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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
01/08/1992 |
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Data da última atualização: |
20/06/2023 |
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Autoria: |
CAMERON, C. M.; MINNAAR, J. L.; ENGELBRECHT, M. M.; PURDOM, M. R. |
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Título: |
Immune response of Merino sheep to inactivated Corynebacterium pseudotuberculosis vaccine. |
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Ano de publicação: |
1972 |
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Fonte/Imprenta: |
Onderstepoort Journal Veterinary Research, v. 39, n. 1, p. 11-24, Mar. 1972. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: The brand of yeast extract used for medium production is critical for the cultivation of large numbers of Corynebacterium pseudotuberculosis. The agglutination test was used to measure the antibody response which followed the inoculation of various inactivated C. pseudotubermlosis vaccines . The best results followed two subcutaneous injections of 5 ml vaccine prepared by inactivation with 0,5% formalin and standardized so that each dose contained a total of 0,025 ml packed cells. The addition of adjuvants to the vaccine had a negligible effect on the antibody response, but increasing the interval between the primary and secondary injections from 2 or 4 to 6 weeks resulted in a higher level of agglutinating antibodies. The antibody titres, however, returned to pre-immunization levels within 3 to 4 months. Freshly prepared vaccine was very toxic, apparently due to incomplete toxoiding of the exotoxin, but older vaccine was shown to be quite safe. A method was devised whereby chronic pulmonary abscesses could be established in experimental animals. Exposure of immunized sheep to artificial infection showed that they were well protected against subacute infection and death but that they were not able to restrict the development of abscesses effectively. The possible reasons for the disappointing results are discussed in terms of the mechanisms of immunity which may be involved. |
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Palavras-Chave: |
Administration dosage; Corynebacterium Infections; Drug effects; Hot Temperature; Vaccines attenuated; Vacina inativa. |
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Thesagro: |
Doença; Linfadenite Caseosa; Ovino. |
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Thesaurus Nal: |
Agglutination tests; Aluminum hydroxide; Enterotoxins; Guinea pigs; Immunization; Immunology; Mice; Pharmacology; Phenols; Phosphates; Sheep diseases; Toxicity. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02549naa a2200409 a 4500
001 1520214
005 2023-06-20
008 1972 bl uuuu u00u1 u #d
100 1 $aCAMERON, C. M.
245 $aImmune response of Merino sheep to inactivated Corynebacterium pseudotuberculosis vaccine.$h[electronic resource]
260 $c1972
520 $aAbstract: The brand of yeast extract used for medium production is critical for the cultivation of large numbers of Corynebacterium pseudotuberculosis. The agglutination test was used to measure the antibody response which followed the inoculation of various inactivated C. pseudotubermlosis vaccines . The best results followed two subcutaneous injections of 5 ml vaccine prepared by inactivation with 0,5% formalin and standardized so that each dose contained a total of 0,025 ml packed cells. The addition of adjuvants to the vaccine had a negligible effect on the antibody response, but increasing the interval between the primary and secondary injections from 2 or 4 to 6 weeks resulted in a higher level of agglutinating antibodies. The antibody titres, however, returned to pre-immunization levels within 3 to 4 months. Freshly prepared vaccine was very toxic, apparently due to incomplete toxoiding of the exotoxin, but older vaccine was shown to be quite safe. A method was devised whereby chronic pulmonary abscesses could be established in experimental animals. Exposure of immunized sheep to artificial infection showed that they were well protected against subacute infection and death but that they were not able to restrict the development of abscesses effectively. The possible reasons for the disappointing results are discussed in terms of the mechanisms of immunity which may be involved.
650 $aAgglutination tests
650 $aAluminum hydroxide
650 $aEnterotoxins
650 $aGuinea pigs
650 $aImmunization
650 $aImmunology
650 $aMice
650 $aPharmacology
650 $aPhenols
650 $aPhosphates
650 $aSheep diseases
650 $aToxicity
650 $aDoença
650 $aLinfadenite Caseosa
650 $aOvino
653 $aAdministration dosage
653 $aCorynebacterium Infections
653 $aDrug effects
653 $aHot Temperature
653 $aVaccines attenuated
653 $aVacina inativa
700 1 $aMINNAAR, J. L.
700 1 $aENGELBRECHT, M. M.
700 1 $aPURDOM, M. R.
773 $tOnderstepoort Journal Veterinary Research$gv. 39, n. 1, p. 11-24, Mar. 1972.
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