Data/hora: 24/06/2024 11:08:55

Biblioteca(s): 	Embrapa Pecuária Sudeste.	
Tipo da produção científica: 	Artigo em Periódico Indexado	
Circulação/Nível: 	B - 5	
Data corrente: 	31/10/2018	
Data da última atualização: 	03/01/2019	
Autoria: 	DINIZ, W. J. S.; ROSA, K. O.; COUTINHO, L. L.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; SOUZA, M. M. de S.; CHAVES, A. S.; LANNA, D. P. D.; MOURÃO, G. B.; REGITANO, L. C. de A.	
Afiliação: 	Wellison J. S. Diniz, UFSCAR; Kamila O. Rosa, UNESP; Luiz L. Coutinho, USP/ESALQ; Polyana C. Tizioto, USP/ESALQ; Priscila Silva Neubern de Oliveira; Marcela M. de Souza; Amália S. Chaves, UFMG; Dante P. D. Lanna, USP/ESALQ; Gerson B. Mourão, ESALQ/USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.	
Título: 	KCNJ11 gene expression is associated to feed consumption and growth traits in Nelore beef cattle.	
Ano de publicação: 	2018	
Fonte/Imprenta: 	Agri Gene, v. 9, p. 1-4, 2018.	
DOI: 	10.1016/j.aggene.2018.05.004	
Idioma: 	Inglês	
Conteúdo: 	Feed efficiency is a complex trait influenced by several genes and biological processes. However, there is limited knowledge about the genes and pathways involved in this trait. KCNJ11, related to the insulin secretion pathway, was shown to be a functional candidate gene for beef quality traits in Nelore. Given its role in energy metabolism, we evaluated the effects of KCNJ11 gene expression level on feed efficiency-related, carcass and growth traits in Nelore steers. Skeletal muscle KCNJ11 mRNA levels were positively and significantly associated with dry matter intake (DMI), total digestible nutrients consumption (TDN), average daily gain (ADG), and relative growth rate (RGR) from a general linear mixed model approach. Co-expression analysis, using RNA sequencing data obtained from Longissimus dorsi (LD) muscle of 30 Nelore steers, identified key signalling pathways related to the regulation of energy metabolisms, such as mitogen-activated protein kinases and insulin pathways. Our findings indicate a linear relationship between KCNJ11 gene expression and the phenotypic measures for feed intake, weight gain, and relative growth rate in Nelore steers, but not for residual feed intake or fat deposition traits.	
Palavras-Chave: 	KCNJ11.	
Thesagro: 	Gado de Corte; Gado Nelore; Novilho de Corte.	
Thesaurus Nal: 	Beef cattle; Dry matter intake.	
Categoria do assunto: 	L Ciência Animal e Produtos de Origem Animal	
Registro original: 	Embrapa Pecuária Sudeste (CPPSE)	
Exemplares: 	CPPSE - (24551-1) - UPC - AP - DD - PROCI-2018.00126 - DIN - 2018.00131 - DIS