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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste; Embrapa Pecuária Sul; Embrapa Suínos e Aves. |
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Data corrente: |
22/08/2022 |
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Data da última atualização: |
22/08/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
NICIURA, S. C. M.; BENAVIDES, M. V.; OKINO, C. H.; IBELLI, A. M. G.; MINHO, A. P.; ESTEVES, S. N.; CHAGAS, A. C. de S. |
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Afiliação: |
SIMONE CRISTINA MEO NICIURA, CPPSE; MAGDA VIEIRA BENAVIDES, CPPSUL; CINTIA HIROMI OKINO, CPPSE; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; ALESSANDRO PELEGRINE MINHO, CPPSE; SERGIO NOVITA ESTEVES, CPPSE; ANA CAROLINA DE SOUZA CHAGAS, CPPSE. |
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Título: |
Genome-wide association study for Haemonchus contortus resistance in Morada Nova sheep. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Pathogens, v. 11, n. 8, aug. 2022, 939. |
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Páginas: |
12 p. |
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DOI: |
https://doi.org/10.3390/pathogens11080939 |
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Idioma: |
Inglês |
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Conteúdo: |
Among the gastrointestinal nematodes affecting sheep, Haemonchus contortus is the most prevalent and virulent, resulting in health problems and production losses. Therefore, selecting sheep resistant to H. contortus is a suitable and sustainable strategy for controlling endoparasites in flocks. Here, 287 lambs of the native Brazilian Morada Nova hair sheep breed were subjected to two consecutive artificial infections with H. contortus and assessed for fecal egg count (FEC), packed cell volume (PCV), and live weight (LW). Forty-four animals ranked as having extreme resistance phenotypes were genotyped using the Illumina OvineSNP50v3 chip. A case?control genome-wide association study (GWAS) detected 37 significant (p < 0.001) markers in 12 ovine chromosomes in regions harboring quantitative trait loci (QTL) for FEC, Trichostrongylus spp. adults and larvae, weight, and fat; and candidate genes for immune responses, mucins, hematological parameters, homeostasis, and growth. Four single-nucleotide polymorphisms (SNP; OAR1_rs427671974, AR2_rs419988472, OAR5_rs424070217, and OAR17_rs401006318) genotyped by qPCR followed by high-resolution melting (HRM) were associated with FEC and LW. Therefore, molecular markers detected by GWAS for H. contortus resistance in Morada Nova sheep may support animal selection programs aimed at controlling gastrointestinal nematode infections in flocks. Furthermore, genotyping of candidate genes using HRM qPCR may provide a rapid and efficient tool for animal identification. MenosAmong the gastrointestinal nematodes affecting sheep, Haemonchus contortus is the most prevalent and virulent, resulting in health problems and production losses. Therefore, selecting sheep resistant to H. contortus is a suitable and sustainable strategy for controlling endoparasites in flocks. Here, 287 lambs of the native Brazilian Morada Nova hair sheep breed were subjected to two consecutive artificial infections with H. contortus and assessed for fecal egg count (FEC), packed cell volume (PCV), and live weight (LW). Forty-four animals ranked as having extreme resistance phenotypes were genotyped using the Illumina OvineSNP50v3 chip. A case?control genome-wide association study (GWAS) detected 37 significant (p < 0.001) markers in 12 ovine chromosomes in regions harboring quantitative trait loci (QTL) for FEC, Trichostrongylus spp. adults and larvae, weight, and fat; and candidate genes for immune responses, mucins, hematological parameters, homeostasis, and growth. Four single-nucleotide polymorphisms (SNP; OAR1_rs427671974, AR2_rs419988472, OAR5_rs424070217, and OAR17_rs401006318) genotyped by qPCR followed by high-resolution melting (HRM) were associated with FEC and LW. Therefore, molecular markers detected by GWAS for H. contortus resistance in Morada Nova sheep may support animal selection programs aimed at controlling gastrointestinal nematode infections in flocks. Furthermore, genotyping of candidate genes using HRM qPCR may provide a rapid and efficient tool for... Mostrar Tudo |
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Palavras-Chave: |
Gastrointestinal nematode control; GWAS; Molecular markers; Ovine; Parasite resistance. |
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Thesagro: |
Marcador Molecular; Ovino; Parasito. |
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Thesaurus Nal: |
Genotyping. |
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Categoria do assunto: |
H Saúde e Patologia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1145606/1/GenomeWideAssociation.pdf
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Marc: |
LEADER 02449naa a2200325 a 4500
001 2145606
005 2022-08-22
008 2022 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.3390/pathogens11080939$2DOI
100 1 $aNICIURA, S. C. M.
245 $aGenome-wide association study for Haemonchus contortus resistance in Morada Nova sheep.$h[electronic resource]
260 $c2022
300 $a12 p.
520 $aAmong the gastrointestinal nematodes affecting sheep, Haemonchus contortus is the most prevalent and virulent, resulting in health problems and production losses. Therefore, selecting sheep resistant to H. contortus is a suitable and sustainable strategy for controlling endoparasites in flocks. Here, 287 lambs of the native Brazilian Morada Nova hair sheep breed were subjected to two consecutive artificial infections with H. contortus and assessed for fecal egg count (FEC), packed cell volume (PCV), and live weight (LW). Forty-four animals ranked as having extreme resistance phenotypes were genotyped using the Illumina OvineSNP50v3 chip. A case?control genome-wide association study (GWAS) detected 37 significant (p < 0.001) markers in 12 ovine chromosomes in regions harboring quantitative trait loci (QTL) for FEC, Trichostrongylus spp. adults and larvae, weight, and fat; and candidate genes for immune responses, mucins, hematological parameters, homeostasis, and growth. Four single-nucleotide polymorphisms (SNP; OAR1_rs427671974, AR2_rs419988472, OAR5_rs424070217, and OAR17_rs401006318) genotyped by qPCR followed by high-resolution melting (HRM) were associated with FEC and LW. Therefore, molecular markers detected by GWAS for H. contortus resistance in Morada Nova sheep may support animal selection programs aimed at controlling gastrointestinal nematode infections in flocks. Furthermore, genotyping of candidate genes using HRM qPCR may provide a rapid and efficient tool for animal identification.
650 $aGenotyping
650 $aMarcador Molecular
650 $aOvino
650 $aParasito
653 $aGastrointestinal nematode control
653 $aGWAS
653 $aMolecular markers
653 $aOvine
653 $aParasite resistance
700 1 $aBENAVIDES, M. V.
700 1 $aOKINO, C. H.
700 1 $aIBELLI, A. M. G.
700 1 $aMINHO, A. P.
700 1 $aESTEVES, S. N.
700 1 $aCHAGAS, A. C. de S.
773 $tPathogens$gv. 11, n. 8, aug. 2022, 939.
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Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Arroz e Feijão. Para informações adicionais entre em contato com cnpaf.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Arroz e Feijão. |
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Data corrente: |
29/11/2005 |
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Data da última atualização: |
13/10/2021 |
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Tipo da produção científica: |
Capítulo em Livro Técnico-Científico |
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Autoria: |
MORAIS, O. P. de. |
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Afiliação: |
ORLANDO PEIXOTO DE MORAIS, CNPAF. |
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Título: |
Genetic mean and variability in recurrent selection. |
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Ano de publicação: |
2005 |
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Fonte/Imprenta: |
In: GUIMARÃES, E. P. (Ed.). Population improvement: a way of exploiting the rice genetic resources of Latin America. Rome: FAO, 2005. |
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Páginas: |
p. 19-35. |
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Idioma: |
Inglês |
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Conteúdo: |
This chapter discusses the desirability of establishing and equilibrium between means and variances of the traits of populations developed for improvement through recurrent selection. |
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Thesagro: |
Arroz; Melhoramento Genético Vegetal; Oryza Sativa; Seleção Recorrente. |
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Thesaurus NAL: |
rice. |
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Categoria do assunto: |
G Melhoramento Genético |
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Marc: |
LEADER 00778naa a2200193 a 4500
001 1213803
005 2021-10-13
008 2005 bl uuuu u00u1 u #d
100 1 $aMORAIS, O. P. de
245 $aGenetic mean and variability in recurrent selection.
260 $c2005
300 $ap. 19-35.
520 $aThis chapter discusses the desirability of establishing and equilibrium between means and variances of the traits of populations developed for improvement through recurrent selection.
650 $arice
650 $aArroz
650 $aMelhoramento Genético Vegetal
650 $aOryza Sativa
650 $aSeleção Recorrente
773 $tIn: GUIMARÃES, E. P. (Ed.). Population improvement: a way of exploiting the rice genetic resources of Latin America. Rome: FAO, 2005.
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Registro original: |
Embrapa Arroz e Feijão (CNPAF) |
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