Data/hora: 16/06/2024 08:02:41

Biblioteca(s): | Embrapa Instrumentação.
Data corrente: | 25/09/2023
Data da última atualização: | 25/09/2023
Autoria: | GRIZZO, A.; SANTOS, D. M. dos; COSTA, V. P. V. da; LOPES, R. G.; INADA, N. M.; CORREA, D. S.; CAMPANA-FILHO, S. P.
Afiliação: | Sao Carlos Institute of Chemistry/University of Sao Paulo; Nanotechnology National Laboratory for Agriculture (LNNA); Center for Exact Sciences and Technology, Federal University of Sao Carlos (UFSCar); Sao Carlos Institute of Physics/University of Sao Paulo; Sao Carlos Institute of Physics/University of Sao Paulo; DANIEL SOUZA CORREA, CNPDIA; CAMPANA-FILHO, S. P., Sao Carlos Institute of Chemistry/University of Sao Paulo.
Título: | Multifunctional bilayer membranes composed of poly(lactic acid), beta-chitin whiskers and silver nanoparticles for wound dressing applications
Ano de publicação: | 2023
Fonte/Imprenta: | International Journal of Biological Macromolecules, v. 251, 126314, 2023.
ISSN: | 0141-8130
DOI: | https://doi.org/10.1016/j.ijbiomac.2023.126314
Idioma: | Inglês
Conteúdo: | Nanomaterial-based wound dressings have been extensively studied for the treatment of both minor and lifethreatening tissue injuries. These wound dressings must possess several crucial characteristics, such as tissue compatibility, non-toxicity, appropriate biodegradability to facilitate wound healing, effective antibacterial activity to prevent infection, and adequate physical and mechanical strength to withstand repetitive dynamic forces that could potentially disrupt the healing process. Nevertheless, the development of nanostructured wound dressings that incorporate various functional micro- and nanomaterials in distinct architectures, each serving specific purposes, presents significant challenges. In this study, we successfully developed a novel multifunctional wound dressing based on poly(lactic acid) (PLA) fibrous membranes produced by solution-blow spinning (SBS) and electrospinning. The PLA-based membranes underwent surface modifications aimed at tailoring their properties for utilization as effective wound dressing platforms. Initially, beta-chitin whiskers were deposited onto the membrane surface through filtration, imparting hydrophilic character. Afterward, silver nanoparticles (AgNPs) were incorporated onto the beta-chitin layer using a spray deposition method, resulting in platforms with antimicrobial properties against both Staphylococcus aureus and Escherichia coli. Cytotoxicity studies demonstrated the biocompatibility of the membranes with the neonatal human dermal fibroblast (HDFn) cell line. Moreover, bilayer membranes exhibited a high surface area and porosity (> 80%), remarkable stability in aqueous media, and favorable mechanical properties, making them promising candidates for application as multifunctional wound dressings.
Palavras-Chave: | Beta-chitin whiskers; Biocompatible material; Electrospun nanofibers; Natural polymer; Solution blow spinning; Wound dressing.
Categoria do assunto: | --
Registro original: | Embrapa Instrumentação (CNPDIA)
Exemplares: | CNPDIA - (18277-1) - UPC - AP - DD - PROCI.23/87 -  - 2023/92 - DIS