Data/hora: 04/06/2024 09:12:13

Biblioteca(s): 	Embrapa Amazônia Oriental.	
Data corrente: 	18/05/2020	
Data da última atualização: 	18/05/2020	
Autoria: 	ALVARENGA, M. O. P.; BITTENCOURT, L. O.; MENDES, P. F. S.; RIBEIRA, J. T.; LAMEIRA, O. A.; MONTEIRO, M. C.; BARBOZA, C. A. G.; MARTINS, M. D.; LIMA, R. R.	
Afiliação: 	María Olimpia Paz Alvarenga, UFPA; Leonardo Oliveira Bittencourt, UFPA; Paulo Fernando Santos Mendes, UFPA; Julia Turra Ribeiro, UFRGS; OSMAR ALVES LAMEIRA, CPATU; Marta Chagas Monteiro, UFPA; Carlos Augusto Galvão Barboza, UFRGS; Manoela Domingues Martins, UFRGS; Rafael Rodrigues Lima, UFPA.	
Título: 	Safety and effectiveness of Copaiba Oleoresin (C. reticulata Ducke) on inflammation and tissue repair of oral wounds in rats.	
Ano de publicação: 	2020	
Fonte/Imprenta: 	International Journal of Molecular Science, v. 21, n. 10, article 3568, 2020.	
DOI: 	https://doi.org/10.3390/ijms21103568	
Idioma: 	Inglês	
Conteúdo: 	In traditional communities of the Brazilian Amazon, the copaiba oleoresin (C. reticulata Ducke) is widely known for its therapeutic activity, especially its wound healing and anti-inflammatory actions. Our study aimed to evaluate these effects in oral lesions and the safety of the dosage proposed. A punch biopsy wound was induced on the ventral surface of the tongue of forty-five male Wistar rats under anesthesia. Animals were randomly allocated to one of three groups based on the treatment: control, corticoid and copaiba. A daily dose of each treatment and vehicle was administrated by oral gavage for three consecutive days. Sample collections took place on the third, seventh and 15th days post-wounding for clinical and histopathological analyses. Blood was collected on the third and seventh days for kidneys and liver function tests. Semi-quantitative analyses were performed based on scores of inflammation and reepithelization. Tissue collagen deposition was detected by PicroSirius red staining. Copaiba-treated wounds revealed a smaller wound area, decreased of acute inflammatory reaction and enhanced reepithelization. The levels of kidney and liver function tests did not reveal presence of damage post-treatments. Our findings suggest that copaiba oleoresin is a safe and effective alternative therapy for inflammation and tissue repair of oral wounds in this animal model.	
Thesagro: 	Antiinflamatório; Cicatrização; Copaíba; Oleorresina; Terapia.	
Categoria do assunto: 	F Plantas e Produtos de Origem Vegetal	
URL: 	http://ainfo.cnptia.embrapa.br/digital/bitstream/item/213059/1/ijms-21-03568.pdf	
Registro original: 	Embrapa Amazônia Oriental (CPATU)	
Exemplares: 	CPATU - (56363-1) - UPC - AP - DD -  -  -  - DIS