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| Registros recuperados : 14 | |
| 1. |  | MAGNABOSCO, C. de U.; LOS REYES, A. de; SAINZ, R.; FARIA, C. U. de; SAUERESSIG, M.; MADUREIRA, A. P. Melhoramento genetico: um caso de sucesso. Revista Nelore, Sao Paulo, p. 15-26, 2002. Edicao de Anais do Simposio 2002: Nelore Natural, Ribeirao Preto, SP, ago. 2002.| Biblioteca(s): Embrapa Cerrados. |
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| 3. | | MAGNABOSCO, C. de U.; FARIA, C. U. de; MADUREIRA, A. P.; ROSA, G. J.; BEZERRA, L. A. F.; LÔBO, R. B.; SAINZ, R. D. Análise genética de características morfológicas em bovinos da raça nelore utilizando modelos de limiar. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 42., 2005, Goiânia. A produção animal e o foco no agronegócio: anais eletrônico. Goiânia: SBZ, 2005. 1 CD-ROM.| Biblioteca(s): Embrapa Cerrados. |
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| 4. | | BARBOSA, V.; MAGNABOSCO, C. de U.; DIAS, D. S. de O.; FARIA, C. U. de; MADUREIRA, A. P.; LOBO, R. B.; BRITO, R. A. M. Inferencia bayesiana na analise de caracteristicas de crescimento pos desmame em bovinos da raca Nelore. In: REUNIAO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 40., 2003, Santa Maria, RS. Otimizando a producao animal: anais. Santa Maria: SBZ: UFSM, 2003. 1 CD-ROM.| Biblioteca(s): Embrapa Cerrados. |
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| 5. | | SILVEIRA, S. R.; RIBEIRO, R. S.; CARVALHO, D.; SACRAMENTO, J. P.; MADUREIRA, A. P.; PEREIRA, L. G. R.; MOREIRA, E. A.; MAURICIO, R. M. Evaluation of native grass (Echinolaena inflexa) by chemical composition and ruminal fermentation kinetics. In: ANNUAL MEETING BRAZILIAN SOCIETY OF ANIMAL SCIENCE, 50., 2013, Campinas. Proceedings... Campinas: Sociedade Brasileira de Zootecnia, 2013.| Biblioteca(s): Embrapa Gado de Leite. |
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| 6. | | BRITO, R. A. M.; DIAS, D. S. de O.; MAGNABOSCO, C. de U.; FARIA, C. U. de; LOBO, R. B.; BARBOSA, V.; MADUREIRA, A. P. Estimativas de herdabilidade, DEP's e correlacao entre a DEP's para peso e perimetro escrotal aos 365 dias de idade da raca Nelore. In: REUNIAO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 40., 2003, Santa Maria, RS. Otimizando a producao animal: anais. Santa Maria: SBZ: UFSM, 2003. 1 CD-ROM.| Biblioteca(s): Embrapa Cerrados. |
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| 7. | | MENDONÇA, M. C. de; AUAD, A. M.; MADUREIRA, A. P.; MAURÍCIO, R. M.; SILVA, N. B. N.; SILVA, A. C. C. R.; ROSA, L. H.; CAMPOS, W. G. Inoculação endofítica de fungos entomopatogênicos em Brassica oleracea var. acephala L. para o controle biológico de Plutella xylostella (Lepdoptera) e Brevicoryne brassicae (Hemiptera). In: CONGRESSO BRASILEIRO DE MICROBIOLOGIA, 32., 2023, Foz do Iguaçu. Resumos. São Paulo: Sociedade Brasileira de Microbiologia, 2023.| Biblioteca(s): Embrapa Gado de Leite. |
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| 8. | | RIBEIRO, R. S.; SILVEIRA, S. R.; CALSAVARA, L. H. F.; CARVALHO, D.; MADUREIRA, A. P.; PEREIRA, L. G. R.; FILHO, W. D.; MAURICIO, R. M. The use of Tithonia diversifolia (Hems L) gray as forage to contribute to reduction on the enteric methane emission. In: ANNUAL MEETING BRAZILIAN SOCIETY OF ANIMAL SCIENCE, 50., 2013, Campinas. Proceedings... Campinas: Sociedade Brasileira de Zootecnia, 2013. | Biblioteca(s): Embrapa Gado de Leite. |
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| 9. | | CAMPAGNANI, M. O.; MADUREIRA, A. P.; VIANA, J. P. R.; AMORIM, S. S.; ROSA, L. H.; AUAD, A. M.; CANGUSSU, M. A.; MAURICIO, R. M.; CAMPOS, W. G. Virulência em lagartas (lepidoptera) de novos fungos entomopatogênicos isolados de Mahanarva spectabilis (Distant) (Hemiptera: Cercopidae). In: SIMPÓSIO DE MICROBIOLOGIA DA UFMG, 5., 2018, Belo Horizonte. Resumos... Belo Horizonte: Universidade Federal de Minas Gerais, 2018. p. 93.| Biblioteca(s): Embrapa Gado de Leite. |
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| 10. | | SACRAMENTO, J. P.; RIBEIRO, R. S.; SILVEIRA, S. R.; FREITAS, D. S.; SILVA, P. L. P.; PEREIRA, L. G. R.; MADUREIRA, A. P.; MAURICIO, R. M. In vitro fermentation kinetics and potential degradability of Tithonia diversifolia cut in two developmental stages. In: ANNUAL MEETING BRAZILIAN SOCIETY OF ANIMAL SCIENCE, 50., 2013, Campinas. Proceedings... Campinas: Sociedade Brasileira de Zootecnia, 2013. | Biblioteca(s): Embrapa Gado de Leite. |
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| 11. | | CAMPAGNANI, M. O.; MADUREIRA, A. P.; OLIVEIRA, M. M. B.; MAGALHÃES SILVA, N. B.; RIOS SILVA, A. C.; COELHO, L. C.; ROSA, L. H.; AUAD, A. M.; CANGUSSÚ, M. A.; MAURÍCIO, R. M.; CAMPOS, W. G. Eficiência de fungos entomopatogênicos contra Mahanarva spectabilis (distant) (hemiptera: cercopidae) a campo. In: SIMPÓSIO DE MICROBIOLOGIA DA UFMG, 5., 2018, Belo Horizonte. Resumos... Belo Horizonte: Universidade Federal de Minas Gerais, 2018. p. 94.| Biblioteca(s): Embrapa Gado de Leite. |
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| 12. | | MENDONÇA, M. C. de; AUAD, A. M.; MADUREIRA, A. P.; MAURÍCIO, R. M.; CANGUSSU, M.; ROSA, L. H.; PEREIRA, M. F.; MUNIZ, M.; SOUZA, S. R. O.; SILVA, A. C. R.; SILVA, N. B. N.; CAMPOS, W. G. Eficiência de fungos isolados em sistema silvipastoril no controle biológico de Mahanarva spectabilis (hemiptera: cercopidae) em condições de campo. In: CONGRESSO BRASILEIRO DE MICROBIOLOGIA, 32., 2023, Foz do Iguaçu. Resumos. São Paulo: Sociedade Brasileira de Microbiologia, 2023.| Biblioteca(s): Embrapa Gado de Leite. |
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| 13. | | SOUSA, T. N.; TARAZONA-SANTOS, E. M.; WILSON, D. J.; MADUREIRA, A. P.; FALCAO, P. R. K.; FONTES, C. J. F.; GIL, L. H. S.; FERREIRA, M. U.; CARVALHO, L. H.; BRITO, C. F. A. Genetic variability and natural selection at the ligand domain of the Duffy binding protein in Brazilian Plasmodium vivax populations. Malaria Journal, London, v. 9, n. 334, 2010. 12 p.| Biblioteca(s): Embrapa Agricultura Digital. |
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| 14. | | CAMPAGNANI, M. O.; AUAD, A. M.; MAURÍCIO, R. M.; MADUREIRA, A. P.; CANGUSSÚ, M. A.; ROSA, L. H.; PEREIRA, M. F. A.; MUNIZ, M.; SOUZA, S. R. O.; SILVA, N. B. M.; SILVA, A. C. R.; CAMPOS, W. G. Endophytic capacity of entomopathogenic fungi in a pasture grass and their potential to control the Spittlebug Mahanarva spectabilis (Hemiptera: Cercopidae). Agronomy, v. 14, 943, 2024.| Biblioteca(s): Embrapa Gado de Leite. |
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| Registros recuperados : 14 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Agricultura Digital. |
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Data corrente: |
24/11/2010 |
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Data da última atualização: |
04/04/2013 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
SOUSA, T. N.; TARAZONA-SANTOS, E. M.; WILSON, D. J.; MADUREIRA, A. P.; FALCAO, P. R. K.; FONTES, C. J. F.; GIL, L. H. S.; FERREIRA, M. U.; CARVALHO, L. H.; BRITO, C. F. A. |
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Afiliação: |
TAIS N. SOUSA, CPqRR/FIOCRUZ; EDUARDO M. TARAZONA-SANTOS, ICB/UFMG; DANIEL J. WILSON, University of Chicago; ANA P. MADUREIRA, Universidade Federal de São João del Rei; PAULA REGINA KUSER FALCAO, CNPTIA; COR J. F. FONTES, UFMT; LUIZ H. S. GIL, IPEPATRO; MARCELO U. FERREIRA, USP; LUZIA H. CARVALHO, CPqRR/FIOCRUZ; CRISTIANA F. A. BRITO, CPqRR/FIOCRUZ. |
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Título: |
Genetic variability and natural selection at the ligand domain of the Duffy binding protein in Brazilian Plasmodium vivax populations. |
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Ano de publicação: |
2010 |
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Fonte/Imprenta: |
Malaria Journal, London, v. 9, n. 334, 2010. |
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Páginas: |
12 p. |
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DOI: |
doi:10.1186/1475-2875-9-334 |
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Idioma: |
Inglês |
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Conteúdo: |
Background. Plasmodium vivax malaria is a major public health challenge in Latin America, Asia and Oceania, with 130-435 million clinical cases per year worldwide. Invasion of host blood cells by P. vivax mainly depends on a type I membrane protein called Duffy binding protein (PvDBP). The erythrocyte-binding motif of PvDBP is a 170 amino-acid stretch located in its cysteine-rich region II (PvDBPII), which is the most variable segment of the protein. Methods. To test whether diversifying natural selection has shaped the nucleotide diversity of PvDBPII in Brazilian populations, this region was sequenced in 122 isolates from six different geographic areas. A Bayesian method was applied to test for the action of natural selection under a population genetic model that incorporates recombination. The analysis was integrated with a structural model of PvDBPII, and T- and B-cell epitopes were localized on the 3-D structure. Results. The results suggest that: (i) recombination plays an important role in determining the haplotype structure of PvDBPII, and (ii) PvDBPII appears to contain neutrally evolving codons as well as codons evolving under natural selection. Diversifying selection preferentially acts on sites identified as epitopes, particularly on amino acid residues 417, 419, and 424, which show strong linkage disequilibrium. Conclusions. This study shows that some polymorphisms of PvDBPII are present near the erythrocyte-binding domain and might serve to elude antibodies that inhibit cell invasion. Therefore, these polymorphisms should be taken into account when designing vaccines aimed at eliciting antibodies to inhibit erythrocyte invasion. MenosBackground. Plasmodium vivax malaria is a major public health challenge in Latin America, Asia and Oceania, with 130-435 million clinical cases per year worldwide. Invasion of host blood cells by P. vivax mainly depends on a type I membrane protein called Duffy binding protein (PvDBP). The erythrocyte-binding motif of PvDBP is a 170 amino-acid stretch located in its cysteine-rich region II (PvDBPII), which is the most variable segment of the protein. Methods. To test whether diversifying natural selection has shaped the nucleotide diversity of PvDBPII in Brazilian populations, this region was sequenced in 122 isolates from six different geographic areas. A Bayesian method was applied to test for the action of natural selection under a population genetic model that incorporates recombination. The analysis was integrated with a structural model of PvDBPII, and T- and B-cell epitopes were localized on the 3-D structure. Results. The results suggest that: (i) recombination plays an important role in determining the haplotype structure of PvDBPII, and (ii) PvDBPII appears to contain neutrally evolving codons as well as codons evolving under natural selection. Diversifying selection preferentially acts on sites identified as epitopes, particularly on amino acid residues 417, 419, and 424, which show strong linkage disequilibrium. Conclusions. This study shows that some polymorphisms of PvDBPII are present near the erythrocyte-binding domain and might serve to elude antibodies that... Mostrar Tudo |
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Palavras-Chave: |
Genetic variability; Modelagem estrutural; Seleção natural; Structural modelling; Variabilidade genética. |
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Thesagro: |
Polimorfismo. |
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Thesaurus NAL: |
malaria; Natural selection; Plasmodium vivax; Polymorphism. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/80555/1/1475-2875-9-334-4.pdf
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Marc: |
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024 7 $adoi:10.1186/1475-2875-9-334$2DOI
100 1 $aSOUSA, T. N.
245 $aGenetic variability and natural selection at the ligand domain of the Duffy binding protein in Brazilian Plasmodium vivax populations.$h[electronic resource]
260 $c2010
300 $a12 p.
520 $aBackground. Plasmodium vivax malaria is a major public health challenge in Latin America, Asia and Oceania, with 130-435 million clinical cases per year worldwide. Invasion of host blood cells by P. vivax mainly depends on a type I membrane protein called Duffy binding protein (PvDBP). The erythrocyte-binding motif of PvDBP is a 170 amino-acid stretch located in its cysteine-rich region II (PvDBPII), which is the most variable segment of the protein. Methods. To test whether diversifying natural selection has shaped the nucleotide diversity of PvDBPII in Brazilian populations, this region was sequenced in 122 isolates from six different geographic areas. A Bayesian method was applied to test for the action of natural selection under a population genetic model that incorporates recombination. The analysis was integrated with a structural model of PvDBPII, and T- and B-cell epitopes were localized on the 3-D structure. Results. The results suggest that: (i) recombination plays an important role in determining the haplotype structure of PvDBPII, and (ii) PvDBPII appears to contain neutrally evolving codons as well as codons evolving under natural selection. Diversifying selection preferentially acts on sites identified as epitopes, particularly on amino acid residues 417, 419, and 424, which show strong linkage disequilibrium. Conclusions. This study shows that some polymorphisms of PvDBPII are present near the erythrocyte-binding domain and might serve to elude antibodies that inhibit cell invasion. Therefore, these polymorphisms should be taken into account when designing vaccines aimed at eliciting antibodies to inhibit erythrocyte invasion.
650 $amalaria
650 $aNatural selection
650 $aPlasmodium vivax
650 $aPolymorphism
650 $aPolimorfismo
653 $aGenetic variability
653 $aModelagem estrutural
653 $aSeleção natural
653 $aStructural modelling
653 $aVariabilidade genética
700 1 $aTARAZONA-SANTOS, E. M.
700 1 $aWILSON, D. J.
700 1 $aMADUREIRA, A. P.
700 1 $aFALCAO, P. R. K.
700 1 $aFONTES, C. J. F.
700 1 $aGIL, L. H. S.
700 1 $aFERREIRA, M. U.
700 1 $aCARVALHO, L. H.
700 1 $aBRITO, C. F. A.
773 $tMalaria Journal, London$gv. 9, n. 334, 2010.
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