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 | Acesso ao texto completo restrito à biblioteca da Embrapa Trigo. Para informações adicionais entre em contato com cnpt.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Trigo. |
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Data corrente: |
10/01/2010 |
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Data da última atualização: |
07/12/2012 |
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Autoria: |
PLIKAT, U.; VOSHOL, H.; DANGENDORF, Y.; WIEDMANN, B.; DEVAY, P.; MÜLLER, D.; WIRTH, U.; SZUSTAKOWSKI, J.; CHIM, GUNG-WEI.; INVERARDI, B.; PUYANG, X.; BROWN, K.; KAMP, H.; HOVING, S.; RUCHTI, A.; BRENDLEN, N.; PETERSON, R.; BUCO, J.; OOSTRUM, J. van; PEITSCH, M. C. |
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Título: |
From proteomics to systems biology of bacterial pathogens: approaches, tools, and applications. |
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Ano de publicação: |
2007 |
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Fonte/Imprenta: |
Proteomics, v. 7, n. 6, p. 992-1003, 2007. |
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Idioma: |
Inglês |
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Conteúdo: |
The hallmark of a systems biology approach is the integration of computational tools with experimental data encompassing multiple classes of biomolecules across different functional levels. Equally important as the availability of reasonably comprehensive information at the gene, protein, and metabolite levels is the development of adequate analysis and visualization tools to reduce the inherent complexity to interpretable dimensions. In this paper, we describe the integration of a 2-D gel-based proteome map of Staphylococcus aureus Mu50 with genomic and transcriptomic information through a customized data integration and user interface built on the Ensembl genome browser. We illustrate its application and potential through the analysis of a defined system perturbation caused by a mutation in the formyltransferase gene. We envision that this software package, which we called Insieme, can support the development of novel antibiotics by allowing a systems-based view of the bacterial response pathways. |
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Palavras-Chave: |
Aplicação; Proteômica. |
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Thesagro: |
Ferramenta. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01995naa a2200385 a 4500
001 1840963
005 2012-12-07
008 2007 bl --- 0-- u #d
100 1 $aPLIKAT, U.
245 $aFrom proteomics to systems biology of bacterial pathogens$bapproaches, tools, and applications.
260 $c2007
520 $aThe hallmark of a systems biology approach is the integration of computational tools with experimental data encompassing multiple classes of biomolecules across different functional levels. Equally important as the availability of reasonably comprehensive information at the gene, protein, and metabolite levels is the development of adequate analysis and visualization tools to reduce the inherent complexity to interpretable dimensions. In this paper, we describe the integration of a 2-D gel-based proteome map of Staphylococcus aureus Mu50 with genomic and transcriptomic information through a customized data integration and user interface built on the Ensembl genome browser. We illustrate its application and potential through the analysis of a defined system perturbation caused by a mutation in the formyltransferase gene. We envision that this software package, which we called Insieme, can support the development of novel antibiotics by allowing a systems-based view of the bacterial response pathways.
650 $aFerramenta
653 $aAplicação
653 $aProteômica
700 1 $aVOSHOL, H.
700 1 $aDANGENDORF, Y.
700 1 $aWIEDMANN, B.
700 1 $aDEVAY, P.
700 1 $aMÜLLER, D.
700 1 $aWIRTH, U.
700 1 $aSZUSTAKOWSKI, J.
700 1 $aCHIM, GUNG-WEI.
700 1 $aINVERARDI, B.
700 1 $aPUYANG, X.
700 1 $aBROWN, K.
700 1 $aKAMP, H.
700 1 $aHOVING, S.
700 1 $aRUCHTI, A.
700 1 $aBRENDLEN, N.
700 1 $aPETERSON, R.
700 1 $aBUCO, J.
700 1 $aOOSTRUM, J. van
700 1 $aPEITSCH, M. C.
773 $tProteomics$gv. 7, n. 6, p. 992-1003, 2007.
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| 1. |  | RAMOS, J. H. B.; LINS, D. da S.; FURTADO, R. N.; DANTAS, A. R.; LIRA-GUEDES, A. C. Biometria de frutos de urucurizeiro de floresta de várzea do estuário amazônico. In: JORNADA CIENTÍFICA DA EMBRAPA AMAPÁ, 7., 2021, Macapá. Transversalidade da ciência, tecnologia e inovações para o planeta: resumos. Macapá: Embrapa Amapá, 2022. p. 25-26. Editoras técnicas: Cristiane Ramos de Jesus, Ana Cláudia Lira-Guedes e Adelina do Socorro Serrão Belém. ODS-15.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Amapá. |
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