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| Registros recuperados : 91 | |
| 61. |  | GERHARDT, I. R.; ZERLOTINI, A.; GIACHETTO, P. F.; SILVA, F. R. da; LOBO, F.; PENCHEL, R. M.; MISSIAGGIA, A. A.; ARICETTI, J. A.; GIANOTTO, A. C.; CALDANA, C. Understanding molecular mechanisms of carbon allocation in Eucalyptus. In: INTERNATIONAL CONGRESS OF PLANT MOLECULAR BIOLOGY, 11., 2015, Iguassu Falls. Papers... [S.l.: s.n.], 2015. p. 514. p. 0551. IPMB 2015.| Biblioteca(s): Embrapa Agricultura Digital. |
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| 62. | | BARROS, M. P. de; ZANETTI, V. B.; FRAGA, C. I. de M.; NINCE, P. C. do C.; CAMPELO JÚNIOR, J. H.; LOBO, F. de A. Unidades fototérmicas e temperatura-base inferior de frutos de mangueira alfa, na baixada cuiabana. Revista Brasileira de Fruticultura, Jaboticabal, v. 32, n. 2, p. 479-485, jun. 2010. Também disponívem em: .| Biblioteca(s): Embrapa Mandioca e Fruticultura. |
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| 63. | | MOURÃO, M. de M.; BITAR, M.; LOBO, F. P.; PECONICK, A. P.; GRYNBERG, P.; PROSDOCIMI, F.; WAISBERG, M.; CERQUEIRA, G. C.; MACEDO, A. M.; MACHADO, C. R.; YOSHINO, T.; FRANCO, G. R. A directed approach for the identification of transcripts harbouring the spliced leader sequence and the effect of trans-splicing knockdown in Schistosoma mansoni. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 108, n. 6, p. 707-717, Sept. 2013.| Biblioteca(s): Embrapa Agricultura Digital. |
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| 64. | | LOBO, F. P.; GONÇALVES, D. L.; ALVES JÚNIOR, S. L.; GERBER, A. L.; VASCONCELOS, A. T. R. de; BASSO, L. C.; FRANCO, G. R.; SOARES, M. A.; CADETE, R. M.; ROSA, C. A.; STAMBUK, B. U. Draft genome sequence of the D-xylose-fermenting yeast Spathaspora arborariae UFMG-HM19.1AT. Genome Announcements, Washington DC, v. 2, n. 1, p. 1-2, Jan./Feb. 2014.| Biblioteca(s): Embrapa Agricultura Digital. |
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| 65. | | CAETANO, A. R.; ALVES, A. L.; VARELA, E. S.; VILLELA, L. C. V.; SILVA, N. M. A. da; LOBO, F. P.; YAMAGISHI, M. E. B.; GIACHETTO, P. F.; HIGA, R. H.; PAIVA, S. R. Desenvolvimento de ferramentas genômicas para manejo e melhoramento genético de peixes nativos do Brasil. In: CONGRESSO BRASILEIRO DE RECURSOS GENÉTICOS, 3., 2014, Santos. Anais... Brasília, DF: Sociedade Brasileira de Recursos Genéticos, 2014.| Biblioteca(s): Embrapa Pesca e Aquicultura. |
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| 66. | | CAETANO, A. R.; ALVES, A. L.; VARELA, E. S.; VILLELA, L. C. V.; SILVA, N. M. A. da; LOBO, F. P.; YAMAGISHI, M. E. B.; GIACHETTO, P. F.; HIGA, R. H.; PAIVA, S. R. Desenvolvimento de ferramentas genômicas para manejo e melhoramento genético de peixes nativos do Brasil. In. CONGRESSO BRASILEIRO DE RECURSOS GENÉTICOS, 3., 2014, Santos. Anais... Brasília, DF: Sociedade Brasileira de Recursos Genéticos, 2014. Resumo. 367. 1 CD-ROM.| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Recursos Genéticos e Biotecnologia. |
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| 67. | | ZERLOTINI NETO, A.; STAFUZZA, N. B.; LOBO, F. P.; YAMAGISHI, M. E. B.; CHUD, T. C. S.; CAETANO, A. R.; MUNARI, D. P.; GARRICK, D. J.; MACHADO, M. A.; MARTINS, M. F.; CARVALHO, M. R.; SILVA, M. V. G. B. Detection of potential genetic variants affecting gene function in Guzerat cattle. In: INTERNATIONAL CONFERENCE OF THE AB3C, 12., 2016, Belo Horizonte. Proceedings... [S.l.]: AB3C, 2016. p. 47. X-meeting 2016.| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 68. | | ZERLOTINI NETO, A.; STAFUZZA, N. B.; LOBO, F. P.; YAMAGISHI, M. E. B.; CHUD, T. C. S.; CAETANO, A. R.; MUNARI, D. P.; GARRICK, D. J.; MACHADO, M. A.; MARTINS, M. F.; CARVALHO, M. R.; SILVA, M. V. G. B. Detection of potential genetic variants affecting gene function in Guzerat cattle. In: INTERNATIONAL CONFERENCE OF THE AB3C, 12., 2016, Belo Horizonte. Proceedings... [S.l.]: AB3C, 2016. p. 47. X-meeting 2016.| Biblioteca(s): Embrapa Agricultura Digital. |
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| 69. | | CARRIERO, M. M.; HENRIQUE-SILVA, F.; CAETANO, A. R.; LOBO, F. P.; ALVES, A. L.; VARELA, E. S.; COLLADO, M. del; MOREIRA, G. S. A.; MAIA, A. A. M. Characterization and gene expression analysis of pacu (Piaractus mesopotamicus) inducible nitric oxide synthase (iNOS) following Aeromonas dhakensis infection. Fish and Shellfish Immunology, v. 74, p. 94-100, 2018. Short communication.| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pesca e Aquicultura; Embrapa Recursos Genéticos e Biotecnologia. |
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| 70. | | MENDES, T. A. de O.; LOBO, F. P.; RODRIGUES, T. S.; LUIZ, G. F. R.; ROCHA, W. D. da; FUJIWARA, R. T.; TEIXEIRA, S. M. R.; BARTHOLOMEU, D. C. Enrichment of repeats in proteins of protozoan parasites relates to the ability to invade host cells and evade host immune response. In: INTERNATIONAL CONFERENCE OF THE BRAZILIAN ASSOCIATION FOR BIOINFORMATICS AND COMPUTATIONAL BIOLOGY, 8., 2012, Campinas. Abstract book... Ribeirão Preto: AB3C, 2012. Não paginado. X-MEETING 2012.| Biblioteca(s): Embrapa Agricultura Digital. |
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| 71. | | LIMA, R. S.; LOBO, F. P.; CARAZZOLLE, M. F.; COSTA, G. G. L.; RODRIGUES, E. L. C.; ALVES, A. A.; YAMAGISHI, M. E. B.; SOUZA JUNIOR, M. T.; FORMIGHIERI, E. F. Elaeis oleifera genome draft: genomics of american oil palm. In: X-MEETING, 2012, Campinas, SP. [Anais?]. Brasilia, DF: CAPES: CNPq, 2012.| Biblioteca(s): Embrapa Agroenergia. |
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| 72. | | LIMA, R. S.; LOBO, F. P.; CARAZZOLLE, M. F.; COSTA, G. G. L.; RODRIGUES, E. L. de C.; ALVES, A. A.; YAMAGISHI, M. E. B.; SOUZA JUNIOR, M. T.; FORMIGHIERI, E. F. Elaeis oleifera genome draft - genomics of american oil palm. In: INTERNATIONAL CONFERENCE OF THE BRAZILIAN ASSOCIATION FOR BIOINFORMATICS AND COMPUTATIONAL BIOLOGY, 8., 2012, Campinas. Abstract book... Ribeirão Preto: AB3C, 2012. Não paginado. X-MEETING 2012.| Biblioteca(s): Embrapa Agricultura Digital. |
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| 73. | | NODA, R. W.; LAAT, D. M. de; GUIMARÃES, C. T.; SOUZA, T. C. de; DIAS, L. L. C.; LOBO, F. P.; MAGALHÃES, J. V. de; COIMBRA, R. S.; MAGALHÃES, P. C.; ZERLOTINI, A.; FRANCO, G. M.; CARNEIRO, N. P. GO enrichment of microarray data from maize root under drough. In: ANNUAL INTERNATIONAL CONFERENCE ON INTELLIGENT SYSTEMS FOR MOLECULAR BIOLOGY, 21.; EUROPEAN CONFERENCE ON COMPUTATIONAL BIOLOGY, 12., 2013, Berlin. Posters... Berlin: ISCB, 2013. Pôster F53.| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Milho e Sorgo. |
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| 74. | | CARRIERO, M. M.; HENRIQUE SILVA, F.; MEIRA, C. M.; GATO, I. M. Q.; CAETANO, A. R.; LOBO, F. P.; ALVES, A. L.; VARELA, E. S.; MAIA, A. A. M. Molecular characterization and gene expression analysis of the pro-inflammatory cytokines IL-1beta and IL-8 in the South American fish Piaractus mesopotamicus challenged with Aeromonas dhakensis. Genetics and Molecular Biology, v. 43, n. 4, e20200006, 2020.| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pesca e Aquicultura; Embrapa Recursos Genéticos e Biotecnologia. |
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| 75. | | BITAR, M.; DRUMMOND, M. G.; COSTA, M. G. S.; LOBO, F. P.; CALZAVARA-SILVA, C. E.; BISCH, P. M.; MACHADO, C. R.; MACEDO, A. M.; PIERCE, R. J.; FRANCO, G. R. Modeling the zing finger protein SmZF1 from Schistosoma mansoni: Insights into DNA binding and gene regulation. Journal of Molecular Graphics and Modelling, New York, v. 39, p. 29-38, 2013.| Biblioteca(s): Embrapa Agricultura Digital. |
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| 76. | | MURGA-ORRILLO, H.; ABANTO-RODRIGUEZ, C.; DIONISIO, L. F. S.; CHU-KOO, F. W.; SCHWARTZ, G.; BUSTAMANTE, E. N.; STEWART, P. M.; AMORIM, R. S. S.; VOURLITIS, G. L.; LOBO, F. de A.; BARDALES-LOZANO, R. M. Tara (Caesalpinia spinosa) in natural and agroforestry systems under an altitudinal gradient in the Peruvian Andes: responses to soil and climate variation. Agronomy, v. 13, n. 2, Article 282, 2023.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 77. | | CINTRA, L. C.; ZERLOTINI, A.; LOBO, F. P.; SILVA, F. R. da; GIACHETTO, P. F.; KUSER-FALCÃO, P. R. K.; SILVA, L. O. C. da; EGITO, A. A. do; SIQUEIRA, F.; SILVA, N. M. A. da; PAIVA, S. R.; YAMAGISHI, M. E. B.; CAETANO, A. R. De novo assembly of a Nelore (Bos indicus) bull genome based on short read sequences. In: PLANT & ANIMAL GENOME CONFERENCE, 22., 2014, San Diego, CA. [Abstracts]. San Diego: [s.n.], 2014. Não paginado. P554.| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 78. | | CINTRA, L. C.; ZERLOTINI, A.; LOBO, F. P.; SILVA, F. R. da; GIACHETTO, P. F.; KUSER-FALCÃO, P. R. K.; SILVA, L. O. C. da; EGITO, A. A. do; SIQUEIRA, F.; SILVA, N. M. A. da; PAIVA, S. R.; YAMAGISHI, M. E. B.; CAETANO, A. R. De novo assembly of a Nelore (Bos indicus) bull genome based on short read sequences. In: PLANT & ANIMAL GENOME CONFERENCE, 22., 2014, San Diego, CA. [Abstracts...]. San Diego: [s.n.], 2014. Não paginado. P554.| Biblioteca(s): Embrapa Agricultura Digital. |
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| 79. | | CINTRA, L. C.; ZERLOTINI NETO, A.; LOBO, F. P.; GIACHETTO, P. F.; FALCAO, P. R. K.; SILVA, L. O. C. da; EGITO, A. A. do; SIQUEIRA, F.; SILVA, N. M. A. da; PAIVA, S. R.; YAMAGISHI, M. E. B.; CAETANO, A. R. Next generation sequencing and de novo assembly of a Nelore (Bos indicus) bull genome. In: ANNUAL MEETING OF THE EUROPEAN FEDERATION OF ANIMAL SCIENCE, 64., 2013, Nantes. Abstracts... Session 25, Poster 34| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 80. | | CINTRA, L. C.; ZERLOTINI NETO, A.; LOBO, F. P.; GIACHETTO, P. F.; FALCAO, P. R. K.; SILVA, L. O. C. da; EGITO, A. A. do; SIQUEIRA, F.; SILVA, N. M. A. da; PAIVA, S. R.; YAMAGISHI, M. E. B.; CAETANO, A. R. Next generation sequencing and de novo assembly of a Nelore (Bos indicus) bull genome. In: ANNUAL MEETING OF THE EUROPEAN FEDERATION OF ANIMAL SCIENCE, 64., 2013, Nantes. Abstracts... Session 25, Poster 34| Biblioteca(s): Embrapa Gado de Corte. |
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| Registros recuperados : 91 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Agricultura Digital. |
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Data corrente: |
14/02/2013 |
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Data da última atualização: |
08/01/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
BITAR, M.; DRUMMOND, M. G.; COSTA, M. G. S.; LOBO, F. P.; CALZAVARA-SILVA, C. E.; BISCH, P. M.; MACHADO, C. R.; MACEDO, A. M.; PIERCE, R. J.; FRANCO, G. R. |
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Afiliação: |
MAINÁ BITAR, UFRJ, UFMG; MARCELA GONÇALVES DRUMMOND, UFMG, Univ. Lille Nord de France; MAURICIO GARCIA SOUZA COSTA, UFRJ; FRANCISCO PEREIRA LOBO, CNPTIA; CARLOS EDUARDO CALZAVARA-SILVA, Fiocruz; PAULO MASCARELLO BISCH, UFRJ; CARLOS RENATO MACHADO, UFMG; ANDRÉA MARA MACEDO, UFMG; RAYMOND J. PIERCE, Univ. Lille Nord de France; GLÓRIA REGINA FRANCO, UFMG. |
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Título: |
Modeling the zing finger protein SmZF1 from Schistosoma mansoni: Insights into DNA binding and gene regulation. |
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Ano de publicação: |
2013 |
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Fonte/Imprenta: |
Journal of Molecular Graphics and Modelling, New York, v. 39, p. 29-38, 2013. |
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Idioma: |
Inglês |
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Conteúdo: |
Zinc finger proteins are widely found in eukaryotes, representing an important class of DNA-binding proteins frequently involved in transcriptional regulation. Zinc finger motifs are composed by two antiparallel b-strands and one a-helix, stabilized by a zinc ion coordinated by conserved histidine and cysteine residues. In Schistosoma mansoni, these regulatory proteins are known to modulate morphological and physiological changes, having crucial roles in parasite development. A previously described C2H2 zinc finger protein, SmZF1, was shown to be present in cell nuclei of different life stages of S. mansoni and to activate gene transcription in a heterologous system. A high-quality SmZF1 tridimensional structure was generated using comparative modeling. Molecular dynamics simulations of the obtained structure revealed stability of the zinc fingers motifs and high flexibility on the terminals, comparable to the profile observed on the template X-ray structure based on thermal b-factors. Based on the protein tridimensional features and amino acid composition, we were able to characterize four C2 H2 zinc finger motifs, the first involved in protein?protein interactions while the three others involved in DNA binding. We defined a consensus DNA binding sequence using three distinct algorithms and further carried out docking calculations, which revealed the interaction of fingers 2?4 with the predicted DNA. A search for S. mansoni genes presenting putative SmZF1 binding sites revealed 415 genes hypothetically under SmZF1 control. Using an automatic annotation and GO assignment approach, we found that the majority of those genes code for proteins involved in developmental processes. Taken together, these results present a consistent base to the structural and functional characterization of SmZF1. MenosZinc finger proteins are widely found in eukaryotes, representing an important class of DNA-binding proteins frequently involved in transcriptional regulation. Zinc finger motifs are composed by two antiparallel b-strands and one a-helix, stabilized by a zinc ion coordinated by conserved histidine and cysteine residues. In Schistosoma mansoni, these regulatory proteins are known to modulate morphological and physiological changes, having crucial roles in parasite development. A previously described C2H2 zinc finger protein, SmZF1, was shown to be present in cell nuclei of different life stages of S. mansoni and to activate gene transcription in a heterologous system. A high-quality SmZF1 tridimensional structure was generated using comparative modeling. Molecular dynamics simulations of the obtained structure revealed stability of the zinc fingers motifs and high flexibility on the terminals, comparable to the profile observed on the template X-ray structure based on thermal b-factors. Based on the protein tridimensional features and amino acid composition, we were able to characterize four C2 H2 zinc finger motifs, the first involved in protein?protein interactions while the three others involved in DNA binding. We defined a consensus DNA binding sequence using three distinct algorithms and further carried out docking calculations, which revealed the interaction of fingers 2?4 with the predicted DNA. A search for S. mansoni genes presenting putative SmZF1 binding sites reve... Mostrar Tudo |
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Palavras-Chave: |
Ligação de DNA; Regulação gênica. |
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Thesagro: |
Schistosoma Mansoni. |
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Thesaurus NAL: |
DNA-binding proteins; Gene expression regulation; Zinc finger motif. |
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Categoria do assunto: |
-- |
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Marc: |
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100 1 $aBITAR, M.
245 $aModeling the zing finger protein SmZF1 from Schistosoma mansoni$bInsights into DNA binding and gene regulation.$h[electronic resource]
260 $c2013
520 $aZinc finger proteins are widely found in eukaryotes, representing an important class of DNA-binding proteins frequently involved in transcriptional regulation. Zinc finger motifs are composed by two antiparallel b-strands and one a-helix, stabilized by a zinc ion coordinated by conserved histidine and cysteine residues. In Schistosoma mansoni, these regulatory proteins are known to modulate morphological and physiological changes, having crucial roles in parasite development. A previously described C2H2 zinc finger protein, SmZF1, was shown to be present in cell nuclei of different life stages of S. mansoni and to activate gene transcription in a heterologous system. A high-quality SmZF1 tridimensional structure was generated using comparative modeling. Molecular dynamics simulations of the obtained structure revealed stability of the zinc fingers motifs and high flexibility on the terminals, comparable to the profile observed on the template X-ray structure based on thermal b-factors. Based on the protein tridimensional features and amino acid composition, we were able to characterize four C2 H2 zinc finger motifs, the first involved in protein?protein interactions while the three others involved in DNA binding. We defined a consensus DNA binding sequence using three distinct algorithms and further carried out docking calculations, which revealed the interaction of fingers 2?4 with the predicted DNA. A search for S. mansoni genes presenting putative SmZF1 binding sites revealed 415 genes hypothetically under SmZF1 control. Using an automatic annotation and GO assignment approach, we found that the majority of those genes code for proteins involved in developmental processes. Taken together, these results present a consistent base to the structural and functional characterization of SmZF1.
650 $aDNA-binding proteins
650 $aGene expression regulation
650 $aZinc finger motif
650 $aSchistosoma Mansoni
653 $aLigação de DNA
653 $aRegulação gênica
700 1 $aDRUMMOND, M. G.
700 1 $aCOSTA, M. G. S.
700 1 $aLOBO, F. P.
700 1 $aCALZAVARA-SILVA, C. E.
700 1 $aBISCH, P. M.
700 1 $aMACHADO, C. R.
700 1 $aMACEDO, A. M.
700 1 $aPIERCE, R. J.
700 1 $aFRANCO, G. R.
773 $tJournal of Molecular Graphics and Modelling, New York$gv. 39, p. 29-38, 2013.
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