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Registro Completo |
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Biblioteca(s): |
Embrapa Clima Temperado. |
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Data corrente: |
16/12/2021 |
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Data da última atualização: |
17/12/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
HAILE, T.; CARDOSO, S. M.; RAPHAELLI, C. de O.; PEREIRA, O. R.; PEREIRA, E. dos S.; VIZZOTTO, M.; NORA, L.; ASFAW, A. A.; PERIASAMY, G.; KARIM, A. |
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Afiliação: |
TESFAY HAILE, Mekelle University; SUSANA M. CARDOSO; CHIRLE DE OLIVEIRA RAPHAELLI; OLÍVIA R. PEREIRA; ELISA DOS SANTOS PEREIRA; MARCIA VIZZOTTO, CPACT; LEONARDO NORA; ADISSU ALEMAYEHU ASFAW, Mekelle University; GOMATHI PERIASAMY, Mekelle University; AMAN KARIM, Mekelle University. |
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Título: |
Chemical Composition, Antioxidant Potential, and Blood Glucose Lowering Effect of Aqueous Extract and Essential Oil of Thymus Serrulatus Hochst. Ex Benth. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Frontiers in Pharmacology, v. 12, article 621536, April 2021. |
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Idioma: |
Português |
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Conteúdo: |
Thymus serrulatus, an endemic plant of Ethiopia, is traditionally used to cure various diseases and as a food ingredient. In the Ethiopian folk medicine, the decoction is orally taken as a remedy to treat diabetes and high blood pressure. The purpose of the present study was to evaluate the antioxidant and antihyperglycemic effects of the aqueous extract and of the essential oil of Thymus serrulatus. The chemical composition of the aqueous extract was determined by LC-MS and the essential oil was characterized by GC-MS analysis. Radical scavenging assays, namely scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH?), hydroxyl (?OH), and nitric oxide (?NO), were used as a first approach to screen the potential antioxidant abilities of the samples. Alpha-amylase and α-glucosidase inhibitory studies were also employed to evaluate the in vitro antihyperglycemic potential of the plant. The in vivo blood glucose lowering effect of the extracts was assessed using hypoglycemic activity and the oral glucose tolerance test in normal and in streptozotocin induced diabetic mice. When compared to the aqueous extract, the essential oil showed superior radical scavenging activity, particularly for ?NO, as well as greater inhibitory potency against α-amylase and α-glucosidase (IC50 0.01 mg/ml and 0.11 mg/ml, respectively). Both tested samples showed a statistically significant antihyperglycemic effect. The aqueous extract at 600 mg/kg exerted maximum antihyperglycemic activity (44.14%), followed by the essential oil (30.82%). Body weight and glucose tolerance parameters were also improved by the samples both in normal and diabetic mice. The findings of this study support the hypothesis that aqueous extract and essential oil of T. serrulatus are promising therapeutic agents. MenosThymus serrulatus, an endemic plant of Ethiopia, is traditionally used to cure various diseases and as a food ingredient. In the Ethiopian folk medicine, the decoction is orally taken as a remedy to treat diabetes and high blood pressure. The purpose of the present study was to evaluate the antioxidant and antihyperglycemic effects of the aqueous extract and of the essential oil of Thymus serrulatus. The chemical composition of the aqueous extract was determined by LC-MS and the essential oil was characterized by GC-MS analysis. Radical scavenging assays, namely scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH?), hydroxyl (?OH), and nitric oxide (?NO), were used as a first approach to screen the potential antioxidant abilities of the samples. Alpha-amylase and α-glucosidase inhibitory studies were also employed to evaluate the in vitro antihyperglycemic potential of the plant. The in vivo blood glucose lowering effect of the extracts was assessed using hypoglycemic activity and the oral glucose tolerance test in normal and in streptozotocin induced diabetic mice. When compared to the aqueous extract, the essential oil showed superior radical scavenging activity, particularly for ?NO, as well as greater inhibitory potency against α-amylase and α-glucosidase (IC50 0.01 mg/ml and 0.11 mg/ml, respectively). Both tested samples showed a statistically significant antihyperglycemic effect. The aqueous extract at 600 mg/kg exerted maximum antihyperglycemic activity (... Mostrar Tudo |
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Palavras-Chave: |
Thymus serrulatus. |
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Thesagro: |
Antioxidante; Extrato; Extrato Vegetal; Óleo Essencial. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/229329/1/9-HAILE.pdf
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Marc: |
LEADER 02681naa a2200289 a 4500
001 2138005
005 2021-12-17
008 2021 bl uuuu u00u1 u #d
100 1 $aHAILE, T.
245 $aChemical Composition, Antioxidant Potential, and Blood Glucose Lowering Effect of Aqueous Extract and Essential Oil of Thymus Serrulatus Hochst. Ex Benth.$h[electronic resource]
260 $c2021
520 $aThymus serrulatus, an endemic plant of Ethiopia, is traditionally used to cure various diseases and as a food ingredient. In the Ethiopian folk medicine, the decoction is orally taken as a remedy to treat diabetes and high blood pressure. The purpose of the present study was to evaluate the antioxidant and antihyperglycemic effects of the aqueous extract and of the essential oil of Thymus serrulatus. The chemical composition of the aqueous extract was determined by LC-MS and the essential oil was characterized by GC-MS analysis. Radical scavenging assays, namely scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH?), hydroxyl (?OH), and nitric oxide (?NO), were used as a first approach to screen the potential antioxidant abilities of the samples. Alpha-amylase and α-glucosidase inhibitory studies were also employed to evaluate the in vitro antihyperglycemic potential of the plant. The in vivo blood glucose lowering effect of the extracts was assessed using hypoglycemic activity and the oral glucose tolerance test in normal and in streptozotocin induced diabetic mice. When compared to the aqueous extract, the essential oil showed superior radical scavenging activity, particularly for ?NO, as well as greater inhibitory potency against α-amylase and α-glucosidase (IC50 0.01 mg/ml and 0.11 mg/ml, respectively). Both tested samples showed a statistically significant antihyperglycemic effect. The aqueous extract at 600 mg/kg exerted maximum antihyperglycemic activity (44.14%), followed by the essential oil (30.82%). Body weight and glucose tolerance parameters were also improved by the samples both in normal and diabetic mice. The findings of this study support the hypothesis that aqueous extract and essential oil of T. serrulatus are promising therapeutic agents.
650 $aAntioxidante
650 $aExtrato
650 $aExtrato Vegetal
650 $aÓleo Essencial
653 $aThymus serrulatus
700 1 $aCARDOSO, S. M.
700 1 $aRAPHAELLI, C. de O.
700 1 $aPEREIRA, O. R.
700 1 $aPEREIRA, E. dos S.
700 1 $aVIZZOTTO, M.
700 1 $aNORA, L.
700 1 $aASFAW, A. A.
700 1 $aPERIASAMY, G.
700 1 $aKARIM, A.
773 $tFrontiers in Pharmacology$gv. 12, article 621536, April 2021.
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Registro original: |
Embrapa Clima Temperado (CPACT) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Clima Temperado. Para informações adicionais entre em contato com cpact.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Clima Temperado. |
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Data corrente: |
25/04/2005 |
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Data da última atualização: |
31/03/2020 |
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Autoria: |
SANTOS, A. M. dos; MEDEIROS, A. R. M. de (ed.). |
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Título: |
Morango: produção. |
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Ano de publicação: |
2003 |
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Fonte/Imprenta: |
Pelotas: Embrapa Clima Temperado; Brasília, DF: Embrapa Informação Tecnológica, 2003. |
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Páginas: |
81 p. |
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Série: |
(Frutas do Brasil, 40). |
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Idioma: |
Português |
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Conteúdo: |
Aspecto socioeconômicos; Classificação botânica, origem e evolução; Exigências de clima e solo; Escolha da área e preparo do solo; Cultivares; Produção de mudas básicas; Produção de mudas comerciais; Nutrição, calagem e adubação; Irrigação e fertirrigação; Implantação da cutura; Práticas culturais; Pragas; Nematóides; Doenças; Colheita, classificação e embalagem; Colheita e pós-colheita; Comercialização. |
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Palavras-Chave: |
Brasil; Cultivo; Embrapa Clima Temperado; Pelotas; Rio Grande do Sul. |
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Thesagro: |
Morango; Produção. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01050nam a2200229 a 4500
001 1744952
005 2020-03-31
008 2003 bl uuuu 00u1 u #d
100 1 $aSANTOS, A. M. dos
245 $aMorango$bprodução.
260 $aPelotas: Embrapa Clima Temperado; Brasília, DF: Embrapa Informação Tecnológica$c2003
300 $a81 p.
490 $a(Frutas do Brasil, 40).
520 $aAspecto socioeconômicos; Classificação botânica, origem e evolução; Exigências de clima e solo; Escolha da área e preparo do solo; Cultivares; Produção de mudas básicas; Produção de mudas comerciais; Nutrição, calagem e adubação; Irrigação e fertirrigação; Implantação da cutura; Práticas culturais; Pragas; Nematóides; Doenças; Colheita, classificação e embalagem; Colheita e pós-colheita; Comercialização.
650 $aMorango
650 $aProdução
653 $aBrasil
653 $aCultivo
653 $aEmbrapa Clima Temperado
653 $aPelotas
653 $aRio Grande do Sul
700 1 $aMEDEIROS, A. R. M. de
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