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| 1. |  | ROCHA, A.; ELIAS, A. R.; SOBRAL, L. F.; SOARES, D. F.; SANTOS, A. C.; MARSICO, A.-G.; HACKER, M. A.; CALDAS, P. C.; PARENTE, L. C.; SILVA, M. R.; FONSECA, L.; SUFFYS, P.; BOÉCHAT, N. Genotyping did not evidence any contribution of Mycobacterium bovis to human tuberculosis in Brazil. Tuberculosis, v. 91, n. 1, p. 14-21, 2011.| Biblioteca(s): Embrapa Gado de Leite. |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
01/02/2012 |
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Data da última atualização: |
05/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
B - 1 |
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Autoria: |
ROCHA, A.; ELIAS, A. R.; SOBRAL, L. F.; SOARES, D. F.; SANTOS, A. C.; MARSICO, A.-G.; HACKER, M. A.; CALDAS, P. C.; PARENTE, L. C.; SILVA, M. R.; FONSECA, L.; SUFFYS, P.; BOÉCHAT, N. |
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Afiliação: |
ADALGIZA ROCHA, FIOCRUZ; ATINA R. ELIAS, FIOCRUZ; LUCIANA F. SOBRAL, UFRJ; DIEGO F. SOARES, FIOCRUZ; ALEXANDRE C. SANTOS, FIOCRUZ; ANA-GRAZIA MARSICO, UFRJ; MARIANA A. HACKER, FIOCRUZ; PAULO C. CALDAS, FIOCRUZ; LUIZ C. PARENTE, Tuberculosis Regional Reference Center, Campos RJ; MARCIO ROBERTO SILVA, CNPGL; LEILA FONSECA, UFRJ; PHILIP SUFFYS, FIOCRUZ; NEIO BOÉCHAT, UFRJ. |
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Título: |
Genotyping did not evidence any contribution of Mycobacterium bovis to human tuberculosis in Brazil. |
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Ano de publicação: |
2011 |
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Fonte/Imprenta: |
Tuberculosis, v. 91, n. 1, p. 14-21, 2011. |
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DOI: |
https://doi.org/10.1016/j.tube.2010.10.003 |
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Idioma: |
Inglês |
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Conteúdo: |
The contribution of Mycobacterium bovis to the global burden of tuberculosis (TB) in man is likely to be underestimated due to its dysgonic growth characteristics and because of the absence of pyruvate in most used media is disadvantageous for its primary isolation. In Brazil Mycobacterium culture, identification and susceptibility tests are performed only in TB reference centers, usually for selected cases. Moreover, solid, egg-based, glycerol-containing (without pyruvate supplementation) Löwenstein-Jensen (L-J) or Ogawa media are routinely used, unfavouring M. bovis isolation. To determine the importance of M. bovis as a public health threat in Brazil we investigated 3046 suspected TB patients inoculating their clinical samples onto routine L-J and L-J pyruvate enriched media. A total of 1796 specimens were culture positive for Mycobacterium spp. and 702 TB cases were confirmed. Surprisingly we did not detect one single case of M. bovis in the resulting collection of 1674 isolates recovered from M. bovis favourable medium analyzed by conventional and molecular speciation methods. Also, bacillary DNA present on 454 sputum smears from 223 TB patients were OxyR genotyped and none was recognized as M. bovis. Our data indicate that M. bovis importance on the burden of human TB in Brazil is marginal. |
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Palavras-Chave: |
Spoligotyping. |
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Thesaurus NAL: |
Mycobacterium tuberculosis complex; tuberculosis. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 02231naa a2200313 a 4500
001 1914082
005 2024-02-05
008 2011 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.tube.2010.10.003$2DOI
100 1 $aROCHA, A.
245 $aGenotyping did not evidence any contribution of Mycobacterium bovis to human tuberculosis in Brazil.$h[electronic resource]
260 $c2011
520 $aThe contribution of Mycobacterium bovis to the global burden of tuberculosis (TB) in man is likely to be underestimated due to its dysgonic growth characteristics and because of the absence of pyruvate in most used media is disadvantageous for its primary isolation. In Brazil Mycobacterium culture, identification and susceptibility tests are performed only in TB reference centers, usually for selected cases. Moreover, solid, egg-based, glycerol-containing (without pyruvate supplementation) Löwenstein-Jensen (L-J) or Ogawa media are routinely used, unfavouring M. bovis isolation. To determine the importance of M. bovis as a public health threat in Brazil we investigated 3046 suspected TB patients inoculating their clinical samples onto routine L-J and L-J pyruvate enriched media. A total of 1796 specimens were culture positive for Mycobacterium spp. and 702 TB cases were confirmed. Surprisingly we did not detect one single case of M. bovis in the resulting collection of 1674 isolates recovered from M. bovis favourable medium analyzed by conventional and molecular speciation methods. Also, bacillary DNA present on 454 sputum smears from 223 TB patients were OxyR genotyped and none was recognized as M. bovis. Our data indicate that M. bovis importance on the burden of human TB in Brazil is marginal.
650 $aMycobacterium tuberculosis complex
650 $atuberculosis
653 $aSpoligotyping
700 1 $aELIAS, A. R.
700 1 $aSOBRAL, L. F.
700 1 $aSOARES, D. F.
700 1 $aSANTOS, A. C.
700 1 $aMARSICO, A.-G.
700 1 $aHACKER, M. A.
700 1 $aCALDAS, P. C.
700 1 $aPARENTE, L. C.
700 1 $aSILVA, M. R.
700 1 $aFONSECA, L.
700 1 $aSUFFYS, P.
700 1 $aBOÉCHAT, N.
773 $tTuberculosis$gv. 91, n. 1, p. 14-21, 2011.
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