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21. | | KLEIN, C. S.; REBELATTO, R.; MORES, M. A. Z.; KICH, J. D.; MORES, N. Caracterização fenotípica de isolados de Pasteurella multocida A provenientes de lesões pneumônicas em suínos. In: CONGRESSO BRASILEIRO DE RECURSOS GENÉTICOS, 3., 2014, Santos. Anais... Brasília, DF: Sociedade Brasileira de Recursos Genéticos, 2014. 1 CD-ROM. Biblioteca(s): Embrapa Suínos e Aves. |
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27. | | REBELATTO, R.; KLEIN, C. S.; SURIAN, C. R.; KICH, J. D.; CARON, L.; MORES, M. A. Z. Experimental model: reproduction of erysipelas in pigs. In: INTERNATIONAL PIG VETERINARY SOCIETY CONGRESS, 26., 2022, Rio de Janeiro. Proceedings... Rio de Janeiro, RJ: IPVS: Abraves, 2022. p. 318. Biblioteca(s): Embrapa Suínos e Aves. |
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28. | | KUCHIISHI, S. S.; KICH, J. D.; MORES, M. A. Z.; REICHRT, S.; NEZZI, L.; SOUZA, G. R. M.; MIOTO, C. Infecção urinária por salmonella typhimurium em matrizes no sul do Brasil: Relato de caso. In: CONGRESSO BRASILEIRO DE VETERINÁRIOS ESPECIALISTAS EM SUÍNOS, 15., 2011, Fortaleza. Anais de palestras e resumos. Fortaleza: Abraves, 2011. 1 CD-ROM. Projeto: 04.10.06.001. Biblioteca(s): Embrapa Suínos e Aves. |
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29. | | ROCHA FILHO, N.; MORES, M. A. Z.; REBELATTO, R.; MORES, N.; KLEIN, C. S.; KICH, J. D. Pleurites crônicas responsáveis pelo desvio de carcaças suínas para o DIF: bacteriologia e histopatologia. In: CONGRESSO DA ABRAVES, 18., 2017, Goiânia. Suinocultura brasileira na era da tecnologia e da sustentabilidade: anais. Concórdia: Embrapa Suínos e Aves, 2017. v. 1. Palestras. p. 65-66. Biblioteca(s): Embrapa Suínos e Aves. |
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30. | | MORES, N.; CARON, L.; MORES, M. A. Z.; GAVA, D.; ESTEVES, P. A.; ZANELLA, J. R. C. Mumificação fecal associado ao circovírus suíno tipo 2 (PCV2) em um rebanho livre de patógenos específicos (SPF). In: SIMPÓSIO INTERNACIONAL DE SUINOCULTURA, 7., Porto Alegre, RS. Anais... Porto Alegre: UFRGS, 2012. p. 283-286. Projeto: 03.07.05.019. SINSUI. Biblioteca(s): Embrapa Suínos e Aves. |
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31. | | CARON, L.; MORES, M. A. Z.; COLDEBELLA, A.; SCHEUERMANN, G. N.; ASSAYAG JÚNIOR, M. S.; BILGILI, S. F. Aspectos patológicos de miopatias em frangos de corte. In: CONFERÊNCIA APINCO DE CIÊNCIA E TECNOLOGIA AVÍCOLAS, 2017, Campinas, SP. Anais... Campinas: FACTA, 2017. Biblioteca(s): Embrapa Suínos e Aves. |
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33. | | ROCHA, N.; MORES, M. A. Z.; DEZEN, D.; MORÉS, N.; COLDEBELLA, A.; REBELATTO, R.; KICH, J. D. Economic impact of chronic pleural lesions and consequent disqualification of carcasses for export during inspection in swine slaughterhouses. Pesquisa Veterinária Brasileira, v. 42, n. e07118, 2022. Biblioteca(s): Embrapa Suínos e Aves. |
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34. | | COLDEBELLA, A.; ALBUQUERQUE, E. R.; MORES, M. A. Z.; DUARTE, S. C.; SGARBOSSA, M. D.; CARON, L. Condenações de frangos abatidos sob inspeção federal no Brasil. Avicultura Industrial, Itu, ed. 1312, ano 112, n. 08, p. 42-47, 2021. Biblioteca(s): Embrapa Suínos e Aves. |
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35. | | KLEIN, C. S.; REBELATTO, R.; BELLAVER, F. A. V.; LOCATELLI, C.; MORES, M. A. Z.; MORES, N.; COLDEBELLA, A. Inoculação experimental de suínos para padronização de um teste de Elisa para detecção de anticorpos contra Mycoplasma hyopneumoniae. In: CONGRESSO BRASILEIRO DE VETERINÁRIOS ESPECIALISTAS EM SUÍNOS, 15., 2011, Fortaleza. Anais de palestras e resumos. Fortaleza: Abraves, 2011. 1 CD-ROM. Projeto: 03.09.00.046. Biblioteca(s): Embrapa Suínos e Aves. |
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36. | | CARRIJO, K. de F.; NASCIMENTO, E. R. do; MORES, N.; MORES, M. A. Z.; ALMEIDA, L. P. de; TORTELLY, R. Leptospira spp. em rins de suínos abatidos sob inspeção sanitária: potencial risco de transmissão a trabalhadores de matadouro frigorífico. Revista Brasileira de Medicina Veterinária, v. 34, n. 4, p. 279-282, 2012. Projeto: 02.10.61600-02. Biblioteca(s): Embrapa Suínos e Aves. |
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38. | | VAZ, C. S. L.; RECH, D. V.; FONSECA, F. M. da; MORES, M. A. Z.; COLDEBELLA, A. Redução de Salmonella Heidelberg em frangos pelo uso de bacteriófagos. Avicultura Industrial, Itu, ed. 1306, ano 112, n. 02, p. 16-18, 2021. Biblioteca(s): Embrapa Suínos e Aves. |
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39. | | GAVA, D.; HAACH, V.; MORES, M. A. Z.; MORES, N.; GRINGS, V. H.; ZANELLA, J. R. C.; SCHAEFER, R. Senecavirus A outbreak affecting piglets and sows in southern Brazil. . In: INTERNATIONAL PIG VETERINARY SOCIETY CONGRESS, 24., Dublin. Abstracts Book... Dublin, Ireland: IPVS, 2016. p. 456. Biblioteca(s): Embrapa Suínos e Aves. |
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Registros recuperados : 127 | |
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Registro Completo
Biblioteca(s): |
Embrapa Pecuária Sudeste. |
Data corrente: |
28/08/2018 |
Data da última atualização: |
21/05/2019 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
OKINO, C. H.; MORES, M. A. Z.; TREVISOL, I. M.; COLDEBELLA, A.; MONTASSIER, H. J.; BRENTANO, L. |
Afiliação: |
CINTIA HIROMI OKINO, CPPSE; MARCOS ANTONIO ZANELLA MORES, CNPSA; IARA MARIA TREVISOL, CNPSA; ARLEI COLDEBELLA, CNPSA; Hélio José Montassier, UNESP; LIANA BRENTANO, CNPSA. |
Título: |
Early immune responses and development of pathogenesis of avian infectious bronchitis viruses with different virulence profiles. |
Ano de publicação: |
2017 |
Fonte/Imprenta: |
Plos One, v. 12, p. 1-17, fev. 2017. |
Volume: |
12 |
Páginas: |
1-17 |
Idioma: |
Inglês |
Conteúdo: |
Avian infectious bronchitis virus (IBV) primarily replicates in epithelial cells of the upper respiratory tract of chickens, inducing both morphological and immune modulatory changes. However, the association between the local immune responses induced by IBV and the mechanisms of pathogenesis has not yet been completely elucidated. This study compared the expression profile of genes related to immune responses in tracheal samples after challenge with two Brazilian field isolates (A and B) of IBV from the same genotype, associating these responses with viral replication and with pathological changes in trachea and kidney. We detected a suppressive effect on the early activation of TLR7 pathway, followed by lower expression levels of inflammatory related genes induced by challenge with the IBV B isolate when compared to the challenge with to the IBV A isolate. Cell-mediated immune (CMI) related genes presented also lower levels of expression in tracheal samples from birds challenged with B isolate at 1dpi. Increased viral load and a higher percentage of birds with relevant lesions were observed in both tracheal and renal samples from chickens exposed to challenge with IBV B isolate. This differential pattern of early immune responses developed after challenge with IBV B isolate, related to the downregulation of TLR7, leading to insufficient pro-inflammatory response and lower CMI responses, seem to have an association with a most severe renal lesion and an enhanced capability of replication of this isolate in chicken. MenosAvian infectious bronchitis virus (IBV) primarily replicates in epithelial cells of the upper respiratory tract of chickens, inducing both morphological and immune modulatory changes. However, the association between the local immune responses induced by IBV and the mechanisms of pathogenesis has not yet been completely elucidated. This study compared the expression profile of genes related to immune responses in tracheal samples after challenge with two Brazilian field isolates (A and B) of IBV from the same genotype, associating these responses with viral replication and with pathological changes in trachea and kidney. We detected a suppressive effect on the early activation of TLR7 pathway, followed by lower expression levels of inflammatory related genes induced by challenge with the IBV B isolate when compared to the challenge with to the IBV A isolate. Cell-mediated immune (CMI) related genes presented also lower levels of expression in tracheal samples from birds challenged with B isolate at 1dpi. Increased viral load and a higher percentage of birds with relevant lesions were observed in both tracheal and renal samples from chickens exposed to challenge with IBV B isolate. This differential pattern of early immune responses developed after challenge with IBV B isolate, related to the downregulation of TLR7, leading to insufficient pro-inflammatory response and lower CMI responses, seem to have an association with a most severe renal lesion and an enhanced capability ... Mostrar Tudo |
Thesagro: |
Bronquite; Frango. |
Thesaurus NAL: |
Bronchitis; Chickens; Infectious bronchitis; Infectious bronchitis virus. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/182004/1/Okino-PONE-2017.pdf
|
Marc: |
LEADER 02335naa a2200277 a 4500 001 2094609 005 2019-05-21 008 2017 bl uuuu u00u1 u #d 100 1 $aOKINO, C. H. 245 $aEarly immune responses and development of pathogenesis of avian infectious bronchitis viruses with different virulence profiles.$h[electronic resource] 260 $c2017 300 $a1-17 12 490 $v12 520 $aAvian infectious bronchitis virus (IBV) primarily replicates in epithelial cells of the upper respiratory tract of chickens, inducing both morphological and immune modulatory changes. However, the association between the local immune responses induced by IBV and the mechanisms of pathogenesis has not yet been completely elucidated. This study compared the expression profile of genes related to immune responses in tracheal samples after challenge with two Brazilian field isolates (A and B) of IBV from the same genotype, associating these responses with viral replication and with pathological changes in trachea and kidney. We detected a suppressive effect on the early activation of TLR7 pathway, followed by lower expression levels of inflammatory related genes induced by challenge with the IBV B isolate when compared to the challenge with to the IBV A isolate. Cell-mediated immune (CMI) related genes presented also lower levels of expression in tracheal samples from birds challenged with B isolate at 1dpi. Increased viral load and a higher percentage of birds with relevant lesions were observed in both tracheal and renal samples from chickens exposed to challenge with IBV B isolate. This differential pattern of early immune responses developed after challenge with IBV B isolate, related to the downregulation of TLR7, leading to insufficient pro-inflammatory response and lower CMI responses, seem to have an association with a most severe renal lesion and an enhanced capability of replication of this isolate in chicken. 650 $aBronchitis 650 $aChickens 650 $aInfectious bronchitis 650 $aInfectious bronchitis virus 650 $aBronquite 650 $aFrango 700 1 $aMORES, M. A. Z. 700 1 $aTREVISOL, I. M. 700 1 $aCOLDEBELLA, A. 700 1 $aMONTASSIER, H. J. 700 1 $aBRENTANO, L. 773 $tPlos One$gv. 12, p. 1-17, fev. 2017.
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Embrapa Pecuária Sudeste (CPPSE) |
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