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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
12/11/2018 |
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Data da última atualização: |
24/01/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
GIONBELLI, T. R. S.; VELOSO, C. M.; ROTTA, P. P.; VALADARES FILHO, S. C.; CARVALHO, B. C. de; M. I. MARCONDES; CUNHA, C. S.; NOVAES, M. A. S.; PREZOTTO, L. D.; DUARTE, M. S.; GIONBELLI, M. P. |
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Afiliação: |
T. R. S. Gionbelli, UFLA; C. M. Veloso, UFV; P. P. Rotta, UFV; S. C. Valadares Filho, UFV; BRUNO CAMPOS DE CARVALHO, CNPGL; Marcondes, M. I., UFV; C. S. Cunha, UFV; M. A. S. NOVAES, UFV; L. D. PREZOTTO, Montana State University, Havre, MT, USA; M. S. Duarte, UFV; M. P. GIONBELLI, UFLA. |
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Título: |
Foetal development of skeletal muscle in bovines as a function of maternal nutrition, foetal sex and gestational age. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Journal of Animal Physiology and Animal Nutrition, v. 102, p. 545-556, 2018. |
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DOI: |
10.1111/jpn.12786 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract To determine the effects of maternal nutrition on modifications of foetal development of the skeletal muscle and possible increase in the potential of skeletal muscle growth in cattle, gestating cows were either fed 190% NRC recommendations (overnourished; ON) or 100% NRC recommendation (control; CO). Interaction between maternal nutrition (MN) and the foetal sex (FS) was also investigated. Foetuses were necropsied at four different time points throughout gestation (139, 199, 241 and 268 days of gestation) to assess the mRNA expression of myogenic, adipogenic and fibrogenic markers in skeletal muscle. Phenotypic indicators of the development of skeletal muscle fibres, intramuscular lipogenesis and collagen development were also evaluated. Modifications in mRNA expression of skeletal muscle of foetuses were observed in function of MN and FS despite the lack of effect of MN and FS on foetal weight at necropsy. Maternal ON increased the mRNA expression of the myogenic marker Cadherin-associated protein, beta 1 (CTNNB1) and adipogenic markers Peroxissome proliferator-activated receptor gamma (PPARG) and Zinc finger protein 423 (ZNF423) at midgestation. However, no differences on foetal skeletal muscle development were observed between treatments at late gestation indicating that a compensatory development may have occurred on CO foetuses making the effect of MN on skeletal muscle development not significant at late gestation. Moreover, our data have shown an evidence of sexual dimorphism during foetal stage with a greater skeletal muscle development in male than in female foetuses. In conclusion, providing a higher nutritional level to pregnant cows changes the trajectory of the development of skeletal muscle during midgestation, but apparently does not change the potential of post-natal growth of muscle mass of the offspring, as no differences in skeletal muscle development were observed in late gestation. MenosAbstract To determine the effects of maternal nutrition on modifications of foetal development of the skeletal muscle and possible increase in the potential of skeletal muscle growth in cattle, gestating cows were either fed 190% NRC recommendations (overnourished; ON) or 100% NRC recommendation (control; CO). Interaction between maternal nutrition (MN) and the foetal sex (FS) was also investigated. Foetuses were necropsied at four different time points throughout gestation (139, 199, 241 and 268 days of gestation) to assess the mRNA expression of myogenic, adipogenic and fibrogenic markers in skeletal muscle. Phenotypic indicators of the development of skeletal muscle fibres, intramuscular lipogenesis and collagen development were also evaluated. Modifications in mRNA expression of skeletal muscle of foetuses were observed in function of MN and FS despite the lack of effect of MN and FS on foetal weight at necropsy. Maternal ON increased the mRNA expression of the myogenic marker Cadherin-associated protein, beta 1 (CTNNB1) and adipogenic markers Peroxissome proliferator-activated receptor gamma (PPARG) and Zinc finger protein 423 (ZNF423) at midgestation. However, no differences on foetal skeletal muscle development were observed between treatments at late gestation indicating that a compensatory development may have occurred on CO foetuses making the effect of MN on skeletal muscle development not significant at late gestation. Moreover, our data have shown an evidence of... Mostrar Tudo |
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Palavras-Chave: |
Fibrogenesis; Foetal programming; Myogenesis. |
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Thesaurus NAL: |
Adipogenesis; Sexual dimorphism; Zebu. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02927naa a2200325 a 4500
001 2099172
005 2023-01-24
008 2018 bl uuuu u00u1 u #d
024 7 $a10.1111/jpn.12786$2DOI
100 1 $aGIONBELLI, T. R. S.
245 $aFoetal development of skeletal muscle in bovines as a function of maternal nutrition, foetal sex and gestational age.$h[electronic resource]
260 $c2018
520 $aAbstract To determine the effects of maternal nutrition on modifications of foetal development of the skeletal muscle and possible increase in the potential of skeletal muscle growth in cattle, gestating cows were either fed 190% NRC recommendations (overnourished; ON) or 100% NRC recommendation (control; CO). Interaction between maternal nutrition (MN) and the foetal sex (FS) was also investigated. Foetuses were necropsied at four different time points throughout gestation (139, 199, 241 and 268 days of gestation) to assess the mRNA expression of myogenic, adipogenic and fibrogenic markers in skeletal muscle. Phenotypic indicators of the development of skeletal muscle fibres, intramuscular lipogenesis and collagen development were also evaluated. Modifications in mRNA expression of skeletal muscle of foetuses were observed in function of MN and FS despite the lack of effect of MN and FS on foetal weight at necropsy. Maternal ON increased the mRNA expression of the myogenic marker Cadherin-associated protein, beta 1 (CTNNB1) and adipogenic markers Peroxissome proliferator-activated receptor gamma (PPARG) and Zinc finger protein 423 (ZNF423) at midgestation. However, no differences on foetal skeletal muscle development were observed between treatments at late gestation indicating that a compensatory development may have occurred on CO foetuses making the effect of MN on skeletal muscle development not significant at late gestation. Moreover, our data have shown an evidence of sexual dimorphism during foetal stage with a greater skeletal muscle development in male than in female foetuses. In conclusion, providing a higher nutritional level to pregnant cows changes the trajectory of the development of skeletal muscle during midgestation, but apparently does not change the potential of post-natal growth of muscle mass of the offspring, as no differences in skeletal muscle development were observed in late gestation.
650 $aAdipogenesis
650 $aSexual dimorphism
650 $aZebu
653 $aFibrogenesis
653 $aFoetal programming
653 $aMyogenesis
700 1 $aVELOSO, C. M.
700 1 $aROTTA, P. P.
700 1 $aVALADARES FILHO, S. C.
700 1 $aCARVALHO, B. C. de
700 1 $aM. I. MARCONDES
700 1 $aCUNHA, C. S.
700 1 $aNOVAES, M. A. S.
700 1 $aPREZOTTO, L. D.
700 1 $aDUARTE, M. S.
700 1 $aGIONBELLI, M. P.
773 $tJournal of Animal Physiology and Animal Nutrition$gv. 102, p. 545-556, 2018.
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