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Registro Completo |
Biblioteca(s): |
Embrapa Recursos Genéticos e Biotecnologia. |
Data corrente: |
25/06/2019 |
Data da última atualização: |
30/09/2019 |
Tipo da produção científica: |
Capítulo em Livro Técnico-Científico |
Autoria: |
FIDELIS, E. G.; BARBOSA, F. F. L.; SILVA, M. L. da; PESSOA, M. C. P. Y.; RASKI, K. R.; MICHEREFF FILHO, M.; HIROSE, E.; SANCHES, M. M.; MELLO, A. F. S.; XAUD, M. R.; SA, L. A. N. de. |
Afiliação: |
ELISANGELA GOMES FIDELIS, CPAF-RR; FRANCISCO FERRAZ LARANJEIRA BARBOSA, CNPMF; MARCELO LOPES DA SILVA, Cenargen; MARIA CONCEICAO PERES YOUNG PESSOA, CNPMA; MIGUEL MICHEREFF FILHO, CNPH; EDSON HIROSE, CNPSO; MARCIO MARTINELLO SANCHES, Cenargen; ALEXANDRE FURTADO SILVEIRA MELLO, CNPH; MARISTELA RAMALHO XAUD, CPAF-RR; LUIZ ALEXANDRE NOGUEIRA DE SA, CNPMA. |
Título: |
Análise de resultado para Estabelecimento e Dispersão. |
Ano de publicação: |
2018 |
Fonte/Imprenta: |
In: FIDELIS, E. G.; LOHMANN, T. R.; SILVA, M. L. da; PARIZZI, P.; BARBOSA, F. F. L. (Ed.). Priorização de pragas quarentenárias ausentes no Brasil. Brasília, DF: Embrapa, 2018 510 p. il. |
Páginas: |
p. 73-94 |
Idioma: |
Português |
Palavras-Chave: |
Pragas quarentenárias. |
Thesagro: |
Dispersão; Praga Quarentenária. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/198050/1/Cap.Livro-PragasPriorizadas-1ed-2018-Ainfo.pdf
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Marc: |
LEADER 00922naa a2200277 a 4500 001 2110052 005 2019-09-30 008 2018 bl uuuu u00u1 u #d 100 1 $aFIDELIS, E. G. 245 $aAnálise de resultado para Estabelecimento e Dispersão.$h[electronic resource] 260 $c2018 300 $ap. 73-94 650 $aDispersão 650 $aPraga Quarentenária 653 $aPragas quarentenárias 700 1 $aBARBOSA, F. F. L. 700 1 $aSILVA, M. L. da 700 1 $aPESSOA, M. C. P. Y. 700 1 $aRASKI, K. R. 700 1 $aMICHEREFF FILHO, M. 700 1 $aHIROSE, E. 700 1 $aSANCHES, M. M. 700 1 $aMELLO, A. F. S. 700 1 $aXAUD, M. R. 700 1 $aSA, L. A. N. de 773 $tIn: FIDELIS, E. G.; LOHMANN, T. R.; SILVA, M. L. da; PARIZZI, P.; BARBOSA, F. F. L. (Ed.). Priorização de pragas quarentenárias ausentes no Brasil. Brasília, DF: Embrapa, 2018 510 p. il.
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Registro original: |
Embrapa Recursos Genéticos e Biotecnologia (CENARGEN) |
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Registro Completo
Biblioteca(s): |
Embrapa Gado de Corte. |
Data corrente: |
29/03/2016 |
Data da última atualização: |
28/03/2017 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
AGUIRRE, A. de A. R.; LOBO, F. P.; ANDREOTTI, R. |
Afiliação: |
ANDRÉ DE ABREU RANGEL AGUIRRE, FAMEZ/UFMS; FRANCISCO PEREIRA LOBO, CNPTIA; RENATO ANDREOTTI E SILVA, CNPGC. |
Título: |
Design of the ATAQ peptide and its evaluation as an immunogen to develop a Rhipicephalus vaccine. |
Ano de publicação: |
2016 |
Fonte/Imprenta: |
Veterinary Parasitology, v. 221, p. 30-38, 2016 |
Idioma: |
Inglês |
Conteúdo: |
Tick infestation may cause several problems including affecting domestic animal health and reducing the production of meat and milk, among others. Resistance to several classes of acaricides have been reported, forcing researchers to search for alternative measures, such as vaccines against ticks, to ensure tick control while having no or at least low negative impacts on the environment and public health. However, the current commercially available vaccines in different strains of Rhipicephalus microplus are reported to be of low efficacy. Fortunately, reverse vaccinology approaches have shown positive results in the new generation of vaccines. On this basis, a synthetic peptide from the ATAQ protein, which is present in the gut and Malpighi tubes of R. microplus, was synthesized. The ATAQ proteins were isolated, characterized and sequenced from several species of the genus Rhipicephalus. The alignment showed 93.3% identity among DNA sequences of ATAQs from these species. Because of this, immunization trials with this peptide were conducted on mice, rabbits and cattle to evaluate the humoral immune response and the efficacy against Rhipicephalus sanguineus in addition to R. microplus. Based on recent results, we conclude that reverse vaccinology is a promising approach because it is more accurate and faster than conventional methods in the detection of potential antigens to use in anti-tick vaccines. It is not only applicable against R. microplus but also against tick species that play important roles in spreading other diseases. ATAQ proteins should be considered as the antigen in new trials to develop a multi-antigenic vaccine. Although these peptides behave as hapten and are not able to be recognized by the immune system on its own, using carriers and adjuvants helps its presentation and induces strong immune responses. Furthermore, an efficiency of 35% reduction in overall life cycle parameters was reported for R. microplus (98% for ELISA responder animals) and 47% for R. sanguineus. Although not yet enough to prevent the environment to infestation of ticks, this still constitutes a promising strategy that could be applied to integrated measures on tick control and in new research that develops anti-tick vaccines. MenosTick infestation may cause several problems including affecting domestic animal health and reducing the production of meat and milk, among others. Resistance to several classes of acaricides have been reported, forcing researchers to search for alternative measures, such as vaccines against ticks, to ensure tick control while having no or at least low negative impacts on the environment and public health. However, the current commercially available vaccines in different strains of Rhipicephalus microplus are reported to be of low efficacy. Fortunately, reverse vaccinology approaches have shown positive results in the new generation of vaccines. On this basis, a synthetic peptide from the ATAQ protein, which is present in the gut and Malpighi tubes of R. microplus, was synthesized. The ATAQ proteins were isolated, characterized and sequenced from several species of the genus Rhipicephalus. The alignment showed 93.3% identity among DNA sequences of ATAQs from these species. Because of this, immunization trials with this peptide were conducted on mice, rabbits and cattle to evaluate the humoral immune response and the efficacy against Rhipicephalus sanguineus in addition to R. microplus. Based on recent results, we conclude that reverse vaccinology is a promising approach because it is more accurate and faster than conventional methods in the detection of potential antigens to use in anti-tick vaccines. It is not only applicable against R. microplus but also against tick specie... Mostrar Tudo |
Palavras-Chave: |
ATAQ; Reverse vaccinology; Synthetic peptide. |
Thesaurus NAL: |
Immunization; Rhipicephalus microplus; Rhipicephalus sanguineus. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/158239/1/Design-of-the-ATAQ-peptide-and-its-evaluation.pdf
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Marc: |
LEADER 02914naa a2200217 a 4500 001 2041997 005 2017-03-28 008 2016 bl uuuu u00u1 u #d 100 1 $aAGUIRRE, A. de A. R. 245 $aDesign of the ATAQ peptide and its evaluation as an immunogen to develop a Rhipicephalus vaccine.$h[electronic resource] 260 $c2016 520 $aTick infestation may cause several problems including affecting domestic animal health and reducing the production of meat and milk, among others. Resistance to several classes of acaricides have been reported, forcing researchers to search for alternative measures, such as vaccines against ticks, to ensure tick control while having no or at least low negative impacts on the environment and public health. However, the current commercially available vaccines in different strains of Rhipicephalus microplus are reported to be of low efficacy. Fortunately, reverse vaccinology approaches have shown positive results in the new generation of vaccines. On this basis, a synthetic peptide from the ATAQ protein, which is present in the gut and Malpighi tubes of R. microplus, was synthesized. The ATAQ proteins were isolated, characterized and sequenced from several species of the genus Rhipicephalus. The alignment showed 93.3% identity among DNA sequences of ATAQs from these species. Because of this, immunization trials with this peptide were conducted on mice, rabbits and cattle to evaluate the humoral immune response and the efficacy against Rhipicephalus sanguineus in addition to R. microplus. Based on recent results, we conclude that reverse vaccinology is a promising approach because it is more accurate and faster than conventional methods in the detection of potential antigens to use in anti-tick vaccines. It is not only applicable against R. microplus but also against tick species that play important roles in spreading other diseases. ATAQ proteins should be considered as the antigen in new trials to develop a multi-antigenic vaccine. Although these peptides behave as hapten and are not able to be recognized by the immune system on its own, using carriers and adjuvants helps its presentation and induces strong immune responses. Furthermore, an efficiency of 35% reduction in overall life cycle parameters was reported for R. microplus (98% for ELISA responder animals) and 47% for R. sanguineus. Although not yet enough to prevent the environment to infestation of ticks, this still constitutes a promising strategy that could be applied to integrated measures on tick control and in new research that develops anti-tick vaccines. 650 $aImmunization 650 $aRhipicephalus microplus 650 $aRhipicephalus sanguineus 653 $aATAQ 653 $aReverse vaccinology 653 $aSynthetic peptide 700 1 $aLOBO, F. P. 700 1 $aANDREOTTI, R. 773 $tVeterinary Parasitology$gv. 221, p. 30-38, 2016
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