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| Registros recuperados : 9 | |
| 2. |  | MEIRELLES, M. R.; MALAFATTI, J. O. D.; DOMINGUES, M. A.; PARIS, E. C. Obtenção de nanocompósito magnético de faujasita decorada com nanopartículas de ferrita para adsorção de poluentes em meio aquoso. In: JORNADA CIENTÍFICA - EMBRAPA SÃO CARLOS, 12., 2020, São Carlos, SP. Anais... São Carlos: Embrapa Instrumentação: Embrapa Pecuária Sudeste, 2020. Editores técnicos: Cristiane Sanchez Farinas, Daniel Souza Corrêa, José Manoel Marconcini, Maria Fernanda Berlingieri Durigan, Paulo Sérgio de Paula Herrmann Junior. 68 Embrapa Instrumentação. Documentos, 71.| Biblioteca(s): Embrapa Instrumentação. |
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| 3. | | MEIRELLES, M. R.; PRADO, A. C. F.; MALAFATTI, J. O. D.; PARIS, E. C. Obtenção de nanofibras de Nb2O5 para conversão fotocatalítica de gases do efeito estufa. In: JORNADA CIENTÍFICA - EMBRAPA SÃO CARLOS, 13., 2021, São Carlos, SP. Anais... São Carlos: Embrapa Pecuária Sudeste: Embrapa Instrumentação, 2021. Editores técnicos: Alexandre Berndt, Ana Rita de Araujo Nogueira, Lea Chapaval Andri, Marcelo Mattos Cavallari, Manuel Antonio Chagas Jacinto.| Biblioteca(s): Embrapa Instrumentação. |
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| 4. | | DOMINGUES, M. A.; MALAFATTI, J. O. D.; MEIRELLES, M. R.; PARIS, E. C. Obtenção de nanopartículas de CuO via método de precipitação visando aplicações antimicrobianas. In: JORNADA CIENTÍFICA - EMBRAPA SÃO CARLOS, 12., 2020, São Carlos, SP. Anais... São Carlos: Embrapa Instrumentação: Embrapa Pecuária Sudeste, 2020. Editores técnicos: Cristiane Sanchez Farinas, Daniel Souza Corrêa, José Manoel Marconcini, Maria Fernanda Berlingieri Durigan, Paulo Sérgio de Paula Herrmann Junior. 67 Embrapa Instrumentação. Documentos, 71.| Biblioteca(s): Embrapa Instrumentação. |
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| 7. | | MEIRELLES, M. R.; MALAFATTI, J. O. D.; SCIENA, C. R.; RABA, A. M.; ZENATTI, A.; ESCOTE, M. T.; PARIS, E. C. Avaliação da modificação de superfície do nanocompósito magnético à base de zeólita FAU para absorção de corante em meio aquoso. In: SIMPÓSIO NACIONAL DE INSTRUMENTAÇÃO AGROPECUÁRIA, 4., 2019, São Carlos, SP. Ciência, inovação e mercado: anais. São Carlos, SP: Embrapa Instrumentação, 2019. Editores: Paulino Ribeiro Villas-Boas, Maria Alice Martins, Débora Marcondes Bastos Pereira Milori, Ladislau Martin Neto. SIAGRO 2019. 617-621| Biblioteca(s): Embrapa Instrumentação. |
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| 9. | | MALAFATTI, J. O. D.; RUELLAS, T. M. O.; SCHILDT, L. F. L.; DOMINGUES, M. A.; MARINHO, B. S.; MEIRELLES, M. R.; PARIS, E. C. Propriedades mecânicas de filmes de amido termoplástico na presença de ureia. In: ARENARE, E. C. C. (org.). A Geração de Novos Conhecimentos na Química 2. Ponta Grossa, PR: Atena, 2021. 356 p.| Biblioteca(s): Embrapa Instrumentação. |
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| Registros recuperados : 9 | |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Instrumentação. Para informações adicionais entre em contato com cnpdia.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
08/11/2021 |
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Data da última atualização: |
25/11/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
MALAFATTI, J. O. D.; RUELLAS, T. M. de O.; MEIRELLES, M. R.; THOMAZI, A. C.; RENDA, C. G.; PARIS, E. C. |
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Afiliação: |
ADRIANA COATRINI THOMAZI, CNPDIA; ELAINE CRISTINA PARIS, CNPDIA. |
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Título: |
Nanocarriers of Eu3+ doped silica nanoparticles modified by APTES for luminescent monitoring of cloxacillin. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
AIMS Materials Science, v. 8, n. 5. |
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Páginas: |
760?775 |
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ISSN: |
2372-0484 |
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DOI: |
10.3934/matersci.2021046 |
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Idioma: |
Inglês |
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Conteúdo: |
Drug nanocarriers have been continuously improved to promote satisfactory release control. In this sense, luminescent materials have become an alternative option in clinical trials due to their ability to monitor drug delivery. Among the nanocarriers, silica stands out for structural stability, dispersibility, and surface reactivity. When using ceramic nanocarriers, one of the challenges is their interaction and selectivity capability for organic molecules, such as drugs. In order to overcome such adversity, superficial modifications can be carried out to enable a higher affinity for the desired drug. Thus, the present study aimed to obtain silica nanoparticles (NPs) doped with low concentrations of europium (III) superficially modified by (3-aminopropyl)triethoxysilane (APTES) to assess their interaction with the model drug cloxacillin benzathine. This drug was chosen because it is part of the ampicillin family and is commonly used in several treatments. Nearspherical and homogeneous silica NPs were obtained via sol-gel synthesis, with particle sizes of approximately 21 nm. It was possible to verify the fluorescence capacity of the silica NPs when doped with europium (III) in a mole percent that varied from 0.5 to 3.0%. A 10% volume percent of APTES caused the silica nanoparticles to increase the degree of hydrophobicity, with a shift in the contact angle from 8° to 51°. After surface modification by APTES, the silica nanocarrier (10 gꞏL−1) achieved a satisfactory degree of CLOX incorporation (25 gꞏL−1), increasing the adsorptive capacity to values above 50%. Therefore, silica NPs doped with europium (III) in a low percent of 0.5% (mole) modified by APTES showed promising results as an alternative option for trials and clinical studies of drug incorporation. MenosDrug nanocarriers have been continuously improved to promote satisfactory release control. In this sense, luminescent materials have become an alternative option in clinical trials due to their ability to monitor drug delivery. Among the nanocarriers, silica stands out for structural stability, dispersibility, and surface reactivity. When using ceramic nanocarriers, one of the challenges is their interaction and selectivity capability for organic molecules, such as drugs. In order to overcome such adversity, superficial modifications can be carried out to enable a higher affinity for the desired drug. Thus, the present study aimed to obtain silica nanoparticles (NPs) doped with low concentrations of europium (III) superficially modified by (3-aminopropyl)triethoxysilane (APTES) to assess their interaction with the model drug cloxacillin benzathine. This drug was chosen because it is part of the ampicillin family and is commonly used in several treatments. Nearspherical and homogeneous silica NPs were obtained via sol-gel synthesis, with particle sizes of approximately 21 nm. It was possible to verify the fluorescence capacity of the silica NPs when doped with europium (III) in a mole percent that varied from 0.5 to 3.0%. A 10% volume percent of APTES caused the silica nanoparticles to increase the degree of hydrophobicity, with a shift in the contact angle from 8° to 51°. After surface modification by APTES, the silica nanocarrier (10 gꞏL−1) achieved a satisfactory degree of... Mostrar Tudo |
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Palavras-Chave: |
Luminescent materials; Surface modification. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02525naa a2200241 a 4500
001 2135885
005 2022-11-25
008 2021 bl uuuu u00u1 u #d
022 $a2372-0484
024 7 $a10.3934/matersci.2021046$2DOI
100 1 $aMALAFATTI, J. O. D.
245 $aNanocarriers of Eu3+ doped silica nanoparticles modified by APTES for luminescent monitoring of cloxacillin.$h[electronic resource]
260 $c2021
300 $a760?775
520 $aDrug nanocarriers have been continuously improved to promote satisfactory release control. In this sense, luminescent materials have become an alternative option in clinical trials due to their ability to monitor drug delivery. Among the nanocarriers, silica stands out for structural stability, dispersibility, and surface reactivity. When using ceramic nanocarriers, one of the challenges is their interaction and selectivity capability for organic molecules, such as drugs. In order to overcome such adversity, superficial modifications can be carried out to enable a higher affinity for the desired drug. Thus, the present study aimed to obtain silica nanoparticles (NPs) doped with low concentrations of europium (III) superficially modified by (3-aminopropyl)triethoxysilane (APTES) to assess their interaction with the model drug cloxacillin benzathine. This drug was chosen because it is part of the ampicillin family and is commonly used in several treatments. Nearspherical and homogeneous silica NPs were obtained via sol-gel synthesis, with particle sizes of approximately 21 nm. It was possible to verify the fluorescence capacity of the silica NPs when doped with europium (III) in a mole percent that varied from 0.5 to 3.0%. A 10% volume percent of APTES caused the silica nanoparticles to increase the degree of hydrophobicity, with a shift in the contact angle from 8° to 51°. After surface modification by APTES, the silica nanocarrier (10 gꞏL−1) achieved a satisfactory degree of CLOX incorporation (25 gꞏL−1), increasing the adsorptive capacity to values above 50%. Therefore, silica NPs doped with europium (III) in a low percent of 0.5% (mole) modified by APTES showed promising results as an alternative option for trials and clinical studies of drug incorporation.
653 $aLuminescent materials
653 $aSurface modification
700 1 $aRUELLAS, T. M. de O.
700 1 $aMEIRELLES, M. R.
700 1 $aTHOMAZI, A. C.
700 1 $aRENDA, C. G.
700 1 $aPARIS, E. C.
773 $tAIMS Materials Science$gv. 8, n. 5.
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