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Registros recuperados : 267 | |
161. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | YOKOO, M. J. I.; ALBUQUERQUE, L. G.; LOBO, R. B.; MAGNABOSCO, C. de U.; SAINZ, R. D.; ARAUJO, F. R. da C. Estimativas de efeitos genéticos e ambientais que afetam as características de carcaça medidas pela ultra-sonografia aos 13 meses de idade, em rebanhos Nelore. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 44., 2007, Jaboticabal. Anais... Jaboticabal: Unesp: SBZ, 2007. 1 CD-ROM Biblioteca(s): Embrapa Cerrados. |
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162. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | MARCONDES, C. R.; ARAÚJO, R. O.; VOZZI, P. A.; GUNSKI, R. J.; GARNERO, A. del V.; BEZERRA, L. A. F.; LÔBO, R. B. Estudo do período de aquecimento e tomada de amostra para característica que associa peso e perímetro escrotal na raça Nelore. In: SIMPÓSIO BRASILEIRO DE MELHORAMENTO ANIMAL, 7., 2008, São Carlos, SP. Anais... São Carlos, SP: SBMA: Embrapa Pecuária Sudeste, 2008. Disponível também on-line. Biblioteca(s): Embrapa Amazônia Oriental. |
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163. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | MAGNABOSCO, C. de U.; BARBOSA, V.; FARIA, C. de U.; LOPES, D. T.; VIU, M. A. de O.; MAMEDE, M. M. S.; LÔBO, R. B. Estudo genético quantitativo de características de carcaça medidas por ultrassom e perímetro escrotal utilizando inferência bayesiana em novilhos nelore. Planaltina, DF: Embrapa Cerrados, 2009. (Embrapa Cerrados. Boletim de Pesquisa e Desenvolvimento, 247) Biblioteca(s): Embrapa Arroz e Feijão; Embrapa Cerrados; Embrapa Unidades Centrais. |
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164. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | FARIA, L. C. DE; VOZZI, P. A.; LÔBO, R. B.; TROVO, J. B. DE F.; MAGNABOSCO, C. de U.; OLIVEIRA, J. A. DE. Estudo genético quantitativo de características de crescimento de bovinos da raça Brahman no Brasil. In: CONGRESSO BRASILEIRO E LATINO-AMERICANO DA RAÇA BRAHMAN, 1.; BRAHMAN SHOW 2009; MOSTRA TÉCNICO-CIENTÍFICA DA RAÇA BRAHMAN, 1., 2009, Rio de Janeiro. Anais... Rio de Janeiro: ACBB, 2009. 1 CD-ROM. Biblioteca(s): Embrapa Cerrados. |
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165. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | FARIA, L. C. DE.; VOZZI, P. A.; LÔBO, R. B.; TROVO, J. B. DE F.; MAGNABOSCO, C. de U.; OLIVEIRA, J. A. DE. Estudo genético quantitativo das características reprodutivas na raça Brahman In: CONGRESSO BRASILEIRO E LATINO-AMERICANO DA RAÇA BRAHMAN, 1.; BRAHMAN SHOW 2009; MOSTRA TÉCNICO-CIENTÍFICA DA RAÇA BRAHMAN, 1., 2009, Rio de Janeiro. Anais... Rio de Janeiro: ACBB, 2009. 1 CD-ROM. Biblioteca(s): Embrapa Cerrados. |
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166. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | MAGNABOSCO, C. de U.; DIAS, D. S. de O.; FARIA, C. U. de; TONHATI, H.; LOBO, R. B.; LOS REYES, A. de. Estudo genetico quantitativo do perimetro em analise multicarater utilizando dados de campo de bovinos da raca Nelore. In: REUNIAO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 40., 2003, Santa Maria, RS. Otimizando a producao animal: anais. Santa Maria: SBZ: UFSM, 2003. 1 CD-ROM. Biblioteca(s): Embrapa Cerrados. |
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170. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | BALDI, F.; FIGUEIREDO, L. G.; OLIVEIRA, H. N. de; MAGNABOSCO, C. de U.; BEZERRA, L. A. F.; FARIA, C. U.; LOBO, R. B. Bioeconomic selection index (EMGTe) for Nellore Brazil breeding program. In: International Conference on Quantitative Genetics, 5., 2016, Madison. Proceedings... Madison , 2016. (ICQG5) Biblioteca(s): Embrapa Cerrados. |
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171. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | MAGNABOSCO, C. de U.; MIGUEL JUNIOR, J. C.; LOBO, R. B.; BRUNES, L. C.; QUEIROZ, L. C. R.; LOPES, F. B. AVALIAÇÃO DA TAXA DE PRENHEZ EM PROGRAMA DE IATF USANDO SÊMENS DE DIFERENTES TOUROS DA RAÇA NELORE. In: CONGRESSO BRASILEIRO DE ZOOTECNIA, 29., 2019, Uberaba. Tecnologias que alimentam o mundo: anais... Uberaba: ABZ: Fazu: ABCZ, 2019. Zootec. 5 p. Biblioteca(s): Embrapa Cerrados. |
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172. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | FARIA, C. U. de; MAGNABOSCO, C. de U.; LOS REYES, A. de; LÔBO, R. B.; BEZERRA, L. A. F.; SAINZ, R. D. Bayesian inference on field data for genetic parameters for some reproctive and related traits of Nellore cattle (Bos indicus). Genetics and Molecular Biology, Ribeirão Preto, v. 30, n. 2 p. 343-348, 2007. Biblioteca(s): Embrapa Cerrados. |
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173. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | FARIA, C. U. de; MAGNABOSCO, C. de U.; LOS REYES, A. de; LÔBO, R. B.; BEZERRA, L. A. F.; SAINZ, R. D. Bayesian inference on field data for genetic parameters for some reproductive and related traits of Nellore cattle ( Bos indicus). Genetics and Molecular Biology, Ribeirão Preto, v. 30, n. 2, p. 343-348, 2007. Biblioteca(s): Embrapa Arroz e Feijão. |
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174. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | FARIA, C. U. de; KOURY FILHO, W.; MAGNABOSCO, C. de U.; ALBUQUERQUE, L. G. de; BEZERRA, L. A. F.; LÔBO, R. B. Bayesian inference in genetic parameter estimation of visual scores in Nellore beef-cattle Genetics and Molecular Biology, v. 32, n. 4, p. 753-760, 2009. Biblioteca(s): Embrapa Cerrados. |
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175. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | FARIA, C. U. de; MAGNABOSCO, C. de U.; REYES, A. de los; LÔBO, R. B.; BEZERRA, L. A. F.; SAINZ, R. D. Bayesian inference in a quantitative genetic study of growth traits in Nelore cattle (Bos indicus). Genetics and Molecular Biology, v. 30, n. 3, p. 545-551, 2007. Biblioteca(s): Embrapa Cerrados. |
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177. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | LÔBO, R. B.; BEZERRA, L. A. F.; OLIVEIRA, H. N.; MAGNABOSCO, C. de U.; ZAMBIANCHI, A. R.; ALBUQUERQUE, L. G.; BERGMANN, J. A. G.; SAINZ, R. D. Avaliação genética de animais jovens, touros e matrizes. Ribeirão Preto: USP-FMRP. Departamento de Genética. GEMAC, 2003. 86 p. il. Biblioteca(s): Embrapa Pantanal. |
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180. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | ARAÚJO, F. M.; SOARES, M. R.; DUARTE, G.; MARCONDES, C. R.; LÔBO, R. B.; GALERANI, M. A. V.; RAMOS, E. S. Associação dos polimorfismos dos genes H19/Rsal e IGF2/Apal com as síndromes hipertensivas gestacionais. In: CONGRESSO BRASILEIRO DE GENÉTICA, 54., 2008, Salvador. Resumos... Salvador: SBG, 2008. Biblioteca(s): Embrapa Amazônia Oriental. |
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Registros recuperados : 267 | |
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Registro Completo
Biblioteca(s): |
Embrapa Cerrados. |
Data corrente: |
12/12/2018 |
Data da última atualização: |
12/12/2018 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
STAFUZZA, N. B.; SILVA, R. M. de O.; PERIPOLLI, E.; BEZERRA, L. A. F.; LOBO, R. B.; MAGNABOSCO, C. de U.; DI CROCE, F.; OSTERSTOCK, J.; MUNARI, D. P.; LOURENCO, D. A. L.; BALDI, F. |
Afiliação: |
Nedenia Bonvino Stafuzza, UNESP; Rafael Medeiros de Oliveira Silva, University of Georgia; ELISA PERIPOLLI, UNESP; Luiz Antônio Framartino Bezerra, USP; Raysildo Barbosa Lôbo, Associaçao Nacional dos Criadores e Pesquisadores; CLAUDIO DE ULHOA MAGNABOSCO, CPAC; Fernando Di Croce, Zoetis; Jason Osterstock, Zoetis; Danísio Prado Munari, UNESP; Daniela A. Lino Lourenco, University of Georgia; Fernando Baldi, UNESP. |
Título: |
Genome-wide association study provides insights into genes related with horn development in Nelore beef cattle. |
Ano de publicação: |
2018 |
Fonte/Imprenta: |
PLoS ONE, v. 13, n. 8, e0202978, August 30, 2018. |
DOI: |
https://doi.org/10.1371/journal.pone.0202978 |
Idioma: |
Inglês |
Conteúdo: |
Abstract The causal mutation for polledness in Nelore (Bos taurus indicus) breed seems to have appeared first in Brazil in 1957. The expression of the polled trait is known to be ruled by a few groups of alleles in taurine breeds; however, the genetic basis of this trait in indicine cattle is still unclear. The aim of this study was to identify genomic regions associated with the hornless trait in a commercial Nelore population. A total of 107,294 animals had phenotypes recorded and 2,238 were genotyped/imputed for 777k SNP. The weighted single-step approach for genome-wide association study (WssGWAS) was used to estimate the SNP effects and variances accounted for by 1 Mb sliding SNP windows. A centromeric region of chromosome 1 with 3.11 Mb size (BTA1: 878,631?3,987,104 bp) was found to be associated with hornless in the studied population. A total of 28 protein-coding genes are mapped in this region, including the taurine Polled locus and the IFNAR1, IFNAR2, IFNGR2, KRTAP11-1, MIS18A, OLIG1, OLIG2, and SOD1 genes, which expression can be related to the horn formation as described in literature. The functional enrichment analysis by DAVID tool revealed cytokine-cytokine receptor interaction, JAK-STAT signaling, natural killer cell mediated cytotoxicity, and osteoclast differentiation pathways as significant (P < 0.05). In addition, a runs of homozygosity (ROH) analysis identified a ROH island in polled animals with 2.47 Mb inside the region identified by WssGWAS. Polledness in Nelore cattle is associated with one region in the genome with 3.1 Mb size in chromosome 1. Several genes are harbored in this region, and they may act together in the determination of the polled/horned phenotype. Fine mapping the locus responsible for polled trait in Nelore breed and the identification of the molecular mechanisms regulating the horn growth deserve further investigation. MenosAbstract The causal mutation for polledness in Nelore (Bos taurus indicus) breed seems to have appeared first in Brazil in 1957. The expression of the polled trait is known to be ruled by a few groups of alleles in taurine breeds; however, the genetic basis of this trait in indicine cattle is still unclear. The aim of this study was to identify genomic regions associated with the hornless trait in a commercial Nelore population. A total of 107,294 animals had phenotypes recorded and 2,238 were genotyped/imputed for 777k SNP. The weighted single-step approach for genome-wide association study (WssGWAS) was used to estimate the SNP effects and variances accounted for by 1 Mb sliding SNP windows. A centromeric region of chromosome 1 with 3.11 Mb size (BTA1: 878,631?3,987,104 bp) was found to be associated with hornless in the studied population. A total of 28 protein-coding genes are mapped in this region, including the taurine Polled locus and the IFNAR1, IFNAR2, IFNGR2, KRTAP11-1, MIS18A, OLIG1, OLIG2, and SOD1 genes, which expression can be related to the horn formation as described in literature. The functional enrichment analysis by DAVID tool revealed cytokine-cytokine receptor interaction, JAK-STAT signaling, natural killer cell mediated cytotoxicity, and osteoclast differentiation pathways as significant (P < 0.05). In addition, a runs of homozygosity (ROH) analysis identified a ROH island in polled animals with 2.47 Mb inside the region identified by WssGWAS. Pollednes... Mostrar Tudo |
Thesagro: |
Bos Indicus; Gado Nelore; Mutação. |
Categoria do assunto: |
G Melhoramento Genético |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/188280/1/Genome-wide-association-study-provides-apagar.pdf
|
Marc: |
LEADER 02768naa a2200289 a 4500 001 2101347 005 2018-12-12 008 2018 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1371/journal.pone.0202978$2DOI 100 1 $aSTAFUZZA, N. B. 245 $aGenome-wide association study provides insights into genes related with horn development in Nelore beef cattle.$h[electronic resource] 260 $c2018 520 $aAbstract The causal mutation for polledness in Nelore (Bos taurus indicus) breed seems to have appeared first in Brazil in 1957. The expression of the polled trait is known to be ruled by a few groups of alleles in taurine breeds; however, the genetic basis of this trait in indicine cattle is still unclear. The aim of this study was to identify genomic regions associated with the hornless trait in a commercial Nelore population. A total of 107,294 animals had phenotypes recorded and 2,238 were genotyped/imputed for 777k SNP. The weighted single-step approach for genome-wide association study (WssGWAS) was used to estimate the SNP effects and variances accounted for by 1 Mb sliding SNP windows. A centromeric region of chromosome 1 with 3.11 Mb size (BTA1: 878,631?3,987,104 bp) was found to be associated with hornless in the studied population. A total of 28 protein-coding genes are mapped in this region, including the taurine Polled locus and the IFNAR1, IFNAR2, IFNGR2, KRTAP11-1, MIS18A, OLIG1, OLIG2, and SOD1 genes, which expression can be related to the horn formation as described in literature. The functional enrichment analysis by DAVID tool revealed cytokine-cytokine receptor interaction, JAK-STAT signaling, natural killer cell mediated cytotoxicity, and osteoclast differentiation pathways as significant (P < 0.05). In addition, a runs of homozygosity (ROH) analysis identified a ROH island in polled animals with 2.47 Mb inside the region identified by WssGWAS. Polledness in Nelore cattle is associated with one region in the genome with 3.1 Mb size in chromosome 1. Several genes are harbored in this region, and they may act together in the determination of the polled/horned phenotype. Fine mapping the locus responsible for polled trait in Nelore breed and the identification of the molecular mechanisms regulating the horn growth deserve further investigation. 650 $aBos Indicus 650 $aGado Nelore 650 $aMutação 700 1 $aSILVA, R. M. de O. 700 1 $aPERIPOLLI, E. 700 1 $aBEZERRA, L. A. F. 700 1 $aLOBO, R. B. 700 1 $aMAGNABOSCO, C. de U. 700 1 $aDI CROCE, F. 700 1 $aOSTERSTOCK, J. 700 1 $aMUNARI, D. P. 700 1 $aLOURENCO, D. A. L. 700 1 $aBALDI, F. 773 $tPLoS ONE$gv. 13, n. 8, e0202978, August 30, 2018.
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