTA1 and ALDOA as potential regulators of fatty acid synthesis. This study provides evidence and insights into the molecular mechanisms and potential target genes involved in fatty acid content differences in Nelore beef cattle, revealing new candidate pathways of phenotype modulation that could positively benefit beef production and human consumption.
650 $aBeef cattle
650 $aConjugated linoleic acid
650 $aOleic acid
650 $aBos Indicus
650 $aGado de Corte
653 $aÁcido linoleico conjugado
653 $aÁcido oleico
653 $aÁcidos graxos
653 $aGenômica
653 $aIntegrative genomics
653 $aMiRNA
653 $aMRNA
653 $aRedes de co-expressão
700 1 $aCOUTINHO, L. L.
700 1 $aCESAR, A. S. M.
700 1 $aDINIZ, W. J. da S.
700 1 $aSOUZA, M. de S.
700 1 $aANDRADE, B. G.
700 1 $aKOLTES, J. E.
700 1 $aMOURÃO, G. B.
700 1 $aZERLOTINI NETO, A.
700 1 $aREECY, J. M.
700 1 $aREGITANO, L. C. de A.
773 $tFrontiers in Genetics$gv. 10, p. 1-14, July 2019.
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Embrapa Pecuária Sudeste (CPPSE) |
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