Data/hora: 23/06/2024 12:58:00

Biblioteca(s): | Embrapa Meio Ambiente.
Tipo da produção científica: | Artigo em Periódico Indexado
Circulação/Nível: | Internacional - A
Data corrente: | 15/01/2008
Data da última atualização: | 25/03/2014
Autoria: | CASTRO, V. L. S. S. de; MELLO, M. A. de; DINIZ, C. A. R.; MORITA, L. H. M.; ZUCCHI, T.; POLI, P.
Afiliação: | Vera Lúcia Scherholz Salgado de Castro, Embrapa Meio Ambiente; Michele A. de Melo, Departamento de Parasitologia-ICB-USP; Carlos Diniz, UFSCAR; Lia Morita, UFSCAR; Tânia Zucchi, Departamento de Parasitologia-ICB-USP; Paola Poli, Departamento de Parasitologia-ICB-USP.
Título: | Neurodevelopmental effects of perinatal fenarimol exposure on rats.
Ano de publicação: | 2007
Fonte/Imprenta: | Reproductive Toxicology, Elmsford, v. 23, n. 1, p. 98-105, 2007.
Idioma: | Inglês
Conteúdo: | Knowledge about the potential toxic effects of fenarimol, a widely used fungicide, is still limited. Fenarimol is an aromatase inhibitor and therefore can affect estrogen/androgen levels in vivo in rodents. In view of these facts, the aim of the present work was to study the effects of fenarimol maternal exposure during different critical phases in the development of central nervous system in rat pups, on early physical and neurobehavioral endpoints essential to their development. For that, the effects of the fungicide fenarimol (150 and 300 mg/kg) were examined at three different developmental stages in the rat: during the first 6 days of gestation, prenatal (15-21 days), or first 6 days of lactation. Three categories of the impact of fenarimol on neonatal growth and neurobehavioral development of offspring were assessed: (1) physical, (2) reflex and strength, and (3) motor coordination. Findings on the pups? physical development did not indicate any significant alterations of the postnatal age at which specific developmental milestones were observed (pinna detachment, development of the fur, eruption of the incisor teeth, opening of the ears and eyes and testes descent). However, there was a reduced rate of weight gain in pups of mothers treated during lactation related to the earlier testing time periods (1-23 days of life). The study of the functional state of the rat pup nervous systems at different stages of postnatal development revealed some neurodevelopmental delays in righting reflex, climbing and grip response and locomotion (20-90 days of life) in the treated groups. Taken together, findings of this study emphasize that, as a result of fenarimol maternal exposure, some neuromuscular and behavioral deficits in nursing pups may occur principally during the last gestational period and lactation. These results could be the basis for further studies on molecular actions of fenarimol in order to predict better the biological consequences of this fungicide.
Palavras-Chave: | Coordenação motora; Desenvolvimento neurocomportamental; Sistema nervoso central; Teste.
Thesagro: | Fungicida; Toxicologia; Toxidez.
Categoria do assunto: | --
Registro original: | Embrapa Meio Ambiente (CNPMA)
Exemplares: | CNPMA - (7177-1) - UPC - AP - -- - Aq5 G2 - PAT 2007 - 2008.00021 - DIS