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Registros recuperados : 4 | |
2. | | OLIVEIRA, C. E.; LIMA, L. R. de; OLIVEIRA, G. R. A. de; GONÇALVES, A. B.; PISTORI, H.; KOLLER, W. W. Computer vision for larval structures identification applied to forensic science. In: WORKSHOP DE VISÃO COMPUTACIONAL WVC'2016, 12., 2016. Campo Grande, MS. Proceedings... Campo Grande: UCDB/UFMS/UFGD, p. 266-270, nov. 2016. Biblioteca(s): Embrapa Gado de Corte. |
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3. | | FREITAS, H. S.; ALCALDE, C. R.; LIMA, L. S. de; ZEOULA, L. M.; COSTA, L. S. E. da; LIMA, L. R. de. Digestibilidade total e balanço de nitrogênio em cabritos recebendo rações contendo levedura seca. Acta Scientiarum. Animal Sciences Maringá, v. 33, n. 3, p. 281-286, 2011. Biblioteca(s): Embrapa Caprinos e Ovinos. |
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4. | | LIMA, L. R. de; MENDES, H. M. F.; SORIANI, F. M.; SOUZA, D. G. de; ALVES, G. E. S.; TEIXEIRA, M. M.; FALEIROS, R. R. Histologic and inflammatory lamellar changes in horses with oligofructose-induced laminitis treated with a CXCR1/2 antagnist. Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 36, n. 1, p. 13-18, jan. 2016. Biblioteca(s): Embrapa Unidades Centrais. |
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Registros recuperados : 4 | |
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Registro Completo
Biblioteca(s): |
Embrapa Unidades Centrais. |
Data corrente: |
01/04/2016 |
Data da última atualização: |
29/12/2017 |
Autoria: |
LIMA, L. R. de; MENDES, H. M. F.; SORIANI, F. M.; SOUZA, D. G. de; ALVES, G. E. S.; TEIXEIRA, M. M.; FALEIROS, R. R. |
Afiliação: |
LEONARDO R. DE LIMA, UFMG; HELOISA M. F. MENDES, UFMG; FREDERICO M. SORIANI, IBC/UFMG; DANIELLE G. DE SOUZA, ICB/UFMG; GERALDO ELENO S. ALVES, UFMG; MAURO M. TEIXEIRA, ICB/UFMG; RAFAEL R. FALEIROS, UFMG. |
Título: |
Histologic and inflammatory lamellar changes in horses with oligofructose-induced laminitis treated with a CXCR1/2 antagnist. |
Ano de publicação: |
2016 |
Fonte/Imprenta: |
Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 36, n. 1, p. 13-18, jan. 2016. |
Idioma: |
Inglês |
Conteúdo: |
With the hypothesis that blocking chemokine signaling can ameliorate acute laminitis, the aim was to evaluate the therapeutic effect of intravenous DF1681B, a selective antagonist for CXCR1 and CXCR2 (chemokine receptors), in an oligofructose equine laminitis model. To twelve mixed breed clinically healthy hoses with no previous history of hoof-related lameness was administered oligofructose (10g/kg given by nasogastric tube) and divided into two groups: treated (intravenous DF1681B at 30mg/kg 6, 12, 18, and 24h after oligofructose) and non-treated groups. Laminar biopsies were performed before and 12, 36, and 72h after administering oligofructose. Samples were stained with periodic acid-Schiff (PAS) and scored from 0 to 6 according to epidermal cell and basal membrane changes. The IL-1β, IL-6, and CXCL1 RNA expressions were determined by RT-PCR. Parametric and non-parametric tests were used to compare times within each group (P<0.05). The PAS grades and IL-1β and IL-6 RNA expression increased in the non-treated group, but remained constant in the treated horses. In conclusion, DF1681B therapy reduced laminar inflammation and epidermal deterioration in treated horses. CXCR1/2 blockage should be considered therapeutically for equine acute laminitis. |
Palavras-Chave: |
CXC receptors; Laminite; Neutrófilo; Quimiocina; Receptores CXC. |
Thesaurus NAL: |
Chemokines; Horses; Laminitis; Neutrophils. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/141897/1/Histologic-and-inflamatory-lamellar.pdf
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Marc: |
LEADER 02150naa a2200301 a 4500 001 2042319 005 2017-12-29 008 2016 bl uuuu u00u1 u #d 100 1 $aLIMA, L. R. de 245 $aHistologic and inflammatory lamellar changes in horses with oligofructose-induced laminitis treated with a CXCR1/2 antagnist. 260 $c2016 520 $aWith the hypothesis that blocking chemokine signaling can ameliorate acute laminitis, the aim was to evaluate the therapeutic effect of intravenous DF1681B, a selective antagonist for CXCR1 and CXCR2 (chemokine receptors), in an oligofructose equine laminitis model. To twelve mixed breed clinically healthy hoses with no previous history of hoof-related lameness was administered oligofructose (10g/kg given by nasogastric tube) and divided into two groups: treated (intravenous DF1681B at 30mg/kg 6, 12, 18, and 24h after oligofructose) and non-treated groups. Laminar biopsies were performed before and 12, 36, and 72h after administering oligofructose. Samples were stained with periodic acid-Schiff (PAS) and scored from 0 to 6 according to epidermal cell and basal membrane changes. The IL-1β, IL-6, and CXCL1 RNA expressions were determined by RT-PCR. Parametric and non-parametric tests were used to compare times within each group (P<0.05). The PAS grades and IL-1β and IL-6 RNA expression increased in the non-treated group, but remained constant in the treated horses. In conclusion, DF1681B therapy reduced laminar inflammation and epidermal deterioration in treated horses. CXCR1/2 blockage should be considered therapeutically for equine acute laminitis. 650 $aChemokines 650 $aHorses 650 $aLaminitis 650 $aNeutrophils 653 $aCXC receptors 653 $aLaminite 653 $aNeutrófilo 653 $aQuimiocina 653 $aReceptores CXC 700 1 $aMENDES, H. M. F. 700 1 $aSORIANI, F. M. 700 1 $aSOUZA, D. G. de 700 1 $aALVES, G. E. S. 700 1 $aTEIXEIRA, M. M. 700 1 $aFALEIROS, R. R. 773 $tPesquisa Veterinária Brasileira, Rio de Janeiro$gv. 36, n. 1, p. 13-18, jan. 2016.
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