Data/hora: 23/09/2024 15:56:42

Biblioteca(s): 	Embrapa Semiárido.	
Tipo da produção científica: 	Artigo em Periódico Indexado	
Circulação/Nível: 	B - 2	
Data corrente: 	09/09/2022	
Data da última atualização: 	16/01/2023	
Autoria: 	LOUBET FILHO, P. S.; BASEGGIO, A. M.; VUOLO, M. R.; REGUENGO, L. M.; BIASOTO, A. C. T.; CORREA, L. C.; BOGUSZ JUNIOR, s.; CAGNON, V. H. A.; CAZARIN, C. B. B.; MARÓSTICA JÚNIOR, M. R.	
Afiliação: 	PAULO SÉRGIO LOUBET FILHO, UNICAMP; ANDRESSA MARA BASEGGIO, UNICAMP; MILENA MORANDI VUOLO, UNICAMP; LÍVIA MATEUS REGUENGO, UNICAMP; ALINE TELLES BIASOTO MARQUES, CPATSA; LUIZ CLAUDIO CORREA, CPATSA; STANISLAU BOGUSZ JUNIOR, USP, São Carlos; VALÉRIA HELENA ALVES CAGNON, UNICAMP; CINTHIA BAÚ BETIM CAZARIN, UNICAMP; MÁRIO ROBERTO MARÓSTICA JÚNIOR, UNICAMP.	
Título: 	Gut microbiota modulation by jabuticaba peel and its effect on glucose metabolism via inflammatory signaling.	
Ano de publicação: 	2022	
Fonte/Imprenta: 	Current Research in Food Science, v. 5, p. 382-391, 2022.	
DOI: 	https://doi.org/10.1016/j.crfs.2022.02.001	
Idioma: 	Inglês	
Conteúdo: 	Jabuticaba is a Brazilian berry known for its therapeutic potential against cancer, obesity, insulin resistance (IR), and others. It is a natural source of bioactive compounds, leading to better glucose metabolism, and attenuating obesity and IR through the reduction of pro-inflammatory status. The present study aimed to observe the prebiotic effect of freeze-dried jabuticaba peel (J) consumption on gut bacteria profile and describe its effects on IR derived from the lipopolysaccharides/Toll-like receptor-4 inflammatory pathway. Jabuticaba peel was chemically characterized, and its bioactive compounds were quantified. Twenty-four C57BL/6 mice were feed with a control diet (n = 6), control diet + J (n = 6), high-fat diet (HF) (n = 6), and HF + J (n = 6) for thirteen weeks. Gut bacteriota (16s RNA sequencing), glucose metabolism (fasting glucose and insulin, OGTT, ITT, HOMA-IR, and &#946;, QUICKI), and inflammatory status (serum lipopolysaccharide, and protein expression) were assessed. The main bioactive compounds found in J were dietary fiber, and anthocyanins, and its consumption along with a healthy diet reduced the abundance of Firmicutes and Actinobacteriota phyla (p < 0.01), increased the Muribaculaceae and Lachnospiraceae families, and Faecalicatena genus (p < 0.05). The correlation test indicates a negative correlation between the Muribaculaceae and glucose metabolism. Jabuticaba peel is a nutritive source of bioactive compounds with prebiotic effects.	
Palavras-Chave: 	Bactérias intestinais; Baga; Compostos bioativos; Consumo de casca de jabuticaba; Disbiose; Microbiota intestinal; Prebióticos; Resistência a insulina.	
Thesagro: 	Jabuticaba; Obesidade.	
Thesaurus Nal: 	Bioactive compounds; Insulin resistance; Obesity; Prebiotics.	
Categoria do assunto: 	X Pesquisa, Tecnologia e Engenharia	
Registro original: 	Embrapa Semiárido (CPATSA)	
Exemplares: 	CPATSA - (60017-1) - UPC - AP - DD -  -  -  - DIS