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Registro Completo
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Biblioteca(s): |
Embrapa Florestas. |
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Data corrente: |
28/08/2019 |
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Data da última atualização: |
03/10/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
LIMA, G. G. de; ELTER, J. K.; CHEE, B. S.; MAGALHAES, W. L. E.; DEVINE, D. M.; NUGENT, M. J. D.; SÁ, M. J. C. de. |
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Afiliação: |
Gabriel Goetten de Lima, Materials Research Institute, Athlone Institute of Technology; Johanna Katrin Elter, Materials Research Institute, Athlone Institute of Technology; Bor Shin Chee, Materials Research Institute, Athlone Institute of Technology; WASHINGTON LUIZ ESTEVES MAGALHAES, CNPF; Declan M. Devine, Materials Research Institute, Athlone Institute of Technology; Michael J. D. Nugent, Materials Research Institute, Athlone Institute of Technology; Marcelo J. C. de Sá, Materials Research Institute, Athlone Institute of Technology. |
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Título: |
A tough and novel dual-response PAA/P(NiPAAM-co-PEGDMA) IPN hydrogels with ceramics by photopolymerization for consolidation of bone fragments following fracture. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Biomedical Materials, v. 14, n. 5, Sept. 2019. 14 p. |
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DOI: |
10.1088/1748-605X/ab2fa3 |
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Idioma: |
Inglês |
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Conteúdo: |
In this work, a novel dual-response hydrogel for enhanced bone repair following multiple fractures was investigated. The conventional treatment of multiple bone fracture consists on removing smaller bone fragments from the body in a surgery, followed by the fixation of the bone using screws and plates. This work proposes an alternative for this treatment via in situ UV-initiated radical polymerization of a novel IPN hydrogel composed of PAA/P(NiPAAM-co-PEGDMA)incorporated with ceramic additives. The influence of different additives on mechanical properties and sensitivity of the polymer, as well as the prepolymer mixture, were investigated in order to analyse the suitability of the composites for bone healing applications. This material exhibited an interpenetrating network, confirmed by FTIR, with ceramics particles dispersed in between the polymer network. These structures presented high strength by tensile tests, sensitivity to pH and temperature and a decrease on Tg values of NiPAAm depending on the amount of PEGDMA and ceramics added; although, the addition of ceramics to these composites did not decrease their stability drastically. Finally, cytotoxicity tests revealed variations on the toxicity, whereas the addition of TCP presented to be nontoxic and that the cell viability increased when ceramics additives were incorporated into the polymeric matrix with an increased reporter activity of NF-κB, associated with aiding fibroblast adhesion. Hence, it was possible to optimise feedstock ratios to increase the applicability of the prepolymer mixture as a potential treatment of multiple fractures. MenosIn this work, a novel dual-response hydrogel for enhanced bone repair following multiple fractures was investigated. The conventional treatment of multiple bone fracture consists on removing smaller bone fragments from the body in a surgery, followed by the fixation of the bone using screws and plates. This work proposes an alternative for this treatment via in situ UV-initiated radical polymerization of a novel IPN hydrogel composed of PAA/P(NiPAAM-co-PEGDMA)incorporated with ceramic additives. The influence of different additives on mechanical properties and sensitivity of the polymer, as well as the prepolymer mixture, were investigated in order to analyse the suitability of the composites for bone healing applications. This material exhibited an interpenetrating network, confirmed by FTIR, with ceramics particles dispersed in between the polymer network. These structures presented high strength by tensile tests, sensitivity to pH and temperature and a decrease on Tg values of NiPAAm depending on the amount of PEGDMA and ceramics added; although, the addition of ceramics to these composites did not decrease their stability drastically. Finally, cytotoxicity tests revealed variations on the toxicity, whereas the addition of TCP presented to be nontoxic and that the cell viability increased when ceramics additives were incorporated into the polymeric matrix with an increased reporter activity of NF-κB, associated with aiding fibroblast adhesion. Hence, it was possible ... Mostrar Tudo |
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Palavras-Chave: |
Composite biomaterials; Multiple bone fragment surgery; Trauma. |
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Thesagro: |
Fratura; Osso. |
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Thesaurus NAL: |
Bone fractures. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
LEADER 02513naa a2200277 a 4500
001 2111696
005 2019-10-03
008 2019 bl uuuu u00u1 u #d
024 7 $a10.1088/1748-605X/ab2fa3$2DOI
100 1 $aLIMA, G. G. de
245 $aA tough and novel dual-response PAA/P(NiPAAM-co-PEGDMA) IPN hydrogels with ceramics by photopolymerization for consolidation of bone fragments following fracture.$h[electronic resource]
260 $c2019
520 $aIn this work, a novel dual-response hydrogel for enhanced bone repair following multiple fractures was investigated. The conventional treatment of multiple bone fracture consists on removing smaller bone fragments from the body in a surgery, followed by the fixation of the bone using screws and plates. This work proposes an alternative for this treatment via in situ UV-initiated radical polymerization of a novel IPN hydrogel composed of PAA/P(NiPAAM-co-PEGDMA)incorporated with ceramic additives. The influence of different additives on mechanical properties and sensitivity of the polymer, as well as the prepolymer mixture, were investigated in order to analyse the suitability of the composites for bone healing applications. This material exhibited an interpenetrating network, confirmed by FTIR, with ceramics particles dispersed in between the polymer network. These structures presented high strength by tensile tests, sensitivity to pH and temperature and a decrease on Tg values of NiPAAm depending on the amount of PEGDMA and ceramics added; although, the addition of ceramics to these composites did not decrease their stability drastically. Finally, cytotoxicity tests revealed variations on the toxicity, whereas the addition of TCP presented to be nontoxic and that the cell viability increased when ceramics additives were incorporated into the polymeric matrix with an increased reporter activity of NF-κB, associated with aiding fibroblast adhesion. Hence, it was possible to optimise feedstock ratios to increase the applicability of the prepolymer mixture as a potential treatment of multiple fractures.
650 $aBone fractures
650 $aFratura
650 $aOsso
653 $aComposite biomaterials
653 $aMultiple bone fragment surgery
653 $aTrauma
700 1 $aELTER, J. K.
700 1 $aCHEE, B. S.
700 1 $aMAGALHAES, W. L. E.
700 1 $aDEVINE, D. M.
700 1 $aNUGENT, M. J. D.
700 1 $aSÁ, M. J. C. de
773 $tBiomedical Materials$gv. 14, n. 5, Sept. 2019. 14 p.
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