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| 8. |  | BRAGANÇA, G. M.; SOUZA-FABJAN, J. M. G.; BATISTA, R. I. T. P.; RIBEIRO, L. S.; BRAIR, V. L.; CÔRTES, L. R.; SOUZA, C. V.; TRAIRA, A. R.; FONSECA, J. F. da; MENCHACA, A.; BRANDÃO, F. Z. Different progestagens sources do not affect the follicular population and the morphological quality of oocytes during ovarian stimulation in Santa Inês ewes. Animal Reprodroduction, v. 15, n. 3, p. 451, Jul./Sept. 2018. Abstracts A151. Edição dos Proceedings of the 32nd Annual Meeting of the Brazilian Embryo Technology Society (SBTE); Florianópolis, SC, Brazil, August 16th to 18th, 2018.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 9. | | BRAGANÇA, G. M.; SOUZA-FABJANA, J. M. G.; RIBEIRO, L. S.; BRAIRA, V. L.; CÔRTES, L. R.; SOUZA, C. V.; BATISTA, R. I. T. P.; FONSECA, J. F. da; MENCHACA, A.; BRANDÃO, F. Z. Exogenous progestogen does not affectfirst-wave folliclepopulations and oocyte quality during ovarian stimulationwith FSH in sheep. Domestic Animal Endocrinology, v. 72, e106369, Jul. 2020. Online ahead of print.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 10. | | BRAGANÇA, G. M.; BATISTA, R. I. T. P.; SOUZA-FABJAN, J. M. G.; ALFRADIQUE, V. A. P.; ARASHIRO, E. K. N.; PINTO, P. H. N.; SANTOS, J. D. R.; CAMARGO, L. S. de A.; MENCHACA, A.; FONSECA, J. F. da; BRANDÃO, F. Z. Exogenous progestogens differentially alter gene expression of immature cumulus-oocyte complexes in sheep. Domestic Animal Endocrinology, v. 74, e106518, 2021.| Biblioteca(s): Embrapa Caprinos e Ovinos; Embrapa Gado de Leite. |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Caprinos e Ovinos; Embrapa Gado de Leite. |
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Data corrente: |
12/01/2021 |
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Data da última atualização: |
15/09/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
BRAGANÇA, G. M.; BATISTA, R. I. T. P.; SOUZA-FABJAN, J. M. G.; ALFRADIQUE, V. A. P.; ARASHIRO, E. K. N.; PINTO, P. H. N.; SANTOS, J. D. R.; CAMARGO, L. S. de A.; MENCHACA, A.; FONSECA, J. F. da; BRANDÃO, F. Z. |
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Afiliação: |
Universidade Federal Fluminense; Universidade Federal Fluminense; Universidade Federal Fluminense; Universidade Federal Fluminense; Universidade Federal Fluminense; Universidade Federal Fluminense; Universidade Federal Fluminense; LUIZ SERGIO DE ALMEIDA CAMARGO, CNPGL; Fundacion IRAUy, Cno. Cruz del Sur, Montevideo, Uruguay; JEFERSON FERREIRA DA FONSECA, CNPC; Universidade Federal Fluminense. |
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Título: |
Exogenous progestogens differentially alter gene expression of immature cumulus-oocyte complexes in sheep. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Domestic Animal Endocrinology, v. 74, e106518, 2021. |
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DOI: |
https://doi.org/10.1016/j.domaniend.2020.106518 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstracts: This study evaluated the role of progesterone (P4) and medroxyprogesterone acetate (MAP) on the molecular status of immature cumulus-oocyte complexes (COCs) and the implications for oocyte quality in sheep. The number of viable COCs per ewe and the rate of COCs screened for developmental competence by brilliant cresyl blue positive (BCBþ) were similar (P > 0.05), respectively, across treatments (P4: 7.7 ± 0.7 and 4.7 ± 1.2; MAP: 5.7 ± 1.0 and 3.5 ± 2.3; and control: 5.7 ± 1.1 and 3.6 ± 2.4). The COCs' gene expression was altered by exogenous progestogens compared with the control group: markers of steroidogenic pathway (FSH receptor [FSHr], LH receptor [LHr], and estradiol receptor a) and of quality (zygote arrest 1, growth differentiation factor 9, and B-cell lymphoma 2) were in abundance in P4 (P < 0.05). In addition, reelin protein (RELN) was downregulated, and Bcl-2 was upregulated in MAP (P < 0.05). In the P4 vs MAP comparison, FSHr, LHr, and RELN genes were upregulated (P < 0.05) in the P4 group. In conclusion, P4 and MAP promoted dissimilar effects on transcriptome profiling of immature BCB-selected COCs, possibly due to the differences in the chemical structure of progestogens and concentrations of serum P4. Exogenous P4 impacted positively on the profile of genes related to oocyte quality. |
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Palavras-Chave: |
Oocyte competence; Progestins. |
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Thesagro: |
Ovelha; Ovino; Reprodução Animal. |
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Thesaurus NAL: |
Ewes; Gene expression; Medroxyprogesterone; Oocytes; Progesterone; Small ruminants. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
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100 1 $aBRAGANÇA, G. M.
245 $aExogenous progestogens differentially alter gene expression of immature cumulus-oocyte complexes in sheep.$h[electronic resource]
260 $c2021
520 $aAbstracts: This study evaluated the role of progesterone (P4) and medroxyprogesterone acetate (MAP) on the molecular status of immature cumulus-oocyte complexes (COCs) and the implications for oocyte quality in sheep. The number of viable COCs per ewe and the rate of COCs screened for developmental competence by brilliant cresyl blue positive (BCBþ) were similar (P > 0.05), respectively, across treatments (P4: 7.7 ± 0.7 and 4.7 ± 1.2; MAP: 5.7 ± 1.0 and 3.5 ± 2.3; and control: 5.7 ± 1.1 and 3.6 ± 2.4). The COCs' gene expression was altered by exogenous progestogens compared with the control group: markers of steroidogenic pathway (FSH receptor [FSHr], LH receptor [LHr], and estradiol receptor a) and of quality (zygote arrest 1, growth differentiation factor 9, and B-cell lymphoma 2) were in abundance in P4 (P < 0.05). In addition, reelin protein (RELN) was downregulated, and Bcl-2 was upregulated in MAP (P < 0.05). In the P4 vs MAP comparison, FSHr, LHr, and RELN genes were upregulated (P < 0.05) in the P4 group. In conclusion, P4 and MAP promoted dissimilar effects on transcriptome profiling of immature BCB-selected COCs, possibly due to the differences in the chemical structure of progestogens and concentrations of serum P4. Exogenous P4 impacted positively on the profile of genes related to oocyte quality.
650 $aEwes
650 $aGene expression
650 $aMedroxyprogesterone
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650 $aSmall ruminants
650 $aOvelha
650 $aOvino
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700 1 $aBRANDÃO, F. Z.
773 $tDomestic Animal Endocrinology$gv. 74, e106518, 2021.
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