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Registro Completo |
Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
Data corrente: |
23/06/2017 |
Data da última atualização: |
23/06/2017 |
Autoria: |
PICTON, H. M.; TSONIS, C. G.; MCNEILLY, A. S. |
Título: |
FSH causes a time-dependent stimulation of preovulatory follicle growth in the absence of pulsatile LH secretion in ewes chronically treated with gonadotrophin-releasing hormone agonist. |
Ano de publicação: |
1990 |
Fonte/Imprenta: |
Journal of Endocrinology, v. 126, n. 2, p. 297-307, Aug. 1990. |
DOI: |
10.1677/joe.0.1260297 |
Idioma: |
Inglês |
Conteúdo: |
Abstract: The study investigated the relationship between the plasma concentration of FSH and the stimulation of preovulatory follicle growth in vivo in ewes chronically treated with the gonadotrophin-releasing hormone (GnRH) agonist buserelin (HOE 766). Welsh Mountain ewes with regular oestrous cycles were treated for 6 weeks with two discs implants placed s.c., each containing 5 mg of the agonist in a matrix of polyhydroxybutyric acid. Treatment with the agonist for 35 days produced a sustained suppression of the plasma concentration of FSH, stopped the pulsatile release of LH and prevented follicular development beyond 2.5 mm diameter. There was no difference between the total number of follicles greater than 1.0 mm diameter present in the ovaries of GnRH agonist-treated ewes and day 8 luteal phase control ewes. During the sixth week of agonist treatment ewes were infused with ovine FSH (6 micrograms NIADDK-oFSH-16/h) in the presence of only basal concentrations of LH. After 24, 48, 72 or 120 h of FSH infusion, the mean number of follicles greater than 1.0 mm diameters per ewe was not significantly different between treated and control animals. Infusion of FSH caused a time-dependent increase in (1) the number of follicles per ovary greater than 2.5 mm, (2) the mean diameter of these follicles and (3) the proportion of the large follicles which could be classified as oestrogenic (greater than 3.7 nmol oestradiol/follicle per h in vitro). Injection of human chorionic gonadotrophin (750 IU i.m.) after 120 h of FSH infusion caused the majority of these large follicles to ovulate and form apparently normal corpora lutea. These results indicate that, in the absence of pulsatile LH, FSH stimulates the growth of normal large oestrogenic follicles which, when stimulated, ovulate to produce viable corpora lutea. MenosAbstract: The study investigated the relationship between the plasma concentration of FSH and the stimulation of preovulatory follicle growth in vivo in ewes chronically treated with the gonadotrophin-releasing hormone (GnRH) agonist buserelin (HOE 766). Welsh Mountain ewes with regular oestrous cycles were treated for 6 weeks with two discs implants placed s.c., each containing 5 mg of the agonist in a matrix of polyhydroxybutyric acid. Treatment with the agonist for 35 days produced a sustained suppression of the plasma concentration of FSH, stopped the pulsatile release of LH and prevented follicular development beyond 2.5 mm diameter. There was no difference between the total number of follicles greater than 1.0 mm diameter present in the ovaries of GnRH agonist-treated ewes and day 8 luteal phase control ewes. During the sixth week of agonist treatment ewes were infused with ovine FSH (6 micrograms NIADDK-oFSH-16/h) in the presence of only basal concentrations of LH. After 24, 48, 72 or 120 h of FSH infusion, the mean number of follicles greater than 1.0 mm diameters per ewe was not significantly different between treated and control animals. Infusion of FSH caused a time-dependent increase in (1) the number of follicles per ovary greater than 2.5 mm, (2) the mean diameter of these follicles and (3) the proportion of the large follicles which could be classified as oestrogenic (greater than 3.7 nmol oestradiol/follicle per h in vitro). Injection of human chorionic gonad... Mostrar Tudo |
Palavras-Chave: |
Buserelin; Drug effects; FSH; LH; Time Factors. |
Thesaurus Nal: |
Ewes; Ovarian follicles; Pharmacology; Physiology; Sheep. |
Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
Marc: |
LEADER 02670naa a2200277 a 4500 001 2071394 005 2017-06-23 008 1990 bl uuuu u00u1 u #d 024 7 $a10.1677/joe.0.1260297$2DOI 100 1 $aPICTON, H. M. 245 $aFSH causes a time-dependent stimulation of preovulatory follicle growth in the absence of pulsatile LH secretion in ewes chronically treated with gonadotrophin-releasing hormone agonist. 260 $c1990 520 $aAbstract: The study investigated the relationship between the plasma concentration of FSH and the stimulation of preovulatory follicle growth in vivo in ewes chronically treated with the gonadotrophin-releasing hormone (GnRH) agonist buserelin (HOE 766). Welsh Mountain ewes with regular oestrous cycles were treated for 6 weeks with two discs implants placed s.c., each containing 5 mg of the agonist in a matrix of polyhydroxybutyric acid. Treatment with the agonist for 35 days produced a sustained suppression of the plasma concentration of FSH, stopped the pulsatile release of LH and prevented follicular development beyond 2.5 mm diameter. There was no difference between the total number of follicles greater than 1.0 mm diameter present in the ovaries of GnRH agonist-treated ewes and day 8 luteal phase control ewes. During the sixth week of agonist treatment ewes were infused with ovine FSH (6 micrograms NIADDK-oFSH-16/h) in the presence of only basal concentrations of LH. After 24, 48, 72 or 120 h of FSH infusion, the mean number of follicles greater than 1.0 mm diameters per ewe was not significantly different between treated and control animals. Infusion of FSH caused a time-dependent increase in (1) the number of follicles per ovary greater than 2.5 mm, (2) the mean diameter of these follicles and (3) the proportion of the large follicles which could be classified as oestrogenic (greater than 3.7 nmol oestradiol/follicle per h in vitro). Injection of human chorionic gonadotrophin (750 IU i.m.) after 120 h of FSH infusion caused the majority of these large follicles to ovulate and form apparently normal corpora lutea. These results indicate that, in the absence of pulsatile LH, FSH stimulates the growth of normal large oestrogenic follicles which, when stimulated, ovulate to produce viable corpora lutea. 650 $aEwes 650 $aOvarian follicles 650 $aPharmacology 650 $aPhysiology 650 $aSheep 653 $aBuserelin 653 $aDrug effects 653 $aFSH 653 $aLH 653 $aTime Factors 700 1 $aTSONIS, C. G. 700 1 $aMCNEILLY, A. S. 773 $tJournal of Endocrinology$gv. 126, n. 2, p. 297-307, Aug. 1990.
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Embrapa Caprinos e Ovinos (CNPC) |
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Registro Completo
Biblioteca(s): |
Embrapa Soja. |
Data corrente: |
03/12/2009 |
Data da última atualização: |
19/04/2010 |
Tipo da produção científica: |
Resumo em Anais de Congresso |
Autoria: |
ABDELNOOR, R. V.; NEPOMUCENO, A. L.; BARROS, E. G. de; SA, M. de F. G. de; BINNECK, E.; MARCELINO, F. C.; BROMMONSCHENKEL, S. H.; ALMEIDA, J.; ISEPPON, A. M. B.; SCHUSTER, I.; KIDO, E. A.; LOUREIRO, M. E.; MARGIS, R.; HUNGRIA, M.; MOREIRA, M. A.; BACARAT-PEREIRA, M. C.; FIETTO, L. G.; BODANESE-ZANETTINI, M. H.; ROMANO, E.; ZERBINI, F. M.; LEMOS, E. G. de M.; PEREIRA, G. A. G. |
Afiliação: |
RICARDO VILELA ABDELNOOR, CNPSo; ALEXANDRE LIMA NEPOMUCENO, CNPSo; E. G. DE BARROS, UFV; MARIA FATIMA GROSSI DE SA, CENARGEN; ELISEU BINNECK, CNPSo; FRANCISMAR CORREA MARCELINO, CNPSo; S. H. BROMMONSCHENKEL, UFV; JULIANA DANTAS DE ALMEIDA, CENARGEN; A. M. B. ISEPPON, Universidade de Pernambuco; I. SHUSTER, COODETEC; E. A. KIDO, Universidade de Pernambuco; M. E. LOUREIRO, UFV; R. MARGIS, UFRGS; MARIANGELA HUNGRIA DA CUNHA, CNPSo; M. A. MOREIRA, UFV; M. C. BACARAT-PEREIRA, UFV; L. G. FIETTO, UFV; M. H. BODANESE-ZANETTINI, UFRGS; EDUARDO ROMANO DE CAMPOS PINTO, CENARGEN; F. M. ZERBINI, UFV; E. G. DE MACEDO LEMOS, UNESP; G. A. G. PEREIRA, UNICAMP. |
Título: |
GENOSOJA - A brazilian soybean genome consortium. |
Ano de publicação: |
2009 |
Fonte/Imprenta: |
In: WORLD SOYBEAN RESEARCH CONFERENCE, 8., 2009, Beijing. Developing a global soy blueprint for a safe secure and sustainable supply: abstracts. Beijing: Chinese Academy of Agricultural Sciences: Institute of Crop Science, 2009. p. 108, ref. O201. WSRC 2009. Editado por Lijuan Qiu, Rongxia Guan, Jian Jin, Qijan Song, Shuntang Guo, Wenbin Li, Yuanchao Wang, Tianfu Han, Xiaobing Liu, Deyue Yu, Lianzhou Jiang, Deliang Peng. |
Idioma: |
Inglês |
Palavras-Chave: |
Consórcio. |
Thesagro: |
Genoma; Soja. |
Thesaurus NAL: |
Genome; Soybeans. |
Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
Marc: |
LEADER 01479naa a2200421 a 4500 001 1577260 005 2010-04-19 008 2009 bl uuuu u00u1 u #d 100 1 $aABDELNOOR, R. V. 245 $aGENOSOJA - A brazilian soybean genome consortium. 260 $c2009 650 $aGenome 650 $aSoybeans 650 $aGenoma 650 $aSoja 653 $aConsórcio 700 1 $aNEPOMUCENO, A. L. 700 1 $aBARROS, E. G. de 700 1 $aSA, M. de F. G. de 700 1 $aBINNECK, E. 700 1 $aMARCELINO, F. C. 700 1 $aBROMMONSCHENKEL, S. H. 700 1 $aALMEIDA, J. 700 1 $aISEPPON, A. M. B. 700 1 $aSCHUSTER, I. 700 1 $aKIDO, E. A. 700 1 $aLOUREIRO, M. E. 700 1 $aMARGIS, R. 700 1 $aHUNGRIA, M. 700 1 $aMOREIRA, M. A. 700 1 $aBACARAT-PEREIRA, M. C. 700 1 $aFIETTO, L. G. 700 1 $aBODANESE-ZANETTINI, M. H. 700 1 $aROMANO, E. 700 1 $aZERBINI, F. M. 700 1 $aLEMOS, E. G. de M. 700 1 $aPEREIRA, G. A. G. 773 $tIn: WORLD SOYBEAN RESEARCH CONFERENCE, 8., 2009, Beijing. Developing a global soy blueprint for a safe secure and sustainable supply: abstracts. Beijing: Chinese Academy of Agricultural Sciences: Institute of Crop Science, 2009. p. 108, ref. O201. WSRC 2009. Editado por Lijuan Qiu, Rongxia Guan, Jian Jin, Qijan Song, Shuntang Guo, Wenbin Li, Yuanchao Wang, Tianfu Han, Xiaobing Liu, Deyue Yu, Lianzhou Jiang, Deliang Peng.
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